Fermented Stevia extract as cure for pancreatic cancer possible, Japanese scientists make a breakthrough using sugar substitute
fermented stevia leaf extract
possesses potent
anti-cancer properties
specifically targeting
pancreatic cancer
cells while sparing healthy cells. This discovery offers new hope against pancreatic cancer, one of the most aggressive and deadly cancers with a notoriously low five-year survival rate of less than 10%.
Stevia leaves come from the Stevia rebaudiana plant and have been used for centuries as a
natural sweetener
. The leaves contain compounds called steviol glycosides, which are intensely sweet—many times sweeter than sugar—but have zero calories. Because of this, stevia leaf extract is widely used as a sugar substitute in foods and beverages to provide sweetness without adding calories or affecting blood sugar levels.
Productivity Tool
Zero to Hero in Microsoft Excel: Complete Excel guide
By Metla Sudha Sekhar
View Program
Finance
Introduction to Technical Analysis & Candlestick Theory
By Dinesh Nagpal
View Program
Finance
Financial Literacy i e Lets Crack the Billionaire Code
By CA Rahul Gupta
View Program
Digital Marketing
Digital Marketing Masterclass by Neil Patel
By Neil Patel
View Program
Finance
Technical Analysis Demystified- A Complete Guide to Trading
By Kunal Patel
View Program
Productivity Tool
Excel Essentials to Expert: Your Complete Guide
By Study at home
View Program
Artificial Intelligence
AI For Business Professionals Batch 2
By Ansh Mehra
View Program
The study, recently published in the
International Journal of Molecular Sciences
, highlights that when stevia leaf extract is fermented using a natural, plant-based good bacterium called
Lactobacillus plantarum SN13T
, the extract becomes much more powerful in its effects. During this fermentation process, the bacteria change some of the original chemicals found in stevia into new active compounds.
by Taboola
by Taboola
Sponsored Links
Sponsored Links
Promoted Links
Promoted Links
You May Like
Villas For Sale in Dubai Might Surprise You
Dubai villas | search ads
Get Deals
Undo
One of these newly formed compounds is called
chlorogenic acid methyl ester
(CAME). In lab experiments, this compound was found to be especially effective at killing a type of pancreatic cancer cell called PANC-1, without harming other cells. This means fermenting stevia could potentially help develop better treatments against certain cancers.
This microbial transformation results in a sixfold decrease of chlorogenic acid itself while yielding this more potent anticancer agent.
Live Events
Key experimental findings include:
The fermented stevia leaf extract was much better at killing pancreatic cancer cells compared to the regular (non-fermented) extract, even when used in the same amount.
It didn't harm healthy kidney cells much, which means it might be safer to use.
The key substance made during fermentation, called CAME, helps cancer cells to self-destruct (this is called programmed cell death). It also stops cancer cells from growing and multiplying by affecting how their internal processes and genes work.
CAME turns on certain genes that encourage cancer cells to die and turns off genes that help cancer cells survive.
The extract also prevented cancer cells from moving around and forming new groups, which is important because that's how cancer spreads to other parts of the body.
Pancreatic cancer's resistance to conventional treatments like surgery, chemotherapy, and radiation underscores the urgent need for novel therapeutic approaches. According to Narandalai Danshiitsoodol, associate professor and co-author, the fermented stevia compounds could potentially offer a new avenue for treating this disease because of their targeted effects and low toxicity.
Medical experts caution that while laboratory results are extremely promising, these effects have yet to be confirmed in animal models or human clinical trials. Dr. Paul E. Oberstein, medical oncologist at NYU Langone Perlmutter Cancer Center, emphasized that fermentation enhances the plant extract's potency but urged cautious optimism pending further research.
This discovery aligns with a growing scientific interest in utilizing microbial biotransformation and natural plant extracts as adjunct treatments in oncology. Fermentation not only enhances the antioxidant properties of stevia but also unlocks rare metabolites with potent biological activities.
While more development and comprehensive testing are required, fermented stevia extract stands out as a promising candidate in the search for safer, more effective treatments against pancreatic cancer, offering potential to improve outcomes for patients currently facing limited options.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Time of India
an hour ago
- Time of India
Exercise does not help lose weight, says award-winning epidemiologist
There are infinite workout regimes on the internet that claim to help you lose weight. But what if we tell you that none of them work? From fitness gurus to wellness experts, until now, you must have heard people raving about how exercise can help you lose weight. However, Tim Spector, an award-winning British epidemiologist and expert on gut health, diet, and microbiomes, challenges that idea. Yes, you read it right. According to him, no data proves that exercise can help you lose weight. Exercise and weight loss 'Long-term studies show it doesn't help weight loss and it's been grossly exaggerated as an easy fix for our obesity problem,' Tim Spector says. So, exercise cannot help in weight loss? 'No, all the studies show that,' he shared in a podcast with Steve Bartlett. Spector explains that exercise will work only in preventing weight gain. 'The only caveat to that is if you have changed your diet, improved your diet, and you've lost some weight, maintaining some exercise does help prevent it going back up again,' he says. Fitness gurus are lying if they advise eating anything you want and only focusing on the workout. 'I think that's a huge myth, particularly perpetuated by gyms and fitness apps and everything else. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Learn More - How Watching Videos Can Boost Your Income TheDaddest And it is complete nonsense.' Significance of diet One of the most significant factors that helps weight loss is diet; however, it is often overlooked. 'But as on its own, if you don't change your diet, it's of no use. And that's well known now by all the obesity experts and all the studies,' Spector said. A nutritious and balanced diet rich in vegetables, fruits, and whole grains are crucial for fueling the body and also for weight loss. Calorie deficit is another significant factor that has been shown to help reduce weight. Exercise alone won't give you weight loss. No more guesswork: Doctor busts common myths about women's health Is sugar the culprit Sugar is often referred to as the villain when it comes to weight loss. When Spector was asked if sugar contributes to weight gain, he added, 'No, again, that's reductionism.' He also explained why exercise alone won't give you any results, in terms of weight loss: 'When you go for a walk, you build up hunger before a meal. That's what your parents told you. And everything about exercise is after it, your body slows down, your metabolism slows down, and it tries to regain the energy that you've lost. That's just our evolution. It's great for your health. I exercise, fantastic for your mood. It's great for your heart, anti-cancer, and all kinds of things. We should all do it. But absolutely not if your goal is weight loss .' If you are wondering what to do to shed a few pounds, Spector suggests, 'You have to do something about changing your diet.'
Time of India
an hour ago
- Time of India
US Immigrant Visa: A quick guide concerning vaccination requirements
Did you know that immigrant visa applicants are required to obtain certain vaccinations prior to the issuance of an immigrant visa? Yes, this is in accordance with the US Immigration Law. The applicants will need to meet certain requirements in terms of proof of vaccinations. As part of the medical examination process for immigrant visa applicants, US immigration law mandates that individuals receive a list of specific vaccines, unless it's determined by a physician that one or more of them are medically inappropriate for you. For more clarity and details, visit: Vaccination requirements . Why vaccines are required The goal of this vaccination requirement is to help protect public health in the United States. Vaccines help prevent the spread of communicable diseases, especially in a global movement of people. To ensure compliance, panel physicians, the authorised doctors who perform immigration medical exams, are tasked with verifying that each applicant has received the required vaccinations. According to current US immigration policy, the following vaccinations are among those that may be required: Hepatitis A and B Influenza Influenza type b (Hib) Measles Meningococcal Mumps Pneumococcal Pertussis Polio Rotavirus Rubella Tetanus and Diphtheria Toxoids Varicella (Chickenpox) The specific vaccines you'll need depend on factors such as your age, medical history, current health condition, and vaccination records. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Emergency Generators in Arismar: (Prices May Surprise You) Emergency Generator | Search Ads Search Now Undo Read more: Which country has the most leopards? A look at global numbers What you should bring to the medical examination To avoid unnecessary delays, all immigrant visa applicants are advised to bring their complete vaccination records when attending the medical examination. If you're not sure where to find your immunisation history, start by contacting your regular healthcare provider. If you don't have a vaccination record, don't worry, the panel physician will work with you to determine which vaccines you may still need and whether any exemptions apply. For example, in some cases, a medical waiver may be issued if a vaccine is not considered appropriate for you. Who decides what's medically appropriate? Only the panel physician assigned to your case can decide whether any vaccine is medically suitable for you or whether it may be skipped. This determination is based on US guidelines and public health standards, as well as your individual medical circumstances. Read more: Top 9 Countries with the Cleanest Air in the World (WHO 2025 Report) For more information For more details, including technical vaccination guidelines used by panel physicians, applicants are encouraged to refer to the Centers for Disease Control and Prevention (CDC) website and review the Panel Physician Technical Instructions for Vaccination.
Time of India
2 hours ago
- Time of India
NASA's Perseverance rover delivers high-resolution Mars panorama from Jezero Crater rim
NASA's Perseverance rover has produced a high-resolution panorama from a location called 'Falbreen' on the rim of Jezero Crater . The mosaic, assembled from 96 images taken by the Mastcam-Z instrument on May 26, 2025, the mission's 1,516th Martian day, or sol, offers one of the clearest views recorded so far. The enhanced-color version of the image shows the Martian sky with a blue tint, while the natural-color version reveals its typical reddish hue. 'Our bold push for human space exploration will send astronauts back to the Moon,' said Sean Duffy, acting NASA administrator. 'Stunning vistas like that of Falbreen, captured by our Perseverance rover, are just a glimpse of what we'll soon witness with our own eyes. NASA's groundbreaking missions, starting with Artemis, will propel our unstoppable journey to take human space exploration to the Martian surface.' Productivity Tool Zero to Hero in Microsoft Excel: Complete Excel guide By Metla Sudha Sekhar View Program Finance Introduction to Technical Analysis & Candlestick Theory By Dinesh Nagpal View Program Finance Financial Literacy i e Lets Crack the Billionaire Code By CA Rahul Gupta View Program Digital Marketing Digital Marketing Masterclass by Neil Patel By Neil Patel View Program Finance Technical Analysis Demystified- A Complete Guide to Trading By Kunal Patel View Program Productivity Tool Excel Essentials to Expert: Your Complete Guide By Study at home View Program Artificial Intelligence AI For Business Professionals Batch 2 By Ansh Mehra View Program In this natural-color version of the 'Falbreen' panorama, colors have not been enhanced and the sky appears more reddish. Visible still is Perseverance's 43rd rock abrasion (the white patch at center-left). The 96 images stitched together to create this 360-degree view were acquired May 26, 2025. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Undo Also read: Trump orders NASA to kill 2 satellites that can function for many more years - the reason will shock all Jim Bell, principal investigator for Mastcam-Z at Arizona State University, noted that relatively dust-free skies gave a clear view of surrounding terrain. Enhanced color contrast was applied to highlight differences between the terrain and sky. Live Events Geologic features include float rock and boundary line The panorama features a large rock situated atop a dark, crescent-shaped sand ripple about 14 feet (4.4 meters) from the rover. Known as a 'float rock,' it likely originated elsewhere and was transported to its current location, possibly before the sand ripple formed. Another notable element is an abrasion patch near the image's center, marking the 43rd rock Perseverance has abraded. The patch, two inches (5 centimeters) wide, allows scientists to study the unweathered interior of a rock before deciding to extract a core sample. The abrasion was made on May 22, followed by proximity science observations on May 24. Tracks from the rover's path to Falbreen are visible along the mosaic's right edge, curving left toward a prior research site called 'Kenmore.' Midway through the panorama, lighter-toned olivine-rich rocks transition to darker, clay-bearing rocks that are believed to be much older. NASA's Jet Propulsion Laboratory, managed by Caltech, operates Perseverance for NASA's Science Mission Directorate as part of the Mars Exploration Program. Arizona State University leads Mastcam-Z operations in collaboration with Malin Space Science Systems.
