EnPlusOne Biosciences To Present New Data at TIDES USA
WATERTOWN, Mass.--(BUSINESS WIRE)--EnPlusOne Biosciences, Inc., a biotechnology company pioneering enzymatic solutions for RNA manufacturing, will present new data from its proprietary ezRNA™ platform at TIDES USA, the leading conference focused on oligonucleotide and peptide therapeutics, taking place May 19-22 in San Diego at the Manchester Grand Hyatt.
'Our enzymatic approach removes long-standing barriers in RNA manufacturing that center around the use and disposal of hazardous organic solvents,' said Mr. Ahlstedt. 'We're excited to show the industry what scalable enzymatic synthesis looks like."
Share
In a featured talk titled 'Solving the Scale Problem: Template-independent Enzymatic Synthesis of siRNA Oligonucleotides,' EnPlusOne's Chief Operating Officer and co-founder Dan Ahlstedt will share recent advances in the company's aqueous-based, template-free RNA synthesis technology. The presentation will highlight the platform's ability to synthesize complex and fully-modified siRNA while offering the benefits of improved scalability, cost, and sustainability compared with traditional phosphoramidite chemistry.
'Our enzymatic approach removes long-standing barriers in RNA manufacturing that center around the use and disposal of hazardous organic solvents,' said Mr. Ahlstedt. 'We're excited to show the industry what scalable enzymatic synthesis looks like in practice and how it opens the door for broader therapeutic applications.'
The presentation will also preview a new independent facility cost comparison study revealing that EnPlusOne's enzymatic process can reduce capital expenditures by at least 20% versus traditional RNA synthetic methods, while achieving comparable throughput and significantly reducing solvent and hazardous waste generation.
This presentation builds on recent momentum for EnPlusOne, including the appointment of Clare Murray, PhD, as CEO to lead the company's commercialization strategy, and a recent $10 million financing round aimed at expanding strategic partnerships and scaling up synthesis capabilities. Dr. Murray and Mr. Ahlstedt will be onsite at TIDES USA to meet with current and prospective partners.
About EnPlusOne Biosciences
EnPlusOne is enabling the future of RNA therapeutics. Its ezRNA™ platform is a next-generation enzymatic synthesis technology that leverages water-based, template-free reactions to manufacture high-quality RNA at scale. Capable of incorporating a wide range of natural and modified nucleotides, ezRNA™ is designed to meet the evolving needs of RNA therapeutic developers. Learn more at https://www.enplusonebio.com/.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Business Wire
13 minutes ago
- Business Wire
Caring Together: Carefull to Partner with the Alzheimer's Association to Protect Families
NEW YORK--(BUSINESS WIRE)-- Carefull, the first financial safety platform built specifically for older adults and their families, is proud to support the Alzheimer's Association in raising awareness of the financial warning signs of cognitive decline and equipping families with tools to take early, protective action to prevent fraud and mistakes. Carefull is proud to support the care, services and research initiatives of the Alzheimer's Association. The Alzheimer's Association will provide information and resources aimed at helping families affected by dementia navigate financial challenges on Carefull's website. "Alzheimer's disease comes with a daily financial reality for families, and we are beyond proud to be working with the Alzheimer's Association to ensure financial safety is part of the cognitive health conversation" Share Designed to detect early behavioral signals and safeguard day-to-day finances, Carefull offers both a window into the early stages of cognitive change and a system to help preserve the financial independence and wellbeing of those affected. Carefull partners with financial institutions nationwide to bring these protections directly to the families they serve. Each year, more than 900,000 Americans develop Alzheimer's disease, with 7.2 million people aged 65 and older currently living with the condition. Behind each diagnosis is a network of loved ones offering critical support— nearly 12 million unpaid caregivers in the U.S. provide more than 19 billion hours of care annually for individuals with Alzheimer's or other dementias. 'We're committed to working with organizations that share our mission to protect and support older adults and their families. This effort is about helping families see what's happening sooner and act with confidence,' said Todd Rovak, Co-Founder of Carefull. 'Alzheimer's disease comes with a daily financial reality for families, and we are beyond proud to be working with the Alzheimer's Association to ensure financial safety is part of the cognitive health conversation.' Growing evidence shows that financial missteps—like missed bill payments, rising credit card debt, or unusual generosity—can signal early cognitive decline, including Alzheimer's. Research from institutions such as Johns Hopkins, Georgetown, and the National Institute on Aging suggests these behaviors may surface up to six years before a clinical diagnosis. Identifying these financial warning signs offers a powerful opportunity for early intervention and support. Carefull turns this insight into action, offering families and caregivers proactive tools that can detect behavioral changes in financial activity. Through real-time alerts, Carefull ScamCheck, trusted contact infrastructure, and an expert and empathetic care team, Carefull provides early signals that allow families to act before small issues become life-altering crises, and deploy a system to safeguard someone who may become vulnerable to inbound financial scams. Long before a diagnosis, subtle financial changes like missed bills, unusual spending, or increased vulnerability to scams, can be among the first signs that something is wrong. Early detection of Alzheimer's can make a significant difference in how families respond, plan, and care for a loved one. About Carefull Carefull is the first financial safety platform designed to protect aging adults and their families, from elder fraud, scams, and money mistakes. Built to support the unique needs of older adults, Carefull's proprietary AI provides 24/7 account monitoring, a suite of identity and home protections, along with expert resources to help families, advisors, and financial institutions safeguard families' financial well-being. Banks, credit unions, and wealth advisors use Carefull to deepen relationships across generations, provide proactive protection, and enhance trust with clients navigating both aging and financial caregiving for older adults. Recognized for its innovation in financial safety, Carefull partners with leading institutions to put financial care into financial services. Learn more at About the Alzheimer's Association The Alzheimer's Association is a worldwide voluntary health organization dedicated to Alzheimer's care, support and research. Our mission is to lead the way to end Alzheimer's and all other dementia — by accelerating global research, driving risk reduction and early detection, and maximizing quality care and support. Our vision is a world without Alzheimer's and all other dementia®. Visit or call 800.272.3900.
Yahoo
17 minutes ago
- Yahoo
Award-Winning Toy Creator and Family Physician Team Launch Playhouse MD™ to Reimagine Pediatric Healthcare
The female-founded brand is on a mission to revolutionize the pediatric healthcare space with Playful Pediatrics™ LOS ANGELES, June 11, 2025 /PRNewswire/ -- Sisters Sydney Wiseman, an award-winning toy creator, and Dr. Kaitlin Wiseman, a trusted family physician, are shaping the future of pediatric healthcare with the launch of Playhouse MD™, the first brand built entirely around reimagining children's healthcare through the transformative power of play. Sick days are never easy, for kids or their caregivers. From giving medicine to a squirming baby to battling midnight boogers, these small yet recurring tasks can feel huge and stressful. Playhouse MD™ was born from those very moments, designed to bring comfort, connection and just a little more ease to pediatric care. Playhouse MD™ seamlessly combines pediatric healthcare with the universal language of play through its doctor-designed medical devices with kid-friendly characters and playful prompts. "As a doctor and mom of two, I know firsthand how challenging pediatric care can be," says Dr. Kaitlin Wiseman, Co-Founder and Chief Medical Officer of Playhouse MD™. "At Playhouse MD, we're not reinventing the science behind medical devices — we're reimagining the care experience. By telling a story through friendly characters like narwhals, butterflies and elephants, we help turn tough healthcare moments into playful, cooperative ones. The result isn't just more smiles; it's a stronger connection between children and their parents and a more positive relationship with healthcare." Turning their vision of doctor-designed medical devices supplemented by playful storytelling into a reality took more than innovation — it required assembling a world-class team of healthcare experts alongside a network of leading business minds and renowned play specialists. Each Playhouse MD™ medical device features a kid-friendly character design and includes the brand's signature Playful Prompts Guide, which helps empower both kids and adults. "As a toymaker, I've always believed in the magic of a child's imagination — it's pure, powerful and endlessly creative," says Sydney Wiseman, Co-Founder and Chief Play Officer of Playhouse MD™. "We saw a unique opportunity to bring that same spark into healthcare by reimagining everyday challenges through the lens of play. With our playful prompts and characters, our goal is to turn tough moments into imaginative ones and help kids feel more at ease, and give parents a little more peace of mind." Playhouse MD™'s innovative approach to transforming pediatric healthcare through play has also garnered support from industry leaders in the play space. "My life's work has been rooted in the belief that play is more than entertainment - it's a vital part of how children grow, learn and understand the world around them," says Alan Hassenfeld, former Chairman and CEO of Hasbro, Inc and investor in Playhouse MD™. "That same philosophy lives in Playhouse MD with their innovative approach that brings clinical care into a child's world with empathy, creativity and joy. By integrating play into healthcare, they're not only easing fear; they're building trust, confidence and lasting emotional well-being and I'm honored to partner with a team that's so aligned with my own personal values." Available now at the brand's debut collection includes: Booger Buddy™ — A Nasal Aspirator and Nasal Bulb that allows for quick and gentle congestion relief, because when your baby can't breathe easily, no one can rest. The Booger Buddy™ collection helps turn stuffy noses into manageable moments with friendly characters featuring optional soft lighting for bedtime use; suitable for all ages 0M+ Elephant Light-Up Nasal Aspirator $19.99: adult-controlled suction nasal aspirator with a fun elephant character design for less stressful booger removal; includes 10 disposable filters Narwhal Light-Up Nasal Bulb $17.99: nasal bulb for adult-controlled suctioning with a playful narwhal character to relieve nasal congestion; the removable horn tip allows for easy, thorough cleaning for no hidden mold Medicine Buddy™ — Medicine Dispensers with removable pacifier attachment allows for precise and fuss-free medication delivery; suitable for all ages 0M+ Riley the Rocket or Bella the Butterfly $16.99: two-piece design with a pacifier attachment and curved medicine channel to bypass baby's taste buds and help reduce spit-ups; includes one 5 mL and one 10 mL syringe Playhouse MD™ will also be rolling out at major retailers including Amazon, Babylist and Target, making it easier than ever for families to bring home their imaginative, child-friendly care essentials. About Playhouse MD™At Playhouse MD™, we believe a dose of play goes a long way — especially on sick days. That's why we're reimagining pediatric care through play, transforming some of the toughest healthcare moments in early childhood into playful, story-led experiences for modern families. Co-founded by sisters Dr. Kaitlin Wiseman, a trusted family physician, and Sydney Wiseman, an award-winning toy creator, along with serial entrepreneur Michael Kamins, Playhouse MD™ combines pediatric healthcare with playful stories and kid-friendly designs to deliver medical devices that aren't just functional, but truly transformational. Our mission is simple: to make healthcare moments less intimidating and a whole lot more engaging, turning chaos into calm and stress into smiles. For more information, visit PLAYHOUSE™, PLAYHOUSE MD™ and all product names, designations and logos are trademarks of Playhouse MD Inc. or Playhouse Method Inc. © 2025 Playhouse MD Inc. All rights reserved. Pat. View original content to download multimedia: SOURCE Playhouse MD™ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Wire
18 minutes ago
- Business Wire
VergeSense Launches Breakpoint Analyzer to Transform Space Planning with AI-Powered Precision
SAN FRANCISCO--(BUSINESS WIRE)-- VergeSense, the leader in occupancy intelligence, today announced the beta release of Breakpoint Analyzer, a powerful new AI-powered tool that enables real estate and workplace teams to identify hidden inefficiencies in their floor plans, reclaim wasted space, and optimize their existing footprints. Breakpoint Analyzer is the first release in a new suite of predictive space planning tools from VergeSense designed to bring speed, clarity, and data-driven insights to portfolio planning. Breakpoint Analyzer is the first release in a new suite of predictive space planning tools from VergeSense designed to bring speed, clarity, and data-driven insights to portfolio planning. Share Breakpoint Analyzer leverages a proprietary AI model from VergeSense trained on over 200 million square feet of occupancy data to predict which spaces on a floor plan will fill up first, identify where you have too much of a space type, and where you can rebalance spaces to reduce space waste and improve efficiency. In a time when workplace teams are under pressure to optimize space while protecting employee experience, traditional planning methods—like expensive consulting engagements that yield static ratios or rely on outdated benchmarks—no longer meet the moment. Breakpoint Analyzer changes that. 'Space planning has historically been slow, siloed, and assumption-driven,' said Dan Ryan, CEO at VergeSense. 'Breakpoint Analyzer gives teams a faster, smarter way forward—grounded in how their spaces actually perform, not how they were designed on paper.' A New Standard for Measuring Capacity and Performance Powered by over 200 million square feet of real-world occupancy data, Breakpoint Analyzer leverages a customer's floor plans and occupancy data—like WiFi or sensor data—to evaluate: True usable capacity based on actual employee behavior Which space types will run out first, triggering productivity or experience issues How much capacity is lost due to inefficient room sizes or poor space mix Where layout changes could unlock hidden capacity Even in areas without full sensor coverage, Breakpoint Analyzer leverages VergeSense's proprietary benchmark dataset to simulate usage with high confidence—eliminating blind spots and guesswork. What It Means for Workplace and Real Estate Teams Breakpoint Analyzer helps teams: Replace static planning with dynamic, real-world analysis Act confidently even when occupancy data is incomplete Avoid costly overbuilds or under-provisioning Accelerate decisions that previously took weeks or months This release marks the first step in VergeSense's broader vision for predictive workplace planning. In the near future, customers will be able to take advantage of a new scenario planning tool to simulate the impact of policy changes, headcount growth, or layout adjustments—before making costly decisions. Beta Now Available Through August 31, 2025 Breakpoint Analyzer is now available in beta through August 31, 2025. To learn more, sign up for the Occupancy Intelligence Summit happening today, June 11, 2025 at 12PM ET.
