logo
Fake scientific publications are a serious and growing problem, Northwestern University researchers say

Fake scientific publications are a serious and growing problem, Northwestern University researchers say

CBS News2 days ago
Published scientific research fuels the breakthroughs that shape our world — but what happens when that research is totally fake?
Researchers at Northwestern University said the number of junk scientific publications is growing, and bad actors are profiting.
"These people are ruining it for all of us," said Northwestern University researcher and professor of engineering science and applied math Luís Amaral.
Amaral and fellow Northwestern researcher Reese Richardson said they have always known there were fake scientific studies floating around.
But it wasn't until they started studying the issue — with the help of several helpful sleuths — that they discovered the problem was much bigger than anyone thought. They showed CBS News Chicago four research papers on four different types of cells — but the papers all "borrowed" the same set of images.
"We did this analysis, and we found out something that was extraordinarily scary," said Amaral. "Essentially, the number of fraudulent papers is doubling every year and a half."
Amaral and Richardson's study on the problem was published earlier this month. In a nutshell, the publication of fraudulent science is outpacing the publication of legitimate science.
"Everywhere we looked, we were seeing indications that there was systematic fraud being produced," Richardson said.
But why would anyone spend the time publishing fake research? Amaral and Richardson say there are two main reasons.
The first is buying a reputation.
"They do this out in the open," said Richardson. "It is not hard to find paper-mill advertisements at all."
Amaral and Richardson showed CBS News Chicago hundreds of advertisements that have appeared online — asking for anywhere from $100 a publication to about $3,000 in exchange for authorship.
The second reason for the fakes is to push for a certain point of view — for example, backing a dietary supplement for financial gain.
"So there are lots of people with a point of view, and it has become very easy for them to make it appear like there are hundreds of experts, thousands of publications that are very highly cited about all of these," said Amaral.
In a 2024 post on his blog, Richardson specifically cited an example of how a researcher with a financial interest in the turmeric industry was able to push fake research on the benefits of turmeric.
Richardson wrote that Bharat Aggarwal, who worked at the MD Anderson Cancer Center in Houston from 1989 to 2015, authored more than 120 articles about the compound curcumin in turmeric — claiming that it therapeutic potential for cancers, Alzheimer's disease, and most recently, COVID-19.
At first, MD Anderson seemed to endorse Aggarwal's research, and the FAQ page on the cancer center's website even recommended that visitors buy curcumin wholesale from a company that paid Aggarwal as a speaker, Richardson wrote. But in 2012, MD Anderson Cancer Center launched a research fraud probe against Aggarwal, which led to the retraction of 30 articles — some of them about curcumin, Richardson wrote.
Still, while Aggarwal retired from MD Anderson in 2015, he has gone on authoring articles and appearing at conferences, Richardson wrote.
Curcumin does not work well as a treatment for any disease, Richardson wrote. But even though Aggarwal's research has been discredited, the volume of studies published on curcumin keeps growing — and they also often show signs of fraud, Richardson wrote.
Amaral and Richardson say they're raising the red flag about the fakes now — at a time when the future of federal funding for some legitimate science is uncertain.
"There is only greater competition, and a more scarce pool of resources, for scientists to use and do genuine science," said Richardson.
"If actually, there is an entire stream of research that is actually making false claims… it puts all of our health at risk," added Amaral.
The authors argue their findings should serve as a wake-up call to the scientific community, which needs to act before we all lose confidence in the scientific process.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Alien: Earth premiere review: a deep, dark sci-fi masterpiece
Alien: Earth premiere review: a deep, dark sci-fi masterpiece

Digital Trends

time6 minutes ago

  • Digital Trends

Alien: Earth premiere review: a deep, dark sci-fi masterpiece

Alien: Earth episode 1 Score Details 'FX's hit series, Alien: Earth, brings intense sci-fi terror to Earth and new life to the Alien franchise.' Pros Terrific performances Compelling characters Haunting atmosphere Expansive worldbuilding Cons Many plotlines with a slow pace 'Why you can trust Digital Trends – We have a 20-year history of testing, reviewing, and rating products, services and apps to help you make a sound buying decision. Find out more about how we test and score products.' Noah Hawley's (Fargo, Legion) long-awaited sci-fi horror series, Alien: Earth, has premiered on FX and Hulu, kicking off a bold, frightening new chapter in the Alien franchise. The pilot, written and directed by Howley, shows the spaceship Maginot crash-landing on Earth while delivering some of the deadliest alien creatures in the universe, including the franchise's dreaded mascot, the Xenomorph. Recommended Videos From the very beginning, Alien: Earth replicates the look and feel of Ridley Scott's original horror film, from the music to the set design to the cinematography. Even the awakening of the Maginot's crew mirrors that of Ripley and her crew in the 1979 film. Though the show's beginning is familiar to franchise fans, it quickly forges its own stellar identity within the world of Alien. And like the franchise's vicious aliens, this new series gets under viewers' skin until their chest bursts with sheer terror. A brave new world The first episode of Alien: Earth takes its time introducing its main characters, specifically Wendy, CJ, and Morrow. Much of the pilot is dedicated to building up their respective stories, which ultimately converge when the Maginot crashes into a city on Earth. This sets off Wendy's thrilling adventure, not just to stop the Xenomorph, but also to reunite with her brother, CJ, with their loving bond adding plenty of heartwarming drama and childlike wonder to this dark tale. Also, in its first episode, Alien: Earth greatly expands the world of the franchise, not just by introducing new, creepy extraterrestrials, including a crawling eyeball with tentacles. The series delves deep into the bleak, dystopian sci-fi world that Earth has become, with five megacorporations ruling over entire countries and planets throughout the solar system like royal houses. At the same time, the show puts a unique spin on synthetic androids, introducing a group of terminally ill children whose minds are transferred into robot bodies by the Prodigy Corporation. Much like Stranger Things, Prodigy holds these special children captive in their 'Neverland' lab, observing them until they leave to battle otherworldly creatures that appear on Earth. Nevertheless, this setup makes Alien: Earth its own story within the franchise's world, and the latter is better off for it. The characters Alien: Earth features a variety of eerie and entertaining characters. Sydney Chandler leads this new series as Wendy, who is introduced as the first child to have her mind transferred to a synthetic body. Though she now inhabits a grown-up's body, ironically, she is unable to grow physically older in a clear allusion to the story of Peter Pan. Chandler delivers an entrancing performance portraying a wide-eyed, playful child living in an adult's body. It is clear that Wendy has some growing up to do, as she's still learning about the world and her new, ageless form. However, she is forced to grow up fast when she decides to save her brother. Speaking of him, Alex Lawther also sells his respective role as CJ, who, despite being a soldier, is clearly still a kid who's way in over his head as he ventures into the Maginot's crash site and witnesses world-shattering horrors. Meanwhile, actor Samuel Blenkin rules over Prodigy as Boy Kavalier, whose persona as an immature, kidnapping 'tech bro' parallels young Wendy with a sinister mix of Peter Pan and Mark Zuckerberg. However, the series features even greater menace from its sinister androids. Babou Ceesay stands out as the callous, emotionless robot Morrow, who, like Ian Holm's Ash, is driven solely by his directive from his company to capture the Xenomorph. Timothy Olyphant's android, Kirsh, is just as unsettling with his icy demeanor. He also delivers an especially chilling monologue about humans being food, wrapping up the episode on a high note and setting the stage for humanity's bloody, existential war against their alien guests. On Earth, everyone can hear the screams Like Ridley Scott's Alien, Hawley's new series takes its time building up terror and suspense. In true reverence to its predecessor, Alien: Earth crafts a dark, chilling atmosphere as it turns the Maginot into another haunted house in space. This is a sharp contrast to the bright, lush 'paradise' of Neverland. While scenes in such Earth-bound locations steer away from alien gore, its horror hits close to home. With Prodigy no longer considering its children human due to their new synthetic bodies, the series shows more of the corrupt, exploitative nature of one of the franchise's multiple evil corporations, using lies and technicalities to further their twisted agendas. It's a slow-burning horror, but all that careful construction pays off with frightening scenes like the Xenomorph's rampage on the Maginot and the ship's crash into the city. Composer Jeff Russo's foreboding music, reminiscent of the original Alien's score, fills the air with an even greater sense of impending doom. The show pairs it well with dreamlike imagery, including flash cuts and superimposed shots, to bring a surreal, sci-fi nightmare to life. Is Alien: Earth worth a watch? Though few Alien projects have come close to rivaling Ridley Scott's iconic original film, Alien: Earth is one of those exceptional few that lives up to its legacy and stands tall on its own. Diehard fans of Alien will enjoy the show's faithful, frightening style. Fans of Prometheus should also enjoy its philosophical exploration of humanity and evolution through its compelling cast of characters. While the dense, slow-burning story may turn off some viewers, the show's second episode (which premiered on the same day) goes all in on the alien terror as it unleashes a gory, sci-fi slasher-fest. This all makes Alien: Earth a distinctive addition to the franchise's canon, with the pilot setting up a vast, thoughtful epic that demands audiences' attention. The first two episodes of Alien: Earth are now streaming on Hulu. Episode 3 will air at 8 p.m. ET on Tuesday, August 19.

Should You Take a Vitamin B12 Supplement?
Should You Take a Vitamin B12 Supplement?

Yahoo

time34 minutes ago

  • Yahoo

Should You Take a Vitamin B12 Supplement?

Credit - Photo-Illustration by TIME (Source Images: eyenigelen/Getty Images, Sersol/Getty Images) Everyone needs vitamin B12: It helps the body produce red blood cells and maintain healthy brain function, along with so many other things. But are you getting enough of it? Here's what to know about vitamin B12 and whether you should consider upping your levels. A boon for brain health 'Vitamin B12 is important for brain health because it helps protect nerve cells in the brain, which support memory and thinking skills,' says Michelle Routhenstein, a preventive cardiology dietitian and certified diabetes educator in New York. It's water-soluble, so the body does not store it in large amounts, and daily intake is essential. The current federal recommendations are for adults to get 2.4 mcg of vitamin B12 per day. Great food sources of B12 include seafood like oysters, salmon and tuna, beef, and fortified products like nutritional yeast, plant-based milks, some breads and breakfast cereals, says Routhenstein. But some recent research suggests that some people may need even more than that. Vitamin B12 deficiencies can impact your brain function even when your intake levels are considered normal, says Dr. Ari J. Green, a professor at the University of California, San Francisco's department of ophthalmology. In a recent study, Green and his colleagues found that people with B12 levels that were technically normal but on the lower end of the range had impaired brain function. 'We could detect neurological impairment at levels currently considered 'normal,' independently of other factors like years of education," particularly in older people, says Dr. Alexandra Beaudry-Richard, a resident at McGill University and co-author of the study. 'To us, this should reinvigorate a conversation about how much B12 is needed for optimal neurological function.' Read More: Should You Take a Vitamin D Supplement? Other studies have found that people with Alzheimer's disease and mild cognitive impairment tend to have lower B12 levels—and supplementation with B12 can reduce the rate of brain atrophy. However, on the opposite end, the study showed signs of a possible detrimental effect on the brain when people had high B12 levels in their blood. 'This warrants further studies to evaluate what healthy B12 levels are on both ends of the spectrum,' says Dr. Ahmed Abdelhak, one of the study's authors and a clinical instructor in neurology at UCSF School of Medicine. Should you take a B12 supplement? You can (and should) get B12 from your diet, but some people may have a tough time getting adequate levels of the nutrient from food alone. Older adults are more likely to develop vitamin B12 deficiencies because the vitamin requires stomach acid to be absorbed, and stomach acid production starts to decline with age. Routhenstein recommends people look closer into their B12 status starting around age 50 or if they are at higher risk of a B12 deficiency. This category includes vegans and vegetarians, people taking specific medications that interfere with B12 absorption such as metformin or proton pump inhibitors, and those who have gastrointestinal disorders like Crohn's, celiac, or atrophic gastritis. You can get tested for a vitamin B12 deficiency at your annual physical. If you are deficient, your doctor might recommend supplementation. Read More: 7 Surprising Symptoms of Lyme Disease The UCSF study authors recommend checking levels starting at age 70, but you can get it checked on a standard blood test at any age through your primary care physician. Dr. Ralph Green, a professor of pathology and lab medicine at the University of California, Davis—and another author on that recent study—says that checking B12 may also be valuable for people who have unexplained symptoms that have been linked to B12 deficiency. For those with declining gastric function, he says taking supplements is likely the best way to promote absorption, and the level of supplementation a person should consume depends on whether their absorption is normal or not. Pregnant women, too, need higher B12 intake to support fetal brain development; if you're pregnant, consult with your ob-gyn about optimal B12 levels for you. What kind of B12 supplement is best? B12 in supplements and fortified foods can be more easily absorbed than from food, especially for older adults and those with absorption issues, says Routhenstein. If your doctor has advised you to take a B12 supplement, it's best to ask them to recommend specific dosages and brands. But Routhenstein recommends following these general guidelines when selecting a B12 supplement. Always look for those with methylcobalamin on the label, as this is the most bioavailable form of B12, meaning the body can absorb it the best. It's also the optimal form for heart and brain health and nerve function, she says. Sublingual (under the tongue) or liquid B12 is often touted for better absorption. This form of B12 does so 'by bypassing the digestive system and entering the bloodstream directly,' says Routhenstein. Of course, no supplement is a cure-all, and there are other ways to support brain health, including maintaining a healthy diet and exercise regimen. Activities that stimulate multiple brain areas simultaneously are excellent at promoting cognitive longevity, Beaudry-Richard says. Practicing a musical instrument, dancing, and studying a foreign language daily, for example, all recruit 'brain circuits responsible for vision, hearing, movement, emotions' and more. 'It's like a full-body workout for the brain,' she says. Contact us at letters@

New Tools for Lung Cancer, Harder Job for Clinicians
New Tools for Lung Cancer, Harder Job for Clinicians

Medscape

timean hour ago

  • Medscape

New Tools for Lung Cancer, Harder Job for Clinicians

This transcript has been edited for clarity. Hello. It's Mark Kris, from Memorial Sloan Kettering, with a month-later review of the 2025 ASCO meeting in Chicago. I think everybody who was there and attended the lung cancer sessions left with the, I'll have to say, difficult time unpacking what we learned during that meeting. There was a dizzying array of trials presented and a huge amount of data, but sadly, there was no breakthrough. There was no one treatment or approach that told each of us we had to start doing this in every patient on Tuesday when we got home again. What it did was give us more tools and more ways we could fight cancers, but it really made our jobs much harder. I think that we need to spend some time thinking about how those data could be used, and I'll pick a couple of examples. I think one would be in the small cell lung cancer area. There was a large amount of attention to the use of tarlatamab as a treatment at relapse. It was a comparison trial to topotecan and lurbinectedin, and there was an improvement in outcomes in those groups. While that benefit was there, what was not addressed was the benefit of repeating standard therapy, which is what many of us do, particularly when there has been a longer time between the end of the induction treatment and recurrence. The second trial that I thought was useful in the small cell area was a randomized trial adding lurbinectedin to the checkpoint inhibitor after induction chemotherapy. There was an improvement in disease-free survival there also. Personally, I was more impressed by the latter trial, in that it gave our patients a longer time with disease control rather than focusing the time of relapse, where people may already have suffered symptoms brought on by the progressive lung cancer — which sadly is an all-too-common occurrence. In the perioperative space, my colleague Jamie Chaft reported on neoadjuvant osimertinib. In her trial of osimertinib alone, osimertinib plus chemotherapy, and osimertinib and chemotherapy alone, they showed a benefit for the osimertinib-containing arms but not a clear benefit of osimertinib alone versus osimertinib plus chemotherapy. What's the take-home message there? Well, again, it's not simple. I think that we need to give chemotherapy to every patient with stage IB disease and beyond, whether they have an EGFR mutation or not. Based on the fact that we can give chemotherapy more safelyand more completely in the neoadjuvant setting, I would tend to use osimertinib with chemotherapy upfront and then surgery. If you do go the other way and use osimertinib alone, you would need to give chemotherapy afterward, which is, frankly, tougher. I think my take-home message from that was osimertinib and chemotherapy, our standard of care for advanced disease, should also be our standard for neoadjuvant disease in patients with EGFR mutations. There was a fantastic lecture by Patricia LoRusso, from Yale, about antibody-drug conjugates (ADCs). I think that was the most confusing moment of all during the ASCO meeting — the number of ADCs under evaluation. Yet, as Dr LoRusso pointed out, despite the number, it's the same targets, largely the same warheads, and very often, antibodies without activity in and of themselves. When you look at the overall benefits of the group, there are none that truly stand out. We now have three available in the lung cancer arena. The benefit, side effects, and the whole field is really quite confusing. One other message was that, with the bispecific antibodies, the more targets you have, the more toxicity you're going to see. It's a real balance between benefit and risk. What are you going to do? Again, there was no breakthrough at ASCO this year. Clearly, there are more therapies and there are even more in the pipeline. I think what we need to do now is to learn more, and to — unfortunately — spend a large amount of time going through the data and see exactly the benefit versus risk ratio for each of the new therapies and for each of our patients deciding where that goes. For example, I would be a big fan of giving lurbinectedin because of its ability to improve disease-free survival, which is so important in small cell [lung cancer], where relapse is almost certain, and that disease-free time is the best time for our patients. For the neoadjuvant, it would be giving both chemotherapy and osimertinibpre-surgery, in that is better tolerated there and you can also assess benefit very well. For tarlatamab, it's a tough decision there. Again, it's the time of relapse. We have many choices at relapse, giving the same drugs again, giving another perhaps less toxic agent like temozolomide, giving tarlatamab and the standard drugs. Clearly, tarlatamab was better than some of the standard drugs, but they're not the ones that most of us use for the patients. We usually go with the same treatment by and large. Lastly, it's going to be incumbent on us to work harder to take that information we got at ASCO this year and make the best decisions for each patient. We have to focus on the nuance. We have to learn more, and there is no knee-jerk that every patient needs tarlatamab or every patient should get induction chemotherapy with the combination. We have to choose our patients wisely. You've heard me before, and I'll say it again. Our jobs are better, but they're harder.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store