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Police say a Ford Falcon collided with a Toyota Corolla on Camms Rd in Cranbourne about 8.40pm on Tuesday.
Two women and a man from the Corolla were taken to hospital with serious but non-life-threatening injuries.
Two children who were passengers in the Corolla were taken to hospital with non-life-threatening injuries.
The two occupants inside the Ford remained at the scene and are helping police with their investigation into the crash.
Anyone who witnessed the collision or has any with dashcam/CCTV footage is urged to contact Crime Stoppers.
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