Latest news with #DHEA
Time of India
a day ago
- Health
- Time of India
PGI researchers give new hope for treatment of severe liver disease
Lucknow: Advanced scientific research conducted by scientists at Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) has shown a new way to treat Non-Alcoholic Steatohepatitis (NASH) – a severe but common liver disease. Tired of too many ads? go ad free now The research, led by Rohit A Sinha, a scientist and associate professor in the endocrinology department, along with his team comprising Sana Raza and Pratima Gupta, proved that a naturally occurring hormone called dehydroepiandrosterone (DHEA) can help in checking liver damage caused by NASH by removing harmful fat from liver cells, reducing inflammation, and preventing liver damage. A Union health ministry document notes that NASH is the severest form of Non-Alcoholic Fatty Liver Disease (NAFLD). Terming it as "a silent epidemic", the document noted that NAFLD's community prevalence ranges from 9% to 32%, depending on age, gender, area of residence, and socioeconomic status. This means that up to three people out of 10 could have fatty liver or a related disease. What raises concerns is that 20% of people with NAFLD develop NASH. "DHEA is a parent hormone that acts as a precursor to sex hormones in humans. While scanning several case studies of NASH patients, we noted that the level of DHEA in them was on the lower side. Keeping this as the base, we proposed to study the impact of increasing this hormone in NASH patients with a significant extent of fibrosis – a symptom of NASH," said Sinha, adding that the study was published in the journal 'Molecular and Cellular Endocrinology'. "We began with animal studies. In the mouse model, we fed the experimental group with a NASH-inducing diet. When the condition was confirmed in them, we injected DHEA. The outcome showed that the severity of liver damage in 80% of the sample decreased by about 60%," he said. The results paved the way for a cellular study in which the researchers worked upon lab-grown human liver cells. "Here too, in the experimental group, we loaded the cells with excessive fat to create a NASH-like condition. Thereafter, we introduced DHEA and found that the fat percentage decreased by up to 80%," said Sinha. "The result has been heartening. We now look forward to clinical trials for hormone replacement therapy," he said.
NDTV
2 days ago
- Health
- NDTV
Abortion Pill Inventor Etienne-Emile Baulieu Dies At 98
Rome: French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill, died on Friday aged 98 at his home in Paris, his institute said in a statement. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," the Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on Dec. 12, 1926, he took the name "Emile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute added. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honored with the grand crosses of the Légion d'honneur (legion of honor) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom." "Few French people have changed the world to such an extent," he added. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren, his institute said.
The Advertiser
3 days ago
- Health
- The Advertiser
French inventor of the abortion pill dies at 98
French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren. French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren. French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren. French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren.
West Australian
3 days ago
- Health
- West Australian
French inventor of the abortion pill dies at 98
French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren.
Perth Now
3 days ago
- Health
- Perth Now
French inventor of the abortion pill dies at 98
French scientist Etienne-Emile Baulieu, best known as the inventor of the abortion pill RU 486, has died aged 98 at his home in Paris. Both a doctor and a researcher, Baulieu was known around the world for the scientific, medical and social significance of his work on steroid hormones. "His research was guided by his attachment to the progress made possible by science, his commitment to women's freedom, and his desire to enable everyone to live better, longer lives," Institut Baulieu said in the statement posted on its website. Born Etienne Blum in Strasbourg on December 12, 1926, he took the name "Émile Baulieu" when he joined the French Resistance against the Nazi occupation at the age of 15. An endocrinologist with a doctorate in medicine completed in 1955 and one in science eight years later, in 1963 Baulieu founded a pioneering research unit working on hormones at INSERM, the French institute for health and medical research. He remained as head of the unit until 1997. He is best known for his development, in 1982, of RU 486, the so-called "abortion pill" that changed the lives of millions of women throughout the world, offering them the possibility of voluntary medical termination of pregnancy, in physical and psychological safety. The Institut Baulieu said it was "a non-invasive method, less aggressive and less delayed than surgery," noting that following his discovery, the researcher faced fierce criticism and even threats from opponents of women's abortion rights. "Even today, access to this method is opposed, banned in some countries, and is currently being challenged in the United States, where it is the most widely used abortion method," the institute said. Baulieu's research into DHEA, a hormone whose secretion and anti-aging activity he had discovered, led him to work on neurosteroids -- or steroids of the nervous system. He also developed an original treatment to combat depression, for which a clinical trial is currently underway in several university hospitals. In 2008, he founded the Institut Baulieu to understand, prevent and treat neurodegenerative diseases such as Alzheimer's. Honoured with the grand crosses of the Légion d'honneur (legion of honour) and the Ordre national du Mérite (national order of merit), he was elected to the French Academy of Sciences in 1982, which he chaired in 2003 and 2004. He was a member of the national advisory committee on life sciences and health (1996-2002) and received numerous awards, both in France and abroad. French President Emmanuel Macron paid tribute to Baulieu in a post on X, calling him "a beacon of courage" and "a progressive mind who enabled women to win their freedom". "Few French people have changed the world to such an extent," he said. After the death of his first wife, Yolande Compagnon, he remarried, to Simone Harari Baulieu. He is survived by three children, eight grandchildren and nine great-grandchildren.
