Latest news with #Estrella
Business Wire
5 days ago
- Business
- Business Wire
Estrella Immunopharma Announces Activation of Additional Site for Phase I/II STARLIGHT-1 Trial in B-cell Non-Hodgkin's Lymphoma
EMERYVILLE, Calif.--(BUSINESS WIRE)--Estrella Immunopharma, Inc. (NASDAQ: ESLA) ('Estrella' or the 'Company'), a clinical stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS ® T-cell therapies to treat cancer and autoimmune diseases, today announced the activation of a second clinical site for its ongoing STARLIGHT-1 Phase I/II clinical trial evaluating EB103, a CD19-Redirected ARTEMIS® T-cell therapy, in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL). The new site, Baylor Research Institute d/b/a Baylor Scott & White Research Institute in Dallas, Texas, is now open for patient enrollment. 'Partnering with Baylor Research Institute, a nationally recognized medical institution, represents a key step forward in broadening the reach of our STARLIGHT-1 trial,' said Cheng Liu, Chief Executive Officer of Estrella. 'The expansion of our clinical footprint will help accelerate development and increase patient access to EB103, while we remain focused on our mission to deliver safer, more effective treatments for patients with advanced NHL.' The Phase I/II clinical trial for EB103 is an open-label, dose escalation, multi-center, Phase I/II clinical trial to assess the safety of EB103 autologous T-cell therapy and to determine the Recommended Phase II Dose (RP2D) in adult subjects (≥ 18 years of age) who have relapsed/refractory (R/R) B-cell NHL. The study includes a dose escalation phase followed by an expansion phase. Further details of the trial can be found at under NCT identifier: NCT06343311. About EB103 EB103, a T-cell therapy, also referred to as Estrella's 'CD19-Redirected ARTEMIS ® T-Cell Therapy,' utilizes ARTEMIS ® technology licensed from Eureka Therapeutics, Inc. ('Eureka'), Estrella's parent company. Unlike a traditional CAR-T cell, the unique design of an ARTEMIS ® T-Cell, like EB103 T-cell, allows it to be activated and regulated upon engagement with cancer targets that use a cellular mechanism more closely resembling the one from an endogenous T-cell receptor. Once infused, EB103 T-cells seek out CD19-positive cancer cells, bind to these cells, and destroy them. About Estrella Immunopharma Estrella is a clinical-stage biopharmaceutical company developing CD19 and CD22-targeted ARTEMIS ® T-cell therapies to treat cancers and autoimmune diseases. Estrella's mission is to harness the evolutionary power of the human immune system to transform the lives of patients fighting cancer and other diseases. To accomplish this mission, Estrella's lead product candidate, EB103, utilizes Eureka's ARTEMIS ® technology to target CD19, a protein expressed on the surface of almost all B-cell leukemias and lymphomas. Estrella is also developing EB104, which also utilizes Eureka's ARTEMIS ® technology to target not only CD19, but also CD22, a protein that, like CD19, is expressed on the surface of most B-cell malignancies. For more information about Estrella, please visit Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements, including but not limited to those regarding the potential benefits and therapeutic advantages of EB103 and ARTEMIS ® T-cell therapy, the anticipated progress and milestones of the STARLIGHT-1 Phase I/II clinical trial, and the future development plans for EB103, are based on our management's current expectations, estimates, forecasts, and projections about the industry and markets in which we operate and our management's current beliefs and assumptions. These statements may be identified by the use of forward-looking expressions, including, but not limited to, 'expect,' 'anticipate,' 'intend,' 'plan,' 'believe,' 'estimate,' 'potential,' 'predict,' 'project,' 'should,' 'would' and similar expressions and the negatives of those terms. These statements relate to future events or our financial performance and involve known and unknown risks, uncertainties, and other factors that could cause actual results, levels of activity, performance, or achievements to differ materially from those expressed or implied by these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those listed under 'Risk Factors' and elsewhere in our filings with the Securities and Exchange Commission. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should, therefore, not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.
Yahoo
6 days ago
- General
- Yahoo
Make-A-Wish: Estrella's story
Marshall County, Ala. (WHNT) – In the weeks leading up to News 19's Wishes Can't Wait telethon benefiting Make-A-Wish Alabama, we want to introduce you to just a few of the 78 children in North Alabama waiting for the foundation to grant their wishes. Estrella wants a pool, not just for herself, but for her nieces and nephews to enjoy too. Make-A-Wish Alabama to host 'WishStock' benefit concert '[We can] swim and have fun,' Estrella said. Right now, they splash around in a small round plastic kiddie pool. She's asking Make-A-Wish Alabama for an upgrade. Her mom, Maria, said Estrella is always thinking about others. It isn't surprising, given how quickly the 12-year-old was forced to grow up. 'She's never had a childhood. She's always been in the hospital, so she's never enjoyed what a childhood should be,' her Dad, Efrain, said. She has been sick since she was just three years old, but at the time, the family did not know what was making her ill. Make-A-Wish: Micah's story '[Doctors] would always tell me that she had flu,' Maria said. 'A year went by, two years went by, and that's what they would tell me.' As Estrella got older, her parents said her health worsened. They said she started having fainting spells on the bus and seizures. In 2019, they were called to Estrella's school, and a translator aide told them about UAB Children's Hospital in Birmingham. They took her there as an emergency. 'They saw that she had a tumor [in her head] and it was very big,' Maria said. Make-A-Wish: MaKya's story She needed emergency surgery; however, removing the tumor meant taking the child's pituitary gland with it. That had massive implications. 'She's going to be on medicine for the rest of her life,' Maria said. 'It affects all of the hormones of the body, she's not going to be able to have kids.' To make matters worse, a year after the initial surgery, the tumor returned. This time, doctors could only successfully remove part of it. 'If they had cut that part, they told us that she could lose memory or her eyesight,' Maria said. 'That little part that stayed in her brain, it overtook other areas of her brain that are more dangerous now.' She's almost completely blind in her right eye now. Doctors said to shrink what's left, she needed radiation, but after some time, she started to have problems with her liver. She was diagnosed with Fatty Liver. The organ failed quickly. She would need a transplant. 'Her extremities would not like to bend and her eyes were now turning gray,' Efrain said. She traded radiation for Dialysis while the family waited for a donor. 'Its very sad. I don't wish this on anybody,' Maria said. Estrella never lost faith. 'I think God. I am tough,' she said. After months of waiting and praying, the family received a call. 'I feel like that was the salvation of my daughter,' Maria said. After that, the family was given a letter. The liver came from a little boy. His family wrote, telling Estrella a little bit about him and what he was like and how he died. 'We are very grateful. We pray that this child is resting in peace and that the parents have peace and God blesses them.' That family's sacrifice has given Efrain and Maria three years and counting with Estrella. 'She is very strong,' Maria said. Through the transplant, they were connected with Make-A-Wish Alabama. When Estrella said she wanted a pool, the family knew exactly where it should be. 'We're thinking in the front yard because we can watch them from [the kitchen],' Maria said. Even as Estrella returns to radiation to treat what's left of her tumor, in between treatments, her family said she'll be busy as the best Aunt to the little ones she loves. Efrain and Maria don't want to miss a single moment. 'I pray that God allows her to live a lot of years with us.' If you're interested in helping Make-A-Wish Alabama grant wishes like Estrella's, you can donate to News 19's 'Wishes Can't Wait' telethon right now! Click here. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Boston Globe
7 days ago
- Entertainment
- Boston Globe
The show will go on: After doubts, ‘Rock and Roll Yard Sale' in Providence set for Saturday
Related : But Chris Daltry, who co-organizes the 'yard sale' with his wife, Jennifer, told the Globe the show will continue on after all, with new partners, Moniker Brewery and the West Broadway Neighborhood Association. Advertisement 'As long as the weather cooperates, it feels really good,' Daltry said Monday, when asked how it feels knowing the fair is returning. (A rain date is scheduled for Sunday, he said.) Get Globe Rhode Island Food Club A weekly newsletter about food and dining in Rhode Island, by Globe Rhode Island reporter Alexa Gagosz. Enter Email Sign Up The Daltrys, who own the online retail shop, What Cheer?, have organized the event for more than 20 years, which had been held on Westminster Street in downtown Providence for the last 15. But Chris Daltry said earlier this year the 'part marketplace and part block party' was on the rocks after In Downcity, a small business marketing group focused on the city's downtown, opted to end its partnership with the event. Joanna Levitt, In Downcity's marketing manager, said at the time the event had 'become larger than we have the capacity to manage in the way we have been in the past.' Advertisement Daltry had also said city officials had complained about alcohol issues at last year's 'Rock and Roll Yard Sale.' Josh Estrella, a city spokesman, said in February there were several regulatory protocols that were not followed, including 'insufficient oversight in the beer garden area, failure to conduct ID checks, and the absence of a clear designated space for alcohol service, which is required at outdoor events like this one.' A food truck also unlawfully served alcohol, Estrella said. This year, with the event moving to West Fountain Street, drinking areas will be contained to two breweries there, Moniker Brewery and Origin Beer Project, Chris Daltry said. 'We have made an effort to bring on extra security and volunteers, and, you know, to make sure that the people that want to drink can stay within the parking lots and areas that are on the property where the breweries are, and then the rest is more of a just an open air marketplace,' he said. 'So in a way, it works better than downtown, because there's more space than there was for the bars and stuff.' In an email on Monday, Estrella wrote that after the concerns around last year's event, a meeting between the organizers and city officials was held to 'review all necessary protocols and ensure compliance with regulations moving forward, including an agreed upon revision to the event's sanitation plan.' 'The City's existing requirements for these events have not changed, which include mandatory ID checks for alcohol purchases, a designated and enclosed area for alcohol service and an event organizer or designated security personnel monitoring the space whenever alcohol is being served,' Estrella wrote. 'As of today, event organizers have met the guidelines and requirements outlined in the application process and we look forward to a successful event.' Advertisement Chris Daltry said he is already thinking how the 'Rock and Roll Yard Sale' could grow next year, pointing to the bevy of restaurants and bars that call West Fountain Street home. 'This little strip, it's kind of a gem,' he said. 'It's still cobblestone. It's turning from what used to be all like auto and auto body [places]. There's been investment in some of the infrastructure in the buildings to turn it into more of a kind of a place to hang out and to eat and drink and whatnot. So there's a future there as well.' Christopher Gavin can be reached at
West Australian
03-06-2025
- Business
- West Australian
Estrella hits massive manganese oxides in Timor-Leste debut
Estrella Resources has made a landmark discovery in its maiden exploration program in Timor-Leste, intersecting a thick 6.45-metre zone of massive manganese oxides just 1.35m below surface at its Ira Miri prospect. In what marks the first modern metallic minerals drillhole sunk in the country, Estrella's initial diamond hole confirmed high-grade manganese mineralisation right from the outset. The mineralisation is still open at 7.8m depth. The discovery comes hot on the heels of an original outcrop found six months ago and just 3m away. Rock chip samples from the surface discovery returned jaw-dropping assays of up to 58.6 per cent manganese. The latest X-ray fluorescence readings from the drill core have now backed up the earlier numbers. They average an impressive 40.1 per cent manganese over the 6.45m interval and confirm more high-grade mineralisation beneath surface. The drill hole ended early because of intermittent core recovery and a scheduled roster break under Timor-Leste mining laws. Estrella will use the downtime to mobilise a more powerful diamond rig in the next two weeks, capable of punching deeper into the friable manganese-rich zones. Core has now been removed for a presentation in June at the International Manganese Institute's conference in Tokyo. Notably, a trench dug just 8m southeast of the drill hole also encountered massive manganese oxides starting 0.7m below surface, despite the area showing no visible surface mineralisation. The find suggests the potential for widespread, near-surface mineralisation hidden under shallow cover throughout the area. Estrella says the rapid turnaround to drilling is a strong sign of the in-country co-operation. Its joint venture partner, state-owned Murak Rai Timor has been instrumental in fast-tracking the campaign. Murak Rai Timor's managing director Jose Goncalves also welcomed the result, calling it a strong endorsement of the joint venture's strategy and a powerful first step in uncovering Timor-Leste's critical minerals potential. The current drilling program is being run by Darwin-based CoreSearch, which also impressively mobilised both diamond and reverse circulation drill rigs into Timor-Leste's remote Lautém district in record time. Since Timor-Leste is still an underexplored region, Estrella says it holds a substantial first mover advantage, which could crack open a treasure trove of untapped targets and turn the region into something special. Estrella is also eyeing the country's broader mineral potential, with a significant high-grade limestone deposit sitting directly above its manganese horizon. Two weeks ago, the company struck a major deal to export up to 500 million tonnes of premium, coral-rich limestone over five years to meet booming industrial demand in South East Asia. The limestone, part of the Baucau Formation, is high-purity calcite with minimal impurities, making it ideal for cement, glass, agriculture and nickel processing. It also sits straight above the manganese targets, allowing for streamlined dual resource exploration. A major 20,000m drilling blitz is now on the cards, combining 10,000m of reverse circulation drilling and 3000m of deeper diamond drilling in the first phase, followed by a further 10,000m of reverse circulation drilling after a geological review. With Timor-Leste aiming to make its mark in the global supply chain for industrial metals, Estrella's Ira Miri manganese find could be the opening salvo of something much bigger. Is your ASX-listed company doing something interesting? Contact:
Yahoo
02-06-2025
- Business
- Yahoo
Estrella MediaCo Announces Key Leadership Promotions in National and Digital Sales
NEW YORK, June 02, 2025--(BUSINESS WIRE)--Estrella MediaCo is pleased to announce the promotions of two standout leaders as part of its continued investment in cross-platform growth and multicultural market leadership. Rogerio Alves has been promoted to Vice President, Digital Sales – CTV and Audio Streaming, where he will lead monetization strategies across Estrella's growing digital video and audio portfolio, including FAST channels, CTV, and streaming audio platforms. "Rogerio has been instrumental in shaping our digital growth strategy, consistently driving innovation and results across our CTV and audio platforms," said Brian Fisher, SVP of Video Sales. "His promotion to Vice President of Digital Sales is a testament to his leadership, vision, and deep understanding of the evolving media landscape." Sandra Sanchez has been promoted to Vice President, National Sales, where she will oversee Estrella's broadcast and digital sales across all national spot markets. Sandra has played a critical role in deepening relationships with top agencies and clients, consistently delivering results and elevating Estrella's national presence. "Sandra brings both precision and passion to every client partnership. Her ability to lead with clarity and build trust across the industry has been a driving force behind our national growth," added Fisher. Both Alves and Sanchez will report directly to Brian Fisher, Senior Vice President of Video Sales, who oversees all sales across Estrella MediaCo's digital and broadcast video platforms. "These promotions are a reflection of the exceptional talent driving Estrella MediaCo's momentum," said Fisher. "Rogerio and Sandra are trusted leaders who understand how to deliver results for brands while representing the power and authenticity of multicultural media." About MediaCo: MediaCo Holding Inc. (Nasdaq: MDIA) is a diverse-owned, diverse-targeted media business. MediaCo stands at the forefront of entertainment and news, uniquely positioned as a leader in reaching multicultural audiences. Through its diverse portfolio of digital, television and radio properties including EstrellaTV, Estrella News, Hot 97, WBLS and Que Buena LA, MediaCo engages over 20 million people every month, delivering a dynamic mix of free, ad-supported streaming and terrestrial entertainment, music, and news across all major media platforms and on all devices. More info at View source version on Contacts For press inquiries: press@ Sign in to access your portfolio
