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METiS Technologies Showcases AI-Powered Nanodelivery Platform at the 2025 Controlled Release Society Annual Meeting
METiS Technologies Showcases AI-Powered Nanodelivery Platform at the 2025 Controlled Release Society Annual Meeting

Malaysian Reserve

timea day ago

  • Health
  • Malaysian Reserve

METiS Technologies Showcases AI-Powered Nanodelivery Platform at the 2025 Controlled Release Society Annual Meeting

HANGZHOU, BEIJING, China and CAMBRIDGE, Mass., July 22, 2025 /PRNewswire/ — METiS Technologies, a global leader in AI-driven nanodelivery innovation, today announced the presentation of its latest research findings at the poster session of the 2025 Controlled Release Society (CRS) Annual Meeting. The company demonstrated that its proprietary AiLNP platform enables the rapid design of tissue-targeted lipid nanoparticles (LNPs), which exhibit high delivery efficiency, strong tissue specificity, and excellent translatability in non-human primates (NHPs). Founded in 1978, the Controlled Release Society is the world's foremost nonprofit scientific organization dedicated to advanced drug delivery. At this year's meeting, METiS Technologies stood out as the only Chinese biotechnology company participating with a featured poster presentation. Dr. Hongming Chen, Co-founder and Chief R&D Officer of METiS and a Member of the U.S. National Academy of Engineering, together with Dr. Andong Liu, Vice President of METiS, presented the poster titled: 'AI-Empowered LNP Discovery for Organ-Targeted RNA Delivery.' The AiLNP platform is METiS' proprietary AI-driven system for nucleic acid delivery design. It integrates a de novo lipid generation foundation model, a high-throughput microfluidics-based LNP assembly and screening system, and a large-scale, proprietary lipid library. Collectively, these innovations expand the design space of nanomaterials by over 1,000-fold compared to conventional approaches—effectively overcoming long-standing discovery bottlenecks in the field. By combining predictive AI models with molecular dynamics simulations, the AiLNP platform provides mechanistic insights into lipid behavior and enables prediction of more than 10 physicochemical parameters. It further allows for rational design and optimization of LNP components and ratios to construct customized, high-performance delivery systems. Key findings from the poster highlight the platform's ability to accelerate LNP design cycles while significantly improving discovery speed and quality across multiple tissue targets: Liver-targeted LNPs developed through AiLNP demonstrated best-in-class performance for gene editing, achieving high efficiency and safety in NHPs. Using CRISPR-Cas9-mediated TTR knockdown as a model, LNP developed by AiLNP achieved ~90% reduction in serum TTR levels with only a transient, mild elevation in liver enzymes. Lung-targeted LNPs exhibited high delivery efficiency and specificity in rodents, with successful translation to NHPs. At the cellular level, these LNPs transfected a broad range of pulmonary cell types in NHPs—including stem-like cells, alveolar type II cells (>30%), and airway basal cells (>10%) at 1 mg/kg—supporting their potential for durable genetic correction. METiS' Musle-targeted LNPs also enabled successful in vivo delivery and gene editing in multiple types of muscle cells in mice. 'This year's CRS theme, 'Next-Generation Delivery Innovation', reflects the rapid evolution in drug delivery technologies. Among the 410 accepted posters across 12 research tracks, more than 200 focused on nanomedicine, nanodelivery, and gene editing—demonstrating these as the most active areas of exploration,' said Dr. Hongming Chen, Co-founder and Chief R&D Officer of METiS Technologies. 'We're pleased to present our findings at the world's premier scientific forum for drug delivery and remain committed to pushing the boundaries of LNP discovery.' Dr. Chris Lai, Co-founder and CEO of METiS, added: 'Since day one, METiS has been positioning at the global forefront of AI-powered nanomaterial innovation. We believe nanodelivery is the critical enabler of the next generation of programmable medicines—and that AI will be the key catalyst driving this transformation.' AI Nanodelivery for a Healthier Future. METiS Technologies is a pioneering TechBio company at the intersection of artificial intelligence and nanomaterial science, focused on transforming the delivery and application of active agents across life forms. Founded by a team of MIT-trained scientists with deep expertise in AI, quantum mechanics, nanomaterials, and advanced drug delivery, the company has developed three proprietary platform technologies, AiLNP – AI platform for nucleic acid delivery system design; AiRNA – AI platform for mRNA sequence optimization; and AiTEM – AI platform for small molecule formulation design. METiS' platforms simulate, predict, and interpret nanoscale interactions to enable rational design, optimization, and validation of next-generation nanomaterials and their payloads. By advancing AI-enabled nanotechnology, METiS strives to unlock new therapeutic possibilities across a wide range of diseases, including cancer, metabolic and autoimmune disorders, and neurodegenerative conditions, and improve the health of lives.

Dar terms US, Israeli strikes on Iran unacceptable for SCO states
Dar terms US, Israeli strikes on Iran unacceptable for SCO states

Business Recorder

time16-07-2025

  • Politics
  • Business Recorder

Dar terms US, Israeli strikes on Iran unacceptable for SCO states

ISLAMABAD: Pakistan seeks a relationship of peace and stability with all its neighbours. Islamabad remains steadfast in its commitment to the ceasefire and the cultivation of a stable regional equilibrium. However, we cannot accept that the arbitrary use of force is normalised. 'We believe that disputes and differences are resolved through dialogue and diplomacy, instead of conflict and coercion. In that backdrop, initiation of a comprehensive and structured dialogue can meaningfully address the full spectrum of issues that have long bedevilled the peace and security in South Asia. Strict adherence to bilateral agreements would be equally important in this regard.' Deputy Prime Minister/Foreign Minister Ishaq Dar stated this while addressing the Meeting of SCO Council of Foreign Ministers 15 July 2025–Tianjin, China on Tuesday. Iran has right to defend itself, Dar tells OIC However, he said the last three months witnessed extremely disturbing developments in South Asia. It is most unfortunate that the attribution of the Pahalgam attack to Pakistan – without a credible investigation or verifiable evidence –brought the two nuclear-armed states to the brink of a major conflict. In the wake of mounting tensions, Dar pointed out Pakistan's restrained and responsible approach was met with legal transgressions, rhetorical belligerence, and strategic recklessness. The events unfolding since 22 April 2025 also reaffirm a central truth of South Asian geopolitics: the peaceful settlement of the longstanding unresolved disputes is imperative for an enduring peace in the region, Dar added. Dar said Pakistan appreciates China's deep-rooted commitment to multilateralism and its role in strengthening SCO as the Chair this year. In our pursuit to peace and security, he highlighted we believe in non-aggression, non-interference in internal affairs; non-use of force or threat of its use in international relations, as well as seeking no unilateral military superiority in the region. We emphasize on resolution of longstanding disputes through peaceful means, dialogue, diplomacy and according to the principles of international law, justice and fairness. We are seriously concerned at the trends of using aggression as a tool of policy. We have strongly condemned the unjustified and illegitimate aggression by Israel against the Islamic Republic of Iran and the US strikes on its nuclear facilities. Such illegal actions directed against SCO member states are unacceptable. Israel has shown a reckless disregard for international norms and humanity through its relentless and disproportionate use of force in Gaza resulting in the death of tens of thousands of civilians causing the worst humanitarian crisis in Gaza. We call for immediate halt to Israel's atrocities. The only viable remedy to Palestine dispute is the realization of two-State solution which includes the establishment of Palestine as a viable, secure and contiguous State on the basis of pre-1967 borders with Al Quds as its capital. Unilateral and illegal measures to change the status of disputed territories in violation of UN Security Council resolutions must be strongly condemned and opposed by all. Enduring peace and stability in Afghanistan constitute a cornerstone of our shared aspiration. In this context, the revival of the SCO-Afghanistan Contact Group could serve as a valuable platform for pragmatic and results-oriented cooperation, he asserted. As the permanent chair of the SCO's Special Working Group dedicated to combating poverty, Pakistan is fully committed to providing the necessary momentum to our collaborative endeavours to address poverty. Copyright Business Recorder, 2025

Need to avoid trade curbs to normalise ties: Jaishankar to Wang Yi
Need to avoid trade curbs to normalise ties: Jaishankar to Wang Yi

Business Standard

time14-07-2025

  • Business
  • Business Standard

Need to avoid trade curbs to normalise ties: Jaishankar to Wang Yi

In his first visit to China in almost six years, External Affairs Minister (EAM) S Jaishankar on Monday told his Chinese counterpart Wang Yi that the two neighbours resolving 'friction' on the India-China border had led to an easing of tensions, and they should now build on it to address other aspects related to their border, including border management and de-escalation. Jaishankar said the two neighbours should also normalise people-to-people contacts and avoid 'restrictive trade measures and roadblocks'. He underlined the need for cooperation on trans-border rivers and urged the Chinese side to resume providing hydrological data. In his opening remarks at his meeting with the Chinese foreign minister in Beijing, Jaishankar said relations between the two countries can continue to develop on a 'positive trajectory' on the foundation that differences should not become disputes and competition should not become conflict. Alluding to China restricting the supply of critical minerals and flagging the need to foster mutually beneficial cooperation, including through people-to-people exchanges, Jaishankar said, 'It is also essential in this context that restrictive trade measures and roadblocks are avoided.' He said he hoped to discuss these issues in further detail with Wang. Jaishankar landed in Beijing on Sunday, after a day-long visit to Singapore, to attend the Meeting of the Shanghai Cooperation Organisation (SCO) Foreign Ministers Council in Tianjin, which is 135 kilometre from Beijing. China is the current president of the SCO and will host the SCO Summit in Tianjin later this year, which Prime Minister Narendra Modi is likely to attend. Jaishankar last visited China from August 11-13, 2019 — his first visit to the country after assuming office as India's EAM in June that year. As Jaishankar noted in his remarks, India-China relations have been gradually moving in a 'positive direction' after Modi and Chinese President Xi Jinping met in China's Kazan in October 2024. 'Our responsibility is to maintain that momentum,' Jaishankar said, adding that the India-China bilateral relationship requires that 'we take a far-seeing approach to our ties'. India's EAM noted that Wang and he have met in recent months on several occasions at international events and carried out strategic communication. 'It is our expectation that this will now be regular and take place in each other's countries,' Jaishankar said. India-China foreign ministers' level talks had been discontinued after the Galwan clashes of June-July 2020. Jaishankar noted that India and China mark the 75th year of the establishment of diplomatic relations between the two countries, and appreciated Chinese cooperation in the resumption of the Kailash Manasarovar Yatra after a gap of five years. He said the resolution of friction along the India-China border and the ability of the two countries to maintain peace and tranquillity there was the 'fundamental basis' of the 'good progress' made in the past nine months for the normalisation of bilateral relations. Jaishankar called for 'stable and constructive ties' between the two neighbours, which he said could best be achieved by handling relations on the basis of mutual respect, mutual interest, and mutual sensitivity. 'We have also earlier agreed that differences should not become disputes, nor should competition ever become conflict. On this foundation, we can now continue to develop our ties along a positive trajectory,' he said. Jaishankar and Wang will also exchange views on global and regional issues. As for the SCO meeting, scheduled for Monday, Jaishankar said India 'hopes' that the grouping will 'strongly' uphold its mandate of zero tolerance for terrorism. At the SCO's meeting of defence ministers in China's Qingdao in June, Defence Minister Rajnath Singh had refused to sign a joint communiqué as it omitted the Pahalgam terror attack and did not explicitly address India's concerns over Pakistan-backed cross-border terrorism. In Beijing, the EAM also called on Chinese Vice President Han Zheng, where he noted the 'steadily improving' bilateral ties since the Modi-Xi meeting in Kazan last October. He said it is 'very important' for India and China, as neighbouring countries and major economies, to have an open exchange of views and perspectives in the context of the complex international situation. In Singapore on Saturday, Jaishankar met Singapore President Tharman Shanmugaratnam and other ministers, including Teo Chee Hean, who is the coordinating minister for national security and chairman-designate of Temasek Holdings. Their discussion focused on the transformation underway in India and opportunities for Temasek to expand its investments in India, the Ministry of External Affairs said.

Avoid restrictive trade measures to normalise ties, Jaishankar tells Wang
Avoid restrictive trade measures to normalise ties, Jaishankar tells Wang

Business Standard

time14-07-2025

  • Business
  • Business Standard

Avoid restrictive trade measures to normalise ties, Jaishankar tells Wang

In his first visit to China in almost six years, External Affairs Minister S. Jaishankar on Monday told his Chinese counterpart Wang Yi that the two neighbours resolving 'friction' on the India–China border has led to easing of tensions, and they should now build on this to address other aspects related to the boundary, including border management and de-escalation. Jaishankar said the two countries should also normalise people-to-people contacts and avoid 'restrictive trade measures and roadblocks'. He underlined the need for cooperation on trans-border rivers and urged the Chinese side to resume providing hydrological data. In his opening remarks at the meeting with Chinese Foreign Minister Wang in Beijing, Jaishankar said relations between the two countries can continue to develop in a 'positive trajectory' based on the understanding that differences should not become disputes and competition should not become conflict. Alluding to China's restrictions on the supply of critical minerals, and flagging the need to foster mutually beneficial cooperation, including through people-to-people exchanges, Jaishankar said, 'It is also essential in this context that restrictive trade measures and roadblocks are avoided.' He said he hoped to discuss these issues in further detail with Wang. Jaishankar landed in Beijing on Sunday, after a day-long visit to Singapore, to attend the Meeting of the Shanghai Cooperation Organisation (SCO) Foreign Ministers' Council in Tianjin, which is 135 km from Beijing. China currently holds the SCO presidency and will host the SCO Summit in Tianjin later this year, which Prime Minister Narendra Modi is likely to attend. Jaishankar last visited China from 11–13 August 2019, his first trip to the country after assuming office as External Affairs Minister in June that year. As Jaishankar noted in his remarks, India–China relations have been gradually moving in a 'positive direction' after Modi and Chinese President Xi Jinping met in Kazan in October 2024. 'Our responsibility is to maintain that momentum,' he said, adding that the India–China bilateral relationship requires that 'we take a far-seeing approach to our ties'. Jaishankar noted that he and Wang have met on several occasions in recent months at international events and carried out strategic communication. 'It is our expectation that this will now be regular and take place in each other's countries,' he said. Foreign ministers' level talks between India and China were discontinued after the Galwan clashes of June–July 2020. He also noted that India and China are marking the 75th year of the establishment of diplomatic relations, and appreciated Chinese cooperation in resuming the Kailash Manasarovar Yatra after a gap of five years. He said the resolution of friction along the India–China border and the ability of the two countries to maintain peace and tranquillity there were the 'fundamental basis' of the 'good progress' made in the past nine months towards normalising bilateral relations. Jaishankar called for 'stable and constructive ties' between the two neighbours, best achieved by handling relations on the basis of mutual respect, mutual interest, and mutual sensitivity. 'We have also earlier agreed that differences should not become disputes, nor should competition ever become conflict. On this foundation, we can now continue to develop our ties along a positive trajectory,' he said. Jaishankar and Wang will also exchange views on global and regional issues. As for the SCO meeting scheduled for Monday, Jaishankar said India 'hopes' that the grouping will 'strongly' uphold its mandate of zero tolerance for terrorism. At the SCO's meeting of defence ministers in Qingdao, China, in June, Defence Minister Rajnath Singh had refused to sign a joint communiqué as it omitted the Pahalgam terror attack and did not explicitly address India's concerns over Pakistan-backed cross-border terrorism. In Beijing, the EAM also called on Chinese Vice-President Han Zheng, where he noted the 'steadily improving' bilateral ties since the Modi–Xi meeting in Kazan last October. He said it is 'very important' for India and China, as neighbouring countries and major economies, to have an open exchange of views and perspectives in the context of the complex international situation. In Singapore on Saturday, Jaishankar met President of Singapore Tharman Shanmugaratnam and other ministers, including Teo Chee Hean, the Coordinating Minister for National Security and Chairman-designate of Temasek Holdings. Their discussion focused on the transformation underway in India and opportunities for Temasek to expand its investments in the country, the Ministry of External Affairs (MEA) said.

Time to add up to 17 more seats: Jeffrey
Time to add up to 17 more seats: Jeffrey

Daily Express

time14-07-2025

  • Politics
  • Daily Express

Time to add up to 17 more seats: Jeffrey

Published on: Monday, July 14, 2025 Published on: Mon, Jul 14, 2025 By: Iskandar Dzulkifli Text Size: Jeffrey said the proposal serves as a stepping stone to increase the number of parliamentary seats in Sabah in the future, particularly in the Borneo region. Kota Kinabalu: Parti Solidariti Tanah Air Ku (Star) has proposed adding 14 to 17 new State Legislative Assembly (DUN) seats in Sabah. Party President Datuk Seri Dr Jeffrey Kitingan said this follows the recent approval of additional DUN seats in Sarawak and Sabah should take similar action. 'Since Sarawak has started (passed the Bill to add DUN seats), we should do the same thing. I will raise this issue at the coming Cabinet meeting. 'My estimate is that between 14 and 17 new seats need to be added,' he said when met at the 'Oppa' Film Screening on Scam Awareness at the Marina Club, Sunday. Also present was Luyang Star Division Chief Eliza Leong, who is also Persatuan Inspirasi Sabah President who organised the event. Jeffrey, who is also Deputy Chief Minister, said the proposal serves as a stepping stone to increase the number of parliamentary seats in Sabah in the future, particularly in the Borneo region. He noted that Sabah and Sarawak currently have 25 and 31 parliamentary seats respectively, representing about 25 per cent of the total 222 parliamentary seats. 'This means Peninsular Malaysia already has more than a two-thirds advantage (in parliament), while Sabah-Sarawak only have 56 parliamentary seats and we have agreed to change this situation. 'Before that, we need to first increase the number of DUN seats in Sabah and we expect an addition of around 34 new parliamentary seats (in Sabah), in my opinion,' he said. In another development, Jeffrey hopes the Technical Meeting on the Malaysia Agreement 1963 (MA63) scheduled for today (July 14) will reach a resolution on the issue of returning 40 per cent net revenue to Sabah. He said this should be fulfilled as stipulated in the Federal Constitution and implemented, but the matter has been dragging on for more than 40 years without the required five-yearly review. 'The 40 per cent net revenue is not about petroleum royalty, this involves revenue from all sources such as business and so on obtained from Sabah and the Federation. 'Sixty per cent belongs to the Federal Government, while 40 per cent returns to us (Sabah) and the Federal Government must determine an appropriate amount (for that 40 per cent) and Sabah will also present the amount based on records,' he said. 'Therefore, I hope the MA63 Technical Meeting will reach a resolution on this 40 per cent issue and subsequently implement it as stipulated in the Constitution,' he said. * Follow us on our official WhatsApp channel and Telegram for breaking news alerts and key updates! * Do you have access to the Daily Express e-paper and online exclusive news? Check out subscription plans available. Stay up-to-date by following Daily Express's Telegram channel. Daily Express Malaysia

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