Latest news with #MichaelEdwards
The Sun
10 hours ago
- Business
- The Sun
Liverpool ready to pay full £126million asking price for Florian Wirtz to avoid drawn-out transfer saga
LIVERPOOL are preparing to pay the full £126million asking price to capture Florian Wirtz as soon as possible. The Bayern Leverkusen playmaker is understood to have agreed a five–year deal. Although the clubs have yet to agree a final fee. But boss Arne Slot wants to avoid a drawn–out saga. His club first offered £110m then went back with an improved offer. Now Anfield's chief executive of football Michael Edwards has been given permission by owners Fenway Sports Group to go all–in. There is growing Kop optimism that the 22-year-old will put pen to paper after the end of the international break on Sunday. Wirtz featured in Germany's Nations League semi-final defeat to Portugal. He opened the scoring at the Allianz Arena with a well-taken header just after half-time. But Francisco Conceicao and . Julian Nagelsmann's side will now face either France or Spain who play tonight in Sunday's third-fourth play-off. After that, Wirtz will be free to have a medical. And, as is now all but certain, become the showpiece signing of Slot's squad summer splurge with £29m Leverkusen team-mate Jeremie Frimpong already on board. Liverpool had been prepared to go to £120m including add-ons for Wirtz. But they now accept the Bundesliga club will not back down on their original valuation. They are hoping all negotiations can now be completed by the weekend and that Wirtz will be signed and sealed before heading out on holiday in readiness to join his new club for pre-season training which starts early next month. The attacker's number at Anfield remains unclear. Reports suggested he wanted to take the No10 off Alexis Mac Allister - but he quashed those suggestions with an Instagram post. Wirtz, who wears No10 for Leverkusen but No17 for Germany, wrote: "Who says I want the 10 [emoji]. "I respect players. "Don't believe everything that's written," followed by a clown emoji. Elsewhere, Bournemouth left-back Milos Kerkez is also expected to sign next week for £45m – taking the Anfield spend to £200m. 2
Yahoo
3 days ago
- Business
- Yahoo
RELEASE: Falling for the Loop campaign shifts Chicago Loop Alliance programming to celebration of arts and culture
Sundays on State, new Loop bar crawl and monthlong activation enliven State Street and the Loop CHICAGO, June 02, 2025 (GLOBE NEWSWIRE) -- Chicago Loop Alliance is announcing programming for the fall season under the campaign, Falling for the Loop, positioning the month of October as a celebration of arts and culture. Sundays on State, returns for its fifth year on September 7 and October 5; a niche urban planning and design film festival, Better Cities Film Festival on October 9-11; LUMA8's 11th Annual Arts in the Dark Parade on October 18; a new Lurking in the Loop bar crawl at 14 Loop bars and restaurants on October 25; and Skeletons on State, an interactive display of 20 oversized skeletons showcasing iconic Chicago and Loop institutions from October 1-November 3. 'Based on the success of Sundays on State, and the power of arts and culture on both the Loop's economy and its recovery, we felt compelled to expand our programming to uplift Chicago's plethora of cultural assets,' said Michael Edwards, President and CEO of Chicago Loop Alliance. 'For 20 years, our programming has celebrated the city's iconic culture with award-winning initiatives like Sundays on State, and we are excited to bolster that momentum with new events and programs, while supporting major existing events that enliven the Loop, like the Chicago Marathon; Open House Chicago; and State Street's very own, Arts in the Dark Parade.' Sundays on StateSundays on State is free and open to the public and will take place this year on State Street from Randolph to Jackson. Those who register to attend Sundays on State are automatically entered for a chance to win a $1,000 Loop staycation package. Learn more and register for free at Applications for small businesses, local entrepreneurs, artists, non-profits, and food vendors to participate in Sundays on State are open now through June 16. Sundays on State performers include Collaboraction, Chicago Latin Groove Band, DLOW and Malik, Good Girls DJs, Matt Ulery, The Joffrey Ballet, O'Mys, The Rust Riders, The Strangers, and SKIRT The Band. To apply for participation, visit Sundays on State is a project of Chicago Loop Alliance in partnership with the Chicago Department of Cultural Affairs and Special Events, Chicago Loop Alliance Foundation and Special Service Area #1-2015. Supporting sponsors are Allstate Insurance Company, Macy's and Target. The event sponsor is Block 37. Community sponsors are Faegre Drinker, Flyover, Millennium Garages, and Walgreens. Other sponsorship options are still available for interested businesses. Lurking in the LoopLurking in the Loop is free and open to the public, and serves as the Loop's official Halloween bar crawl, exploring nearly a dozen unique bars. The event takes place on October 25 from 8 p.m.-midnight. Participating establishments include Bandol Brasserie, Bar Sotto, Brando's Speakeasy, Elephant & Castle, Emerald Loop Bar & Grill, Exchequer Pub, Hoyt's Royal Sonesta Chicago, Industry Ales, Land & Lake Kitchen, Palmer House Hilton, Petterino's and The Berghoff Restaurant & Adams Street Brewery. Registration is encouraged. Learn more and register for free at Skeletons on StateSkeletons on State is free and open to the public, activating various State Street planters with 12-ft. skeletons adorned with tributes to local Loop and Chicago institutions. Chicagoans and visitors are encouraged to interact with the initiative and share their experiences on social media by tagging Chicago Loop Alliance and #SkeletonsonState. About Falling for the LoopFalling for the Loop is a monthlong series of events that celebrates and uplifts the city's iconic arts organizations and cultural institutions, supports the Loop's vital commerce and fosters community with Chicago's 77 neighborhoods and beyond. About Sundays on StateThe internationally acclaimed, award-winning event series, Sundays on State, transforms Chicago's most iconic street, State Street, when it closes to vehicular traffic on select dates each summer. Neighbors from every Chicago community and beyond unite for a free, interactive block party, while safely enjoying art, culture, active recreation, food, drinks, shopping, and local attractions in the heart of everyone's neighborhood – the Loop. Chicago Loop Alliance's Sundays on State series accelerates the economic recovery, unites the community, and creates joy! Sundays on State events have welcomed over one million people to Chicago's most iconic street. #SundaysOnState About Chicago Loop AllianceChicago Loop Alliance (CLA)'s leads the community by creating and supporting inclusive programs that attract people and investment to the Loop. CLA is a membership organization as well as the sole service provider for Special Service Area #1-2015, and the Chicago Loop Alliance Foundation produces free public art projects and events. For more information, visit MEDIA: Photos and video available for download SOCIAL: Instagram: @loopchicago Facebook: @ChicagoLoopAlliance Twitter: @ChiLoopAlliance LinkedIn: @Chicago-Loop-Alliance TikTok: @loopchicago CONTACT: Ariella Gibson Chicago Loop Alliance 7085434002 ariella@
The Sun
28-05-2025
- Business
- The Sun
Liverpool ‘hold talks over Hugo Ekitike transfer' as they join Chelsea in race for £84million striker
LIVERPOOL have entered the race to sign Eintracht Frankfurt striker Hugo Ekitike, according to reports. The Reds are looking to add attacking reinforcements to their squad with rumours that Darwin Nunez could be swapping Merseyside for the Middle East this summer. 1 According to Sky Germany, Frankfurt forward Ekitike is on the list of targets for Liverpool. It's claimed that the newly crowned champions have already opened talks over a potential move. While Arne Slot and exec Michael Edwards are both keen on the French youth international. It won't be an easy deal to get over the line with Chelsea also thought to be in the running to sign the 22-year-old Bundesliga bagsman. Ekitike, who scored 15 goals and registered eight assists in the league this season, won't come cheap. It's reported that Frankfurt CEO Markus Krosche is holding out for a fee of around £84MILLION for the club's star man. Liverpool already splashed £85m on Darwin Nunez in the summer of 2022, but the Uruguayan has fallen out of favour at Anfield. Nunez managed just five league goals this season as Liverpool stormed to a 20th league title. Boss Slot rarely chose to use the former Benfica man from the off, starting him just eight times in the league all season. And it looks as if Nunez's time with Liverpool could be coming to a close. Trent Alexander-Arnold breaks down in tears and kisses badge as he gets emotional send-off from Liverpool fans Rumours have suggested that clubs in Saudi Arabia a considering a move to bring the striker to the Saudi Pro League next season. While La Liga giants Atletico Madrid have also been suggested as potential suitors. THIS IS A DEVELOPING STORY..
Yahoo
26-05-2025
- Business
- Yahoo
Liverpool offer player swap deal to land £126m-rated Florian Wirtz
Liverpool's transfer window strategy appears to be shifting dramatically, with talks intensifying over Bayer Leverkusen's attacking talisman Florian Wirtz. According to the Daily Star, the Reds are looking to structure a deal that sends a player the other way in order to soften the blow of Leverkusen's reported £126 million valuation — a sum that would shatter the current British transfer record. This negotiation tactic could be decisive, especially after 'other clubs withdrew from negotiations due to Wirtz's hefty price tag.' The idea of a player-plus-cash offer is gaining traction, with Anfield chiefs Michael Edwards and Richard Hughes driving talks at pace. Leverkusen are reportedly on the hunt for reinforcements in several key areas. A goalkeeper, central defender, striker and attacking midfielder are all on their radar — and Liverpool may have the assets to oblige. The likes of Caoimhin Kelleher, Joe Gomez, Darwin Núñez, Diogo Jota, Curtis Jones and Harvey Elliott are 'potential options in negotiations,' giving the Reds flexibility in structuring a deal. Discussions remain ongoing as to whether any outgoing Liverpool player would depart permanently or on loan. Regardless, 'any of those players heading to the BayArena would likely bring Wirtz's fee below the record £115m that Chelsea shelled out to sign Moises Caicedo from Brighton in 2023.' The balance of power in this high-stakes transfer battle appears to be tipping towards Merseyside. Bayern Munich president Herbert Hainer has openly conceded that 'Max Eberl (Bayern sporting director) informed me that Florian Wirtz is probably leaning towards Liverpool. I can't say how things will transpire with Leverkusen.' It marks a remarkable U-turn. Bayern were 'previously believed to be favourites,' having engaged in quiet talks with Wirtz's father, Hans-Joachim. Initially, there was belief that Wirtz would remain in Germany, but a shift in preference occurred just before the player's summer holiday, with his father reportedly informing Bayern's hierarchy that Liverpool had emerged as the desired destination. It's hard not to get excited about this. Florian Wirtz isn't just a name — he's a generational talent with the vision, control and technical sharpness that Liverpool fans dream about. With Arne Slot now overseeing a transitional period at Anfield, adding a player like Wirtz would be a definitive statement of intent. Fans may be concerned about losing the likes of Harvey Elliott or Curtis Jones, who represent the club's future. But if one of them is the key to unlocking a deal for Wirtz, many would argue it's a risk worth taking. 'You have to give up quality to gain world-class,' one could say. Wirtz could be the creative heartbeat Liverpool have lacked since Philippe Coutinho. With Bayern admitting defeat and Liverpool's top brass moving swiftly, this feels like a defining summer. If Edwards and Hughes get this over the line, it could be one of the boldest and smartest plays in recent Liverpool history.
Business Wire
08-05-2025
- Health
- Business Wire
VirTus Respiratory Research Ltd的人体鼻病毒攻毒模型研究结果推动Altesa BioSciences的主导药物进入高级临床试验阶段
伦敦--(BUSINESS WIRE)--(美国商业资讯)-- 专注呼吸系统研究的知名合同研究公司VirTus Respiratory Research Ltd今日宣布，其针对慢性阻塞性肺疾病（COPD）患者开展的鼻病毒人体攻毒模型研究结果，为Altesa BioSciences提供了关键证据，支持将其主导候选药物vapendavir推进至大规模后期临床试验阶段。 鼻病毒感染是导致数百万慢性阻塞性肺病患者出现急性呼吸功能恶化的主要原因，占比至少50%。Altesa首席执行官、美国前卫生部助理部长兼FDA代理局长Brett Giroir博士表示，'在投入数千万美元将vapendavir推进至涉及数千名患者的临床试验之前，通过概念验证研究证实该药物的疗效至关重要。经过全球范围的严格筛选，我们确认VirTus是唯一能够安全、有效且可靠地在真实COPD志愿者中开展此项研究的机构。' 这项随机、安慰剂对照研究招募并评估了40名慢性阻塞性肺病（COPD）志愿者，COPD是全球第三大死亡原因。经过预先筛查的COPD受试者在接种已知安全型鼻病毒毒株后，于症状出现时完成随机分组。本次研究将精准社交媒体推广作为主要招募渠道，触达逾万名潜在志愿者，这一创新性招募策略充分彰显了VirTus为确保受试者高效入组所采用的先进方法。 VirTus联合创始人兼首席医疗官Sebastian Johnston教授表示，'这些积极成果印证了我们人体病毒攻毒模型能够有效地在新药临床研发早期快速评估疗效。该方法能让生物科技和制药合作伙伴获得具有临床意义的早期数据，帮助他们在药物研发管线中做出可靠的继续/终止决策。' VirTus人体病毒攻毒模型为临床试验主办方提供了在受控环境下评估治疗方案的机会，与传统的大规模早期临床开发研究相比，可显著降低不确定性并大幅缩减时间和成本。 Altesa首席医学官、GSK前首席医学官Kate Knobil博士表示，'借助Johnston教授及VirTus团队的丰富经验，我们已掌握如何最优使用vapendavir，使其最大程度改善COPD患者的生活质量——这正是我们矢志追求的终极目标，也是我毕生职业生涯的奋斗方向。' VirTus联合创始人兼董事总经理Michael Edwards博士补充道，'我们非常荣幸能支持Altesa BioSciences取得vapendavir的这些鼓舞性成果。此次成功合作彰显了我们人体攻毒研究的优势与可靠性，进一步强化了我们加速全球呼吸道疾病创新疗法开发的使命。' 关于VirTus Respiratory Research Ltd VirTus Respiratory Research Ltd是由英国帝国理工学院Sebastian Johnston教授与Michael Edwards博士共同领导的合同研究组织（CRO）。VirTus专注于加速呼吸道病毒感染治疗与预防新疗法的开发——这类感染正是哮喘、慢性阻塞性肺疾病（COPD）及支气管扩张等慢性呼吸系统疾病急性发作的首要诱因。VirTus开展从临床前到早期阶段的临床研究，其专长的人体病毒攻毒模型可生成高质量数据，为创新疗法推进至后期研发阶段提供关键支持。 鼻病毒攻毒模型 VirTus Respiratory Research Ltd使用鼻病毒攻毒模型在严格受控、可重复的实验环境中，产生药物临床疗效的早期信号。该模型通过对志愿者实施监测条件下的鼻病毒感染，可全面评估治疗方案对症状、病毒载量及免疫/炎症反应的影响。对合作伙伴而言，这一模型是在开展规模更大、成本更高的IIb/III期试验前至关重要的"继续/终止"决策工具。它能在早期解答包括临床疗效、剂量选择和终点指标优化等关键问题。主办方可借此缩短研发周期、提前获得'继续/终止'决策依据，通过在早期阶段识别有潜力的候选药物或排除无效方案来降低研发风险，最终实现资源优化配置并提高后续研发成功率。 关于Vapendavir 口服片剂vapendavir是一款处于临床阶段的抗病毒药物，对97%的测试鼻病毒株及其他呼吸道肠道病毒均表现出强效活性。该药物通过双重作用机制起效：既能阻断病毒侵入人体细胞，又可抑制病毒复制。目前，Vapendavir针对COPD患者鼻病毒感染的适应症已进入后期临床试验阶段。其作用机制与Gilead Sciences已获FDA批准的HIV衣壳抑制剂lenacapavir类似。 关于COPD 慢性阻塞性肺疾病（COPD）是一种影响全球数亿患者的致命性慢性肺部疾病。作为当前全球第三大死因，COPD患病率随着人口老龄化及持续暴露于吸烟、空气污染等风险因素而不断攀升。该疾病给患者个体和医疗系统均带来沉重负担：一方面因进行性肺功能衰退和频繁急性加重导致高发病率；另一方面长期治疗及反复住院产生的巨额医疗费用（仅美国每年就高达490亿美元）也造成巨大经济压力。 关于Altesa Altesa BioSciences是一家临床阶段制药公司，致力于为人类健康长期面临的重大威胁——高致病性病毒感染，开发新型疗法。这类感染对脆弱人群的影响尤为严重，包括肺部疾病等慢性病患者、老年人以及医疗服务不足社区的众多群体。 免责声明：本公告之原文版本乃官方授权版本。译文仅供方便了解之用，烦请参照原文，原文版本乃唯一具法律效力之版本。
