Latest news with #Parkinson
Yahoo
19 hours ago
- Entertainment
- Yahoo
Ozzy Osbourne, 76, Undergoing Physical Therapy Ahead of Farewell Show
Rock legend Ozzy Osbourne is preparing for his final performance, which is set to take place on July 5 at Villa Park in Birmingham, England. However, things haven't been easy for Osbourne, who was diagnosed with Parkinson's in 2019. On the May 28 episode of SiriusXM's Ozzy Speaks, the Black Sabbath frontman shared an update on his health as he looks forward to the upcoming show. "I've got this trainer guy who helps people get back to normal," Osbourne said. "It's hard going, but he's convinced that he can pull it off for me. I'm giving it everything I've got." When co-host Billy Morrison asked Osbourne if he was stressing about the show, the rocker candidly replied, "Sometimes, but what I do, if I start obsessing all the time, I'll be insane by Friday, you know? So, I'm just taking it one day at a time and when I do it one day at a time. You know, when we were talking about this [obsessive-compulsive disorder], whatever. I have that badly. All I can say is I'm giving 120%. If my God wants me to do the show, I'll do it." Osbourne's comments come weeks after he chatted with The Guardian about his current health. "I have problems walking. I also get blood pressure issues from blood clots on my legs. I'm used to doing two hours on stage, jumping and running around. I don't think I'll be doing much jumping or running around this time. I may be sitting down," he told the outlet. Osbourne hasn't played a show since Osbourne, 76, Undergoing Physical Therapy Ahead of Farewell Show first appeared on Men's Journal on May 30, 2025
Politico
a day ago
- Business
- Politico
AI: A new lab partner in biotech
THE REGULATORS Biotech companies are using a new set of artificial intelligence products to hasten drug discovery and other scientific research, and they're energized by the Food and Drug Administration's apparent embrace of generative AI tools, said biotech leaders at a virtual Google Cloud AI roundtable Thursday. What they said: Generative AI tools can absorb some tedious work that scientists would normally perform, like extracting novel insights from large datasets, including scientific literature or the human genome, the latter of which could take 'thousands of years' to comb through manually, said Ben Mabey, chief technology officer at Recursion, a pharmaceutical company. 'We can have [generative AI] agents do that and save the really hard problems for humans,' he said. The remarks come as the FDA looks to universalize AI use in-house. Earlier this month, FDA Commissioner Marty Makary mandated the agency's divisions to use AI to conduct scientific reviews by the end of June. Mabey and other biotech executives, including Girish Naganathan, chief technology officer of glucose monitoring tech company Dexcom, said that's a good sign for health AI's future as the FDA looks to build a regulatory framework for the technology. Now, companies like Dexcom are 'engaged in providing feedback to and seeking input from the FDA as we take steps to incorporate gen-AI into our products,' Naganathan said. Artificial intelligence could help the FDA achieve other goals it set earlier this year, particularly one that aims to phase out animal testing with 'more effective, human-relevant methods,' Mabey said. 'We can replace [animals] with [AI] models that are more predictive, not just of the animals but of the humans we care about,' he said. 'It's a great North Star to work towards.' Why it matters: Biotech companies are sizing up the FDA's relationship with AI to understand how the agency might regulate those tools. Regulations will likely influence their bottom line and dictate, for example, how many hurdles a company must clear to bring a drug borne out of AI to market. WELCOME TO FUTURE PULSE This is where we explore the ideas and innovators shaping health care. Scientists have developed gene delivery 'trucks' that can target specific brain cells, which could lead to therapies for neurodegenerative diseases like Parkinson's and Alzheimer's, The Washington Post reports. Radiologists are skeptical about how well AI can detect and diagnose cancer, even as the Food and Drug Administration clears the technology to analyze mammograms and imaging centers adopt these programs, STAT reports. Share any thoughts, news, tips and feedback with Danny Nguyen at dnguyen@ Carmen Paun at cpaun@ Ruth Reader at rreader@ or Erin Schumaker at eschumaker@ Want to share a tip securely? Message us on Signal: Dannyn516.70, CarmenP.82, RuthReader.02 or ErinSchumaker.01. Researchers at the National Institutes of Health used machine learning to identify an early biomarker of aggressive breast cancer and help predict which patients could be at high risk of recurrence or death from the disease. The findings: The researchers used machine learning to detect minute changes in more than 9,000 samples of connective breast tissue, called stromal tissue, and found that significant abnormalities were associated with more aggressive forms of breast cancer and greater mortality, particularly in women with invasive forms of the disease. An analysis of the stromal tissue samples — from healthy women, women with benign breast disease and women diagnosed with invasive breast cancer — suggested that so-called disruptive tissue might be tied to common risk factors for aggressive breast cancer, such as being Black, obese or young. The study also found that significantly abnormal tissue was linked to higher risks of aggressive cancer and faster progression from benign breast disease to cancer than tissue with little to no stromal disruption. Those disruptions can be influenced by chronic inflammation and wound healing, but according to Dr. Mustapha Abubakar, one of the study authors, 'We don't know which one comes first: inflammation [and wound healing] or stromal disruptions.' It's also not yet clear how people can prevent stromal anomalies from occurring. Why it matters: The findings come as breast cancer incidence is rising in young women. A 2024 study by the American Cancer Society found that breast cancer incidence among women under 50 was increasing at 1.4 percent a year — about twice as fast compared with women older than 50. The disease is the second-leading cause of cancer death in women — only behind skin cancers. These findings, if replicable and transferable, could offer scientists a therapeutic target. It also gives women another reason to get biopsies, Abubakar said; stromal disruptions don't manifest in anything we can see with our naked eye and can only be detected under a microscope. It could take years for these findings to yield tangible impacts for women in clinical settings, Abubakar added. But scientists are moving faster than ever by using machine learning to identify patterns or anomalies in images of tissue, sequences of genomes and other data sets.
Daily Mirror
a day ago
- Sport
- Daily Mirror
Ryan Reynolds overruled on Wrexham plan as it emerges who has the real power
Wrexham co-owner Ryan Reynolds has shared how manager Phil Parkinson rejected one of his ideas as the Red Dragons prepare for their first season in the Championship Ryan Reynolds has highlighted the significant role of Phil Parkinson at Wrexham after sharing how the manager vetoed one of his proposals. The Welsh team are currently on a high, having secured promotion from League One in April. The club is now gearing up for their first season in the second tier in 43 years. Wrexham recently revealed plans for a pre-season tour of Australia and New Zealand in July, with the Red Dragons gaining worldwide recognition under the stewardship of Reynolds and co-owner Rob McElhenney. The "Wrexham Down Under Tour" will pit them against Melbourne Victory, Sydney FC and Wellington Phoenix. Speaking on the Men in Blazers podcast, Reynolds disclosed that he had also hoped to arrange a friendly match against Auckland FC. However, Parkinson dismissed the idea of playing against the newly formed club, opting instead for an early return home. "I really wanted us to play Auckland FC, which is a new team," Reynolds said. "I just like the idea of the third-oldest football club playing one of the newest. But Phil was like, 'Absolutely not, we are getting these players back to Wales ASAP after Wellington'." Parkinson's decision came in the wake of criticism over poor scheduling, which was blamed for Wrexham's sluggish start to life in League Two in 2023. That year, the club embarked on a summer tour of the United States but didn't return until a week before the season kicked off, leaving little time to readjust. Later on in the podcast, Reynolds mentioned he had complete faith in the manager, providing insight into Parkinson's significant influence at Wrexham. The co-owners have consistently said they would not interfere with football-related decisions since buying the club. It's a strategy that seems to have been successful, given Parkinson's three back-to-back promotions. Former Wrexham and Manchester United goalkeeper Ben Foster believes it is to the co-owners' credit that they have given him so much control. When asked about the dynamics in December, Foster said: "Phil Parkinson is the guy that has the say so on everything, with players in, players out, new contracts, and even when it comes to media duties. He wants to know what's going on. "I love the way that they give him all that power. When you've got two massive A-list Hollywood stars running the football club, money could become a massive problem, and you could be haemorrhaging cash all over the place, but he makes sure it doesn't happen." He added: "The manager nowadays is a coach, and they just get the players that the big dogs have brought in, and they have to work with them. But Phil Parkinson still maintains that he is the guy that brings every single player in." Parkinson is evidently thrilled with the support from Wrexham's owners. He praised their impact after promotion to the Championship was sealed. Parkinson said: "The owners have come in and done an amazing job. I'm so pleased for them because they deserve it. There's lots of ways you can be supportive as owners. "It can be making sure we get a key player when it matters the most. But it can also be support when the results don't go quite as well as you want them to, but still allowing us to do our jobs." He added: "That's what they've always done. They're invested in all of the decisions, but they trust us in our decision making and that's why we've had success over the last three years." Join our new WhatsApp community and receive your daily dose of Mirror Football content. We also treat our community members to special offers, promotions, and adverts from us and our partners. If you don't like our community, you can check out any time you like. If you're curious, you can read our Privacy Notice. Sign up to our newsletter! Wrexham is the Game is great new way to get top-class coverage Wrexham AFC is the arguably the fastest-growing club in the world at the moment thanks to a certain Ryan Reynolds and Rob McElhenney. The Dragons have achieved two consecutive promotions and are cheered on by crowds from not only North Wales but also from all over the globe, thanks to the success of the Disney+ documentary 'Welcome to Wrexham'. But does it have a dedicated, quality source of information piped through to your inbox each week, free of ads but packed with informed opinion, analysis and even a little bit of fun each week? That's where Wrexham is the Game steps in... Available every Wednesday, it provides all the insights you need to be a top red. And for a limited time, a subscription to 'Wrexham is the Game' will cost fans just £15 for the first year.
Yahoo
a day ago
- General
- Yahoo
Sleep disorders increase dementia risk
People who experience sleep disorders are at greater risk of developing neurodegenerative conditions, including dementia, new research has found. The study, conducted by researchers at Cardiff University, found that diagnoses of sleep disorder made people up to twice as likely to develop a neurodegenerative disease in the 15 years that followed. The peer-reviewed study used data from more than a million electronic health records. "This increased risk was occurring independently of genetic risk factors for Alzheimer's and Parkinson's, with sleep disorders almost 'compensating' for low genetic risk," said Prof Valentina Escott-Price, from the UK Dementia Research Institute at Cardiff University. Call for danger warnings to rugby parents over dementia fears I love dad to bits - but being his carer has broken me The researchers examined data from three biobanks – facilities that store biological samples and are used for health research – from which they were "able to obtain accurate, timestamped records of when people experienced sleep disorders". The team analysed those who had been diagnosed with one of more sleep disorder, grouping them into those associated with "circadian rhythm" – or body clock – such as sleepwalking and narcolepsy, and "non-organic" sleep disorders not linked to a known psychological condition, including generalised insomnia and nightmares. The key findings were: Circadian sleep disorders and non-organic sleep disorders were associated with an increased risk of dementia in the 10 to 15 years that followed. The risk was further increased for those with multiple sleep disorders. Circadian sleep disorders increased the risk of Alzheimer's in the 10 to 15 years following sleep disorder diagnosis. Circadian sleep disorders and non-organic sleep disorders increased the risk of vascular dementia in the 5 to 10 years following sleep disorder diagnosis. The risk was further increased for those with multiple sleep disorders. Circadian sleep disorders and non-organic sleep disorders increased risk of Parkinson's in the 10 to 15 years following sleep disorder diagnosis. Dr Emily Simmonds, bioinformatician at the UK Dementia Research Institute at Cardiff University, said the study aimed to "understand the complicated relationship between sleep and dementia". She said: "People living with dementia often experience sleep problems, but there is not yet enough evidence to say for sure whether poor sleep increases risk of dementia. "Our results are compelling, indicating a clear increased risk of neurodegenerative disease following a sleep disorder." Prof Escott-Price, also from Cardiff University, said that while further investigation is needed the research "points towards sleep disorders as a risk factor for these conditions". Future research will examine whether improving sleep through the use of medication leads to a reduction in risk.
Edinburgh Live
a day ago
- Entertainment
- Edinburgh Live
Billy Connolly's life from net worth to health and return to screen after six years
Our community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info Sir Billy Connolly has been bringing a smile to people's faces for more than 50 years, thanks to his long career in comedy. He is sometimes known, especially in his native Scotland, by the nickname The Big Yin, meaning The Big One. Despite being recognised as one of the finest comedians, the much-loved star initially entered the entertainment industry as a folk singer with the Glaswegian group The Humblebums. However, by the mid-70s, he transitioned from being the band's humorous frontman to a full-time stand-up comedian. His debut solo album, a blend of music and comedy sketches, featured one of his most renowned routines, The Crucifixion, where he compares the Last Supper to a boozy night out in Glasgow. The success of the album and subsequent live performances catapulted him to UK fame, making his first appearance on BBC's flagship chat show, Parkinson, in 1975. (Image: Luke MacGregor/PA Wire) Is Billy Connolly married and does he have children? In 1968, at the age of 26, Billy married his first wife, fellow Scot Iris Pressagh and together the pair had two children. They divorced in 1985, and in 1989, Billy went on to tie the knot with New Zealand-born writer and psychologist Pamela Stephenson. The couple are still married and also have three children together. (Image: David M. Benett/for Audi) Billy Connolly's health battle Billy has been battling Parkinson's disease, a degenerative brain condition, since 2013. In 2018, he released a documentary titled Made In Scotland, where he reflected on his life, career, and illness. At the time he said that when he was diagnosed with Parkinson's disease, he felt like his life was "slipping away". He was dealt a devastating blow when he was diagnosed with both prostate cancer, which he later received the all-clear on, and Parkinson's at the same time. Last year, he teased that he may return to screens after retiring from the scene six years ago. He took a break from doing sketches when he started to forget his routines. At the time, Mike Reilly, who has collaborated with Sir Billy for over a decade, has revealed that the comedian has approached him about working on a new project. (Image: BBC) He remained secretive, telling the Metro: "I've been asked about doing something else with him, which we're in conversations about that. "But I'm not allowed to say what it is. But it'll be nice if it happens, it'll be great if it happens." Mike insisted that he was not putting pressure on the actor and comedy legend, saying they are working on new ideas at a pace that works for him. What is Billy Connolly's net worth? Billy has an impressive wealth thanks to his long career as an actor and comedian. It is reported that he has a fortune of £16.5M. This has been earned through Billy's work as a movie actor and stand-up comedian.
