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New Proteomics blood test unlocks better oesophageal cancer detection
New Proteomics blood test unlocks better oesophageal cancer detection

The Age

time5 days ago

  • Health
  • The Age

New Proteomics blood test unlocks better oesophageal cancer detection

Newly published results from ASX-listed diagnostics trailblazer Proteomics International Laboratories have unveiled stunning new clinical findings for its simple PromarkerEso oesophageal cancer blood test, opening the way for the innovative blood test to be commercially released. The test's accuracy was demonstrated in a 259-person study across three patient groups in Australia and the United States. The results were posted overnight in the peer-reviewed journal Proteomes, providing a major academic rubber stamp for the technology. The new findings showed that the test could detect a whopping 91.4 out of 100 patients with the heartburn-related cancer and correctly identify 98.9 per cent of people without it, offering a powerful, non-invasive alternative to costly and uncomfortable endoscopies. Based on the results, PromarkerEso outperforms many tests currently used for screening other types of cancers. For context, the widely used Prostate-Specific Antigen blood test used to diagnose prostate cancer has an Area Under Curve (AUC) measurement of just 0.68, while PromarkerEso hit an exceptional AUC of 0.98. An AUC greater than 0.7 is considered to offer acceptable discrimination, while above 0.9 is considered outstanding. 'The published results represent a major advancement in our mission to transform the lives of people living with chronic acid reflux.' Proteomics International Laboratories managing director Dr Richard Lipscombe Described by the company as a landmark moment in non-invasive diagnostics, PromarkerEso uses a standard blood draw to flag at-risk patients using a traffic light system that grades patients at low, moderate and high risk of developing the cancer. The results are delivered with near-laboratory precision and without the need for specialist procedures. Proteomics says the breakthrough could transform early detection of one of the world's deadliest and most overlooked cancers, which often goes undiagnosed until it's too late. Specifically, the disease targeted by the test is oesophageal adenocarcinoma, which is often caused by chronic heartburn, or acid reflux, and affects up to 20 per cent of people in Western populations. Despite the high incidence, current detection methods rely on invasive endoscopy procedures that are uncomfortable and expensive. In the US, an endoscopy costs about US$2750 (A$4200) per procedure. Even with this rigorous scrutiny, up to 90 per cent of cases go undetected.

New Proteomics blood test unlocks better oesophageal cancer detection
New Proteomics blood test unlocks better oesophageal cancer detection

Sydney Morning Herald

time5 days ago

  • Health
  • Sydney Morning Herald

New Proteomics blood test unlocks better oesophageal cancer detection

Newly published results from ASX-listed diagnostics trailblazer Proteomics International Laboratories have unveiled stunning new clinical findings for its simple PromarkerEso oesophageal cancer blood test, opening the way for the innovative blood test to be commercially released. The test's accuracy was demonstrated in a 259-person study across three patient groups in Australia and the United States. The results were posted overnight in the peer-reviewed journal Proteomes, providing a major academic rubber stamp for the technology. The new findings showed that the test could detect a whopping 91.4 out of 100 patients with the heartburn-related cancer and correctly identify 98.9 per cent of people without it, offering a powerful, non-invasive alternative to costly and uncomfortable endoscopies. Based on the results, PromarkerEso outperforms many tests currently used for screening other types of cancers. For context, the widely used Prostate-Specific Antigen blood test used to diagnose prostate cancer has an Area Under Curve (AUC) measurement of just 0.68, while PromarkerEso hit an exceptional AUC of 0.98. An AUC greater than 0.7 is considered to offer acceptable discrimination, while above 0.9 is considered outstanding. 'The published results represent a major advancement in our mission to transform the lives of people living with chronic acid reflux.' Proteomics International Laboratories managing director Dr Richard Lipscombe Described by the company as a landmark moment in non-invasive diagnostics, PromarkerEso uses a standard blood draw to flag at-risk patients using a traffic light system that grades patients at low, moderate and high risk of developing the cancer. The results are delivered with near-laboratory precision and without the need for specialist procedures. Proteomics says the breakthrough could transform early detection of one of the world's deadliest and most overlooked cancers, which often goes undiagnosed until it's too late. Specifically, the disease targeted by the test is oesophageal adenocarcinoma, which is often caused by chronic heartburn, or acid reflux, and affects up to 20 per cent of people in Western populations. Despite the high incidence, current detection methods rely on invasive endoscopy procedures that are uncomfortable and expensive. In the US, an endoscopy costs about US$2750 (A$4200) per procedure. Even with this rigorous scrutiny, up to 90 per cent of cases go undetected.

Proteomics on fast track to deliver simple endometriosis blood test
Proteomics on fast track to deliver simple endometriosis blood test

Sydney Morning Herald

time26-05-2025

  • Health
  • Sydney Morning Herald

Proteomics on fast track to deliver simple endometriosis blood test

ASX-listed diagnostics innovator Proteomics International Laboratories plans to start a commercial roll-out of its groundbreaking, simple 'traffic light' diagnostic blood test for endometriosis within months, in the process revolutionising healthcare for the disease. The company says its latest trial of its PromarkerEndo test has put it on a fast track to deliver the first clinically viable, real-world, non-invasive diagnostic test for a disease affecting one in nine women and girls and costing the Australian economy nearly $10 billion. Over the weekend, Proteomics released the results of its latest trial, involving 704 blood plasma samples, to leading medical specialists and researchers at the prestigious World Congress on Endometriosis in Sydney. The trial used a diagnostic test consolidated from earlier prototype models to compare cases of endometriosis with general population controls and symptomatic patients. Proteomics said the trial delivered stunning accuracy in diagnosing cases across all stages of the debilitating disease. 'This is a major step forward in making non-invasive endometriosis diagnosis a reality.' Proteomics International Laboratories managing director Dr Richard Lipscombe In a sector where a diagnosis has traditionally taken an average of seven years and involved a painful and invasive laparoscopy and tissue biopsy, this simple blood test is poised to flip the script entirely. For the first time, doctors may soon swap the scalpel for a simple fingerprick blood test, with PromarkerEndo positioned to become the frontline tool in detecting endometriosis in symptomatic patients. PromarkerEndo uses a universal 'traffic light' risk score - low, moderate or high - to indicate a patient's likelihood of having endometriosis. In validation trials, the test clocked an overall accuracy score of 0.92 and reached up to 98 per cent sensitivity in severe cases. It has a robust stage one accuracy performance of 89 per cent in early-stage disease, which is often the hardest to detect. Proteomics International Laboratories managing director Dr Richard Lipscombe said: 'This is a major step forward in making non-invasive endometriosis diagnosis a reality. The advances support our commercialisation strategy and reinforce the potential for PromarkerEndo to become a standard part of the clinical diagnostic pathway.'

Proteomics on fast track to deliver simple endometriosis blood test
Proteomics on fast track to deliver simple endometriosis blood test

The Age

time26-05-2025

  • Health
  • The Age

Proteomics on fast track to deliver simple endometriosis blood test

ASX-listed diagnostics innovator Proteomics International Laboratories plans to start a commercial roll-out of its groundbreaking, simple 'traffic light' diagnostic blood test for endometriosis within months, in the process revolutionising healthcare for the disease. The company says its latest trial of its PromarkerEndo test has put it on a fast track to deliver the first clinically viable, real-world, non-invasive diagnostic test for a disease affecting one in nine women and girls and costing the Australian economy nearly $10 billion. Over the weekend, Proteomics released the results of its latest trial, involving 704 blood plasma samples, to leading medical specialists and researchers at the prestigious World Congress on Endometriosis in Sydney. The trial used a diagnostic test consolidated from earlier prototype models to compare cases of endometriosis with general population controls and symptomatic patients. Proteomics said the trial delivered stunning accuracy in diagnosing cases across all stages of the debilitating disease. 'This is a major step forward in making non-invasive endometriosis diagnosis a reality.' Proteomics International Laboratories managing director Dr Richard Lipscombe In a sector where a diagnosis has traditionally taken an average of seven years and involved a painful and invasive laparoscopy and tissue biopsy, this simple blood test is poised to flip the script entirely. For the first time, doctors may soon swap the scalpel for a simple fingerprick blood test, with PromarkerEndo positioned to become the frontline tool in detecting endometriosis in symptomatic patients. PromarkerEndo uses a universal 'traffic light' risk score - low, moderate or high - to indicate a patient's likelihood of having endometriosis. In validation trials, the test clocked an overall accuracy score of 0.92 and reached up to 98 per cent sensitivity in severe cases. It has a robust stage one accuracy performance of 89 per cent in early-stage disease, which is often the hardest to detect. Proteomics International Laboratories managing director Dr Richard Lipscombe said: 'This is a major step forward in making non-invasive endometriosis diagnosis a reality. The advances support our commercialisation strategy and reinforce the potential for PromarkerEndo to become a standard part of the clinical diagnostic pathway.'

Proteomics bags Chinese patent for innovative muscle stress test
Proteomics bags Chinese patent for innovative muscle stress test

The Age

time15-05-2025

  • Business
  • The Age

Proteomics bags Chinese patent for innovative muscle stress test

A 66 per cent-owned subsidiary of ASX-listed Proteomics International Laboratories has picked up a major win in the world's most populous market after being granted a Chinese patent for its potentially revolutionary muscle stress test. Developed alongside The University of Western Australia, OxiDx Limited's technology uses a quick, low-cost fingerprick blood test to track muscle damage caused by oxidative stress in elite athletes and thoroughbred racehorses. Oxidative stress is caused by an overload of toxic oxidants - known as free radicals, which start to overpower the body's natural defences, throwing the system off balance. It is also linked to more than 70 different human health conditions. The test can be done anywhere, from a lab at home or on the track to deliver instant feedback that can help manage training, injury recovery and even early intervention for chronic health issues such as cancer and diabetes. Muscle injuries account for up to 55 per cent of all sports injuries in professional athletes. The horse racing industry fares even worse, with 85 per cent of thoroughbreds suffering at least one injury by the time they finish their second racing season. Proteomics says the freshly granted Chinese patent effectively future proofs the company's competitive advantage in Asia and remains valid until 2039. The commercial potential of the test appears enormous, particularly in a performance-obsessed market like China, where sports science, wellness, and elite horse racing are all booming. The new patent has also added serious firepower to OxiDx's global intellectual property footprint, which already covers the US, Japan, Europe and Australia. Second-generation protections are still in the pipeline for key markets such as Singapore, India and a fresh round in the US. Proteomics lit up the diagnostics scene in December when its OxiDx test holed out a proof-of-concept trial, tracking muscle damage and recovery in elite marathon runners with pinpoint accuracy.

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