Latest news with #UniversityOfBradford
Yahoo
5 days ago
- General
- Yahoo
Ancient skeleton tests reveal how disease evolved
Researchers at the University of Bradford have taken part in analysis which has found how ancient DNA for a type of bacteria which causes a fever has evolved over thousands of years. Borrelia recurrentis bacteria causes relapsing fever, an illness with many recurring episodes of fever, which is typically found today in areas with poor sanitation or overcrowding, such as refugee camps. It is a distant cousin of the bacteria which causes Lyme disease. Working with the Francis Crick Institute and UCL on samples of archaeological human bone, researchers believe the work can help show how diseases might develop and change in the future. Four samples from across England tested positive for Borrelia recurrentis, caused by bacteria spread through the bites of lice rather than ticks. The samples, dating back to the medieval and Iron Age periods, were obtained from the skeletons of infected people. These included DNA from bone and teeth fragments from a female skeleton from Wetwang Slack, an Iron Age archaeological site in East Yorkshire, and fragments from remains found in Canterbury in Kent, Poulton in Cheshire and South Gloucestershire. Scientists manged to sequence the whole genome, an organism's complete set of DNA, from the four samples. Ranging from 2,300 to 600 years ago, their samples included the oldest Borrelia recurrentis genome to date. The research found how the relapsing fever spread from lice to ticks which may have coincided with changes in human lifestyles, such as living closer together and the beginning of the wool trade. Dr Jo Buckberry, from the University of Bradford's School of Archaeological and Forensic Sciences, said: "It's really exciting to work with ancient DNA specialists, to identify diseases than we cannot see on the skeleton. "As we celebrate Bradford 2025 and reflect on our role in the historic wool trade, it's fascinating to know our archaeological research has contributed to the understanding of how the use of wool has changed the diseases affecting people in the past." Researchers looked at differences in the ancient and modern-day Borrelia recurrentis and found the species likely diverged from its nearest tick-borne cousin, about 4,000 to 6,000 years ago. The study also found a change from the bacteria's transmission from ticks to lice happened during the transition from the Neolithic, or New Stone Age, period to the Early Bronze Age. Pontus Skoglund, group leader of the Ancient Genomics Laboratory at the Francis Crick Institute, said: "Understanding how bacteria such as Borrelia recurrentis became more severe in the past may help us understand how diseases could change in the future. "The time points we've identified suggest that changes in human societies such as new clothing material or living in larger groups may have allowed Borrelia recurrentis to jump vectors and become more lethal, an example of how pathogens and humans have co-evolved." Listen to highlights from West Yorkshire on BBC Sounds, catch up with the latest episode of Look North. Thousand-year-old skeletons found in hotel garden Left for dead again: Ancient Indian skeleton still waiting for permanent address The Francis Crick Institute UCL University of Bradford
BBC News
5 days ago
- Business
- BBC News
Bradford researchers solve mystery of disease and wool trade
Researchers at the University of Bradford have taken part in analysis which has found how ancient DNA for a type of bacteria which causes a fever has evolved over thousands of recurrentis bacteria causes relapsing fever, an illness with many recurring episodes of fever, which is typically found today in areas with poor sanitation or overcrowding, such as refugee is a distant cousin of the bacteria which causes Lyme with the Francis Crick Institute and UCL on samples of archaeological human bone, researchers believe the work can help show how diseases might develop and change in the future. Four samples from across England tested positive for Borrelia recurrentis, caused by bacteria spread through the bites of lice rather than samples, dating back to the medieval and Iron Age periods, were obtained from the skeletons of infected included DNA from bone and teeth fragments from a female skeleton from Wetwang Slack, an Iron Age archaeological site in East Yorkshire, and fragments from remains found in Canterbury in Kent, Poulton in Cheshire and South manged to sequence the whole genome, an organism's complete set of DNA, from the four from 2,300 to 600 years ago, their samples included the oldest Borrelia recurrentis genome to date. The research found how the relapsing fever spread from lice to ticks which may have coincided with changes in human lifestyles, such as living closer together and the beginning of the wool Jo Buckberry, from the University of Bradford's School of Archaeological and Forensic Sciences, said: "It's really exciting to work with ancient DNA specialists, to identify diseases than we cannot see on the skeleton."As we celebrate Bradford 2025 and reflect on our role in the historic wool trade, it's fascinating to know our archaeological research has contributed to the understanding of how the use of wool has changed the diseases affecting people in the past." Researchers looked at differences in the ancient and modern-day Borrelia recurrentis and found the species likely diverged from its nearest tick-borne cousin, about 4,000 to 6,000 years study also found a change from the bacteria's transmission from ticks to lice happened during the transition from the Neolithic, or New Stone Age, period to the Early Bronze Skoglund, group leader of the Ancient Genomics Laboratory at the Francis Crick Institute, said: "Understanding how bacteria such as Borrelia recurrentis became more severe in the past may help us understand how diseases could change in the future."The time points we've identified suggest that changes in human societies such as new clothing material or living in larger groups may have allowed Borrelia recurrentis to jump vectors and become more lethal, an example of how pathogens and humans have co-evolved." Listen to highlights from West Yorkshire on BBC Sounds, catch up with the latest episode of Look North.
Telegraph
19-05-2025
- Health
- Telegraph
Too young for dementia? These are the six warning signs for people under 65
Most of us try not to think about dementia in our younger years. We imagine it as something that, if it must strike us, will only rear its head decades down the line when we're already elderly and frail. But early onset dementia, defined as dementia with symptoms that start when a sufferer is younger than 65, is on the rise. The number of people living with it in Britain has increased by 69 per cent in the past 10 years. It's still a relatively rare phenomenon, accounting for around 7 per cent of all cases, whereas one in 11 over-65s in Britain lives with the disease. Yet as of 2022, nearly 80,000 under-65s in this country have been diagnosed with dementia. 'Most people don't immediately think to attribute any new health symptoms to dementia when they're still young,' says Jan Oyebode, a professor of dementia care at the University of Bradford. It's easy to see why. While Alzheimer's disease accounts for most cases of dementia in older people, younger people often suffer from rarer kinds of dementia, such as frontotemporal dementia and primary progressive aphasia, which can have very different symptoms in the first instance. Memory may not be the first kind of cognitive function that changes. 'I remember one husband whose wife took a pan out of the oven without thinking to put oven gloves on first, because her impulse control was impaired,' Prof Oyebode recalls. 'Another woman told me that she had sped after an ambulance because she was so excited by the flashing lights. Other people shoplift. Some even end up becoming divorced before they're finally diagnosed. Their partners see a huge change in personality and believe that the person living with dementia no longer loves them.' Here are the six unexpected signs of early onset dementia and what it's possible to do about them. 1. You can't see as well as you used to Some subtypes of dementia, like posterior cortical atrophy (PCA), are most likely to begin when someone is aged under 65. PCA typically presents itself for the first time when those who develop it are in their 50s. The posterior part of your brain processes the visual information that comes from your eyes, so typically, the first sign of PCA is changes to your vision. This can show up as 'difficulty reading, judging distances and depth perception,' says Dr Natalie Ryan, a consultant neurologist and senior clinical research fellow at the Dementia Research Centre of University College, London. 'People with PCA might go to an optician and ask for help, but the problem won't be identified, because it's not an issue with your eyes but with your brain,' says Prof Oyebode. Dr Ryan agrees that this is common. 'People often don't appreciate that visual symptoms can result from changes in the brain caused by diseases that underlie dementia,' she explains. People with this kind of dementia are often still young and physically fit, 'so they can use helpful strategies to live with these visual impairments,' says Dr Ryan. 'This might include keeping the home well-lit and clear of obstacles, and avoiding flooring that is heavily patterned, as this can make the space harder to navigate.' 2. You have had a personality change Frontotemporal dementias (FTD), an umbrella term for a group of other rare dementias, are also more likely to occur in people aged under 65. These kinds of dementia develop in the front and sides of the brain, and can present themselves when a sufferer is in their 40s. Frontotemporal dementia can cause the sorts of personality changes that Prof Oyebode says can lead to divorce and the breakdown of other relationships. Where this is the case, it's referred to as behaviour change FTD. 'People with this kind of dementia can find it much harder to put themselves in others' shoes, and to control their impulses,' says Prof Oyebode. 'This is actually a change caused by brain damage, called disinhibition. To people that know the person in question, it would just appear as a personality change.' Of course, this can be incredibly tough to live with. It can also be very difficult for other people to understand. One of the things that can be most helpful for people living with behavioural variant FTD (and their loved ones) is 'to get specialist information, advice, support and opportunities to connect with other people who are living with similar experiences by attending peer support groups, such as through Rare Dementia Support,' says Dr Ryan. A loss of language ability can be caused by a specific kind of frontotemporal dementia called progressive nonfluent aphasia. This kind of dementia affects the brain's language centres and 'makes it hard for people to find the right words for things,' explains Prof Oyebode. Another type of dementia called semantic dementia occurs after damage to the same parts of the brain and can cause trouble understanding the meaning of words. Dr Ryan recommends that people with this problem 'seek out specialist speech and language therapy,' as there are 'several kinds of primary progressive aphasia that present in different ways, so people may benefit from a variety of different strategies to support their communication'. 4. You're fine at home but get lost on holiday While Alzheimer's might not typically be the cause of early onset dementia, it is not unheard of, and can often 'show up because of how it interrupts the activities that an older person might not usually carry out,' says Prof Oyebode. One example of this is that someone might feel confused and disoriented when they visit new places. 'It might be that someone functions well at home, but on holiday they get very lost in the hotel and spend hours looking for their room.' 'If someone with a rare form of dementia moves to a new setting, it is really important that those who are supporting or caring for them know as much as possible about that person – their likes, dislikes and activities they might enjoy, as well as understanding the difficulties that their particular condition may cause,' says Dr Ryan. 'Some general strategies that can help with managing confusion in new settings include bringing in familiar items like favourite objects and photos and maintaining predictable routines,' while loved ones and carers might find it helpful to use 'calm, reassuring and clear communication.' 5. Learning new things is not as easy as before Severe difficulty in picking up new systems of doing things at work, or learning new skills, may also be a sign of Alzheimer's in people under 65, Prof Oyebode says. 'It's easy to put it down to not being as sharp as you once were, or not being good with computers, but if you really do struggle to learn new things, then it might be a sign that cognitive problems are beginning to develop,' she explains. A diagnosis of dementia here is crucial, as we all struggle to pick up new skills from time to time and learning new things is more difficult for us all as we age. However, if this problem is caused by dementia, 'there are helpful strategies that can still help you to learn new things,' says Prof Oyebode. One is 'spaced retrieval': try carrying out a set of instructions once and repeating it after 20 seconds, then doubling the time gap before trying again, and doubling it once more after that, before repeating the action. Trouble and changes to your short-term memory are a hallmark sign of dementia, though in midlife it may easily be put down to the menopause or tiredness. If you struggle to keep track of recent events, to follow conversations or to remember facts, then it could be Alzheimer's disease that is causing your problems. Again, if you develop Alzheimer's at a young age, 'there is really a lot that can be done to support your memory and cognitive functions,' says Prof Oyebode. 'We know that people can remember and understand new information better when it's presented in more than one way. For example, to remember a new phone number or a name, try both writing it down and repeating it out loud.' Find more information about living with rare dementia or early onset dementias at
Jordan Times
13-05-2025
- Science
- Jordan Times
Digital technology projects to strengthen refugee resilience in Jordan conclude
The Royal Scientific Society organises a final workshop for digital technology projects aiming at enhancing refugee resilience (Photo courtesy of the Royal Scientific Society) AMMAN — The Royal Scientific Society (RSS) has organised a final workshop for digital technology projects aiming at enhancing refugee resilience. Funded by the Royal Academy of Engineering-UK, the workshop was organised in collaboration with the University of Bradford, Applied Sciences Private University and Yarmouk University, according to a RSS statement. The event marked the completion of two main projects. The first project, Golden Thread to Sustainability, Inclusivity, Affordability and Futureproofing in Global South through Innovative Advancements in Net-Positive Housing (SIAH-NP), introduced a new model for housing in developing countries, focusing on sustainable, innovative, and affordable housing. The project views housing not just as shelter, but as a tool to promote sustainable development. It seeks to improve energy, water, and food systems, while also raising the quality of life in surrounding areas. SIAH-NP adopts a net positive approach, designing housing systems that create more environmental and socioeconomic value than they consume. This is achieved by integrating Modern Design Methods of Construction, circular economy principles, and smart decentralised systems. These components work together to minimise environmental impact and increase resilience to climate change. The second project, Community Mapping of the WEFE Nexus within Refugee Camps in Jordan (CoMAP), focuses on building community-based mapping frameworks for managing the water, energy, food, and ecosystems nexus in refugee camps, using Baqaa camp as a case study. It emphasises the role of community participation in mapping and decision-making for better resource planning and management. Despite earlier efforts in mapping, much of the existing data in refugee camps is either outdated or inconsistent. CoMAP highlights the need for updated, accurate geospatial data to support long-term planning. The workshop underlined the importance of these projects in improving refugee living conditions, promoting sustainability, and supporting social justice in refugee communities. It also emphasised their potential in helping policymakers, urban planners, and housing experts design practical solutions for the housing sector.
