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CNN
2 days ago
- Health
- CNN
An Arizona resident has just died of the plague. What to know about this disease
FacebookTweetLinkA person died from pneumonic plague in Arizona last week, the first death from the disease in this region in nearly two decades. This death might bring to mind the bubonic plague, the form of the plague that killed millions during the Middle Ages. This latest case is not the same form, and treatments have certainly advanced since that time. That said, I wanted to know what pneumonic plague is, how it's spread and what its symptoms are. How is it diagnosed, and what treatments are available? What can people do to reduce the risk of contracting the disease? And how much should people be worried about plague? To help with these questions, I spoke with CNN wellness expert Dr. Leana Wen. Wen is an emergency physician and clinical associate professor at George Washington University. She previously was Baltimore's health commissioner. CNN: What is pneumonic plague? Dr. Leana Wen: Pneumonic plague is one of three types of plagues that are caused by the bacterium Yersinia pestis. The type of plague someone has is classified based on where the bacteria are concentrated. Bubonic plague infects lymph nodes. Septicemic plague is when the bacteria cause a whole-body infection through the bloodstream, and pneumonic plague affects the lungs. CNN: How does someone contract plague? Can it be spread from person to person? Wen: It depends on the type of plague. Bubonic plague is typically caused by the bite of an infected rodent flea. It can progress to septicemic plague, which can also arise as a result of handling infected animals such as rats and cats. Cats and other animals can contract the plague through eating rodents or through the bite of fleas. Pneumonic plague develops when the bacteria spread to the lungs in someone who started out with bubonic or septicemic plague. It can also occur when the bacteria are directly transmitted through airborne droplets — if someone inhales droplets containing the Yersinia bacteria that are coughed by an infected person or animal. This is the only form of the plague that can be spread from person to person. CNN: What are the symptoms of the three types of plague? Wen: People infected with all three forms develop common infectious symptoms including fever, headache, chills and weakness. Those with bubonic plague have one or more swollen and painful lymph nodes, also called buboes. In septicemic plague, the seeding of bacteria to other parts of the body can cause multi-organ failure and total body shock. Pneumonic plague is characterized by a rapidly progressing pneumonia with symptoms of shortness of breath, cough and chest pain. CNN: Is plague common? Wen: No. There are an average of seven human plague cases reported each year in the United States, according to the US Centers for Disease Control and Prevention. Over 80% of cases are bubonic plague. Most human cases have occurred in two regions: northern Arizona, northern New Mexico and southern Colorado; and California, southern Oregon and far western Nevada. Plague has also been reported in various parts of the world. According to the World Health Organization, most human cases since the 1990s have occurred on the African continent. The three countries where plague is the most endemic are the Democratic Republic of Congo, Madagascar and the South American country of Peru. CNN: How worried should people be about pneumonic plague, if it would be transmitted person to person? Wen: In Arizona, there was only one person diagnosed with pneumonic plague. There have not been reports of other infected individuals. Health experts there reiterate that the 'risk to the public of exposure to plague remains low.' CNN: How is plague diagnosed? Wen: Diagnosis is made through laboratory testing of blood, sputum and parts of a swollen lymph node. Because the disease progresses very quickly and effective antibiotic therapies exist, prompt recognition is crucial. In cases where there is a high level of suspicion, antibiotics are often started in advance of confirmatory testing. CNN: What treatments are available? Wen: The good news is that there are accessible and effective therapies. Several antibiotics are effective against Yersinia pestis. In the US, gentamicin and fluoroquinolones are first-line treatments. It's crucial that antibiotic therapies are promptly started. If left untreated, the case fatality rate can be as high as 30% to 100%. CNN: Is there a vaccine against plague? Wen: A vaccine against plague had been authorized for individuals at high risk of exposure, but this vaccine is no longer available in the United States, in part due to how rare this disease has become. Some potential vaccine candidates are under development. CNN: What can people do to reduce the risk of contracting the plague? Wen: Most Americans do not live in areas where plague can be found. For those in Western US states where plague has occurred, there are several actions they can take to reduce their potential exposure. First, avoid contact with wild animals. Do not handle wild rodents. Do not touch sick or dead animals. Second, because most cases are associated with rodents, people should prevent rodent infestation by storing pet food in rodent-proof containers and removing brush and trash around homes. Third, avoid fleabites. Wear long sleeves and use insect repellent containing DEET if you are hiking, camping or working outdoors. Keep fleas away from household pets by using veterinarian-approved flea control products. Fourth, keep pets out of areas known to be inhabited by wild rodents. Be on the outlook for illnesses in domestic animals, especially indoor-outdoor cats, and seek prompt veterinary care. All of this said, I think it's important to be reminded of how uncommon plague is. People who live in areas where plague has been found should take preventive measures, and clinicians should ask about travel history to these areas. Most Americans, though, do not need to be concerned about plague based on this single recent case in Arizona.
Scientific American
5 days ago
- Health
- Scientific American
Pneumonic Plague Infections in Modern Times Show the Black Death Isn't Dead
Plague is often associated with Medieval history and the centuries-old Black Death epidemic, but a recent death in northern Arizona is a troublesome reminder of the flea-borne disease's lingering hold in parts of the world, including the U.S. Local health officials in Arizona's Coconino County, which includes the city of Flagstaff, confirmed late last week that a person there had died of pneumonic plague —a severe lung infection caused by Yersinia pestis, the bacterium behind the illness. Human infections and fatalities from plague are relatively rare in the U.S.; according to the Centers for Disease Control and Prevention, seven human cases are reported annually on average. Prior to the Arizona case, the most recent death was reported in 2021. Y. pestis arrived in port cities in the U.S. around 1900 and has since become endemic to rats and other rodents in western U.S. states including New Mexico, Arizona, Colorado, California, Oregon and Nevada. 'From a public health standpoint in the U.S., it's a scary thing that it's plague, and it's tragic that that this was a fatal case, but people need to remember that it's extremely rare,' says David Wagner, executive director of the Pathogen and Microbiome Institute at Northern Arizona University, who has studied plague for more than 25 years. 'Not to be flippant, but it's more important that you put your seat belt on going to the grocery store than it is to worry about plague in the western U.S.' On supporting science journalism If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today. Scientific American spoke with Wagner about plague's signs and symptoms, and its persistence across time. [ An edited transcript of the interview follows. ] How do people get sick with plague? Plague is caused by the bacterium Y. pestis and is really a disease of rodents and their fleas. You have an infected rodent; a flea feeds on the blood of that rodent, and it picks up some Y. pestis. Then when the flea feeds on another rodent, it can pass along the Y. pestis. It's constantly cycling back and forth between rodents and fleas in nature; that's how it's been maintained for thousands of years in the environment around the world. What's the difference between bubonic and pneumonic plague? People call it the Black Death; they call it bubonic plague; they call it pneumonic plague—it's all the same disease, just different clinical manifestations. What stands apart [with the recent case is] that it's pneumonic plague. That's kind of rare, especially in the U.S. Pretty much all human cases, with a few exceptions, are acquired from the environment—from the bite of an infected flea. If there isn't a rodent host for that flea to feed on, it will look for other mammals to feed on. And if humans happen to be in proximity, it will feed on humans and can transmit Y. pestis. If the immune system doesn't stop Y. pestis at the source of the flea bite, it will migrate through your lymphatic system to your closest major lymph node. So let's say I was bit on my wrist; then the bacteria would go to that lymph node in my underarm and start to reproduce there. And that mass swelling, that swollen lymph node, is called a bubo—that's why it's called bubonic plague. These days, it's a dead end because there's not flea-borne transmission from one human to another. It just stops there with the treatment or death of that individual. Left untreated, though, bubonic plague can get down into your lungs via the bloodstream. That's called secondary pneumonic plague. Those individuals, then, via cough or direct contact, can spread plague person-to-person, and that's called primary pneumonic plague. What people might not know is that plague has been endemic throughout the western U.S. in rodent populations for more than 100 years. Someone could also get pneumonic plague from an animal—for example, if they were handling an infected animal and that animal coughed. Sometimes hunters in Central Asia will kill [infected] ground squirrels, and when they're skinning them can inhale particles. People also talk about septicemic plague, and that means it's gotten into your bloodstream, and that typically also arises from bubonic plague. You could also get [septicemic plague] directly if you had cuts on your hands and were handling rodents without gloves. Can pets get infected or transmit plague to humans? Pets, especially free-roaming ones, may come into contact with dead rodents that have died of plague. Fleas can hop onto pets, which then bring them into the home. This is pretty rare because there are so few [human] cases in the U.S., but that is something we think about. Flea and tick collars are a good idea. If animals do get sick, most of the evidence shows that dogs fight off the infection and can create antibodies against Y. pestis. Cats are more susceptible and can quickly become sick and actually can progress to pneumonic plague. It's super, super rare, but that's a possible way for humans to be exposed to pneumonic plague. What are the symptoms and treatment? With bubonic plague, typically people develop a fever, headache, chills and fatigue, and then they'll get those swollen lymph nodes called buboes. It typically takes a few days to manifest because it sort of starts off in stealthy mode inside the body to try and avoid the immune system. Plague is easily treated with many different types of antibiotics, as long as it's caught in time. If untreated, bubonic plague mortality rates may be somewhere between 30 to 60 percent, depending on the situation. Pneumonic plague, left untreated, is almost always fatal. So diagnostics become really important. The challenge is that many physicians in the U.S. have never seen plague. The symptoms are a bit common to other things, so rapid testing in the lab can help. Where is plague typically found in the U.S. and around the world? What people might not know is that plague has been endemic throughout the western U.S. in rodent populations for more than 100 years. It just so happened that a lot of the rodent host species in Central Asia, where it evolved, were quite similar to some of the ground squirrels that we have here in the U.S. It was first reported in native ground squirrels in California in 1908 and was in human populations before then. And then it spread really rapidly to the east and just sort of stopped at the western edge of North Dakota, South Dakota, Nebraska, Kansas, Oklahoma and Texas. It's a bit of a mystery why; the rodent diversity and climate changes quite a bit in [that region]. I'm also currently working on plague with colleagues in Madagascar, which has more human plague cases than any other country —around 75 percent of the global [case] total. It has hundreds to thousands of cases every year, with quite a few deaths. How has it persisted over the years? We don't have a good handle on which rodents are actually maintaining it in the U.S. So we've been going out and collecting plague-infected fleas from prairie dogs for more than 25 years because it's our window into plague activity. Prairie dogs are ground squirrels that live in dense colonies, so they're very conspicuous. If the prairie dogs die off, we go out and collect fleas from their burrows. We take a piece of white flannel, breathe on it to bait it with carbon dioxide, and then put it down the burrows. The fleas will hop on, and then we take them back to our laboratory and freeze them to kill them. Then we can study the Y. pestis DNA directly from those fleas. We're very careful when we do this, and we talk with our physicians here at Northern Arizona University. Every year we review the symptoms and they give us a prescription for antibiotics. Then we do what we call fever watch, where we take our temperature before we go out. The prairie dogs can't be maintaining it because they're just so susceptible—it'll just wipe out a whole colony when it gets in. And so there's other rodents out there maintaining plague, but it's still a bit of a mystery in the western U.S. How has it become less dangerous? There were three great historical plague pandemics, and it's estimated that maybe 250 million people died [total]. But we don't have those large pandemics anymore because we have hygiene, which controls rat populations in cities—and then, most importantly, we have antibiotics.
New York Post
5 days ago
- Health
- New York Post
Scientists crack the code on new vaccine for deadly plague bacteria
Israeli researchers have developed a new vaccine that is '100% effective' against bacteria that is deadly to humans. The announcement came from Tel Aviv University, which teamed up with the Israel Institute for Biological Research to create the mRNA-based vaccine, the first to protect against bacteria. 'In the study, we show that our mRNA vaccine provides 100% protection against pneumonic plague (a severe lung infection), which is considered the most dangerous form of the disease,' study co-lead Professor Dan Peer, director of the Laboratory of Precision NanoMedicine at Tel Aviv University, told Fox News Digital. 6 Illustration of the Yersinia pestis bacteria. nobeastsofierce – 'Yersinia pestis, the causative agent of plague, is considered a highly lethal infectious bacterium, against which no approved vaccine exists.' This bacterium is so lethal, even at small doses, that it's been classified as a 'Tier 1 select agent' by the CDC and is considered a 'potential bioterror weapon,' according to Peer. 'Within a week, all unvaccinated animals died, while those vaccinated with our vaccine remained alive and well,' the team reported, noting that a single dose provided full protection after two weeks. The findings were published in the journal Science Advances. Before this study, mRNA vaccines were only shown to protect against viruses, such as COVID-19, but not bacteria, according to Tel Aviv University's Dr. Edo Kon, who co-led the study. 'Until now, scientists believed that mRNA vaccines against bacteria were biologically unattainable,' said Kon in the announcement. 'In our study, we proved that it is, in fact, possible to develop mRNA vaccines that are 100% effective against deadly bacteria.' 6 A photo of Prof. Dan Peer, Dr. Inbal Hazan-Halefy, and Shani Benarroch. Tel Aviv University While vaccines for viruses trigger human cells to produce viral proteins, which then train the immune system to protect against them, that same method hasn't been effective for bacteria. Instead, the scientists used a different method to release bacterial proteins that successfully created a 'significant immune response.' 'To enhance the bacterial protein's stability and make sure that it does not disintegrate too quickly inside the body, we buttressed it with a section of human protein,' they wrote. 'By combining the two breakthrough strategies, we obtained a full immune response.' Dr. Jacob Glanville, CEO of Centivax, a San Francisco biotechnology company, reiterated the importance of the study. 6 Yersinia pestis vaccine vial and syringe. iStock 'This is distinct from research in coronavirus, influenza and cancer, which have so far been driving mRNA vaccine applications,' Glanville, who was not part of the research team, told Fox News Digital. The study shows how mRNA technologies can be rapidly applied to 'novel threat areas,' he confirmed. 'Following blowback from the mandates and rare but admittedly problematic side effects related to initial COVID-19 vaccines, mRNA as a platform has faced additional scrutiny to make sure that the next generation of vaccines to emerge from it has learned the lessons from the initial vaccines, and improved upon them,' Glanville told Fox News Digital. 'This research demonstrates yet another large application area for the technology.' Potential limitations 6 Microscopic image of Yersinia pestis bacteria. Getty Images The primary limitation of the study, according to Peer, is that the vaccine's effectiveness was shown in mice. 'As with any pre-clinical study, it needs to be evaluated in a clinical study in order to assess its effectiveness in humans,' he told Fox News Digital. In addition, the experimental mRNA vaccine is based on the 'lipid nanoparticle (LNP) mRNA vaccine platform' that was recently approved for COVID-19 vaccines, Peer noted, which requires 'cold chain logistics' (a supply chain that uses refrigeration). 'Nevertheless, extensive studies are performed in our lab, focusing on lipid formulation stability optimization that will enable room-temperature storage,' the researcher added. Looking ahead 6 The primary limitation of the study, according to Peer, is that the vaccine's effectiveness was shown in mice. motortion – The goal is for this new technology to fast-track vaccines for bacterial diseases, according to the researchers. This could be particularly beneficial for pathogenic (disease-causing) and antibiotic-resistant bacteria. 'Due to excessive use of antibiotics over the last few decades, many bacteria have developed resistance to antibiotics, reducing the effectiveness of these important drugs,' said Peer. 'Consequently, antibiotic-resistant bacteria already pose a real threat to human health worldwide. Developing a new type of vaccine may provide an answer to this global problem.' As Peer pointed out, the quick development of the COVID-19 vaccine was based on years of mRNA research for similar viruses. 6 The goal is for this new technology to fast-track vaccines for bacterial diseases, according to the researchers. AP 'If tomorrow we face some kind of bacterial pandemic, our study will provide a pathway for quickly developing safe and effective mRNA vaccines.' As this was a pre-clinical proof-of-concept study, Peer noted that several major milestones still need to be fulfilled before this vaccine could be considered for commercial rollout. However, he believes that in an emergency situation, the vaccine could be scaled up and prepared in a 'relatively short time.' Peer concluded, 'Beyond addressing the threat of plague outbreaks and potential bioterrorism, this study opens the door to developing mRNA vaccines against other antibiotic-resistant bacteria, offering a powerful new strategy to combat rising antimicrobial resistance and improve global pandemic preparedness.' The study was supported by the European Research Council, the Israel Institute for Biological Research and the Shmunis Family Foundation.
Medscape
5 days ago
- Health
- Medscape
Pneumonic Plague Death Confirmed in Arizona
Death from pneumonic plague was confirmed in a resident of Coconino County, Arizona, on July 11, 2025, according to a press release from the county's health and human services department. Although plague is rare in humans, it is endemic in the southwestern United States, and Coconino County Health and Human Services (CCHHS) maintains surveillance for the disease, according to the press release. "The source of the exposure is still under investigation; however, the death is not related to a recent report of a prairie dog die-off in the Townsend Winona area, northeast of Flagstaff," a media spokesperson from CCHHS told Medscape Medical News. Prairie dogs are highly susceptible to plague but tend to die off quickly after an infection; they serve as an indicator species for the presence of plague, but not as long-term disease vectors, according to the press release. Plague was not found to be present in the prairie dog colony with the recent die-off, the spokesperson added. The bacterium Yersinia pestis, the source of plague, originates in fleas and is transmissible to animals or humans through a bite from an infected flea, according to the CDC. Humans can get plague from handling infected animals as well. Plague cycles naturally among rodents in the wild, such as prairie dogs, but plague caused by bites is more likely to be bubonic plague or septicemic plague, according to the CDC. Pneumonic plague is spread by inhalation of bacteria-containing droplets and affects the lungs. Notably, cats are highly susceptible to plague and can become infected by eating infected rodents, as well as from flea bites, according to the CDC. Cats with plague pose a risk of transmitting infectious plague droplets resulting in pneumonic plague to their owners or to veterinarians, according to the CDC. In humans, plague symptoms usually appear within about a week of exposure and may include chills and fever, headache, weakness, and muscle pain, as well as swollen lymph nodes in some cases, according to the CCHHS press release. Although the public health risk for plague remains low, Arizona public health officials recommend standard precautions such as avoiding contact with wild animals and fleas and seeking prompt veterinary care for sick pets. Officials also recommend removing piles of brush, rocks, trash, or lumber from homes and outbuildings because these could promote rodent infestations.
Daily Mirror
5 days ago
- Health
- Daily Mirror
Plague makes a chilling return as patient drops dead within 24 hours
Just 24 hours after being admitted to hospital with symptoms of the pneumonic plague - a patient in Arizona tragically passed away from the terrifying illness, which was last seen in the UK in 1918 Centuries ago, the 'Black Death' ravaged Europe, claiming the lives of tens of millions of people and cutting the overall population potentially by as much as half. Now, a case of the pneumonic plague - the most deadly kind of the disease - has been seen in the US, with a patient in Arizona turning up at hospital with symptoms of the fatal disease and dying that same day. Few details have been released about the patient, out of respect for their grieving relatives, but the patient's symptoms were said to be very serious when they were rushed to the Flagstaff Medical Center for treatment. After an autopsy was conducted it was confirmed that Yersinia pestis - the bacteria that causes the plague - had been present in the individual, who tragically lost their life. It's the first recorded death from pneumonic plague death since 2007. The pneumonic plague is the most rare form of the disease, and travels through airborne droplets between people, seriously impacting their lungs. The bubonic plague is more common and spreads through infected fleas. This occurs either by people themselves being bitten by the fleas or coming in contact with an animal that has been bitten by one. People sometimes get the pneumonic plague as a complication from untreated bubonic plague if it spreads to the lungs. Another kind of the illness - called the septicemic plague - sometimes occurs when bubonic plague spreads to the bloodstream, but it also can develop by itself. The bubonic plague is known as the 'Black Death' because of one particularly gruesome symptom: it causes swollen lymph nodes, and the tissue around these 'buboes' can sometimes die, turning black. Medicine has come a long way since the plague ravaged Europe in the 1300s, and the plague can be treated with antibiotics, but it still poses a serious health threat and potential to cause a pandemic. Pneumonic plague in particular needs to be treated straight away, or it can claim lives incredibly quickly - with nearly all cases, reportedly 90 percent, ending with fatalities. The tragic death of this patient in Arizona is the first confirmed to be caused by the plague since 2007 - and there has not been an outbreak in the UK since 1918, when one took place in Suffolk. Risk to people in the UK is "very low" the Sun reports, and officials in Arizona have expressed similar sentiments about the public health risk there. "Our hearts go out to the family and friends of the deceased," said Patrice Horstman, an official from Coconino County said, adding, "We are keeping them in our thoughts during this difficult time. Out of respect for the family, no additional information about the death will be released."
