Latest news with #Zucker
Business Insider
6 days ago
- Business
- Business Insider
Goldbelly is the best gift I've ever given my dad — I use it to send treats every Father's Day
Dads are notoriously hard to buy for. Fortunately, we all know the adage: The way to someone's heart is through their stomach. That's especially true for my dad, and I think I've found the perfect gift strategy: treats from Goldbelly. For the past several years, I've been sending both my dad and father-in-law Goldbelly deliveries for Father's Day. It started when my husband and I were living in Kansas and I had to send a gift since I wouldn't be home for Father's Day. Flowers and chocolates aren't really my dad or father-in-law's thing, so I went with a BBQ sampler from local Kansas City restaurant Joe's for each. It was a huge hit with the dads and a fun way to bring a little bit of Kansas to them on the East Coast. Since then, I've used Goldbelly to send Coney Island hot dogs from Detroit (a staple food from my dad's hometown), bagels and lox from Zucker's, and this year — shhh, don't tell my dad — pastrami from 2nd Ave Deli, a restaurant near where we now live in New York City. Each of these foods is rooted in a memory between me and my dad, so it feels special. Goldbelly makes it super easy and reliable to send, and is now my go-to place for dad gifts, especially when I feel stuck on what to get him. What is Goldbelly? Goldbelly is a food delivery service that partners with famous food purveyors and eateries all over the country — like Magnolia Bakery, Lou Malnati's, and Pat LaFrieda — and ships their signature foods nationwide. There are also meal kits and monthly subscriptions for different types of food, like pizza or bagels, as well as subscriptions to foods from different cities. How Goldbelly works Head over to Goldbelly, and you'll find a page filled with pictures of delicious eats from all over the country. You can browse by category of food, what's popular at the moment, iconic shops, or check out one of Goldbelly's curated gift guides. Once you find what you're looking for, it's just like ordering anything else online. There is also an option to add a gift message and recipient information, which makes Goldbelly packages extra giftable. Shipping time and price is dependent on the product and where it's coming from. Review of Goldbelly I've been both the recipient and the giver of many Goldbelly deliveries. And while a few of my coworkers have been able to try Goldbelly for free, I've personally paid for all 11 orders I've placed with Goldbelly. I've even sent items to myself while I was living in Kansas and far from the foods that I loved. Those shipments included Birthday Cake Babka from Jake Cohen, two separate orders of Zucker's NYC Bagels, Hot & Spicy Cheese Bread from Stella's of Madison, and Kringle from O&H Danish Bakery. I think it's safe to say I'm a big fan. The food is quite a bit more expensive than what you'd pay if you were getting it in person — think $3 per New York bagel instead of $1.50 in person — but most of that cost accounts for shipping and handling. When I was living in the food desert that was rural Kansas, it was worth every penny. Don't just take my word for it though. My teammates have tested Goldbelly on several occasions throughout the years; here are their experiences: Remi Rosmarin, reporter:"After visiting a friend in Seattle in July a few years ago, I was looking for the perfect thank-you-for-hosting-me gift. Of course, there are always flowers, candles, and edible arrangements, but nothing felt personal enough for a friend who had gone out of her way to plan a wonderful weekend on the West Coast. As coincidence would have it, I came across Goldbelly the day after I returned. While in Seattle, my friend had mentioned her only real complaint about the city was that there are no good bagels (sorry, Seattle), so I figured, why not send them? I perused Goldbelly's curated guide to " Best Gifts from NYC," knowing there had to be some great bagels inside. I landed on a package from Ess-a-Bagel — a New York institution and a personal favorite — which included enough bagels and fixings for six. The box cost $109.95 for six bagels, a half-pound nova lox, and a half-pound of any type of cream cheese. You can also add more cream cheese, lox, and spreads for an added price. I ordered it on Tuesday morning, and it was delivered to my friend's doorstep the next day on Wednesday afternoon. Even though I was able to test this service for free, it's clear that Goldbelly provides a pretty good value. A typical nova bagel sandwich at Ess-a-Bagel costs $17, but the Goldbelly price isn't much higher, clocking each bagel and lox combo in at just about $18.30. Of course, there is also a delivery fee to consider, and you may get a heavier helping of lox and schmear at Ess-a-Bagel, but that's beside the point. This delivery brought serious smiles to an East Coast transplant who had a hankering from some New York bagels, and for that, I'd definitely gift it again." Jada Wong, former senior editor:"Goldbelly is great when you're missing certain foods or want to deliver a special treat for someone's birthday. It's a delicious and practical gift for yourself or someone else. So far, I've ordered fresh Maine lobster meat for homemade-ish lobster rolls from McLoon's Lobster Shack and deep-dish pizza from Lou Malnati's after canceling a trip during the pandemic, and cupcakes from Carousel Cakes for my dad's birthday. The lobster meat prices were similar to online grocery store prices but with the added benefit that the meat was fresh from Maine. We ordered two pounds of lobster meat, which was enough to make six rolls with generous piles of meat. If you get a 4-pack of deep-dish pizzas at Lou Malnati's through Goldbelly for $130, each one comes out to $32.50 instead of the $25 or so they'd usually cost at the restaurant, but those won't nearly be as expensive as a flight to Chicago or Maine. All the orders arrived safely in padded styrofoam boxes and, in the case of the lobster and pizza, surrounded by ice packs so they were still fresh. There were easy-to-follow prep and cooking instructions for the lobster and deep-dish pizza, and the results were delicious." The bottom line Nowadays, we're comfortable with buying so many items online. If you can buy a mattress and have it delivered to your door, you should be able to do the same with bagels and lobster rolls. Goldbelly has definitely filled a niche for food-lovers everywhere. While there's nothing like eating the real deal in person, Goldbelly can get you pretty darn close.
Fox News
16-04-2025
- Entertainment
- Fox News
Original 'Naked Gun' director says he would not have cast Liam Neeson in reboot
The "Naked Gun" reboot starring Liam Neeson has generated a lot of excitement online, but one of the original film's directors isn't a fan. "It's painful, but it's just it's not what I would have done," David Zucker told Fox News Digital. "But you know, I don't want to just bash what they're doing, but I'd like to. But it's not what I would have done, it is not our style. It's strange seeing it." Zucker directed the original 1988 comedy, "The Naked Gun: From the Files of Police Squad!" starring Leslie Nielsen and co-written by his brother, Jerry Zucker, Jim Abrahams and Pat Proft. The Zucker brothers and Abrahams, known by the acronym ZAZ, are also the comedy masterminds behind "Airplane!" "Top Secret!" and the "Police Squad" TV series. The director admitted he doesn't want to see the "Naked Gun" reboot with Neeson, comparing it to when "Airplane II" came out, which did not involve ZAZ. "Jim Abrahams said when we would do Q and A's and we'd be asked, 'Why haven't you ever seen 'Airplane II?' And Jim said, 'Well, if your daughter became a prostitute, would you go watch her work?'" "'The Naked Gun' and 'Airplane,' these are our babies. And we spent a lot of time conceiving it, doing it. And then it was kind of a surprise to me when I was excluded from the remake." Zucker continued, "I just assumed I would do it. We wrote a script. And then suddenly Seth MacFarlane came in with Liam Neeson, and it was big studio, big agency, big producer." "Family Guy" creator MacFarlane is a producer on the reboot, directed by Lonely Island alum Akiva Schaffer, starring Neeson, Pamela Anderson and Paul Walter Hauser. WATCH: ORIGINAL 'NAKED GUN' DIRECTOR SAYS IT'S IMPOSSIBLE TO REPLACE LESLIE NIELSEN WITH LIAM NEESON IN REBOOT Had he been involved, Zucker says he would not have cast Neeson. "You can't replace Leslie Nielsen. That's the thing," he said. Zucker added, "They were very sincere and in what they thought they were going to do. They want to do 'Naked Gun.' And these aren't bad people, they worship, they love 'Naked Gun,' 'Top Secret!,' 'Airplane!,' and Seth MacFarlane has done homages in 'Family Guy' and all this stuff, and it's very nice." "He called me, and for 10 minutes he just told me how much he loved my movies. However, when I first heard that he was going to do it, I kind of applied hat in hand to help or to be involved. And he said, 'Not until we do the script.' He didn't want to meet with me. So that's his choice. All I can say is that's Hollywood." According to Zucker, he and original "Naked Fun" co-writer Pat Proft wrote "our version of Naked Gun 4," more in keeping with the style of spoof ZAZ and Proft have been known for over the years, beginning with their Kentucky Fried Theater in Los Angeles, which evolved into their first film, "The Kentucky Fried Movie." "We learned there are rules, and we wrote a book called 'Surely You Can't Be Serious' and it's the true story of 'Airplane!' and we've put in it the 15 rules of comedy, our comedy. I'm not going to tell the Wayans brothers or Mike Myers what to do, even Seth. I wouldn't tell him how to do 'Family Guy,' he's obviously good at it, or 'Ted.' But what we do is very specific, and just being a fan doesn't mean that you can do it." "Remember those ads for kids' things in the '60s? It says, 'Kids don't try this at home?' That's what I would say, but it's too late, this thing is coming out." The trailer for the reboot showcases Neeson as Lt. Frank Drebin Jr., son of Nielsen's character in the original franchise, making the film both a reboot and sequel at the same time. WATCH: 'NAKED GUN' DIRECTOR SHARES HIS PLANS FOR LEGACY SEQUEL THAT DIFFER FROM LIAM NEESON LED REBOOT Zucker says his and Proft's script, along with Mike McManus, "was not even a cop movie" and would have taken "a fresh approach." "It was 'Naked Gun,' but it's a spoof of 'Mission Impossible,' 'The Bourne Identity' and Bond, with the son of Drebin, who's a young guy. It would have been Andy Samberg. We were doing a young cast and a fresh approach. Don't try to replace Leslie Nielsen. It's just another old guy, no matter how good they are." Representatives for Neeson and MacFarlane did not respond to Fox News Digital's request for comment. Zucker and his team's specificity in their comedy stylings led to the discovery of a young Val Kilmer, who made his feature film debut as Nick Rivers, an Elvis-like pop star in "Top Secret!" "Jerry and Jim and I were casting 'Top Secret!' and this was in mid-1983, and we couldn't find a Nick Rivers that we wanted. We were just tearing our hair out," he recalled. "So finally, our casting director, Suzy Jacobson, suggested, well, there's this actor who's in this play called 'Slab Boys' in New York. So, we hopped on a plane, and we saw the play off Broadway with Sean Penn, Kevin Bacon and Val Kilmer. And we thought he was great." He added, "I mean, I don't remember much about the play, but I thought he [was a] very charismatic, handsome guy. I would date him, but you know, that's another story." ZAZ had Kilmer audition, and they thought he was great, and then the young actor did a version of the Elvis tune "Turn Me Loose," and that sold them. "The way he did it was funny," Zucker said. "He just, he blew us away." Zucker recalled Kilmer being "a little uncomfortable" in the first few weeks of shooting and later realized part of the issue came down to the character. "Val was this Juilliard-trained actor, and we were doing the silliest movie. He had to co-star with a cow with boots on. It was crazy," he said. Kilmer's girlfriend at the time, Cher, also wasn't very confident in the film. "Cher would come out of the set, very nice lady, but she kept telling him this is a monumentally stupid movie. It's going to flop at the box office. I mean, never mind that she was right, it was still annoying to me that she was putting this stuff in his ear." Though the movie wasn't a huge box-office success, it's become a beloved cult classic, and there was no bad blood between Kilmer and the team. "I don't go to the Hollywood parties, but I would run into him on occasion every year or two. And we would always say hello. And he had fond memories of me, maybe not of the movie," Zucker said. WATCH: VAL KILMER'S 'TOP SECRET!' DIRECTOR RECALLS CASTING HIM IN HIS DEBUT FILM He added he'd heard a story about a fan telling Kilmer during a Q&A session that "Top Secret!" was their favorite movie, and Kilmer quipped, "It's my least favorite." "Top Secret!" wasn't ZAZ's first movie, but Zucker feels the team learned some lessons from the experience. He recalled Abrahams figuring out years later that Kilmer's discomfort with the character was "our fault." "We took the wrong lessons from 'Airplane!' which was you fill 80 minutes of a movie with jokes, and you got it," Zucker explained. "What we learned, and this is one of the things that you learn from – I mean, I'm old enough to have learned something – you need to build a character. You have to have your main lead have a character who's got an arc, so he's got to have a problem, and he has to learn something in the second act, and he resolves it in the third act," the 77-year-old said. He explained that in "Airplane!" there was a plot and character arc for the lead, Robert Hayes, but that it was parodied from an existing plot from the film "Zero Hour" and they didn't have the same template and rules to follow for "Top Secret!" "Every movie has been a great experience, but mostly we learned lessons from doing the wrong things, and we were able to put those into the rules, which the people who are doing 'Naked Gun,' they don't know the rules. But I think they're nice people anyways."
Martechvibe
15-04-2025
- Business
- Martechvibe
Revionics Releases Multi-Agent AI Pricing System
Revionics announces alpha release for multi-agent AI pricing system at Google Cloud Next in Vegas. Staff Writer 36 minutes ago Revionics has unveiled the alpha release of its multi-agent AI pricing system. A live demonstration and innovation showcase took place at the Google Cloud Next 2025 event in Las Vegas. For the first time in a public forum, Revionics' Aakriti Bhargava, VP of Engineering and AI, and Alex Braylan, Director, Data Science and AI, pulled back the covers on what Revionics has been building – a system in which intelligent AI agents work together to help retailers solve complex pricing problems and optimise pricing decisions. This can understand and interact with users in natural language. 'Leveraging Google Cloud's Agent Development Kit (ADK) on Vertex AI, our pricing agents work in tandem to help retailers unlock a level of productivity, data democratisation and real-time decisioning that has never been possible before in the retail pricing realm,' said Josh Oettle, SVP of Product Management and Engineering at Revionics. 'Our multi-agent pricing system coordinates across the agents, automating the entire workflow. For example, one agent can quickly tell you which products are priced higher than your competitors, another could forecast the impacts to your business if you matched those prices, and another would apply business rules while executing the price changes.' ALSO READ: Zendesk Launches Flexible Pricing for Customised AI Journeys Oettle added, 'We believe our multi-agent AI pricing system has the power to transform several key aspects of retail operations, including pricing team capabilities and scale, how pricing data is utilised across the extended retail enterprise, and overall, how quickly retailers can respond to ever-changing market conditions.' What's groundbreaking with this alpha release, according to Revionics General Manager Scott Zucker, is that Revionics has taken what it's best known for – a predictive AI platform for retail pricing – and layered in agentic AI to boost how retailers interact with pricing solutions – and with pricing data. 'When retailers buy an enterprise software solution, part of what they're buying is the pre-configured workflows that are based on industry best practices and common use cases,' Zucker said. 'While pre-built workflows are important to improve operational efficiency and ensure consistent processes, we have a vision that our customers should be able to interact within the workflows of our solution – and also bypass those workflows entirely by interacting directly with their data and with our AI pricing agents.' Zucker added, 'A pricing manager can tell the Revionics AI pricing agent, 'Find the products that had the biggest change in elasticity, and change the price of those products by 10% while maintaining a 2% margin. In the above scenario, the pricing agents are able to break down the request into multiple parts, orchestrating across tools and agents, to arrive at the action-phase much faster than a user could, working chronologically and step by step.' ALSO READ: Effective Pricing in Retail Critical For Customer Loyalty 'We are entering an exciting new era of pricing, where autonomous agents augment the already impressive work of pricing and merchandising teams, driving productivity and enabling retailers to scale their pricing strategies without limits.' During the presentation at Google Cloud Next, Bhargava and Braylan also emphasised Revionics' recent launch of Conversational Analytics, a data agent that allows users to ask questions of their data in natural language and take informed actions based on the insights they receive. This is a foundational component and precursor to the multi-agent pricing system. The plan is to launch this in 2026, which will include availability on Google Agentspace, following tests with pilot customers this year. 'We're taking retailers on an AI journey with us – from GenAI chatbots to conversational analytics to AI pricing agents,' said Zucker. 'As a longtime innovator in AI powered pricing solutions, Revionics remains committed to providing retailers with intelligent, data driven tools to help them thrive in an increasingly complex, resource constrained and fast paced marketplace.' ALSO READ: Redpanda Raises $100M, Launches Agentic AI for the Enterprise The Martechvibe team works with a staff of in-house writers and industry experts. View More AIAI Pricingintelligent AImulti-agent pricingRevionics Blue Prism is a global software provider, offering ROM 2, an intelligent automation implementation methodology that empowers teams to scale their digital workflow. One of its use cases is sales and marketing solutions, which is powered by artificial intelligence (AI) and machine learning (ML) algorithms. VISIT WEBSITE Pega is a combined business process management and robotic process automation (RPA) platform that comes with workforce analytics features. It offers a wide variety of tools such as Pega Email Bot to automate repetitive tasks with personalised customer replies at scale. VISIT WEBSITE EdgeVerve, a subsidiary of India-based IT company Infosys Technologies, offers RPA software for major enterprise companies. Its AssistEdge Robotic Process Automation provides machine learning and AI tools called Infosys Nia. Its AssistEdge RPA enables global marketing and distribution companies to automate 970+ manual tasks at scale. VISIT WEBSITE Clevertap is a comprehensive platform that allows global marketers to get unified customer data analytics and omnichannel engagement in one place. VISIT WEBSITE UseResponse is a fully customisable customer support and feedback software, helping companies to better understand the needs of their customers. It provides the capabilities of multichannel ticketing, live chat with messengers aggregator, chatbot, feedback community portal, and knowledge base. VISIT WEBSITE Survicate is a drag-and-drop, multichannel survey builder, helping brands effortlessly collect and analyse customer feedback. It offers 23+ one-click, native integrations, enabling advertisers and marketers to create follow-up campaigns based on real-time customer feedback. VISIT WEBSITE SAP Sales Cloud comes with end-to-end solutions and offers AI-fueled insights for understanding customers' preferences. It helps build customer profiles at scale. It also empowers users to automatically manage contact information, which streamlines clients' journeys. VISIT WEBSITE Freshsales by Freshworks is an AI-powered software that streamlines the sales cycle by automating mundane tasks and personalising customer engagement. It generates quality leads and nurtures relationships by understanding visitor intent in real-time. VISIT WEBSITE Developed for midsize enterprises and large organisations, Creatio offers end-to-end CRM software solutions, allowing users to manage sales, marketing, and services all in one place. For marketing professionals, it provides Marketing Creatio, an omnichannel marketing platform to orchestrate customer journeys and accelerate lead-to-revenue. VISIT WEBSITE Salesforce is a global technology provider, offering low code/no-code, AI-powered capabilities. Marketers and advertisers can harness its technologies for multiple use cases like B2B strategies, cross-channel personalisation, real-time analytics, and more. VISIT WEBSITE SAS offers embedded CDP capabilities, letting marketers unify customer data, understand digital activity and enable analytically driven, real-time activation. It comes with data activation facility that enables marketers to pull only the data they want, further reducing data migration costs. VISIT WEBSITE Blueshift is a scalable CDP platform that offers AI-driven capabilities for clubbing real-time events with related data from various sources. It streamlines these insights into unified customer profiles, enabling marketers to automatically personalise their targeting goals. VISIT WEBSITE Wotnot is a genAI-powered , no-code chatbot platform, helping the sales and marketing team to engage with visitors on their website via personalised conversations, catering to their lead-generation goals. It offers platform-based solutions, such as AI Studio, a GPT chatbot builder, and an analytics dashboard. VISIT WEBSITE Aisera is a generative AI platform provider that offers AI Copilot, AiseraGPT, and AiseraLLM for various domains. With Aisera, enterprises can accelerate the development of their LLMs or purchase ready-to-use generative AI solutions with pre-trained LLMs using customer data to reduce hallucinations. VISIT WEBSITE Deliotte offers Ncyte, an all-in-one analytics solution. Utilising patented algorithms, proprietary data models and predictive analytics, Ncyte delivers actionable insights for various marketing functions. With Nycte, data and marketing teams can pre-define events such as attributed campaign performance to evaluate their efforts with live notifications. VISIT WEBSITE CleverTap is a customer engagement and retention platform that offers the functionality to integrate app analytics and marketing. Powered by TesseractDB, a purpose-built database for engagement & retention, it combines the features of audience analytics, omnichannel engagement, and product A/B testing for marketing functions. VISIT WEBSITE Oracle Advertising and Customer Experience (CX), lets advertisers personalise their campaigns. Its flagship product, Oracle Moat, a comprehensive analytics and measurement platform, provides a suite of solutions across marketing and ad intelligence. Moat helps reach prospective customers, capture consumer attention, and measure the outcomes to unlock business potential. VISIT WEBSITE Meta Ads is a social media advertising platform leveraging the user base from Facebook, Instagram and Whatsapp to deliver personalised ads at scale. It offers Meta Business Suite and Meta Business Manager for managing and tracking ad performance. Utilising its AI-powered tools, advertisers can partially or fully automate with complete control over their ads. VISIT WEBSITE WebEngage is an end-to-end customer data platform, helping brands to strategise their customer engagement and retention functions. It supports third-party integration for use cases including customer segmentation, omnichannel engagement, and survey & feedback. VISIT WEBSITE ServiceNow features Robotic Process Automation Hub (RPA Hub), a scalable genAI-powered platform for orchestrating and managing a robotic workforce to execute various business processes. Its workflow automation enables tasks like lead management and campaign execution and supports integration with popular marketing tools to streamline processes. VISIT WEBSITE Tealium is a comprehesive customer data platform helping brands orchestrate and manage their data activation from a marketing standpoint. Its AudienceStream CDP functionality enables marketers to create custom campaigns via 1300+ integration options for several use cases. VISIT WEBSITE Qualaroo is a saas-based online survey creator offering Qualaroo Nudge, a proprietary technology for uploading custom properties for airtight targeting. It enables marketers to 'nudge' when user clicks on a page element, helping them to target visitors on their real-time activity. VISIT WEBSITE Zendesk is a Danish-American company that offers software-as-a-service products with the capabilities of omnichannel integrations. Its omnichannel messaging platform enables sales and marketing teams to easily track and consolidate customer tickets from various sources, ensuring enhanced customer experiences. VISIT WEBSITE WebEngage is an all-in-one marketing platform that integrates omnichannel engagement with live analytics features. It offers AI/ML-driven product recommendations engine that enables marketers to boost conversion for all channels, including the web and mobile apps. VISIT WEBSITE Sprinklr is a comprehensive enterprise software company offering omnichannel support capabilities for all customer-focused marketing functions. It provides no-code, easy-to-build API integrations to access real-time customer data from multiple sources — such as CRM, CDP and ecommerce platforms. VISIT WEBSITE SAP provides omnichannel marketing capabilities through its flagship product: SAP Emarsys. By accessing its purpose-built reports, teams can determine the effectiveness of their marketing campaigns, segments, and channels in achieving sales goals. Its B2B account engagement features let brands deliver predictable and personalised marketing-led B2B insights at scale. VISIT WEBSITE MoEngage is a global AI-driven marketing platform that enables brands to orchestrate omnichannel campaigns from a single intuitive interface. Utilising MoEngage's User Path Analysis capabilities, marketing teams can target customers across 10+ channels, depending on their purchase behaviour. VISIT WEBSITE Intuit Mailchimp is an AI-powered omnichannel platform that offers email and marketing automation functions. With its customised pre-built audience segments, marketers can scale their campaigns based on individual contacts' demographic information and shopping behaviour. VISIT WEBSITE Hubspot is a cloud-based, scalable customer platform that offers various marketing automation solutions with omnichannel support capabilities. It enables marketers to create omnichannel campaigns to connect and interact with customers across multiple channels in real-time. VISIT WEBSITE Bloomreach is an all-inclusive marketing automation platform that comes with omnichannel orchestration supports for various use cases, such as marketing campaign personalisation, and headless CMS commerce platform experience. VISIT WEBSITE Agillic specialises in offering global brands a comprehensive Omnichannel Marketing Automation Platform that enables them to create personalised marketing campaigns. Its multichannel marketing capabilities support multiple integrations, such as Playable and Sleeknote for lead generation, Zapier for automating routine processes, among others. VISIT WEBSITE Adobe Experience Cloud features Adobe Campaign, enabling marketers to synchronise their customer data from various channels for omnichannel marketing. By leveraging its omnichannel integration with Adobe Journey Optimiser, brands can build multi-step journeys, campaigns, and personalised real-time moments that follow their customers across channels. VISIT WEBSITE ActiveCampaign is an intelligent multichannel marketing automation platform that enables marketers to seamlessly connect campaigns across the channels that matter most to them. It helps enterprises streamline personalised marketing, transactional emails, and one-to-one CRM interactions throughout the customer lifecycle. VISIT WEBSITE UiPath offers a comprehensive AI-powered robotic automation platform, enabling marketers to streamline recurring functions, such as lead automation and customer engagement. Utilising its capabilities, marketers can personalise and automate customer interactions, depending on their needs and preferences. VISIT WEBSITE SAP is a composable marketing automation technology provider, offering SAP Intelligent RPA solutions to automate repetitive, rules-based business processes, including marketing and sales. Using its tech stack, marketers can automatically extract product data from manufacturers' websites, update online inventory and import website and email sales. VISIT WEBSITE Microsoft offers Power Automate, a low-code and AI-powered RPA software that helps marketers streamline tasks like lead management, email campaigns, social media management, data analysis, content publishing, and customer feedback. Leveraging its capabilities, businesses can automate repetitive tasks, such as lead capture and email marketing workflows. VISIT WEBSITE IBM offers AI-powered Robotic Process Automation capabilities for CRM and marketing functions. It enables users to automate workflows with integrated OCR and intelligent chatbots, distribute work across multiple bots without human interventions and manage emails via low-code authoring tools. VISIT WEBSITE Hyland offers an AI-powered comprehensive robotic automation software suite, enabling marketers' teams to automate their campaigns. Its Natural Language Processing (NLP) technology allows businesses to automate repetitive marketing functions, such as execution of targeted and personalised strategies in near real-time. VISIT WEBSITE Datamatics is an intelligent automation platform, offering TruBot RPA designer, a low-code bot design tool for marketing teams to create customised bots quickly. It provides 500 pre-built components, enabling low-code design and rapid deployment capabilities with drag-and-drop options. VISIT WEBSITE Automation Anywhere offers Automation Success Platform powered by Vertex AI, enabling enterprises to develop a cloud-based digital workforce at scale. Leveraging its bots, ML, and AI technologies, marketers can automate their marketing and sales processes. One of its popular offerings is Automation Co-Pilot, a genAI-powered assistant that empowers businesses to create and summarise content. VISIT WEBSITE Appian is a global technology provider, delivering end-to-end process automation with RPA, AI, IDP and API integrations. Utilising the readily available APIs of this low-code platform, teams can create a series of connected digital business applications including customer management and marketing. VISIT WEBSITE Powered by Zoho Corporation, Zoho Analytics enables marketers to track all critical metrics in a single platform to enhance marketing outcomes. The company offers 75 pre-built data visualisation reports and dashboards on marketing performance for collaborative analysis. With its AI-powered assistant, marketers can generate automated insights, predict future trends, and configure smart alerts. VISIT WEBSITE Semrush is an online visibility management and content marketing SaaS platform, offering marketing analytics tools to global businesses. Its open-source analytical tools include Market Explorer and Traffic Analytics for understanding market trends and website traffic respectively. VISIT WEBSITE Nielsen is a global audience insights, data and analytics solution provider, helping marketers measure what people listen to and watch. It offers a comprehensive, AI-powered Nielsen Marketing Cloud platform with sub-products such as Audience Segments, Scarborough, and Advanced Audiences to understand audiences for different targeting initiatives. VISIT WEBSITE MoEngage is a full-stack marketing automation platform, offering consumer insights and analytics solutions for marketers to understand customer LTV. With MoEngage Analytics, they can measure user engagement, spot behavioural patterns, and act on retention to prevent app uninstalls. VISIT WEBSITE Microsoft Clarity is a behavioural analysis tool that helps marketers understand user interaction with their website. It supports features like Session recordings, Heatmaps, and ML insights in real time. Processing more than a petabyte of data from over 100 million users per month, Clarity accommodates limitless traffic for various marketing measurements at scale. VISIT WEBSITE Powered by AI-led insights, Merkle offers scalable marketing analytics and CX technology solutions, helping brands to optimise their campaigns. Some of its flagship solutions are Measurement & Media analytics, Consumer & Experience insights, and Product & Market intelligence. VISIT WEBSITE Hubspot offers marketing analytics and dashboard software, enabling businesses to make data-backed decisions for use cases, such as revenue generation, site analytics and detailed reporting. Leveraging the capabilities of its multi-touch revenue attribution model, marketers can monitor real-time website traffic via unique tracking codes. VISIT WEBSITE Google Analytics is an open-source analytics tool by Google, enabling marketing teams within organisations to better understand their customers via valuable insights. Consequently, businesses can use those insights to take action, such as website improvement and tailored audience list creation. VISIT WEBSITE Adverity is an integrated data analytics platform, enabling marketers to automate their customer's data integration and visualisation functions. It offers 600+ pre-built data connectors to popular marketing platforms, social media networks, SEO tools, and marketing automation solutions. The platform also provides pre-build dashboards to generate tailored reports. VISIT WEBSITE Adobe Experience Cloud offers Adobe Analytics and Adobe Target within its analytics tools solutions, enabling marketers to execute in-depth analysis of their customer data. Adobe Analytics allows the sales and marketing teams to mix, match, and analyse data from any digital point in the customer journey. VISIT WEBSITE Ahrefs features a suite of analytics tools under its Ahref Enterprise offering. It offers API and Looker Studio connectors, enabling marketing teams to elevate their SEO strategy with enterprise-grade and insights. Some of the criteria for its API endpoints include Backlinks, Organic & Paid Traffic, SERPs, Website health score and more. VISIT WEBSITE StackAdapt is a multi-channel programmatic advertising platform, enabling digital marketers to customise their strategy. It offers open and flexible DSP (Digital Signal Processing) capabilities for executing tailored ad campaigns. Furthermore, its ad previewer lets marketing teams preview video, display and native ads on desktop or mobile across 500+ publishers, covering 23 verticals. VISIT WEBSITE Rakuten is a global affiliate ad technology company, enabling advertisers to optimise their marketing strategies with data-driven insights. It offers AI-powered forecasting and benchmarking capabilities and dynamic multi-touch commissioning tools, allowing advertisers to customise their campaigns. It also supports first-party data collection integrations for both B2B and B2C marketers. VISIT WEBSITE Nielsen offers Nielsen Ad Intel, a cross-platform advertising intelligence platform with actionable insights to identify prospects, analyse brand strategies and learn from past advertising campaigns. It offers various advertising intelligence features such as ad spend monitoring, competitive benchmarking, global competitive insights and expert data harmonisation. VISIT WEBSITE Magnite is an independent sell-side advertising technology provider, enabling publishers to monetise their content across all screens and formats. It offers Magnite Streaming, a singular supply-side platform that merges technology from the Magnite CTV and SpotX platforms. Utilising this functionality, marketers can identify their potential audiences to restructure their targeting strategies. VISIT WEBSITE IBM offers a comprehensive suite of Watson Advertising to agencies and marketers. With Watson Advertising's AI-powered assistant, advertisers can customise their advertisements, based on real-time ad results. It also supports functionalities of cookieless advertising, ad fraud management and brand safety measurements. VISIT WEBSITE Google features a comprehensive list of AI-powered Ad tools under its Google Ads offering. Some of its popular tools include Keywords Planner, Ads Editor, Reach Planner, Ads Mobile App, Insights Finder, Ads API, and Recommendations Page. Additionally, it offers Google AdMob to help businesses plan their in-app revenue generation strategy. VISIT WEBSITE Criteo is an all-in-one connected commerce media platform, enabling marketers and agencies to scale their digital and physical assets. Leveraging the capabilities of its AI-powered technology, brands can develop strategies for intent-based product recommendations, multi-prolonged accessibility, contextual advertising, and more. VISIT WEBSITE Basis Tecnologies (formerly known as Centro), is a programmatic advertising platform, offering ad management tools for search, social and site direct via a single interface. Its flagship products are Basis Assistant and Basis Automate+. Basis Assistant is a Chrome extension, connecting 20+ platforms and tools, and Basis Automate+ is a digital advertising automation tool for simplifying campaign process. VISIT WEBSITE AppsFlyer is a mobile attribution company, helping mobile advertisers to identify their ad network. It offers a measurement suite, giving app marketers full visibility into their customer journeys while preserving their privacy. Utilising its AI-powered Creative Optimisation platform, marketers can formulate their creative strategy. VISIT WEBSITE Adtriba is a cross-channel digital marketing management platform based on data-driven attribution modelling. Its solutions include Adtriba Triangulation, enabling advertisers to witness the integration of diverse measurement methods, such as Marketing Mix Modelling (MMM), Multi-Touch Attribution (MTA) and Incrementality Testing. VISIT WEBSITE Adobe Experience Cloud offers connected advertising solutions with its natively integrated Adobe Advertising platform. Its consultancy-based reporting options come with AI-powered optimisation features, helping advertisers analyse their ad performance via 200+ measurement metrics. Utilising its connected TV (CTV) and search, social, and commerce tools, marketers can optimise their customer acquisition strategy. VISIT WEBSITE specialises in Conversational AI, generating autonomous conversations that appear human-like. These conversations form the foundation of brand engagement. Their AI-powered, no-code Dynamic Automation Platform manages around two billion conversations from a multitude of channels in numerous languages. VISIT WEBSITE Sprinklr offers a comprehensive suite of 250+ AI-intent bot templates for various industry verticals to accelerate bot development. Its specialised AI and compliant rule engine enables marketers to modify and automate their promotional campaigns for better engagement via suggestion-based personalised bots. VISIT WEBSITE Meta's new class of generative AI features and creative tools allow users to create and share custom stickers or update the visual style of their photos with a simple text prompt. They can also chat with 28 different AIs and get unique perspectives on topics like travel, games and food. VISIT WEBSITE is a UI-based platform that allows marketers to create a chatbot quickly and deploy it easily on multiple channels. Leveraging the capabilities of its conversational builder, enterprises can build the Dialogflow using dialogue messages. Some of its popular offerings include XO: Experience Optimisation and GALE(Beta). VISIT WEBSITE IBM watsonx Assistant is an interactive virtual agent that utilises natural language and AI, enabling users to set it up on their app and website. It offers fast and accurate responses to customers, enhancing their overall experience and satisfaction with its adaptive learning capabilities. VISIT WEBSITE Haptik helps enterprises manage their customer lifecycle with generative AI-powered conversational solutions to boost marketing and sales. It offers Contakt and Interakt to enhance overall CX, where Interakt enables marketers to send hyper-targeted and personalised campaigns to drive customers to take action on WhatsApp. VISIT WEBSITE Dialogflow is an all-in-one platform for developing chatbots, voice bots, and virtual agents using natural language understanding and Google AI. It helps marketing teams create conversational agents that can handle common customer requests and issues, such as FAQs, and order status at scale. VISIT WEBSITE Dialpad is a fully integrated unified conversation intelligence platform that utilises ongoing ML(Machine Learning) algorithms and does not require coding to configure a chatbot. It offers real-time insights and tips, helping marketing teams customise their approach for every customer. VISIT WEBSITE is a low code-no code, enterprise-grade generative AI platform offering readily available LLMs for CX transformations. Its omnichannel reporting and analytics suite for marketing enables organisations to streamline their customer journeys. VISIT WEBSITE is a global conversational AI technology provider optimised for operational efficiency at scale. It offers self-learning AI capabilities that emphasise Natural Language Understanding (NLU) along with intent suggestions. VISIT WEBSITE Avaamo is an all-in-one conversational AI platform for enterprises offering a suite of industry-specific skills developed to automate and resolve common use cases. It offers Outreach, which enables marketers to educate and engage with customers across existing touchpoints through proactive and personalised communication. VISIT WEBSITE Amazon Lex offers fully managed conversational AI interfaces with advanced natural language models to design, build, test, and deploy conversational interfaces in applications. It enables sales and marketing teams to automate user tasks in their applications like the CRM and across any digital channel. VISIT WEBSITE Zendesk is an AI-powered customer feedback software provider, offering customer satisfaction (CSAT) software to businesses across multiple industries. Its marketplace offers 1600+ apps and integrations, enabling marketers to create a complete customer feedback system. VISIT WEBSITE UserVoice provides product feedback management software for SaaS businesses. Its UserVoice Validation tool delivers actionable user insights to inform roadmap strategy. From testing ideas to ensuring satisfaction with released features, it helps research and marketing teams gather quick user feedback throughout the entire product lifecycle. VISIT WEBSITE Twilio provides integrated Mindful Feedback functionality within its Flex offering, enabling marketers to automatically take action based on real-time customer feedback. It automatically collects customer feedback after Flex interactions by capturing feedback over post-call voice IVR, outbound voice IVR, conversational SMS, Web SMS, email, and web surveys. VISIT WEBSITE Trustpilot offers ML and AI-powered feedback management tools, helping marketers build trust and loyalty through customer reviews. Its AI-driven Review Insights tool enables marketers to identify growth areas from negative feedback, whereas its Image Generator tool lets them enhance social media engagement. VISIT WEBSITE Survey Monkey is a global online survey and forms tech stack provider, offering AI-fueled market research solutions to businesses. Its enterprise feedback management program provides 250+ templates with the capabilities of customisation, allowing organisations to build tailored survey forms. VISIT WEBSITE Sprinklr is a unified customer experience platform (CXM), offering AI-powered feedback management capabilities with its flagship product: Sprinklr Surveys. It integrates solicited customer feedback with unified-CXM data, enabling brands to derive meaningful, actionable insights. Utilising its genAI-powered survey builder, marketers can create conversational surveys to streamline their NPS strategies. VISIT WEBSITE Salesforce is a comprehensive customer-oriented technology provider offering a feedback management suite. Salesforce's survey responses help marketers create personalised surveys based on their existing customers' data. Some of the supported applications of its feedback management platform are genAI-powered survey form development and sentiment-insights-based survey collections. VISIT WEBSITE QuestionPro is an online feedback software provider, offering ready-made survey templates to businesses across 40+ countries. Leveraging the capabilities of its customer satisfaction templates, advertisers and marketers can create and gather tailored questions. VISIT WEBSITE Qualtrics is an all-in-one customer experience solution provider, offering website & app feedback tools for organisations to collect customer feedback efficiently. Its digital experience analytics capabilities combined with DXA integrations, bring together verbal and behavioural data for in-depth analysis of user feedback. VISIT WEBSITE HubSpot is a one-stop marketing platform, providing customer feedback software under its Service Hub offerings. Its pre-built APIs include net promote score (NPS), customer effort score (CES), and customer satisfaction (CSAT) surveys, allowing marketers to strengthen their customer loyalty strategy. VISIT WEBSITE Medallia is a comprehensive platform, enabling marketers to capture feedback from all customer touch points. Some of its popular feedback management software capabilities include Sense360 for analysing consumer spending, Medallia Video to automatically extract meaningful insights from customer's feedbacks and Agile Research for creating branded surveys in real-time. VISIT WEBSITE Zeotap lets brands integrate, unify, segment and orchestrate customer data, fostering a cookieless future. It offers a 'Non-Customer Entity Data' feature that helps marketers to integrate both customer and non-customer entity data. VISIT WEBSITE Twilio provides, Twilio Segment, an AI-powered CDP, enabling marketers to streamline their personalised customer engagement journeys. It brings together clean, consented customer data for real-time insights with 450+ pre-built connectors. VISIT WEBSITE Syntasa provides data-ready CDP capabilities, equipping marketers with essential tools to prepare their customer data. It offers real-time sentiment analytics capabilities, helping enterprises derive behavioural insights from unified user profiles to foster hyper-personalised experiences. VISIT WEBSITE SAP is a company-wide customer data management platform, helping marketers improve engagement, conversion, and retention. It offers a genAI-powered data model, enabling enterprises to unify their B2B and B2C customers' profiles to reach their personalisation goals. VISIT WEBSITE Oracle is a global database management company, providing CDP solutions, under its flagship product: Oracle Unity. Its AI-powered models enable marketers to create hyper-personsalised campaigns with predictive insights by streamlining real-time customer data from heterogeneous sources. VISIT WEBSITE Growthloop is a composable CDP platform, allowing marketing and sales team to action their data at scale. It offers GrowthLoop Audience Builder, enabling marketers to initiate their lead generation functions. VISIT WEBSITE Adobe Experience Cloud offers a real-time CDP, letting users create high-value audience segments for B2C and B2B use cases across their marketing funnel. It follows a cookieless marketing approach to automatically unify customer data across various online and offline channels in real-time. VISIT WEBSITE ActionIQ is a composable CDP platform that offers audience segmentation, acquisition marketing, and Customer 360 capabilities. It integrates analytical tools, enabling marketers to collect and analyse their first-party customer data at scale. VISIT WEBSITE Zoho CRM leverages automation and comprehensive analytics to empower any sales team, fostering stronger customer loyalty. Ideal for both small businesses and enterprises, this software enables enhanced productivity and tailored solutions through predictive intelligence. VISIT WEBSITE Zendesk offers Zendesk Sell, an easy-to-deploy CRM platform that is simple to deploy and navigate, catering to businesses of any scale. Its mobile-friendly Sell app has the functionalities of geolocation, helping sales and marketing teams. Offering an all-in-one CRM platform, organisations can implement use cases like prospecting, engagement, lead generation and communication capabilities. VISIT WEBSITE SugarCRM is a global CRM software provider, helping marketing, sales, and service teams improve efficiency through automation, data, and intelligence in near real-time. It offers Sugar Market, an all-in-one marketing automation platform that helps marketers to automate their campaign with higher ROI. VISIT WEBSITE Salesforce is a one-stop sales and support CRM software that regularly updates customer records, tracks emails and calls, and creates organised support processes for quicker customer responses. Its simple and scalable infrastructure is ideal for businesses of all sizes. VISIT WEBSITE Pipedrive stands out with its emphasis on automation, tailorability, and seamless integration. Purposefully built to enhance the efficiency and productivity of sales professionals, this CRM solution has an intuitive setup and robust capabilities. It facilitates lead generation, comprehensive sales analytics, and seamless business expansion. VISIT WEBSITE Oracle NetSuite CRM, a component of Oracle's business software suite, is for all midsize and booming businesses that want a comprehensive, integrated CRM solution with ERP capabilities. Using it, customers and partners can directly interact with the platform, freeing the additional work load for their sales team. VISIT WEBSITE Microsoft Dynamics 365 Sales represents a robust cloud-based CRM solution brimming with features such as pipeline assessment, relationship analytics, and conversational intelligence. It utilises AI-powered insights to provide actionable intelligence via predictive analytics, lead scoring and sentiment analysis. VISIT WEBSITE Less Annoying is a CRM software that utilises a straightforward search feature within its contact management system, making it easy to track contacts. It is ideal for small-sized businesses and offers a highly intuitive and user-friendly interface. VISIT WEBSITE Insightly offers CRM software solutions for enterprises looking to understand their audience data across various marketing functions. It integrates seamlessly with third-party apps, streamlining workflow automation, including bulk emailing and report generation. VISIT WEBSITE HubSpot's sleek dashboard with consolidated CRM tools simplify complex customer data, further transforming it into meaningful insights. Complementing typical CRM functionalities, HubSpot provides tailored options, including conversation intelligence and email monitoring. VISIT WEBSITE Apptivo delivers adaptable and web-based CRM solutions, enabling marketing and sales teams to streamline all customer service requirements across various devices and browsers. Despite its focused feature set, it encompasses over 65 interconnected applications alongside a robust sales pipeline management tool, ensuring efficient tracking of potential leads without any downtime. VISIT WEBSITE Sitecore offers composable cloud solutions with its flagship products, Sitecore Experience Platform(XP) and Sitecore Experience Manager (XM). They help marketers to overcome scalability challenges. Some of its features include intuitive visual editing, headless delivery, marketing automation, scalable personalisation, data and machine learning capabilities. VISIT WEBSITE Salesforce Experience Cloud is a platform that helps enterprises link clients, partners, and employees to securely exchange information and documents. Built on its Customer 360 platform, Salesforce's DXP ensures seamless integration with any solution in the Salesforce ecosystem. VISIT WEBSITE Oracle Cloud offers a comprehensive suite of platform-based marketing automation solutions for personalised B2B and B2C automation campaigns. Some of its featured products are Eloqua Marketing Automation, CrowdTwist Loyalty and Engagement, and Unity Customer Data Platform. VISIT WEBSITE Optimizely is a digital experience platform (DXP) provider that offers Optimizely One, an easy-to-use and fully integrated suite. It provides a single, unified workflow with thoughtfully embedded AI and machine-learning algorithms, accelerating work across the entire marketing lifecycle. VISIT WEBSITE OpenText offers a cloud-native, scalable platform for enterprises to streamline their marketing functions. It provides fully composable content management, digital asset management, creative workflows, personalisation, targeting and customer data technologies in one place, ensuring a holistic approach to B2B, B2E and B2C experiences. VISIT WEBSITE Neptune DXP is a PaaS(Platform-as-a-Service) provider, helping marketing teams build custom apps based on modular, reusable application building blocks. The company offers flexible environments to businesses across different verticals, further providing personalised digital solutions at scale. VISIT WEBSITE Magnolia is a composable DXP that comes with no-code connector packs and low-code micro-frameworks for third-party integrations. It also offers an open-source version alongside its commercial plans enabling enterprises to build tailored use cases. VISIT WEBSITE Liferay DXP helps marketers deliver personalised and connected digital experiences across a broad range of channels, including customer portals, websites, intranets, mobile apps, and connected devices. It offers intuitive CMS, user analytics, and site management tools that businesses need to launch, test and optimise digital experiences for faster go-to-market. VISIT WEBSITE Powered by IBM Consulting, IBM iX offers a composable DXP, providing a comprehensive solution to make enterprises' systems future-ready. Utilising its data-driven insights and intelligent workflows, marketers can design and deliver human-centred experiences across the customer lifecycle. VISIT WEBSITE HCL Digital Experience (DX), forms part of a wider HCL Customer Experience (CX) product portfolio, offering core capabilities such as content management, DAM, CDP called Signals, and low-code application development. It provides services in government, life sciences, insurance, financial services, and other verticals. VISIT WEBSITE Contentstack is a headless CMS and Composable Digital Experience Platform (DXP) solution provider that helps marketers gain a competitive edge. It recently launched into Google Cloud Marketplace, and is also available on Microsoft Azure and AWS. It seamlessly enables mid-market brands to adopt its omnichannel campaign engine to drive higher conversions and sales. VISIT WEBSITE Bloomreach Commerce Experience Cloud provides businesses an edge with its modular capabilities: Content Management System (CMS), Discovery features for search and merchandising optimisation, and Engagement tools such as Customer Data Platforms (CDP) for personalisation and analytics. VISIT WEBSITE Adobe Experience Cloud offers a comprehensive set of services specifically designed to address the day-to-day requirements for personalised customer experience at scale. Its platform helps manage different digital content and assets to improve customer satisfaction. Some of its products include Adobe Gen Studio, Experience Manager Sites, Real-time CDP, and Marketo Engage. VISIT WEBSITE Acquia offers DXP solutions, comprising of two main elements: Acquia Drupal Cloud and Acquia Marketing Cloud. It can be accessed in both platform-as-a-service (PaaS) and software-as-a-service (SaaS) with additional components such as Site Factory for multisite management, digital asset management (DAM), CDP, personalisation, and Campaign Studio. VISIT WEBSITE
Yahoo
14-04-2025
- Health
- Yahoo
New antibiotic is effective against gonorrhea, could be first new treatment since 1990s, study says
A new type of antibiotic for treatment of urinary tract infections in women could also work against gonorrhea infections, a new study finds. This could put the medication, called gepotidacin, on track to become the first new antibiotic for gonorrhea since the 1990s. 'Gepotidacin is a novel oral antibacterial treatment with the potential to become an alternative option for the treatment of gonococcal infections, supported by an acceptable safety and tolerability profile,' the researchers wrote in the study published Monday in The Lancet, adding that the drug 'could mark a meaningful advancement in patient care.' As an antibiotic, gepotidacin works by inhibiting bacteria from replicating in the body. In March, it was approved by the US Food and Drug Administration to treat uncomplicated urinary tract infections in women and girls ages 12 and older. Recurrent UTIs have become a bigger problem as the bacteria that cause them have become more resistant to the antibiotics available to treat them. Now, there is new hope that gepotidacin may help fight drug-resistant gonorrhea. 'The big takeaway is that having additional treatment options for gonorrhea is fantastic,' said Dr. Jason Zucker, an infectious disease and sexually transmitted infections expert and assistant professor of medicine at Columbia University Vagelos College of Physicians and Surgeons, who was not involved in the new study. Effective treatments for gonorrhea have become increasingly limited in recent years due to the global rise of antimicrobial resistance in Neisseria gonorrhoeae, the bacteria that cause gonorrhea, rendering many previously used first-line antibiotics ineffective. The current standard of care involves an intramuscular injection of the antibiotic ceftriaxone, which requires a visit to a care facility. A key benefit of gepotidacin is that it would not involve an injection at the doctor's office, which could make treating gonorrhea more convenient for patients, Zucker said. 'Right now, patients come in, especially if they are not having symptoms, if they test positive, we have to ask them to come back. For some people, that's not so easy,' he said. 'So obviously, the ability to have the pharmacy send treatment to their house, or have them be able to pick it up, would really make things a lot easier for people and reduce the number of doctor visits they have, especially if they have jobs where they don't have a lot of time off.' Gonorrhea can lead to serious health problems if left untreated, and though rare, can even spread to the blood or joints. Among women, untreated gonorrhea can cause an infection of the reproductive organs called pelvic inflammatory disease, which can lead to a greater risk of pregnancy complications and infertility. In men, gonorrhea also can lead to infertility in rare cases. In the United States, gonorrhea and other sexually transmitted infections or STIs have become more common. Reported cases of three nationally notifiable STIs – chlamydia, gonorrhea and syphilis – were up 90% in the US in 2023 compared with about two decades prior in 2004, according to data released last year by the US Centers for Disease Control and Prevention. More than 2.4 million cases of STIs were reported in 2023 nationally. The Phase 3 trial, conducted between October 2019 and October 2023, included more than 600 people ages 12 and older who were diagnosed with gonorrhea in the urogenital area across six countries: Australia, Germany, Mexico, Spain, the United Kingdom and the United States. The study was funded by the pharmaceutical company GSK, which developed the antibiotic, and the development of gepotidacin was funded in part with federal funds from the US Department of Health and Human Services, Administration for Strategic Preparedness and Response, Biomedical Advanced Research and Development Authority, and the Defense Threat Reduction Agency, according to GSK. About half of the study participants were treated with a gepotidacin regimen of two oral doses administered about 10 to 12 hours apart, at 3,000-milligrams per dose. The other participants were provided with the current standard treatment of administering a single dose of the antibiotic ceftriaxone as an injection paired with orally taking the antibiotic azithromycin. The trial data, which is being presented at the European Society of Clinical Microbiology and Infectious Diseases conference, showed that gepotidacin was as effective as the current leading combination treatment, and was also effective against treatment-resistant infections, which occur when strains of gonorrhea are resistant to currently used antibiotics. The gonorrhea infections were cured among 92.6% of the study participants who were administered gepotidacin compared with 91.2% of the study participants who were treated with ceftriaxone plus azithromycin. Among the 7.4% of participants in the gepotidacin group who were not successfully treated, they all were due to missing data, according to GSK, which added that 'in participants with complete data, there was no bacterial persistence at the urogenital body site.' While the study primarily assessed gepotidacin as a treatment for urogenital gonorrhea, some participants with rectal and throat infections were evaluated. Of those with complete data, the study showed that it was more difficult to treat gonorrhea in the throat compared with other body sites, as 14 out of 16 people with throat gonorrhea and complete data – 88% – were successfully treated. The researchers wrote that the prevalence of throat infections 'warrants further investigation' in a larger group of participants, as does studying the efficacy of geptodiacin in the treatment of gonorrhea in the throat. 'Pharyngeal gonorrhea is notoriously harder to treat and plays a key role in silent transmission and resistance development, so having reliable oral options at all anatomical sites is critical,' Zucker, said. The international team of researchers found no life-threatening nor fatal side effects associated with either treatment approach used in the study, but the gepotidacin group had higher rates of side effects compared with the ceftriaxone-plus-azithromycin group, which were mostly gastrointestinal, such as diarrhea and nausea, and almost all were mild or moderate, according to the study. 'One of the challenges is that a lot of oral antibiotics have GI side effects,' Zucker said. The researchers noted that it will be important to investigate the efficacy of gepotidacin for treating gonorrhea in groups not primarily represented in the study especially women and Black and Brown communities, as 92% of participants in the study were men, 74% were White and 71% were men who have sex with men. If gepotidacin is approved for the treatment of gonorrhea in the United States, 'the price will be disclosed when the product will be supplied in a market. Our approach would be for it to reflect the value and outcomes they bring to patients, providers and payers while being sensitive to market and societal expectations,' according to a GSK spokesperson. Bluejepa, the brand name for the version of gepotidacin approved in the United States to treat UTIs, is expected to be available in the second half of 2025. The new study was 'very well-done' with 'rigorous data,' and having more options to treat gonorrhea is critical for slowing down the bacteria's drug resistance, said Dr. Jeffrey Klausner, a clinical professor of public health at the University of Southern California's Keck School of Medicine in Los Angeles, who was not involved in the trial. 'The more options doctors have to treat gonorrhea means that they do not have to use the same drug over and over again, which is a recipe for disaster and more resistance. We know that using the same drug over and over again leads to drug resistance,' Klausner said in the email. 'If gepotidacin is approved and recommended for gonorrhea treatment, that is a true advance and will greatly help our efforts to slow down drug resistance in gonorrhea.' In the study, researchers noted that using gepotidacin to treat gonorrhea as an oral treatment option, not an injection, may be more efficient and reduces the risk of persistent, drug-resistant infections. Yet there is some concern that strains of gonorrhea may eventually develop resistance to gepotidacin, according to a comment paper accompanying the new study in The Lancet. 'In our opinion, N gonorrhoeae will also develop gepotidacin resistance when the selective pressure increases and where compliance to the dual-dose regimen is suboptimal,' Magnus Unemo of Örebro University in Sweden and Teodora Wi of the World Health Organization in Switzerland wrote in the paper. 'Due to the inherent ability of gonococci to develop resistance, difficulties in increasing the gepotidacin dose due to adverse events, and the lack of other treatment options, preclinical and clinical development of additional gonorrhoea treatments remains important,' they wrote. 'In conclusion, gepotidacin is promising for the treatment of gonorrhoea, but the challenges to retain gonorrhoea as a treatable infection will continue.'
CNN
14-04-2025
- Health
- CNN
New antibiotic is effective against gonorrhea, could be first new treatment since 1990s, study says
A new type of antibiotic for treatment of urinary tract infections in women could also work against gonorrhea infections, a new study finds. This could put the medication, called gepotidacin, on track to become the first new antibiotic for gonorrhea since the 1990s. 'Gepotidacin is a novel oral antibacterial treatment with the potential to become an alternative option for the treatment of gonococcal infections, supported by an acceptable safety and tolerability profile,' the researchers wrote in the study published Monday in The Lancet, adding that the drug 'could mark a meaningful advancement in patient care.' As an antibiotic, gepotidacin works by inhibiting bacteria from replicating in the body. In March, it was approved by the US Food and Drug Administration to treat uncomplicated urinary tract infections in women and girls ages 12 and older. Recurrent UTIs have become a bigger problem as the bacteria that cause them have become more resistant to the antibiotics available to treat them. Now, there is new hope that gepotidacin may help fight drug-resistant gonorrhea. 'The big takeaway is that having additional treatment options for gonorrhea is fantastic,' said Dr. Jason Zucker, an infectious disease and sexually transmitted infections expert and assistant professor of medicine at Columbia University Vagelos College of Physicians and Surgeons, who was not involved in the new study. Effective treatments for gonorrhea have become increasingly limited in recent years due to the global rise of antimicrobial resistance in Neisseria gonorrhoeae, the bacteria that cause gonorrhea, rendering many previously used first-line antibiotics ineffective. The current standard of care involves an intramuscular injection of the antibiotic ceftriaxone, which requires a visit to a care facility. A key benefit of gepotidacin is that it would not involve an injection at the doctor's office, which could make treating gonorrhea more convenient for patients, Zucker said. 'Right now, patients come in, especially if they are not having symptoms, if they test positive, we have to ask them to come back. For some people, that's not so easy,' he said. 'So obviously, the ability to have the pharmacy send treatment to their house, or have them be able to pick it up, would really make things a lot easier for people and reduce the number of doctor visits they have, especially if they have jobs where they don't have a lot of time off.' Gonorrhea can lead to serious health problems if left untreated, and though rare, can even spread to the blood or joints. Among women, untreated gonorrhea can cause an infection of the reproductive organs called pelvic inflammatory disease, which can lead to a greater risk of pregnancy complications and infertility. In men, gonorrhea also can lead to infertility in rare cases. In the United States, gonorrhea and other sexually transmitted infections or STIs have become more common. Reported cases of three nationally notifiable STIs – chlamydia, gonorrhea and syphilis – were up 90% in the US in 2023 compared with about two decades prior in 2004, according to data released last year by the US Centers for Disease Control and Prevention. More than 2.4 million cases of STIs were reported in 2023 nationally. The Phase 3 trial, conducted between October 2019 and October 2023, included more than 600 people ages 12 and older who were diagnosed with gonorrhea in the urogenital area across six countries: Australia, Germany, Mexico, Spain, the United Kingdom and the United States. The study was funded by the pharmaceutical company GSK, which developed the antibiotic, and the development of gepotidacin was funded in part with federal funds from the US Department of Health and Human Services, Administration for Strategic Preparedness and Response, Biomedical Advanced Research and Development Authority, and the Defense Threat Reduction Agency, according to GSK. About half of the study participants were treated with a gepotidacin regimen of two oral doses administered about 10 to 12 hours apart, at 3,000-milligrams per dose. The other participants were provided with the current standard treatment of administering a single dose of the antibiotic ceftriaxone as an injection paired with orally taking the antibiotic azithromycin. The trial data, which is being presented at the European Society of Clinical Microbiology and Infectious Diseases conference, showed that gepotidacin was as effective as the current leading combination treatment, and was also effective against treatment-resistant infections, which occur when strains of gonorrhea are resistant to currently used antibiotics. The gonorrhea infections were cured among 92.6% of the study participants who were administered gepotidacin compared with 91.2% of the study participants who were treated with ceftriaxone plus azithromycin. Among the 7.4% of participants in the gepotidacin group who were not successfully treated, they all were due to missing data, according to GSK, which added that 'in participants with complete data, there was no bacterial persistence at the urogenital body site.' While the study primarily assessed gepotidacin as a treatment for urogenital gonorrhea, some participants with rectal and throat infections were evaluated. Of those with complete data, the study showed that it was more difficult to treat gonorrhea in the throat compared with other body sites, as 14 out of 16 people with throat gonorrhea and complete data – 88% – were successfully treated. The researchers wrote that the prevalence of throat infections 'warrants further investigation' in a larger group of participants, as does studying the efficacy of geptodiacin in the treatment of gonorrhea in the throat. 'Pharyngeal gonorrhea is notoriously harder to treat and plays a key role in silent transmission and resistance development, so having reliable oral options at all anatomical sites is critical,' Zucker, said. The international team of researchers found no life-threatening nor fatal side effects associated with either treatment approach used in the study, but the gepotidacin group had higher rates of side effects compared with the ceftriaxone-plus-azithromycin group, which were mostly gastrointestinal, such as diarrhea and nausea, and almost all were mild or moderate, according to the study. 'One of the challenges is that a lot of oral antibiotics have GI side effects,' Zucker said. The researchers noted that it will be important to investigate the efficacy of gepotidacin for treating gonorrhea in groups not primarily represented in the study especially women and Black and Brown communities, as 92% of participants in the study were men, 74% were White and 71% were men who have sex with men. If gepotidacin is approved for the treatment of gonorrhea in the United States, 'the price will be disclosed when the product will be supplied in a market. Our approach would be for it to reflect the value and outcomes they bring to patients, providers and payers while being sensitive to market and societal expectations,' according to a GSK spokesperson. Bluejepa, the brand name for the version of gepotidacin approved in the United States to treat UTIs, is expected to be available in the second half of 2025. The new study was 'very well-done' with 'rigorous data,' and having more options to treat gonorrhea is critical for slowing down the bacteria's drug resistance, said Dr. Jeffrey Klausner, a clinical professor of public health at the University of Southern California's Keck School of Medicine in Los Angeles, who was not involved in the trial. 'The more options doctors have to treat gonorrhea means that they do not have to use the same drug over and over again, which is a recipe for disaster and more resistance. We know that using the same drug over and over again leads to drug resistance,' Klausner said in the email. 'If gepotidacin is approved and recommended for gonorrhea treatment, that is a true advance and will greatly help our efforts to slow down drug resistance in gonorrhea.' In the study, researchers noted that using gepotidacin to treat gonorrhea as an oral treatment option, not an injection, may be more efficient and reduces the risk of persistent, drug-resistant infections. Yet there is some concern that strains of gonorrhea may eventually develop resistance to gepotidacin, according to a comment paper accompanying the new study in The Lancet. 'In our opinion, N gonorrhoeae will also develop gepotidacin resistance when the selective pressure increases and where compliance to the dual-dose regimen is suboptimal,' Magnus Unemo of Örebro University in Sweden and Teodora Wi of the World Health Organization in Switzerland wrote in the paper. 'Due to the inherent ability of gonococci to develop resistance, difficulties in increasing the gepotidacin dose due to adverse events, and the lack of other treatment options, preclinical and clinical development of additional gonorrhoea treatments remains important,' they wrote. 'In conclusion, gepotidacin is promising for the treatment of gonorrhoea, but the challenges to retain gonorrhoea as a treatable infection will continue.'
