Latest news with #acinetobacter
The Independent
27-05-2025
- Business
- The Independent
New ‘superbug' antibiotic to treat sepsis and pneumonia enters last phase of testing
A new antibiotic that has the potential to save millions of lives has entered its last phase of human testing. Swiss drugmaker Roche announced it would advance the testing of an antibiotic against a common bacterium that causes serious hospital infections like pneumonia and sepsis into the third and final stage of testing. The antibiotic zosurabalpin, which is jointly developed with Harvard University, is to be tested against drug-resistant acinetobacter baumannii bacteria. The Centres for Disease Control and Prevention (CDC) labels acinetobacter baumannii as an 'urgent threat', but there have been no antibiotics created which react to it in more than 50 years. Roche announced the phase 3 trial will be a single pivotal study with approximately 400 patients from around the world, randomised to receive either zosuarbalpin or the standard treatment. Michael Lobritz, global head of infectious diseases at Roche, said: 'Our goal is to contribute new innovations to overcome antimicrobial resistance, one of the biggest infectious disease challenges to public health.' Larry Tsai, senior vice president and global head of immunology and product development at Genentech, a unit of Roche, said the drug-resistant bacteria 'are present in every country of the world'. He added that 'the innovative biology involved in this research could potentially reveal new insights into the structure of bacterial membranes, possibly leading to the discovery of new antibiotics in the future'. It is hoped the experimental drug will be approved by the end of the decade. Globally, sepsis is estimated to cause approximately 11 million deaths each year – one death every 2.8 seconds. Worldwide, community-acquired pneumonia (CAP) kills three to four million people each year with high morbidity and mortality, particularly among elderly patients.
Reuters
26-05-2025
- Health
- Reuters
Roche moves antibiotic against superbug into Phase 3 of testing
FRANKFURT, May 26 (Reuters) - Swiss drugmaker Roche (ROG.S), opens new tab said on Monday it would advance testing of an antibiotic against a common drug-resistant bacteria that causes serious hospital infections into the third and last phase of testing on humans. Roche said in a statement that the experimental antibiotic zosurabalpin, jointly developed with Harvard University, would be tested against acinetobacter baumannii, relying on a new mode of action that bacteria have not developed resistance against. Drug-resistant acinetobacter are present across the world and disproportionately impact patients who are in hospital, causing serious infections like pneumonia and sepsis, the company added.
The Sun
08-05-2025
- Health
- The Sun
Teen riddled with killer infection that travelled to his heart after trendy cupping therapy goes horribly wrong
A TEENAGE boy developed a life-threatening heart infection just days after undergoing trendy cupping therapy. The otherwise healthy 17-year-old went to hospital with a high fever, chest pain, and trouble breathing - all symptoms that pointed to an infection of sorts. 2 2 Doctors in Syria ran scans that revealed his liver and spleen were enlarged, and fluid had built up in his tummy, suggesting his heart wasn't pumping properly. A chest scan showed small infected clots in his lungs, which doctors writing about the case in the Journal of the American College of Cardiology said had likely spread there from his heart. An ultrasound of his heart confirmed their suspicions - there was a clump of infected tissue, known as a vegetation, stuck to his valve. They diagnosed him with endocarditis - a severe, and potentially life-threatening infection of the heart lining. If untreated, it can damage the heart valves, making it harder for the heart to pump blood. This can lead to fluid buildup in the lungs and other parts of the body, potentially causing heart failure. Blood tests were taken from several veins, and lab results confirmed the infection was caused by acinetobacter, a rare and dangerous bacteria that's often resistant to antibiotics. The strain was found to be extensively drug-resistant, leaving doctors with only a few antibiotics that could still fight it The medics, from Aleppo University Hospital, Aleppo, were puzzled at first, as most cases of acinetobacter related to linked to intravenous drug use, where bacteria enter the bloodstream through needles. But in this case, since the boy had no known history of taking drugs, doctors suspected the cupping therapy he had received 15 days earlier might be the cause. The sleep position that could be a sign of heart failure - plus three other symptoms to look out for Cupping therapy creates suction on the skin by heating glass cups, which can cause small cuts, allowing bacteria to enter the body. People often use cupping to relieve pain, improve circulation, or reduce inflammation. While it's become popular, especially among athletes, it's often done outside medical settings without proper cleaning, increasing the risk of infections like the one this teen developed. 'Traditional medical practices risks' The boy in the case study had received cupping therapy in the groin area, which doctors believe is where the infection began. Acinetobacter lives on the skin, usually in moist areas like between the toes, armpits, and groin, making it easier for the bacteria to enter the body through the small cuts caused by the therapy. "This case highlights the potential risks associated with traditional medical practices," the experts wrote. "And the importance of recognising atypical pathogens in the etiology of endocarditis." The boy was treated with a combination of antibiotics, including imipenem and doxycycline. Within two weeks, his condition had significantly improved, and after a month of treatment, tests confirmed the infection had cleared. Five months later, scans showed only mild liver congestion - a build--up of blood in the liver - which doctors said indicated he had fully recovered. What is cupping and is it safe? Victoria Beckham, Kim Kardashian and Jennifer Aniston have all tried this treatment, where a vacuum cup is placed over the skin causing bruising. It is claimed to improve circulation, flush toxins, relieve pain and relax muscles. But Professor Edzard Ernst, the author of Alternative Medicine, says: 'There have been several clinical trials. None, however, provides reliable evidence that it has any relevant health effects.' Dr Abrar Ibrahim, a GP at London's Hendon Hospital, says medical research is limited and low quality: 'There are serious potential side-effects including permanent skin discolouration, burns and scars, risk of infection and diseases such as Hepatitis B or C if not done hygienically.'
