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Gene Therapy For Inherited Disease In Infants
Gene Therapy For Inherited Disease In Infants

Forbes

timea day ago

  • General
  • Forbes

Gene Therapy For Inherited Disease In Infants

As newborn screening and rapid DNA sequencing become routine, we are poised to catch and treat ... More inherited diseases at their earliest stages. Today, we can intervene in the first days or weeks of life. Tomorrow, we will intervene before birth. For the first time, we are witnessing therapies that can fundamentally alter the course of inherited disease lifelong. The most recent breakthrough describes treating inherited disease in infants. In a case in Nature Medicine, a premature baby with a devastating genetic epilepsy syndrome achieved a 60% reduction in life-threatening seizures following treatment with an experimental therapy. This is the first installment in a two-part series describing the opportunities for correcting inherited defects before and immediately after birth. These therapies have provided a chance for those inherited diseases to be treated. Part 1 focuses on the treatment of a newborn. In contrast, Part 2 examines novel applications in the uterus as fetuses before they are born. Today, doctors can spot many genetic changes long before they cause problems. Sometimes, this is done through a noninvasive blood test from the mother during pregnancy or from a tiny drop of blood taken from a newborn's heel. These samples are analyzed using powerful genetic sequencing tools to search for signs of hundreds of inherited diseases quickly and accurately. With the help of artificial intelligence, doctors can screen for hundreds of conditions rapidly and accurately, making early detection more accessible than ever before. My new book explores how these breakthroughs are changing the lives of children and adults alike. For some families, this early detection is life-changing. In a recent case, a newborn began having seizures just days after birth. Using rapid genome sequencing to look for changes in the baby's DNA, they searched for anything that might explain the symptoms. They found a mutation in a gene known to cause a rare form of severe epilepsy. The ongoing electrical chaos caused by the mutation impairs brain development. The seizures can also cause delays or regressions in motor skills, language, and social interaction. Additionally, many suffer from sensory issues, losing the ability to track objects visually or respond to sounds. The discovery of the mutated gene allowed them to move quickly to the next step: targeted treatment. More tools than ever before are available to address the root cause when a concerning genetic change is detected. In this case, they used an innovative therapy designed to "quiet" the faulty gene, aiming to reduce the baby's seizures. In the reported case, the preterm infant receiving the therapy saw seizure frequency plummet from 20–25 hourly events to just 5–7. Current data showed that the therapy's effects waned after 4–6 weeks due to declining concentrations of the medicine, requiring repeat injections. The therapy proved safe over 20 months, and 19 treatments were performed, with no severe side effects observed. There is also strong clinical evidence of this treatment being effective in multiple animal models, though there are still challenges. Finding optimal dosing intervals for preterm infants is particularly challenging, as their rapid growth can significantly affect drug metabolism. Furthermore, frequent dosing risks overwhelming infant systems, while longer intervals may allow seizures to reappear and jeopardize developmental progress. Early trials indicate that monthly infusions might help maintain therapeutic levels. Safety is also a top priority as these therapies advance. While early trials have not reported organ toxicity or immune reactions, the long-term effects of chronic treatment with this therapy in developing brains remain uncertain. Prolonged exposure could disrupt key cognitive development processes. Still, the implications are profound. This case is more than a single success—it signals a paradigm shift. As newborn screening and rapid DNA sequencing become routine, we are poised to catch and treat inherited diseases at their earliest stages. Today, we can intervene in the first days or weeks of life. Tomorrow, we will intervene before birth. These kinds of breakthroughs are no longer a distant dream. Science and medical research are still pushing the cutting edge. Already, fetal surgeries have corrected structural defects in utero or the womb. The next leap is here: treating inherited disorders at the molecular level before a child is even born. The following story in this series will highlight the first successful use of gene therapy to treat spinal muscular atrophy before birth. The impact is profound for these children and their families. Early intervention can prevent irreversible damage, offering the potential for a normal childhood and a dramatically improved quality of life. As costs fall and technology improves, all newborns could soon have their DNA sequenced, enabling targeted treatments at the earliest and most effective stage. Over time, this approach will expand access, reduce the burden of inherited disease, and reshape the future of human health care. One profound question remains: If we correct a genetic error in a child, will that change be passed on to future generations? For now, most therapies target the body's somatic cells, not the germline—but as our tools improve, the possibility of heritable cures edges closer, raising hope and new ethical questions. As we stand at the frontier of precision neurology, cases like this illuminate a path forward. For families facing rare genetic epilepsies, this medicine offers more than seizure control. They provide a lifeline to cognitive and developmental gains previously deemed unattainable. While larger trials are needed, the era of disease-modifying therapies for pediatric brain disorders has unequivocally begun. Part 2 will delve into how correcting genetic errors before birth could rewrite the trajectory of inherited diseases.

Orange Fur Created By A Unique Mutation In Domestic Cats
Orange Fur Created By A Unique Mutation In Domestic Cats

Forbes

timea day ago

  • General
  • Forbes

Orange Fur Created By A Unique Mutation In Domestic Cats

A small deletion within a gene on the X-chromosome has unique effects upon cats' fur color, creating orange male tabbies and orange patches in female tortoiseshell cats. Tortoiseshell Cat. (Credit: Shutterstock, via Chris Kaelin) It was long predicted that the source of domestic cats' distinctive pumpkin-orange fur coloring was genetic and was produced by a gene on the sex-determining X-chromosome because 80% of orange cats are male — so the trait's mystery gene came to be known as 'sex-linked orange'. Male cats, like male humans, have an X- and a Y-chromosome. The genes on their lone X-chromosome are all expressed, giving rise to orange tabbies if they possess a copy of the orange fur color gene. Female cats have two X-chromosomes, one of which is randomly inactivated early in embryonic development on a cell-by-cell basis (figures 1 & 2), giving rise to tortoiseshell or calico fur color patterns. This pattern of inheritance suggests there is a gene that controls orange fur color on the X-chromosome, but identifying precisely which gene this is has eluded scientists for decades. Incidentally, white patches seen in calicos, known as 'piebalding', are not encoded by a gene on the X-chromosome. Figure 1: Graphical abstract, doi:10.1016/ 'Cats have lived commensally with humans around the world for thousands of years, giving humans plenty of time to select and preserve unusual colors and color patterns,' lead author of the Stanford study, geneticist Christopher Kaelin, told me in email. Dr Kaelin is a senior scientist in genetics at Stanford Medicine who has been studying the genetics of coloration and color patterns in mammals for more than two decades. Are cats the only domesticated mammal with a sex-linked fur color trait? 'Dogs also come in many color varieties. Some of the colors that are similar between dogs and cats are caused by different mutations in the same gene,' Dr Kaelin added. 'However, a sex-linked color trait has not been observed in dogs or other mammals, which suggests that orange cats could offer an opportunity to learn something new and insightful.' Dr Kaelin has worked alongside two of the Stanford study's co-authors – Greg Barsh and Kelly McGowan – on the genetics of coloration and color patterns for more than 25 years. They all started at Stanford, but Dr Barsh accepted a leadership position at HudsonAlpha 15 years ago, at a critical time when these researchers could adapt some of the emerging technologies being developed for human genomic science and apply them to genetic studies in domestic cats. 'Kelly [McGowan] and I also accepted positions at HudsonAlpha but remained at Stanford, where we were best equipped to pursue other aspects of our research,' Dr Kaelin explained in email. 'Kelly [McGowan] and I are currently affiliated only with Stanford, while Greg maintains affiliations with both institutions.' Additional collaborators on the Stanford study are based at Brown University, Auburn University, and at the National Cancer Institute. A second group of scientists, based at Kyushu University, Kindai University, Azabu University, The University of Tokyo and the National Institute of Genetics in Japan, independently discovered the same molecular mechanism underlying ginger-colored fur in domestic cats: a small deletion mutation on the cats' X-chromosome. The Kyushu team, whose work was largely crowdfunded by cat lovers around the world, published its research alongside the Stanford study in the peer-reviewed journal, Current Biology. 'These ginger and black patches form because, early in development, one X-chromosome in each cell is randomly switched off,' senior author of the Kyushu study, geneticist Hiroyuki Sasaki, a professor at Kyushu University, explained in a statement. 'As cells divide, this creates areas with different active coat color genes, resulting in distinct patches,' Professor Sasaki said. 'The effect is so visual that it has become the textbook example of X-chromosome inactivation, even though the responsible gene was unknown.' X-chromosome inactivation is a process whereby one copy of a female mammal's two X-chromosomes is rendered transcriptionally inactive. This phenomenon, sometimes known as Lyonization, was originally reported by British geneticist Mary Lyon who confirmed this theory in 1961 (ref). She discovered that female mammals' cells randomly silence one of the two X-chromosomes inherited from their parents. The inactivated chromosome can be seen under a microscope as a tiny dark Barr body compacted inside cells. Figure 2: X-Chromosome Inactivation (XCI) and cat fur colors. In cats, the X-chromosome contains a ... More gene controlling the orange/black pigmentation of the fur. If the two X-chromosomes of a female carry the same version of this gene, the coat of the adult cat will be of a single, unified color (either fully orange or fully black). However, if a female carries one X-chromosome with the orange variant and the other X-chromosome with the black variant, the mosaicism of XCI occurring during embryonic development will be visible in the color pattern of the adult cat's fur. In other words, the cat's fur is a mosaic of colors that reflects the random X-chromosome inactivation, that happens during early development. As a side note, and in contrast to the orange and black coloring, the presence of additional white patches in calico cats is not under the control of the X-chromosome. This condition, called 'piebalding', causes unpigmented skin and fur, and is commonly found in both XX and XY cats. (Credit: Image modified from '6-year old tortoiseshell cat," by Michael Bodega (public domain).) Originally, these two teams of scientists were investigating whether cats with orange fur were at a heightened risk for certain genetic disorders or health conditions, but along the way, they discovered that the cellular context (the tissue type, in this situation) of the gene's expression is what makes the difference. 'The orange mutation has not been linked to disease,' Dr Kaelin told me in email. 'In cats, the orange mutation occurs near a gene called Arhgap36 and activates it specifically in pigment cells.' The Arhgap36 gene is also present and active in humans. 'A related type of mutation has been identified in a human patient with a fatal disease that caused abnormal bone growth in areas where bone does not normally exist,' Dr Kaelin added in email. 'In that case, Arhgap36 is also activated, but in a different tissue type. Orange cats are spared that fate because the nature of the mutation appears to limit its activity to pigment cells.' Both Dr Kaelin and collaborators and the Kyushu study's team report that the missing section of DNA not only explains the unique sex-linked genetics of ginger fur in cats, but also points to an entirely new and so far unique mechanism for creating orange fur coloring in mammals. This discovery came after both Dr Kaelin and collaborators and members of the Kyushu collaboration compared the DNA from dozens of cats with and without orange fur. They found that cats with ginger fur color were missing a section of DNA within the Arhgap36 gene. This result of this mutation is that the Arhgap36 gene is more active than normal, leading to the production of pumpkin-orange fur pigment. Did this mutation for orange fur color arise just once? 'Orange cats are found all over the globe today, but our findings indicate that all orange cats can be traced back to a single orange (or tortoiseshell) cat,' Dr Kaelin replied to me in email. 'However, we still don't know when or where the original orange cat lived.' How long ago did this mutation arise? 'The wild progenitors of domestic cats are not orange, so we can infer that the mutation occurred during or after cat domestication. We know the mutation is old because calico cats are depicted in Chinese art dating to the 12th century. Identifying the orange mutation could help scientists who study ancient DNA look further back into prehistory for evidence of orange cats.' A Japanese woodblock print of calico cats in different poses and activities. Edo, Japan. NOTE: this ... More image was cropped from the original. (Credit: Utagawa Kuniyoshi (1798–1861); Japanese ukiyo-e painter / Public Domain.) Strangely, what seems to cause orange fur in cats isn't so much an 'orange gene' as it is an 'orange mutation' within a still-unknown gene, according to Dr Kaelin. Looking closer at the mutation, the researchers found that the deletion lies within a non-coding region of Arhgap36, so the resulting protein remains structurally unchanged. 'This is key,' Professor Sasaki explained. 'Arhgap36 is essential for development, with many other roles in the body, so I had never imagined it could be the orange gene. Mutations to the protein structure would likely be harmful to the cat.' 'The affected gene, Arhgap36, in orange cats is not typically a pigmentation gene,' Dr Kaelin explained in email. 'The unusual nature of the mutation represents a rare example of a gene acquiring a new function due to its accidental activation in a cell type where it is normally inactive. This process – where a gene acquires a new function – is thought to be important for evolution.' A change in genetic function or activity can have powerful consequences. For example, humans and chimpanzees share the same set of genes, but those genes act differently during development. 'Our study identifies a case in which a genetic change has a highly specific effect on gene activity, and understanding how this occurs will contribute to a broader understanding of gene regulation,' Dr Kaelin told me in email. Further analysis showed that high Arhgap36 activity is linked to reduced activity in many genes involved in melanogenesis, the process that produces pigment in skin and hair. Through an unknown mechanism, this change may alter pigment production away from dark eumelanin to lighter pheomelanin – orange. What other roles does this gene normally have? Is it active in neurogenesis or brain development? (I ask these questions because ginger cats are alleged to share a single brain cell between all members of the orange cat community worldwide.) 'Orange cats have their owners convinced that they are friendlier, more mischievous, and perhaps dimmer than other cats. This may all be true – or not,' Dr Kaelin told me in email. 'Rigorous scientific studies linking orange coat color to behavior have yet to be conducted. Arhgap36 is active in certain brain areas; however, in our study, we did not observe altered activity of Arhgap36 in those brain regions in the same way we observed altered activity in pigment cells.' Already, plans are underway to identify the orange gene's origins and additional cellular functions. 'One idea is to study ancient Egyptian cat paintings – or even to test DNA from mummified cats – to see if any cats back then were orange,' Professor Sasaki stated. 'It's ambitious, but I'm excited to try.' Another plan is to develop cat cell cultures to decipher the molecular function of Arhgap36. In addition to understanding molecular function of this gene in cat neurogenesis, this study may have medical implications for humans because this gene is also active in humans and is linked to conditions like skin cancer and hair loss. Hidehiro Toh, Wan Kin Au Yeun, Motoko Unoki, Yuki Matsumoto, Yuka Miki, Yumiko Matsumura, Yoshihiro Baba, Takashi Sado, Yasukazu Nakamura, Miho Matsuda & Hiroyuki Sasaki (2025). A deletion at the X-linked ARHGAP36 gene locus is associated with the orange coloration of tortoiseshell and calico cats, Current Biology | doi:10.1016/ Christopher B. Kaelin, Kelly A. McGowan, Joshaya C. Trotman, Donald C. Koroma, Victor A. David, Marilyn Menotti-Raymond, Emily C. Graff, Anne Schmidt-Küntzel, Elena Oancea & Gregory S. Barsh (2025). Molecular and genetic characterization of sex-linked orange coat color in the domestic cat, Current Biology | doi:10.1016/ Questions emailed to the senior authors of both studies, Hiroyuki Sasaki and to Gregory Barsh, and to the Kyushu study's co-lead author, Wan Kin Au Yeun, went unanswered. © Copyright by GrrlScientist | hosted by Forbes | Socials: Bluesky | CounterSocial | LinkedIn | Mastodon Science | MeWe | Spoutible | SubStack | Threads | Tumblr | Twitter

Archaeologists finally crack origin mystery of Tibet's ‘ghost ancestors'
Archaeologists finally crack origin mystery of Tibet's ‘ghost ancestors'

The Independent

time2 days ago

  • General
  • The Independent

Archaeologists finally crack origin mystery of Tibet's ‘ghost ancestors'

Archaeologists have discovered that the ancestors of the Tibetan people, including a mysterious group known as the 'ghost' population, came from China 's Yunnan province more than 7,100 years ago. Researchers say the discovery helps solve an important mystery about how humans spread across East Asia. Scientists studying ancient DNA from East and Southeast Asia know that humans started spreading across the continent at least 19,000 years ago and that they split into northern and southern branches early on. But there are significant gaps in our understanding of the genetic origin of modern populations such as the Tibetans. Tibetan people carry genes from northern East Asians but also from an unknown group – the 'ghost' population – which some archaeologists think may be linked to ancient humans such as the Denisovans or an early group of modern humans from Asia. Denisovans are 'an extinct group of archaic humans previously known mainly from remains discovered in Siberia and Tibet ', according to the European Research Council. Previous research has pointed to China 's Yunnan region as the key to understanding the origins of Tibetan as well as Austroasiatic populations, referring to ethnic communities in Southeast Asia who speak Austroasiatic languages like Vietnamese, Khmer, and Mon. Studies indicate that about 80 per cent of the genetic makeup of Tibetan people comes from northern Chinese populations who lived between 9,500 and 4,000 years ago. The ancestry of the remaining 20 per cent remains unclear and is referred to as Tibet 's 'ghost' population. In a new study, scientists sequenced DNA from over 125 individuals who lived in Yunnan between 7,100 and 1,500 years ago. They compared the ancient genomes to the DNA of modern Tibetans and found that one person who might belong to the 'ghost' group carried genes of both ancient and modern Tibetans. This 7,100-year-old individual from Yunnan was discovered to be as genetically distinct from most modern East Asians as a 40,000-year-old person from the area now known as Beijing, indicating a previously unknown Asian ancestry. Scientists say this individual is the first known potential representative of Tibet 's previously uncharacterised 'ghost' lineage. Researchers suspect this lineage likely diverged from other early Asian people over 40,000 years ago and managed to survive in southern regions due to more stable climates during the Ice Age. They discovered that a unique 'central Yunnan' ancestry, different from the known northern and southern East Asian groups, appeared some 5,500 years ago and helped shape the genes of people speaking Austroasiatic languages today. This ancestry seems to have emerged before the widespread adoption of agriculture in the region, suggesting demographic expansions likely preceded the spread of farming. The findings show that Yunnan was for long an important crossroads where different groups of people met and mixed. 'This study not only fills a critical gap in the genetic data of prehistoric populations in East and Southeast Asia but also identifies one of the Tibetan Plateau's 'ghost ancestors' for the first time from a genetic perspective,' researchers said.

UAE Prenatal Testing Market to Triple by 2033: Driven by Tech Advancements and Maternal Health Awareness
UAE Prenatal Testing Market to Triple by 2033: Driven by Tech Advancements and Maternal Health Awareness

Yahoo

time2 days ago

  • Business
  • Yahoo

UAE Prenatal Testing Market to Triple by 2033: Driven by Tech Advancements and Maternal Health Awareness

Key drivers include increasing maternal age, healthcare advancements, and government support for early fetal screening. The market benefits from the rise in medical tourism and global diagnostic partnerships, despite challenges like cultural sensitivities and a lack of genetic counseling. Major players such as Eurofins, Roche, and Illumina enhance the UAE's prenatal care through innovative technologies and strategic partnerships. UAE Non-Invasive Prenatal Testing Market Dublin, June 02, 2025 (GLOBE NEWSWIRE) -- The "UAE Non-Invasive Prenatal Testing Market Size and Share Analysis - Growth Trends and Forecast Report 2025-2033" report has been added to UAE Non-Invasive Prenatal Testing Market is expected to reach US$ 64.46 million by 2033 from US$ 21.04 million in 2024, with a CAGR of 13.25% from 2025 to 2033. The UAE's non-invasive prenatal testing market is growing due to a number of factors, including growing maternal age, better access to healthcare, increasing awareness, government assistance, the need for early fetal screening, and a rise in incidences of genetic disorders. UAE Non-Invasive Prenatal Testing Industry OverviewDue to improvements in genetic screening technology and growing awareness among pregnant parents, the non-invasive prenatal testing (NIPT) market in the United Arab Emirates (UAE) is expanding steadily. NIPT uses a straightforward blood test from the mother to safely and effectively identify chromosomal abnormalities in the fetus. Because of its accuracy, early detection potential, and low danger in comparison to more conventional invasive techniques like amniocentesis, it has becoming more and more popular in the United Arab Emirates. Both public and commercial healthcare organizations are implementing NIPT as a common prenatal screening procedure as healthcare standards rise and prenatal care becomes more maternal age is a major risk factor for chromosomal abnormalities like Down syndrome, which raises the need for accurate prenatal screening and is one of the main causes driving this industry's rise. Furthermore, expanding insurance coverage, the presence of foreign healthcare practitioners, and the UAE government's initiatives to improve genetic health services all help to increase NIPT's accessibility and acceptability. The market is also supported by the nation's growing medical tourism industry, which draws patients from nearby areas looking for cutting-edge prenatal diagnostics, especially in locations like Dubai and Abu its promise, the UAE NIPT industry is beset by issues including low awareness among specific demographic groups and the exorbitant expense of testing for those without insurance. These obstacles are being addressed, meanwhile, by continued public education campaigns, the incorporation of genetics into national healthcare plans, and partnerships with international diagnostics firms. With advancements in bioinformatics and non-invasive technologies anticipated to further improve the precision and reach of prenatal screening services, the NIPT sector in the United Arab Emirates is well-positioned for sustained development as precision medicine continues to Drivers for the UAE Non-Invasive Prenatal Testing Market Supportive Government PoliciesThe UAE's non-invasive prenatal testing (NIPT) sector is expanding thanks in large part to supportive government legislation. As part of its larger national healthcare policy, the government has made maternal and fetal health a top priority, investing heavily in early diagnostic technologies and updating hospital infrastructure. The National Genome Strategy and the UAE's Vision 2031 initiatives center on incorporating cutting-edge genetic technology into standard medical treatment. While regulatory agencies make ensuring that these technologies are used in a safe and moral manner, public health campaigns also seek to increase awareness about prenatal screening. These initiatives, together with advantageous laws and alliances with international biotech companies, are creating a healthcare climate that encourages innovation and the broad use of NIPT throughout the Tourism GrowthThe non-invasive prenatal testing (NIPT) industry in the United Arab Emirates is growing due in large part to the rise of medical tourism, particularly in locations like Dubai and Abu Dhabi. The nation has established itself as a regional center for top-notch, specialized medical treatment, drawing clients from Asia, Africa, and the Middle East. The UAE's highly developed healthcare system, internationally recognized facilities, and access to state-of-the-art diagnostic tools like NIPT attract patients from outside. For pregnant moms looking for early and precise fetal screening, prenatal care facilities that offer individualized attention and minimal wait periods are particularly alluring. The UAE's standing as a destination for cutting-edge prenatal diagnostics is further reinforced by government funding for healthcare tourism and continuous initiatives to enhance service of Global Diagnostic CompaniesOne of the main factors propelling the non-invasive prenatal testing (NIPT) industry's expansion in the United Arab Emirates is the arrival of international diagnostic and genomics firms. To increase access to cutting-edge prenatal screening technology, foreign companies are establishing strategic alliances with regional healthcare providers, labs, and governmental organizations. The accuracy, speed, and scope of NIPT services are improved by these partnerships' introduction of cutting-edge technologies including high-throughput sequencing and AI-powered data processing. Furthermore, foreign actors raise the general level of prenatal care in the United Arab Emirates by assisting with knowledge transfer, workforce training, and adherence to international quality standards. The country's larger objectives of becoming a regional leader in precision healthcare and genomic medicine are supported by this infusion of knowledge and in the UAE Non-Invasive Prenatal Testing Market Cultural and Religious SensitivitiesThe UAE's adoption of non-invasive prenatal testing (NIPT) is significantly hampered by cultural and religious sensitivities. The ethical ramifications of prenatal testing, especially with regard to possible judgments about pregnancy termination, might restrict acceptability in an area where traditional values and religious views are crucial in family and healthcare decisions. Because of religious beliefs about the sanctity of life, worries about disrupting natural processes, or fears of social disapproval, some families might be reluctant to undergo genetic testing. Even when NIPT is advised by a doctor, these issues may cause reluctance to choose it. Building understanding and confidence in prenatal screening necessitates ethical counseling, culturally relevant public education, and collaboration with community and religious of Genetic Counseling ServicesOne major obstacle to the efficient use of non-invasive prenatal testing (NIPT) in the United Arab Emirates is the lack of qualified genetic counselors. Even though NIPT's technology is sophisticated and becoming more widely available, many patients may not have the assistance they need to understand complicated genetic data. Expectant parents may misinterpret test findings without the right counseling, which might cause needless worry or poor choices. In a culturally diverse nation like the United Arab Emirates, where language proficiency and cultural awareness are crucial for successful communication, this disparity is especially significant. Existing healthcare providers are likewise strained by the shortage of skilled workers. To remedy this deficiency, it is imperative to integrate remote or tele-counseling services, expand training programs, and provide incentives for genetic counseling expertise. Key Attributes: Report Attribute Details No. of Pages 200 Forecast Period 2024 - 2033 Estimated Market Value (USD) in 2024 $21 Million Forecasted Market Value (USD) by 2033 $64.5 Million Compound Annual Growth Rate 13.2% Regions Covered United Arab Emirates Report Scope: UAE Non-Invasive Prenatal Testing Market Segment Component Instruments Kits and Reagents Services Application Down Syndrome (Trisomy 21) Edwards Syndrome (Trisomy 18) Patau Syndrome (Trisomy 13) Turner Syndrome Other Applications End User Hospitals Diagnostic Labs The key players have been analyzed by: Overview Key Persons Recent Development & Strategies Financial Insights Key Players Analyzed: Eurofins Scientific F. Hoffmann-La Roche Ltd Invitae Corporation Illumina Inc. Natera Inc. Centogene NV Qiagen For more information about this report visit About is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Attachment UAE Non-Invasive Prenatal Testing Market CONTACT: CONTACT: Laura Wood,Senior Press Manager press@ For E.S.T Office Hours Call 1-917-300-0470 For U.S./ CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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