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Washington Post
16 minutes ago
- Washington Post
Biotech pauses trial after second patient death linked to gene therapy
Biotech firm Sarepta Therapeutics said that a second patient died after receiving its gene therapy to treat Duchenne muscular dystrophy, the latest drug to draw scrutiny after winning fast regulatory approval. The Cambridge, Massachusetts-based firm's stock lost more than 40 percent of its value Monday, a day after disclosing the death and announcing that it would temporarily stop shipping the treatments for certain patients, and pause a clinical trial, while it evaluates its protocols.


Fast Company
18 minutes ago
- Fast Company
Eli Lilly is making it cheaper and easier to buy high-doses of blockbuster weight loss drug Zepbound
Eli Lilly announced on Monday it will soon make the two highest-doses of its popular weight-loss drug Zepbound available for self-paying customers on its website. Starting in August, 12.5 mg and 15 mg single-doses will be added to the company's website, effectively making all Zepbound doses available for $499 a month, or less. Unlike the pen form sold at pharamcies like Walgreens and CVS, the drug will be available in vial form through its LillyDirect self-pay pharmacy, which will require patients to draw their own shots into a syringe rather than have them prefilled. The drug will be to any eligible adult with obesity and a valid prescription regardless of insurance coverage. Health care providers and doctors can start prescribing the higher doses on July 7, according to Lilly. Zepbound is an injectable prescription medicine that belongs to a class of drugs known as GLP-1 receptor agonists originally developed for type 2 diabetes, that may help adults for treating obesity and weight-related medical issues. 'Obesity is a serious, chronic disease, and access to obesity medications should be treated with the same urgency as other chronic conditions,' Rhonda Pacheco, group vice president of U.S. Cardiometabolic Health at Lilly said in the press release. 'Lilly was the first company to offer a self-pay solution for an FDA-approved obesity medication, and we continue to work to expand coverage for Zepbound. In the meantime, the availability of the two highest-dose Zepbound vials gives providers and patients another important treatment option.' While the weight-loss drugs are popular with consumers, not so much with insurance companies, who don't always widely cover the drugs, leading Lily, and rival Novo Nordisk, the maker of Wegovy, to start offering their own self-pay options. The company first rolled out its self-pay, single-dose vials last summer in an effort to meet high consumer demand. Shares in the (NYSE: LLY) were trading down less than 2% at the market's close on Monday. Eli Lily: By the numbers In Eli Lily's latest round of earnings for the first quarter of 2025, ending March 31, 2025, the company showed a mixed performance, and reported net income of $2.76 billion and earnings per share (EPS) of $3.34, with revenue guidance between $58 billion and $61 billion. The drug maker has a market capitalization of $724.99 billion, as of this writing.


Forbes
23 minutes ago
- Forbes
Coding For AI And Why YC Backed Wasp Is Poised To Be The Backbone Of The Next Software Revolution
Wasp co-founder, Martin Sosic and Matija Sosic Growth isn't just a goal in the developer tools space—it's the lifeblood. Few know that better than twin brothers Matija and Martin Sosic, Y Combinator backed co-founders of Wasp, the open-source web framework that's quietly reshaping how modern applications are built. With over 26,000 GitHub stars and a fresh $3.7 million seed round led by HV Capital and followed by Fifth Quarter Ventures, Big Bets and Metis, Wasp is more than just another dev tool—it's rapidly becoming the connective tissue of modern web development especially with its 'deploy anywhere' approach which is a major unlock for enterprise usage. In a candid conversation, the Wasp team outlined their bold roadmap and shared how they plan to grow from a beloved open-source project into a foundational player in the AI-powered development stack. Wasp's approach to growth is centered on four key levers: 1. Product Excellence: 'Simply put, we want the product to be so good that developers who try it naturally share it,' said Matija. Reaching their 1.0 release—currently in active development—is a key milestone. 2. Community Building: Already boasting a highly engaged Discord and thousands of developers, Wasp is doubling down on education and visibility. Expect more workshops, dev showcases, and ecosystem content in the coming months. 3. Strategic Partnerships: 'This is where we're intensifying our efforts,' Martin noted. 'The right integrations—whether with hosting platforms, AI coding tools, or backend services—can supercharge adoption for both sides.' Their recent push to align with major players in the AI coding space is one example. 4. Team Expansion: Wasp is growing its engineering and developer relations teams to execute on its expanding roadmap. As demand increases, scalability—both in code and in headcount—becomes essential. While AI is often viewed as a great equalizer, in sense of diminishing the moat of building the product and getting it into the hands of users, that makes the underlying developer tools and technologies even more important. Evolution at every level of the stack (frameworks, libraries) will continue happening even faster than in the pre-AI era, given an exponential volume of new web apps and SaaS-es that will come to the market with the help of AI-driven and assisted development. Every improvement in the tools used for it will further lower the barrier for builders and make both AI and developers more efficient. While AI can democratize building SaaS-es, the underlying toolchain is something that must be widely accepted, verified from, and built by the community. That is the only way to progress towards safe and sustainable development with AI. And that is exactly what the team behind Wasp is building - a new 'protocol', in non-technical terms for building web applications. While many developer tools are still figuring out their place in the AI era, Wasp is already staking a claim. 'We're betting big on AI-assisted development,' Matija explained. 'We believe Wasp is uniquely positioned to become a default framework for AI coding tools and humans alike.' This isn't just lip service: Wasp is already testing (and built their own early version of Bolt/Lovable back in the day) where AI models use Wasp's syntax and structure to generate fully functional apps. The goal? To make it drastically easier for AI to build robust applications by abstracting away full-stack complexity—something Wasp does particularly well. 'AI can now generate a lot of the code for you, even working applications," said Martin. 'But stitching together the frontend, backend, database, auth, and deployment, in a secure, maintainable, and scalable way? That's still hard. Wasp makes that orchestration dead simple—so we're effectively giving AI superpowers.' As TechCrunch puts it, Wasp is becoming the 'glue' between frontend frameworks like React and the backend services that power modern apps. While Wasp's early traction came from indie hackers and startup founders, the framework is now being used in production by enterprise teams. 'Getting from hobby projects to real enterprise-grade apps is a rite of passage,' said Matija. 'We've already crossed that first chasm—now we're focused on scaling it.' This shift includes working with dev teams building internal tools, customer portals, and full-fledged SaaS platforms—all powered by Wasp's opinionated but flexible architecture which currently supports React, and Prisma. How Wasp works Wasp hasn't reached 'community darling' status just yet. 'We're not at 1.0 and still missing some core features,' Martin admitted. 'But once we cross that threshold, we believe adoption will accelerate rapidly.' What Wasp offers is not just convenience, but a rethinking of how full-stack web apps should be built in an AI-driven world. Developers no longer want to spend days gluing tools together or wrangling infrastructure. Wasp abstracts that pain away—while giving AI systems a higher-level interface to build on. Wasp team photo The future of software development is converging around simplicity, automation, and AI. Wasp hits all three. Its bet: that the next wave of developer productivity will come not from piecing together disparate tools, but from using purpose-built platforms that unify the entire stack—from frontend logic to database orchestration to CI/CD. If Wasp's trajectory continues, it may not just be the next big dev tool—it could be the new foundation on which the next generation of software is built.