
We tested all sorts of hydrating serums. The best was a $22 drugstore product
The best hydrating serums we tested
Best hydrating serum: Neutrogena Hydro Boost Hyaluronic Acid Serum
Best hydrating serum for dry skin: The Ordinary Multi-Peptide + HA Serum
Best hydrating serum for textured skin: CosRX Advanced Snail 96 Mucin Power Essence When your skin is looking dull or dry, that usually means it's time to ramp up your skin care routine. Hydrating serums are an easy place to start. They deliver long-lasting hydration, typically leaving skin soft, glowy and ultra-moisturized.
To find the best hydrating serums, we had 10 CNN Underscored staffers with a wide range of skin types put a variety of formulas to the test, from affordable staples to luxe picks. After daily use and careful comparison, three standout serums emerged, with our overall pick being a drugstore find that costs only $22.
Related article
We tested 8 moisturizers for dry skin. Our favorite is a $17 drugstore creamNeutrogena Hydro Boost Hyaluronic Acid Serum
Deals editor Jacqueline Saguin found Neutrogena's Hydro Boost serum deeply hydrating, lightweight and gentle on her sensitive, eczema-prone skin. She appreciated its simple, fragrance-free formula with nourishing ingredients like hyaluronic acid and glycerin.
The Ordinary Multi-Peptide + HA Serum
Home and gifts editor Amina Lake Patel tested The Ordinary Multi-Peptide + HA Serum and loved its lightweight feel, quick absorption and hydrating, nongreasy formula. A longtime fan of the brand, she plans to keep using the $20 serum.
CosRX Advanced Snail 96 Mucin Power Essence
Testing writer Carolina Gazal, who battles cystic acne and scars, found this serum from CosRX to be a soothing, breakout-friendly solution that deeply hydrated her skin without irritation. Despite its gooey texture, she came to rely on the ultra-nourishing formula and would gladly repurchase it for its skin-repairing benefits and affordable $25 price tag. Deals editor Jacqueline Saguin loved the lightweight, water-like texture of Neutrogena's Hydro Boost serum on her dry, sensitive and eczema-prone skin. The simple, hyaluronic acid-based formula delivered long-lasting hydration without irritating her sensitive skin, which was consistent with other products she's tried in the Hydro Boost line.
As someone with eczema, she especially valued the fragrance-free formula, which is ideal for sensitive skin. The serum absorbed quickly and deeply moisturized her skin, thanks to a blend of hyaluronic acid, trehalose and glycerin. Even better? It's also free of parabens and mineral oil, meaning it won't clog pores or cause irritation. Just a few drops locked in hydration and left her skin looking glowy.
While the ultra-hydrating formula stood out, the serum's packaging was also impressive. The unique click-top plastic dropper made application easy and efficient.
Skin care enthusiasts at CNN Underscored have tried, tested and loved The Ordinary brand and its products long before this testing. Beauty and fashion editor Sophie Shaw deemed The Ordinary an affordable starting point for a solid, starter skin care regimen, and our testing results show why. Home and gifts editor Amina Lake Patel raved about the serum's lightweight texture, quick absorption and generous dropper. Although the formula was slightly tacky upon first use, once fully absorbed, it left her combination skin smooth and deeply hydrated without being greasy.
According to The Ordinary, this serum targets common signs of aging too, helping to reduce the appearance of crow's feet while improving skin's smoothness, texture, elasticity and firmness for a more youthful look. Since it contains peptides, it goes beyond providing hydration alone and offered an easy way to incorporate peptides into Patel's routine. The tiny but powerful bottle is also just under $20, making it a great value, and she plans to keep using this specific serum for its affordable price and effective, multitasking ingredients.
Given that testing writer Carolina Gazal struggles with cystic acne and combination skin, especially an acne-riddled chin and hyperpigmentation and scars on her cheeks, she's in the throes of using drying acne creams. That means her skin needs an extra layer of hydration that won't break her out. That's where CosRX's Advanced Snail 96 Mucin Power Essence, a beloved K-beauty product and an editor favorite, comes in.
The lightweight formula not only enhances the skin's glow but also improves texture. It's formulated with 96% snail mucin to help repair skin, boost hydration and elasticity, and reduce the appearance of wrinkles, scars and breakouts. Gazal found the snail essence gooey at first touch but grew to love the ultra-nourishing product for her dried-out skin. It didn't irritate current breakouts, which was a big win, and over time, her skin craved the weirdly goopy but hydrating product. It can be found for only $17 for a full-size bottle, making it a wonder product that's a no-brainer to repurchase.
Naturally, we had to get our hands on the internet's favorite hydrating serums, in addition to drugstore finds and higher-end options. We had 10 CNN Underscored staffers evaluate each product for a week and take detailed notes on the criteria below.
Our testers have different skin types and concerns, ranging from oily skin to eczema, acne to fine lines, and even persistent dry patches.We tested each hydrating serum to see how it would help nourish skin in the long run. Each tester tried one serum to see how it would help nourish skin and reflected on the following criteria.
Formula: Did the formula feel light or heavy on the skin? Was it easy to apply?
Absorption: Did the serum absorb into the skin quickly, or did it take time? Did it layer well with other products?
Moisturizing: Did the serum hydrate the skin? Did your skin feel dry at any point between applications?
Additional benefits: Some serums in our pool had additional benefits like SPF, anti-aging ingredients or extra acids for hydration. Did these products deliver the desired results, considering these bonus criteria?
Value: Did the quality of the product match the price? Was there a fair amount of product for the price?
Above all, hyaluronic acid is a standout ingredient in a hydrating serum that you should be looking for. 'It's a sugar found naturally in the skin that holds water,' said Dr. Corey L. Hartman, the founder of Skin Wellness Dermatology in Birmingham, Alabama. 'It's a clear, thick, gel-like substance that our body produces and can be found in high concentrations in the skin, connective tissue and eyes. It helps to retain and attract water, and keeps tissues hydrated and lubricated.'
In addition to hyaluronic acid, Dr. Brendan Camp, a double board-certified dermatologist at MDCS Dermatology, also recommends looking for other actives. 'Niacinamide can help regulate oil production and reduce clogged pores, and peptides help stimulate collagen,' he said. 'Vitamin C is also great for brightening and evening out skin tone.'
Paula's Choice Niacinamide Booster
Paula's Choice serum could be a solid choice for those looking for skin care loaded with niacinamide. It's made with 10%, to be specific, to help reduce the appearance of pores and texture. It's also packed with vitamin C and licorice extract to soothe any lingering irritation in skin. Photo editor Molly Flores tested Paula's Choice Niacinamide Booster on her combination skin. Her main concern was an oily T-zone and some texture on her chin and jawline. She found the lightweight formula absorbed quickly and provided noticeable hydration but the runny consistency made it difficult to apply directly. She wound up mixing the serum with her moisturizer. Although she appreciated its effectiveness, so much so that her skin felt dry after skipping a day, she preferred a serum with more grip to better support her skin care routine.
Laneige Water Bank Blue Hyaluronic Acid Hydrating Serum
This pick has one standout ingredient: blue hyaluronic acid fermented with deep-sea algae for even dewier, glowier skin. While our tester liked the formula overall, it didn't make a remarkable difference for her skin. Managing editor Rachel Quigley tested Laneige's hyaluronic acid-packed serum on her very dry skin and appreciated its light, nongreasy texture and quick absorption. This K-beauty serum promises dewy, glass skin, thanks to a host of nourishing skin ingredients — namely, hyaluronic acid for deep hydration, peptides to improve firmness and a green tea enzyme to gently exfoliate for a smoother appearance. The Laneige serum is also free of pesky additives like parabens and sulfates. While she found it easy to apply, she didn't notice a significant improvement in hydration and, ultimately, she wouldn't repurchase it because she's used more effective serums in the past.
Clarins Double Anti-Aging and Anti-Wrinkle Serum
The Clarins anti-wrinkle serum is one of the priciest serums we tested. There's a good reason why: The 2-in-1 serum is made with "epi-aging" ingredients to combat environmental aging, like turmeric extract and other natural plant extracts. It also features a thicker consistency that provided ample hydration during our testing. The Clarins Double Serum's slightly thick texture was easy to apply and lightweight on testing writer Michelle Rae Uy's combination skin. The serum absorbed quickly and kept moisture locked in, preventing dryness throughout the day and night; however, it didn't feel exceptionally moisturizing.
According to Clarins, this serum is suitable for all skin types and works to visibly firm and smooth the skin while reducing the look of wrinkles and pores. Like other hydrating serums we tested, it promises to strengthen the moisture barrier, boost radiance and refine texture. After using it for a week, Uy noticed firmer skin, though she didn't yet see all the expected benefits, like reduced wrinkles or minimized pores. Despite being cautious with skin care due to her sensitive skin, the serum worked well with her routine, and she plans to continue using it.
Vichy Minéral 89 Fortifying and Plumping Daily Skin Booster
We get it: Sometimes you just need a serum that does the job, sans snail parts and extracts that sound like a grocery store list. Vichy's skin booster is made with pure hyaluronic acid and mineral-rich volcanic water to boost hydration without the sticky feel. Our tester liked its simple yet effective formula that felt approachable for those just starting to build a skin care routine. Madison Yerke, a digital content strategist at CNN Underscored, struggles with dryness on her forehead and oiliness on her chin and face, but has never used a hydrating serum before. In fact, they always seemed a bit intimidating to her, especially since she only started a moisturizer and sunscreen routine two years ago. But after trying Vichy's Minéral 89 serum, she raved about its jelly-like texture that absorbed quickly into her skin. It felt surprisingly lightweight once applied and left her skin hydrated and refreshed throughout the day. After a week of consistent use, she concluded her skin felt fresher, and at just $40, she thought it was worth the price.
Skin Pharm Youth Serum
Skin Pharm's Youth Serum is often considered a holy-grail serum because it's supposed to be a powerful multitasker when it comes to firming fine lines and hydrating dull skin. However, at $115, it was one of the priciest products we tested and other formulas provided superior hydration. Skin Pharm Youth Serum is packed with hydrating hyaluronic acid and antimicrobial peptides to reduce the appearance of blemishes, as well as sativa rice bran extract to help the skin retain moisture in the long run. Although the serum is crafted with soothing ingredients safe for sensitive skin, senior lifestyle editor Tamara Kraus wasn't pleased with how her skin felt after the serum dried on her mostly normal, slightly dry skin.
Although it was lightweight and absorbed quickly, it left her skin feeling tight. To combat this, she layered on other products to achieve the dewy look she wanted. At a whopping $115, the serum is, ultimately, too pricey, especially when more affordable brands like The Ordinary, Glow Recipe and Mario Badescu delivered better, more immediate results for Kraus' skin.
Rhode Peptide Glazing Fluid
Rhode may have popped up on your Instagram feed, thanks to Hailey Bieber's creative marketing and other fan-favorite products. This lightweight gel serum is Bieber's go-to for dewy, glazed skin, so we had to put it to the test on real, unfiltered skin. It aims to visibly plump and hydrate the skin barrier with hyaluronic acid, niacinamide and peptides. Copy editor Rena Behar found this Rhode serum lightweight but slightly tacky on her acne-prone, sensitive and oily skin. The dispenser was also difficult to use, and although advertised as fragrance-free, the product had a sharp scent. While it absorbed quickly at first, it seemed to sit on the skin without providing deep hydration and didn't outperform her usual favorite, the CosRX Advanced Snail 96 Mucin Power Essence, our pick for textured skin. She noted no major improvements after using the glazing fluid for a week, and while she might use it occasionally in the summer, she wouldn't repurchase due to its underwhelming results and tricky packaging.
Drunk Elephant B-Hydra Intensive Hydrating Serum
While this serum has a lightweight feel and gentle formula — made with pineapple ceramides and vitamin B5 — our tester didn't find this hydrating serum to be as "intense" as its name implies. Katelyn Gendron, our director of global commerce and SEO, tested Drunk Elephant's B-Hydra Intensive Hydration Serum on her dry skin, which was lightweight, gentle and quick to absorb. The $50 serum promises long-lasting hydration while strengthening the skin's barrier and boosting its ability to retain moisture. It's also suitable for all skin types and free of essential oils, silicones, fragrances, dyes and alcohols. All of these perks aside, the serum was ineffective for Gendron. She was disappointed by the lack of hydration, saying it felt like she hadn't used any product at all and wouldn't use it again.
The following questions were answered by double board-certified dermatologist Dr. Brendan Camp.
What is a hydrating serum?
What is a hydrating serum?
A serum goes far beyond a moisturizer. 'A hydrating serum focuses on increasing the skin's hydration to improve concerns like dryness, fine lines, texture and improve the overall appearance and health of the skin,' Camp said.
'The key difference between serum and moisturizer is their formulation and texture,' he added. 'Compared to a moisturizer, a serum is much lighter and absorbs more quickly into the skin. Serums tend to address specific skin concerns like fine lines and wrinkles, while moisturizer hydrates the skin and protects the skin barrier. Serums tend to be formulated with ingredients like hyaluronic acid and other active ingredients to increase the level of water in the skin.'
What ingredients should I look for in a hydrating serum?
What ingredients should I look for in a hydrating serum?
'Hyaluronic acid, niacinamide, ceramides, peptides and vitamin C,' Camp said. These ingredients provide hydration, but they also help the overall health of your skin. Ceramides and peptides, for example, support the skin barrier, and a healthy skin barrier helps retain moisture levels within the skin.
What ingredients should I avoid in a serum?
What ingredients should I avoid in a serum?
Camp suggests staying away from skin care with added fragrances, as they can be irritating and drying. 'If you have sensitive skin, consider doing a [spot test] with a new product before using it more liberally,' he said.
To determine which hydrating serum worked best, we gathered a testing panel of 10 curious and critical CNN Underscored staffers with various skin types. Though they all had varying skin concerns, all had the same goal: glowy, hydrated skin. Out of the 10 testers, half of them used hydrating serums before the testing.
Here's what the testing panel had to say about their skin:
Copy editor Rena Behar has acne-prone, sensitive and oily skin.
Photo editor Molly Flores has an oily T-zone and some texture on her chin and jawline.
Testing writer Carolina Gazal struggles with cystic acne and combination skin, in addition to hyperpigmentation on her cheeks.
Katelyn Gendron, director of global commerce and SEO, has very dry skin.
Senior lifestyle editor Tamara Kraus is blessed with normal skin, although it will get dry every now and then.
Home and gifts editor Amina Lake Patel has combination skin, meaning it's sometimes dry and sometimes oily around her nose, with an occasional breakout near her mouth and chin.
Managing editor Rachel Quigley struggles with dry skin.
Deals editor Jacqueline Saguin described her skin as dry, sensitive, and eczema-prone.
Testing writer Michelle Rae Uy has combination skin that skews toward sensitive.
Digital content strategist Madison Yerke has combination skin, which manifests as dryness on her forehead and body, and oiliness on her chin and face.
For this article, we consulted the following experts to gain their professional insights.
Dr. Brendan Camp, double board-certified dermatologist at MDCS Dermatology in New York
Dr. Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama
CNN Underscored has a skilled team of writers and editors who have many years of experience testing, researching and recommending products, and they ensure each article is carefully edited and products are properly vetted. We talk to top experts, recommending only the best products and considering the pros and cons of each item.
For this story, associate testing writer Carolina Gazal gathered a testing pool of 10 CNN Underscored staffers to test a range of hydrating serums to find the very best options. All testers wore each serum for a week to get a true sense of the feel and efficacy of each product.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Associated Press
32 minutes ago
- Associated Press
New online tool helps women on Medicaid find prenatal care and family planning
At the University of Mississippi Medical Center, one researcher's full-time job for the past nine months has been to find out which clinics around the state offer different kinds of women's health care, and whether they accept various forms of Medicaid. The final result is a recently launched database aimed at helping women locate the nearest clinic that can offer the care they need. The work that went into creating it highlights a pervasive problem: Even making an appointment can be a barrier that keeps women from improving their lives. 'We Need to Talk' is a compilation of all Mississippi clinics offering prenatal care – specifying which ones also offer family planning, and whether they take Medicaid insurance, Medicaid waivers and see women whose Medicaid applications are pending. There is also a hotline designed to give additional support to anyone having questions or feeling overwhelmed about the process. 'Having gone through the work, it was remarkable. It wasn't easy to figure out where you should go for care,' said Dr. Thomas Dobbs, former state health officer and dean of the John D. Bower School of Population Health at UMMC, who oversaw the project. 'And that should be one of the most basic bits of information we have.' The idea was born from the recent 900% increase in babies born with syphilis, Dobbs explained, which he called a 'canary in a coal mine' signaling more danger to come. An investigation into the epidemic showed that one of the driving factors was delayed prenatal care, caused in large part by inaccessible information and concerns about cost, Dobbs said. Finding reproductive and prenatal care can be difficult for several reasons. For one thing, there are many different kinds of clinics in Mississippi, making it hard for patients to know what to search for. The list includes federally qualified health centers, county health department clinics and private OB-GYNs. Another reason is that many clinics don't specify online whether they take Medicaid, much less what their policy is on specific or temporary Medicaid coverage. Calling doesn't always guarantee patients a comprehensive or accurate answer. The new database is an initiative of UMMC's Myrlie Evers-Williams Institute – housed in the Jackson Medical Mall – which is committed to eliminating health disparities by studying the intersection of health and social issues. The institute has a clinic on site that practices what's called 'social medicine,' a key element of eliminating those disparities, the institute's executive director Victoria Gholar explained. 'If you have a patient who has asthma and they're living in a situation where mold is in their environment, it will really be hard for them to get better,' Gholar said. 'Or, if we have a patient who has to use an electronic (medical) device, and their electricity is no longer available because they weren't able to take care of their utility bill, then we try to work with them and connect them to resources that might be able to help.' The institute employs a wide range of professionals who work on health from a non-clinical standpoint, such as researchers, community engagers, social workers and registered dietitians. It hosts events like food drives and offers free support from budgeting strategies to meal preparation for those with conditions like diabetes or high blood pressure. Aside from knowing what to search for, finding clinics that accept Medicaid can also be complicated because Mississippi Medicaid eligibility is constantly changing for a woman based on her age and circumstance – what kinds of services she's seeking, as well as whether she's pregnant. Medicaid eligibility in Mississippi is among the strictest in the nation, with one exception – pregnant women. That means many low-income women only become eligible for Medicaid once pregnant. And since an application can take up to eight weeks to be processed, the chances that a woman in this situation will be able to use her newly acquired Medicaid insurance in the first trimester are slim. A law that would cut out this interim period and allow low-income pregnant women to be immediately seen by a doctor passed the Legislature in 2024, but was never implemented because of legislative errors. The policy went back through the Legislature in 2025, passed overwhelmingly again, but is not yet in effect. Some doctors already see women whose Medicaid application is pending, and the UMMC tool specifies at which clinics that's the case. Women of reproductive age seeking reproductive health care are also eligible for leniency in the typical Medicaid stipulations. These women can apply for a Medicaid family planning waiver, which allows them to access Medicaid for family planning purposes, even if they don't qualify for general Medicaid coverage. The income requirement for pregnancy Medicaid and the family planning waiver is a household income of less than 194% of the federal poverty level, or about $2,500 a month for one person in 2025. Dobbs, who has been the main point person on the project, said he hopes the online database is one more resource improving health care accessibility and women's health metrics in Mississippi. 'This isn't about getting patients to UMMC at all,' Dobbs said. 'It's about empowering patients to be able to get the care they need where they live.' ___ This story was originally published by Mississippi Today and distributed through a partnership with The Associated Press.


Medscape
38 minutes ago
- Medscape
A PCP Guide to Emerging Therapies for Resistant Hypertension
This transcript has been edited for clarity. Matthew F. Watto, MD: Welcome back to The Curbsiders . I'm Dr Matthew Frank Watto, here with my great friend and America's primary care physician, Dr Paul Nelson Williams. Paul, this is a topic you know a ton about, isn't it? Paul N. Williams, MD: It's one I always have questions about; I think this is our 37th episode on high blood pressure, if I'm not mistaken. Watto: The audience can't get enough of it — turns out, neither can I. Williams: Me neither! Watto: I love talking about high blood pressure, and this was with a great guest, Dr Jordy Cohen. She's a hypertension expert and a nephrologist. Paul, to start us off, what are we doing with blood pressure cuffs these days? Those manual ones on the wall, those are the way to go, right? Williams: This is a scenario we talk about all the time, and we've beat this drum a lot in prior episodes. I think we've all experienced a patient whose initial triage blood pressure reading is elevated, and either you or the patient will ask for a recheck and you're tempted to use a blood pressure cuff that's been hanging on the wall, has not been calibrated in 17 years, has a decaying spiral cord, and looks like it would fall apart if you touched it. Turns out that's probably not the best way to do it, Matt. So, to reiterate: Automated cuffs are the preferred option. They are more accurate. In this episode with Dr Cohen, we talked about making sure we use the appropriate cuff size and when we have patients who have large arms, you may have to use a wrist measurement every so often. In these circumstances, positioning matters: feet flat, back supported, elbow resting on a table, and have two fingers on the opposite clavicle so that everything is at heart level. If you're taking the blood pressure reading using a cuff around the arm itself, again, you should make sure the patient's arm is resting on a tabletop, bedside, or even on your own arm to ensure it's at heart level. You also shouldn't talk with the patient during that process so you can give them every chance to have an accurate blood pressure reading. That's the first thing: Get an accurate reading. Then everything else follows that step, as you should only treat a diagnosis that you've appropriately made. Watto: All the goals are based on a properly taken blood pressure, so if your patient's blood pressure hasn't been appropriately measured, you might overtreat or undertreat someone. For most patients who are nonfrail, we're now shooting for a blood pressure that is below 130/80 mm Hg. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for patients with chronic kidney disease state that normal blood pressure should be below 120/80, which is very hard to do. If we're getting people with a systolic in the 120s, that's probably about as good as we're going to get. For treatment, Dr Cohen and I have adopted this practice of using combination pills for hypertension management — either a calcium-channel blocker with an angiotensin-converting enzyme inhibitor or an angiotensin II receptor blocker (ARB). I usually prefer a calcium-channel blocker with an ARB or the 'triple pill,' a single-pill combination of a calcium-channel blocker, an ARB, and a diuretic. That's what I go to now as my first-line agent. I'm using a lot of either low-dose or medium-dose combination therapy. I don't usually go to the highest dose unless I'm in a situation where I have to decide between starting a fourth medication or going to a higher dose. That's really been a practice change for me. Dr Cohen reiterated that point and emphasized that it's easiest for the patient and they usually experience fewer side effects when you choose a low-to-moderate dose in comparison to a high dose. Williams: It's a point that we've made in prior episodes, as well. As you start to max out the doses of these medications, you get diminishing returns in terms of their efficacy in lowering blood pressure efficacy and patients can start to experience increased side effects. It's a far better option to start with a kind of median dose as opposed to really trying to crank up the dose, because you just don't get that much more benefit with that approach. Watto: We're going to discuss some of the newer blood pressure–lowering agents. Paul, the first one I want to ask you about is not quite a blood pressure medication, but it does lower blood pressure. Which medication am I talking about here? Williams: I think you're probably referring to semaglutide, Matt. I think we all have a fair amount of comfort with these diabetes and weight loss medications. These are remarkable medications and the indications keep piling on, which is great. Semaglutide, in particular, is not approved for hypertension, but it does lower blood pressure, likely as a result of the weight loss that is achieved with the medication. So, it's not technically an antihypertensive, but it provides a great blood pressure benefit. I think there's also some 'fancy pants' medications coming down the pipeline that we should probably be aware of, right? Watto: Yes, and the first one I'll mention is endothelin receptor antagonists. As a generalist, you're probably not going to be prescribing these; they will probably be prescribed by a hypertension specialist. Compared with placebo, they have a modest effect in lowering blood pressure (~4 mm Hg), but they are officially approved, so they're out there. What's more exciting, Paul, are aldosterone synthase inhibitors. The generic names for these include baxdrostat and lorundrostat. They're not yet approved, but I believe they are in phase 2 or phase 3 trials, depending on the indications. They seem promising, as they have a much stronger effect on blood pressure (~10-15 mm Hg) compared with placebo. Dr Cohen thinks these medications are probably going to be in the primary care wheelhouse soon. Cost will probably an issue with these medications at the start, but otherwise, these are pills that are taken once a day and they don't have the antiandrogen side effects that you can get with the mineralocorticoid receptor antagonists (MRAs), like spironolactone. Dr Cohen was really excited about being able to prescribe these at some point. Williams: And the MRAs are traditionally a fourth-line medication (unless you have compelling indications), so to have something else in your armamentarium that has less side effects is super exciting. It'll be great to see these in the pipeline. Watto: Now, what would you say, Paul, if I told you there was a medication for blood pressure that is only administered once every 6 months and will shut down the renin-angiotensin-aldosterone system (RAAS)? How does that sound? Williams: As someone who's taken medical school physiology, it sounds lightly terrifying! It feels like you do need the RAAS for some things, but I think for patients that are less interested in taking medications — which turns out to be most patients — it could potentially be exciting. I think as long as we have a way to reverse the effects of this medication if needed, then I think there's potential for excitement around this medication. Watto: I'm of course talking about a small interfering RNA (siRNA) agent. The one we talked about in this episode was zilebesiran; it's an siRNA agent and is administered once every 6 months. But no one would feel comfortable giving this unless there's an antidote, because if a patient gets septic, they probably need their RAAS to help them out there. Williams: Or if you have a patient who is pregnant — lots of reasons why you might actually want that system working. Watto: Exactly. Now, some people just don't want to take medications even if they need them, Paul. What else might be offered to a patient with high blood pressure? And how excited should we be about this next therapy? Williams: I feel like you're asking the wrong guy, Matt! I think you're alluding to renal denervation therapy. I feel it had a lot of wild enthusiasm initially, then it kind of waned, and now I feel like enthusiasm is back, baby — we're back into renal denervation. It sounds like a great option and I think we're doing a little better job with it, but its effect on lowering blood pressure is about equivalent to the effect you observe with a single-agent medication. So, realistically, these patients may still need to be on medications for blood pressure control. It's only effective for about two thirds of patients who get the procedure; that's 33% of your patients who would go through this invasive procedure where we're frying a nerve and in the end, they may not actually experience any blood pressure benefit. I think there's still a population that would benefit from and be interested in this option, but I don't think it's something that we should consider as first-line therapy for the majority of folks because of that potential for treatment failure and the continued need for medications among a substantial portion of the patients who undergo this procedure. It's still exciting that there's evidence for it and it does cause significant blood pressure lowering, so it's nice to have another option. Watto: Yeah, and I think patients are going be coming in and asking about it, so having some knowledge about the pros and cons of the procedure is important.


New York Times
39 minutes ago
- New York Times
Palantir's Collection of Disease Data at C.D.C. Stirs Privacy Concerns
The Centers for Disease Control and Prevention's plans to consolidate data on diseases like measles and polio are raising concerns about patient privacy, delays in spotting long-term trends and ways the Trump administration may use the information. The agency told state officials earlier this week that it would shift disease information to a new system managed by Palantir, the data analysis and technology firm co-founded by Peter Thiel. The change is not entirely unexpected. The Covid pandemic revealed that the C.D.C.'s data systems were antiquated, hobbling the country's response in the crucial early months. A plan to modernize and consolidate the agency's data systems began during the Biden administration. But news that the Trump administration has expanded Palantir's work across the federal government in recent months, allowing it to compile detailed information about Americans, has introduced a new layer of anxiety and mistrust among state and local officials about sharing data with the C.D.C. Palantir's systems, including those at the C.D.C., rely on a platform called Foundry that could merge information from different agencies. The Department of Health and Human Services, the Food and Drug Administration and the National Institutes of Health all use Foundry. Some officials worry that a sprawling data collection system could expose or endanger people with sensitive health needs, like gender care, reproductive health care or disabilities. Some labor and other advocacy groups have tried to block the Trump administration from sharing data across agencies. Want all of The Times? Subscribe.