
‘The last thing you want is sweaty feet': the best moisture-wicking underwear, socks and base layers
I've always run on the warm side. Even in winter, I'll return from a bike ride or run with a sheen of moisture on my forehead and damp patches in my pits. When the mercury rises, so do my levels of perspiration, and a sweat test last year confirmed what I'd always known: unlike Prince Andrew, I'm a heavy sweater.
Sweat-wicking clothing can help. But where do you start?
'Generally for sportswear, you're looking for a knitted fabric with high, multi-dimensional stretch, primarily made from synthetic fibres such as polyester, nylon and acrylic,' says Dr Prabhuraj Venkatraman, senior lecturer in textile technology at Manchester Fashion Institute at Manchester Metropolitan University.
These feature a fibre structure that has many internal channels, he says, giving the fabric a fine, porous construction. Excess sweat or moisture from the skin is transferred to the upper layer of the fabric through the numerous channels, where it evaporates.
'Brands enhance that effect through design,' says sportswear designer Chantell Fenton. 'Zoned mesh constructions, strategically engineered knits and seamless garments target areas of high perspiration, such as the back or underarms.'
While ideal for sweat-wicking, synthetic fibres' fossil fuel origins mean they aren't great for the environment, and Fenton says that even recycled synthetics aren't without their limitations. 'These garments still release microfibres into waterways during washing, which are difficult to capture and contribute to marine pollution. While recycled synthetics are a crucial part of the shift toward sustainability, they're not yet a fully circular solution.'
Before you reach for a cotton T-shirt, the natural fibre has a high level of moisture absorption that will leave you with damp fabric directly on the skin that'll soon make you cold. But there are some plant- and animal-based eco-friendly alternatives that are great for wicking away sweat.
'Merino wool is a standout. It's naturally thermoregulating, manages moisture by absorbing it into the fibre's core without feeling wet, and offers built-in odour resistance. It's especially effective in cold and long-duration activities, and recent innovations like non-woven merino constructions reduce production waste and carbon impact,' says Fenton.
Bamboo viscose also offers moisture-wicking and antibacterial properties, while hemp combines low-input farming, durability and UV protection – studies show it's incredibly effective at blocking UVA and UVB rays.
'These materials may not manage moisture in exactly the same way as synthetics, but they perform well within their own context – and critically, many offer long-term sustainability benefits that traditional synthetics cannot, such as decomposing safely, reducing landfill pressure; aligning with circular design, including recycling and composting; and avoiding persistent microplastic pollution, with wool, lyocell, cotton and hemp microfibres breaking down in marine environments over time,' says Fenton.
I asked some of the sweatiest experts in their fields, from a running coach to a mountaineering guide, for the kit they reach for when they want to stay dry, as well as putting some pieces through their paces myself.
ThruDark Stealth seamless base top
£115 at ThruDark
Montane Dart T-shirt
£30 at Montane£28.50 at Amazon
'It's important in terms of sustainability not to have different kit for different seasons. The base layer I wear most of the year is the Thrudark Stealth: it's military tested, thin enough that I can wear it unless it's a roasting hot day, and well built – I've had mine for years, worn it for hours and hours, and there's still no fraying. If it's really hot, I've got a secondary, lighter one by Montane: it's airy, wicks well, and is a solid go-to top if you're starting out.' Kris King, ultrarunner and co-owner of Beyond the Ultimate
Asics base layer SS top
£28 at Asics
Oex Kelso merino long-sleeved top
From £45 at Go Outdoors£52.25 at Amazon
'I do a lot of running, and I need my base layer to be lightweight, easy to move in and not skin-hugging. I'm also quite a sweaty person, and the newer products on the market are so much better in terms of how they wash – you don't get that staining or unpleasant sweaty aroma that comes back every time you put them on. I've recently got into merino wool layers – they're lightweight, so you can wear them in the summer, and if it's a day where it's not particularly warm, it just gives you that little bit of extra insulation without feeling like it's weighing you down.' Jo Wilkinson, former elite runner and coach at Running Jo
David Archy bamboo briefs
From £23.99 for four at Amazon
Uniqlo Airism boxer briefs
£12.90 at Uniqlo
'The main things I need in a pair of underwear are that they're quick drying and have stretchability, so I look for moisture-wicking fabrics like polyester, modal or mesh blends, and flat-lock or seamless designs to reduce irritation. Structure is also important – you don't want them too high because they'll ride up, which can become uncomfortable when running or cycling. In terms of sustainable materials, bamboo is really good – it has natural antibacterial abilities, it's soft and is naturally breathable.' Michael Baah, personal trainer at Michael Baah
Lululemon Wundermost Nulu high-waist thong
£25 at Lululemon
Goodmove ultimate support serious sports bra
£28 at M&S
'It's super important to have sweat-wicking gym clothes that also look good, as I'm rarely just wearing them in the gym: I might be running to pick up my kids, on public transport, or meeting someone for a coffee, and I can't always shower right after. They also need to keep their shape and colour after many washes. Lululemon underwear's seamless fit is comfortable, gives good coverage and is high-waisted, which is great for working out – with the waistband practically sitting on the mid-stomach, it's more likely to stay in place. Good Move by Marks & Spencer has shown how the high street can do sportswear that looks and performs high-end – for the price, the quality of its sports bras is great.' Rosie Stockley, fitness trainer and founder of Mamawell
Arc'teryx Cormac hoodie
£80 at Arc'teryx£80 at Ellis Brigham
Patagonia Capilene midweight crew neck
£79.99 at SportsShoes£80 at Patagonia
'For a summer base layer, I want something with SPF 40 and a hood to keep the sun off of my ears and neck. I also want freedom and range of movement, and length in the body so it doesn't untuck from my harness when climbing. I prefer synthetic materials because they dry fast and last longer. The Arc'teryx Cormac hoodies are the gold standard, while Patagonia's products are made from recycled materials, and some of the brand's profits are used to fight the climate crisis.' Tom Ripley, IFMGA mountain guide
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Craft Core dry active long-sleeve top
From £25 at Mountain WarehouseFrom £26.20 at Amazon
Salomon Sense Aero seamless top
£80 at Salomon
'I don't buy a lot of kit, but when I do, I use it until it's gone. For base layers, the main thing I look for is comfort. I love my Craft one – it's affordable, I don't feel restricted in it, it's breathable on the uphills but keeps me warm on the downs, and it's lightweight, which is handy if doing multi-day hikes and packing a bag. Chafing can be a problem with a rucksack and a sports bra, but I've never chafed when wearing it – its seamless design means there's one less thing to rub against my skin. I've had it for years and it's still going strong. Alternatively, for summer hikes, I've got a really thin, lightweight Salomon one.' Lauren Munro-Bennett, summer mountain leader and sports coach at LMB Coaching
Stance Run Light crew socks
£16.99 a pair at StanceFrom £12.99 a pair at Amazon
Bam mid-length technical running socks
£11.20 a pair at Bam
'When you're pounding the pavement, the last thing you want is hot, sweaty feet. Not only is it uncomfortable, but a buildup of moisture over time could lead to a race-ending blister. The Run Light crew socks from Stance have been my go-to for everything from recovery runs to ultra marathons for several years – their mesh upper section on the forefoot aids breathability while their nylon blend wicks sweat away from hot spots before they become problematic. For an eco-friendly alternative, Bam's bamboo technical running socks keep your feet dry from the first mile to the last.' Charlie Allenby
Naked Nation bamboo trainer socks
£18.50 for three pairs at Naked NationFrom £11.10 for three pairs at Amazon
Under Armour Performance Tech no-show socks
£10 for three pairs at SportsDirect£11 for three pairs at Under Armour
Lululemon Power Stride socks
£28 for three pairs (men's) at Lululemon£28 for three pairs (women's) at Lululemon
'When I'm in the gym, I'm hunting for a thin training sock that allows my foot to breathe while wearing lifting or hybrid trainers. They're preferably below ankle height or hidden, but with some heel support to avoid rubbing. Cotton is my go-to, but bamboo is a good, sustainable option, such as the ones by Naked Nation. My favourite pair are Lululemon Power Stride socks, but Under Armour Performance Tech no-show socks are more affordable and do the job too. If I were trying to get the most for my money, I'd happily use Primark socks, but they tend to get the odd hole when I run in them, whereas the first two options are more durable.' Louis Walcott, personal trainer and yoga teacher
Bridgedale Cool Comfort socks
£22 a pair at Go OutdoorsFrom £14.08 a pair at Amazon
Smartwool Hike Classic Edition cushion crew socks
£22 a pair at Smartwool£22 a pair at Millets
'Getting your socks right can make or break a walk, particularly when encountering tricky terrain or varied elevation. While something lightweight and breathable is a priority – particularly if wearing a waterproof boot that sacrifices some airflow – it's important not to go too minimalist and be left with cold feet on exposed sections of trail. The Cool Comfort option from Bridgedale is my go-to for the warmest walks, while Smartwool's merino wool-based Classic Hike is my preferred choice for every other occasion. Both have kept my feet blister-free after many miles of testing and feature a good balance of support and structure.' CA
Rapha merino base T-shirt
£75 at Rapha
Pactimo Summit sleeveless top
£34 at Pactimo
'After being a warm-weather cycling base layer sceptic, I'm now a convert and wear them year-round. It might seem counterintuitive to add an extra layer into the mix on hot days, but it can actually speed up the wicking of sweat that's sitting on your skin compared with wearing a jersey or T-shirt – minimising damp spots that can become chilly on descents, and boosting all-round comfort. For most of my riding, the merino base layer from Rapha manages my temperature perfectly (and feels silky soft against the skin), while for all-out efforts or sweltering summer spins, the Summit from Pactimo ups the moisture-wicking ante.' CA
Charlie Allenby is a health and fitness journalist who puts running and cycling gear through its paces on increasingly ridiculous endurance challenges
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The Independent
20 minutes ago
- The Independent
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'When it comes to building a routine for healthspan and longevity, the details really do matter,' he says. 'I believe we get much more benefit when our steps are broken up throughout the day. This approach not only helps you reach your step goals, but also supports muscle and joint health by keeping your body engaged more consistently.' Long periods of sitting leave muscles and joints underutilised, leading to stiffness, discomfort and an increased risk of developing muscular and joint problems over time. 'Moving regularly throughout the day helps maintain circulation, keeps muscles gently engaged and supports joint health, all of which contribute to feeling better and reducing pain risks as you age,' Thompson explains. Thompson's tips: Aim for a daily step count of at least 10,000 steps. I understand this isn't easy for most people, especially with work, family and life commitments, so focus on spreading those steps out across the day. Try to move at least once every 30-60 minutes during your day, whether it's a short walk, climbing the stairs or just pacing around a little. Setting reminders on your phone or watch can help make this a consistent habit. Changing positions regularly, standing up more often or using a walking pad can be an excellent way to integrate more movement into your routine. I also recommend a short 10-15 minute walk directly after a meal – research suggests this can significantly improve blood sugar regulation, help digestion and reduce post-meal energy crashes, making it a great habit to support energy and long-term metabolic h ealth. 2. Build your nutrition around protein and fibre It can be hard to navigate the world of nutritional advice without being bombarded by a new fad diet or dietary hack. Thompson suggests ignoring these in favour of a simpler approach. 'I've found that helping clients focus on just two fundamentals – protein and fibre – can radically improve their energy levels, body composition and long-term health,' he says. 'It's a simple shift that delivers big results. 'Protein supports muscle repair and maintenance, which is especially important as we age. It also plays a key role in satiety, which is key in helping to manage hunger, reduce snacking and support fat loss. 'Fibre, on the other hand, is critical for gut health, blood sugar control and sustaining energy throughout the day. It also helps you feel fuller for longer, which naturally supports healthier portion control.' Thompson's tips: Start each meal with protein and fibre. Aim for a palm-sized portion of protein (about 25-40g, depending on your needs) with every main meal – this could be chicken, fish, eggs, Greek yoghurt, tofu, lentils, protein powder, etc. Each day, you should be aiming for 1.5-2g of protein per kilogram of bodyweight. Aim to include a handful or two of fibrous vegetables and/or whole-food fibre sources like oats, beans, berries or whole grains with each meal. Aim to consume at least 25-30g of fibre per day. By repeating this simple framework at most meals, your energy, appetite and overall Health will improve dramatically without needing a restrictive or complicated diet plan. 3. Don't neglect your hips and posterior chain The posterior chain refers to the muscles that run along the back side of your body – think hamstrings, glutes and back muscles. Thompson has consistently identified these as 'problem areas' among clients, particularly in those who spend a lot of their day sitting at a desk. 'These muscles are essential for maintaining good posture, producing power and strength, and keeping your body moving well and pain-free,' he says. 'But modern life tends to impair the function of these areas. Long hours spent seated can leave the hips tight, the glutes not working as they should, and the pelvis in a rotated position. 'Over time, this can create imbalances that lead to stiffness, a loss of range of motion, lower back discomfort, dysfunction with how you walk and a higher risk of injury.' He has found that consistently strengthening the muscles of the posterior chain and mobilising the hips can counter these unwanted effects, and go 'a long way to future-proofing the body, from both a function and a pain prevention perspective'. Thompson's tips: Train your glutes, hamstrings and key hip muscles – such as the hip flexors, glute medius and adductors – at least once per week, ideally within a full-body or lower-body workout. Prioritise movements like glute bridges, hip thrusts, Romanian deadlifts, kettlebell swings, Copenhagen planks, hamstring curls and single-leg variations of lower-body exercises such as the Bulgarian split squat. Aim to target these key muscle groups with a few challenging sets of 8-12 repetitions each week. I recommend five sets for the hamstrings, five sets for the glutes and two or three sets on each of the key hip muscles mentioned. Alongside direct strength training for these areas, attempt to break up long periods of sitting with short bursts of movement such as standing and walking. Even better, adopt a short stretching routine into your day that involves you stretching these muscles using moves like a hamstring stretch, couch stretch and 90/90 stretch. 4. Make the most of your rest periods Strength training is a key ingredient in any recipe for longevity – the point above makes that abundantly clear. Typically, this means performing one set of an exercise, resting for 60-plus seconds, then repeating. But Thompson says this rest period need not be 'dead time' during a savvy exerciser's session. 'Those short breaks are actually a huge opportunity to work on non-conflicting areas of your body,' he says. 'By staying active between sets – performing mobility drills or doing low-intensity dynamic stretches – you're making more efficient use of your training time by working on these crucial areas that need attention but often get missed out.' 'It's a method I've used for years with many of my clients that has helped them to achieve excellent results without spending more time working out.' Thompson's tips: Use your rest periods to do something intentional. For example: stretch your hip flexors with a couch stretch on a bench; mobilise your thoracic spine [or mid-spine] over a foam roller; hold a deep squat as you slow down your breathing; do a scapula push-up between sets of lunges. Pick movements that target stiff areas but don't conflict with what you're training. For example, hold a deep squat between sets of chest press. 5. Focus on sleep quality, even when quantity isn't perfect Despite being a blanket prescription in most health circles, bedding in for eight hours of sleep per night is a pipe dream for most people. If you are unable to increase your sleep quantity, Thompson recommends honing your sleep quality for tangible results. 'Sleep is the body's most powerful recovery tool. It supports nearly every function of the body, from muscle repair and hormone regulation to mental sharpness, immunity and more,' he says. 'But in real life, aiming for a perfect eight hours every night just isn't always realistic. Work, kids, stress, travel – life gets in the way. 'What I've found makes the biggest difference is having a simple, consistent structure you can stick to, even during busier or more chaotic weeks. It's not about being perfect – it's about maximising sleep quality when quantity is compromised.' Thompson's tips: Establish a consistent wake-up time. This is one of the simplest ways to regulate your body clock, even if your bedtime shifts. Build a short wind-down routine you can stick to. This might involve being screen-free for 15-30 minutes, or doing low-stimulation activities such as reading, writing and light stretching before sleep. Ensure your bedroom is dark, cool and as quiet as you can make it. Cut off caffeine after 2pm and limit alcohol in the evening. I often prescribe my 2/2/2 rule to my clients; no more than two alcoholic drinks, no more than two times per week, and not within two hours of bed. What changes can you expect to see from making these changes? After one day: The first change you are likely to notice is an increase in your energy levels, Thompson says. 'Simply moving more, especially outdoors in natural light, and having a better night of sleep can have an almost immediate impact on how you feel.' After one week: Seven days in, the compounding effects of regular movement and targeted mobility work should be coming to fruition. 'You may start to notice stiffness and muscle tension easing up, and your body feeling a little looser,' Thompson says. After one month: Sticking to the behaviours above, Thompson says you will likely feel more mobile and stronger after a month, with higher energy levels and less stiffness throughout the day. 'By this point, the actions start to feel more like habits and become part of your routine, rather than a chore you need to remind yourself to do,' he adds. After one year: A year is a long time to stick to anything, but if you can habituate some – or all – of Thompson's recommendations, he says you can 'expect to feel substantially better day-to-day'. 'Your movement will feel easier, and both your physical and mental energy will be at new highs. These changes will have become a natural part of your life, and a day where you don't hit 10,000 steps will feel odd and strangely uncomfortable,' he continues. 'You'll be creating opportunities to get outside and move your body; your overall nutrition will look different, with protein, fibre, vegetables and beans taking centre stage; and you'll protect your sleep like you protect your exercise time.' The mindset shift that makes the greatest difference of all There is one further recurring theme Thompson has spotted among his successful clients – and it's not physical. 'One of my biggest learnings over the years is that many clients start their fitness journey with short-term, appearance-driven goals – losing weight for a holiday, looking good for an event or fitting back into some old wardrobe favourites,' he explains. 'But what's been interesting to witness, time and time again, is how quickly those goals shift. Once people begin training consistently and start feeling the benefits, their perspective changes. Aesthetic goals take a back seat to something deeper: how they feel in their bodies and how well they can live their lives. That mindset shift is where the real transformation happens.' Thompson works with a diverse range of clients, from business founders and bankers to stage performers and doctors. And after training with him for some time, one of their greatest goals invariably becomes living better for longer. 'I genuinely love that this mindset shift happens so often,' he says. 'I regularly use it to help clients realise that the ability to feel great and remain physically capable in your sixties, seventies, and eighties doesn't begin when you get there – it starts in your thirties, forties, and fifties. This is the prime window to elevate your health and strength, future-proofing your body for the decades ahead.'


Telegraph
23 minutes ago
- Telegraph
‘My daughter only knew hospitals until I had a son whose bone marrow saved her life'
'I've been thinking a lot about health privilege lately,' says Mina Holland, 'and I absolutely don't take good health for granted any more.' We are sitting in the garden of her house in Tulse Hill, south London, not far from where she grew up. It's a poignant anniversary for Holland. Six years ago today, her life changed forever when a routine check-up at Lewisham hospital turned into an emergency. Her 11-week-old daughter, Vida, was admitted for an urgent blood transfusion. 'I've never seen a baby with haemoglobin levels this low,' one doctor said. Holland is an author, journalist and occasional restaurant and wine list consultant, as evidenced by her large open kitchen, with its amply stocked wine rack and a pyramid of Mutti Polpa – the connoisseur's tinned tomatoes – by the back door. She has just baked some deliciously sticky cookies, which we take into the garden to eat. Her husband Freddie, a sound engineer, is at work; Vida and her four-year-old brother Gabriel are at school. Before that hospital trip in 2019, looking after Vida had been a struggle. Despite her frequent crying and pallor – people complimented her porcelain skin – the couple had no real idea anything was wrong. She wasn't an easy baby: a fussy feeder and an erratic sleeper. But they were first-time parents – what did they know? When they were first told about Vida's haemoglobin levels, they assumed it meant she was severely anaemic. But it soon became clear that it was more serious than that. Vida received a blood transfusion over four days – there's only so much you can give at once – and after just one instalment, the change was remarkable: her colour returned and she fed with gusto. The family took her home and tests began to investigate the cause of her anaemia, which could have stemmed from a number of things. They were vastly relieved to learn it wasn't blood cancer – but unsettled by the emerging discussions around 'bone marrow'. The effects of the transfusion soon wore off. Four weeks later, Vida's haemoglobin levels had dropped again, and her symptoms – poor appetite, restlessness, pallor – had returned. Holland was floored, watching her baby decline. But as a journalist, she threw herself into the research, typing in symptoms and exploring every possible avenue in search of a cause. She was becoming desperate. One condition Holland came across was extremely rare – but it seemed to match all of Vida's symptoms: Diamond-Blackfan anaemia (DBA), a genetic blood disorder in which the bone marrow fails to produce enough red blood cells. DBA affects only five to seven children in a million. But that's what it turned out to be, as the family discovered on a bleak day in July, when Vida was five months old. Neither Holland nor Freddie carry the gene for DBA, they would later learn, and the odds of Vida having it were infinitesimal. It felt like a life sentence of anxiety and grief. As well as an inability to produce sufficient red blood cells, DBA is associated with a predisposition to certain cancers and the risk of other abnormalities. Treatment pathways vary – a lifelong course of steroids or a bone marrow transplant were possibilities for the future – but in the short term, it meant regular blood transfusions, roughly every three weeks. Each time, a cannula had to be inserted into the arm of a screaming baby – often requiring both parents and three nurses – followed by a painstaking effort to keep her still for the next three hours. Holland has now written a book about these early years, called Lifeblood, which gives a visceral impression of the emotions they went through at the time; firstly the worry and uncertainty, followed by incomprehension, then the fear and grief at what they – and Vida – were facing for the rest of their lives. 'I'm really lucky in that we had a very favourable set-up,' she says today. 'Our parents are around, my mother-in-law is a psychotherapist, we've got access to all the top-notch children's hospitals. But I still just felt very, very alone.' Friends did their best, but she came to resent their platitudes. 'I can't tell you what would have helped – I think I just needed to be met in the despair, at that point.' There were endless hospital visits and life gradually reshaped itself around this new reality – DBA was all Holland could talk about. She couldn't work. She couldn't even watch TV. Every aspect of their lives was dictated by Vida's condition. They sold their flat – it felt like 'a crime scene', she writes – and moved in with Louise, Freddie's mother, whose home was near St Mary's Hospital in Paddington, where Vida was being treated, as well as the Evelina Children's Hospital at St Thomas's, south London. Vida was doing well on the transfusions – Freddie described her as 'full of life, but not haemoglobin' – but difficult questions loomed about the future. Around the age of one, she would become eligible for a steroid treatment: prednisolone, given initially at a high dose to jolt the bone marrow into producing red blood cells, then gradually tapered down in the hope it would continue to work at a sustainably low dose. This could mean an end to transfusions – but long-term, low-dose steroids are only effective in a minority of cases. The alternative was lifelong transfusions, which would not only severely limit her mobility but also require further treatment to manage the iron overload they cause. There was a third possibility: the bone marrow transplant. 'The idea of a bone marrow transplant just sounded wild,' says Holland now. 'Before this, bone marrow was a dish at the restaurant St John. Or something that I remember the dogs gnawing on at my grandmother's house. It just sounded so technical and so terrifying. And the idea of the complete destruction of the immune system in order to make your child independent of three-weekly hospital visits, was mind-boggling.' In a bone marrow transplant, the faulty marrow is replaced with healthy marrow from a matched donor, offering the possibility of a haematological cure. Graft-versus-host rejection can occur, though the risk is significantly lower if the donor is a family member, especially a sibling. (It is extremely rare for parents to be a match, and neither Holland nor Freddie were suitable donors.) Preparation for the transplant involves complete isolation and a course of chemotherapy and other drugs designed to destroy the immune system. Before Vida's DBA was even confirmed, Holland was convinced that transplant was her best option. 'I don't want illness to be her life's focus,' she writes. 'I wanted her to have all the freedom of movement and mind that healthy children and adults have.' In early 2020, Holland found out she was pregnant again. She and Freddie had wanted a second child anyway, 'and I really am keen to emphasise that he was never designed to be a saviour sibling', she says. The chances of that child being a match for Vida were one in four, and initially Holland had considered IVF to try to engineer this. 'But it was going to cost so much money, and the chances of it working were tiny. So we thought, well – one in four, let's try. We wanted another child, and if there was any way they could help, brilliant. 'Our second child will not be a 'designer baby',' Holland writes. 'Our child will be a much-loved family member who happens to have a trait that could help their sister in a way no one else could. We want to give Vida the best chance we can.' Gabriel was born in the winter of 2020, and in January 2021 they received the phone call – Gabriel did not have DBA. The relief was immense. 'A geneticist would say that because we already had a child with it, yes, the chances were higher, but actually based on probability it was a very low chance that he would have it as well. But obviously we were still scared.' A month later she and Freddie were informed that, should a transplant be warranted, Gabriel was a match for Vida. They were cautiously euphoric. 'When we found out that he was a match, it became a bit of a no-brainer. It was a big decision to go ahead with the transplant, because it's high-risk, but around that time the advice was changing: when she was diagnosed as a tiny baby, what we were hearing from the other parents in the DBA community and from her doctor, was this is not a decision you take lightly – it's dangerous, it's a year out of mainstream life, and there are a lot of things that could go wrong. Two years later, new research showed much better outcomes, both from donors who are related and not, and that the quality of life outcomes for kids who had had transplants were quite favourable compared to living on blood transfusions. 'I feel apprehensive about saying this because I know that there are lots of parents with children who are on transfusions, who are leading rich lives, but I know it's not easy.' In March 2023, Vida had her transplant, with bone marrow donated by her brother. Their parents did not underestimate the emotional implications of this. 'We have told Vida that Gabriel is 'sharing some of his blood with her',' Holland writes in Lifeblood. 'She is concerned about him 'going to sleep'; having his blood removed; we tell her that he has lots of it and that he won't remember […] Until now, Freddie and I have minimised the significance of what he will have to endure – the many blood tests, the general anaesthetic, the soreness in his lower back where the bone marrow will be taken, and the consequent anaemia which will require months of iron supplementation […] we are signing up our baby for the possibility of pain and distress. This doesn't sit comfortably.' In anticipation of the transplant, Vida had spent weeks in hospital, and had a Hickman line fitted through which to administer her 'conditioning treatment' – a cocktail of meds, including the chemotherapy, which inevitably made her ill, and caused her to lose her hair. But the transplant was a success. Gabriel's stem cell donation was 'abundant', her doctor informed them, and the new cells established successfully. She remained in hospital for five-and-a-half weeks as her immune system was non-existent, whereas Gabriel was sent home the following day and made a very quick recovery. When Vida returned home, there were restrictions. She had to take nine different medications four times a day; she had a controlled diet and could only drink boiled water. 'Every aspect of her day is monitored, curated, limited somehow,' writes Holland. Vida is six now, and flourishing. She started school midway through her reception year and is doing well, though she still has many hospital appointments. DBA makes her susceptible to certain cancers, so she has to be careful with sun protection, and she'll be on penicillin for life. Gabriel is sometimes jealous of these precautions and asks for medicine too. 'She's the patient, and it's obviously been hardest for her, but it's also been tough on Gabriel – in different ways. After the transplant, she often had to be readmitted, and we'd have to leave at a moment's notice to go to A&E at St Mary's. That was really hard for him; he was only three.' Vida hasn't questioned the constant hospital visits, Holland says. It's all she knows. 'I spent so long grieving that she was not going to have a normal life, that we were missing out on all the school activities and the swimming lessons – I was so worried about all that, but there have been aspects of it that have been quite wonderful, and I don't say that lightly.' Remarkably, Holland says, 'Vida loves going to hospital now. She used to get very frightened about the blood tests, it was traumatic for her and for us, but when I look at it as a whole, hospital has been a place where she gets focused time with one or both of her parents, she gets a lot of adult attention, she gets art therapy, she gets music therapy, she gets lots of presents. There have been rich moments too as well as very long, very empty, uncertain and frightening days. 'I think that how Vida's trauma is expressed will obviously evolve over time, and I feel I need to be quite alert as to how things could come out for her as she gets older.' At Easter, Vida's school put on an 'Eggstravaganza' where all the children were asked to make a diorama featuring hard-boiled eggs. 'I said, we've got to win this – let's make the hospital.' So they created 'Egg-elina Children's Hospital', based on the Evelina, with yolk transfusions and an 'eggs-ray'. And Vida won. The idea of the book came up while Holland was pregnant with Gabriel. 'I wrote it in a very sort of stolen-moments way, over about four years. The original plan was for it to be about Vida's first year, and finding acceptance, accommodating the unexpected. When things feel really bleak, it's hard to see how any good can come of them, but I know a lot of good has come from what happened. 'Even with the transfusions, I am glad those days are over but I look back on them fondly because I felt so held – particularly in the early days when I was always trying to second guess how she was doing, what her blood count was; I was always gazing at her face and ears and lips, trying to work out how anaemic she was. But when she went into hospital, I was sharing the responsibility. Obviously I wish that Vida hadn't had to go through what she has, and we could have been spared it – but it's sort of all I know now. I've been rewired.' In the UK, one in 25 babies is born with a genetic condition of some kind, and Holland's book will resonate with other parents facing similar challenges. Writing down what happened really helped, she says, 'and having a sense of – it sounds like a cliché – but being able to take control of the story. It was good to put it in my own words; I often don't know how I feel about things until I've written them down.' She is full of gratitude for the NHS. 'The biggest takeaway is just how hugely lucky we are to have the NHS, and what a precious thing it is. It's been incredible. I would love to know what Vida's medical bill is after six years of this; even the chelation medicine she had to have while she was on transfusion was well into five figures a year.' What people can do to help, she says, is give blood. Her book is out, inadvertently, just after World Blood Donor Day, which is on 14 June. 'For an hour spent in a blood donor centre you can save up to three lives. And in order to maintain blood supplies, 140,000 first-time donors are needed every year. 'I would just like to convey that it is an easy thing to do – having watched countless needles go into Vida, I've probably become hardened to it – and it has profound benefits for society.' How does she feel about Vida reading about herself in Lifeblood in the future? 'I feel quite guilty about the fact that for her first year I was just so sad, and I've been worried about what she might experience reading that. But I like to think that what comes across is extreme love.'