Common herbs like rosemary may have inspired a breakthrough Alzheimer's treatment
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Researchers have found a compound derived from common herbs has successfully enhanced memory and brain density in mice, and could lead to new treatments for Alzheimer's.
A team from The Scripps Research Institute based in the US worked on a derivative of carnosic acid, a molecule found in rosemary and sage.
They synthesised a more stable derivative called diAcCA and then used it to treat mice modified to show Alzheimer's-like symptoms for three months.
The mice that received the new drug showed improved learning and memory skills as well as more synapses, the junctions where neurons connect and communicate with each other, according to the findings published in the journal
Antioxidants
.
The loss of synapses correlates strongly with cognitive decline.
The mice also showed less buildup of amyloid plaques and tau tangles, two harmful proteins among the hallmarks of Alzheimer's disease in humans.
Alzheimer's disease accounts for 70 per cent of dementia cases.
Related
Experimental drug may slow dementia onset for patients with rare genetic form of Alzheimer's
It poses a significant and growing burden across Europe, affecting approximately 7 million people today, with numbers projected to double to 14 million by 2030 due to its ageing population.
'By combating inflammation and oxidative stress with this diAcCA compound, we actually increased the number of synapses in the brain,' Stuart Lipton, a professor at Scripps Research and one of the study's authors,
said in a statement.
'We also took down other misfolded or aggregated proteins such as phosphorylated-tau and amyloid-β, which are thought to trigger Alzheimer's disease and serve as biomarkers of the disease process,' he added.
An anti-oxydant molecule
Carnosic acid is an antioxidant and an anti-inflammatory but it has a very short shelf-life, while the diAcCA can be taken orally before being converted into carnosic acid in the stomach and entering the bloodstream.
The amount in the blood of the test mice was 20 per cent higher with the new method compared to usual ingestion of carnosic acid.
'We did multiple different tests of memory, and they were all improved with the drug,' Lipton said.
'And it didn't just slow down the decline; it improved virtually back to normal,' he added.
The researchers added that the mice tolerated diAcCA well.
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Euronews
27-05-2025
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France's National Assembly backs assisted dying bill on first reading
France's lower house of parliament has adopted a bill to allow adults with incurable illness to take lethal medication, as public demands grow across Europe for legal end-of-life options. The National Assembly vote is a key step on the long-debated issue, though others remain before the bill can become law. "I'm thinking of all the patients and their loved ones that I've met over more than a decade. Many are no longer here and they always told me: Keep fighting," said Olivier Falorni, the general rapporteur of the bill, amid applause from fellow lawmakers. The proposed measure on lethal medication defines assisted dying as allowing use under certain conditions so that people may take it themselves. Only those whose physical condition doesn't allow them to do it alone would be able to get help from a doctor or a nurse. The bill, which received 305 votes in favour and 199 against, will be sent to the Senate for further debate. A definitive vote on the measure could take months to be scheduled amid France's long and complex process. The National Assembly has final say over the Senate. Activists have criticised the complexity and length of the parliamentary process that they say is penalising patients waiting for end-of-life options. In parallel, another bill on palliative care meant to reinforce measures to relieve pain and preserve patients' dignity was also adopted unanimously. To benefit, patients would need to be over 18 and be French citizens or live in France. A team of medical professionals would need to confirm that the patient has a grave and incurable illness "at an advanced or terminal stage," is suffering from intolerable and untreatable pain and is seeking lethal medication of their own free will. Patients with severe psychiatric conditions and neurodegenerative disorders such as Alzheimer's disease won't be eligible. The person would initiate the request for lethal medication and confirm the request after a period of reflection. If approved, a doctor would deliver a prescription for the lethal medication, which could be taken at home or at a nursing home or a health care facility. A 2023 report indicated that most French citizens back legalising end-of-life options and opinion polls show growing support over the past 20 years. Initial discussions in parliament last year were abruptly interrupted by President Emmanuel Macron's decision to dissolve the National Assembly, plunging France into a months-long political crisis. "What a long road it has been, contrary to what the public thought, contrary to what the French people believed," said Jonathan Denis, president of the Association for the Right to Die With Dignity (ADMD). Earlier this month, Macron suggested he could ask French voters to approve the measure via referendum if parliament discussions run off track. Macron called the vote an important step, adding on social media that "with respect for different sensibilities, doubts, and hopes, the path of fraternity I had hoped for is gradually beginning to open. With dignity and humanity." Many French people have travelled to neighbouring countries where medically assisted suicide or euthanasia are legal. Medically assisted suicide involves patients taking, of their own free will, a lethal drink or medication prescribed by a doctor to those who meet certain criteria. Euthanasia involves doctors or other health practitioners giving patients who meet certain criteria a lethal injection at their own request. "I cannot accept that French men and women have to go to Switzerland — if they can afford it — or to Belgium to be supported in their choice, or that French men and women are being accompanied clandestinely in other countries," Denis said. But earlier this month, French religious leaders issued a joint statement denouncing the bill, warning about the dangers of an "anthropological rupture." The Conference of Religious Leaders in France (CRCF), which represents the Catholic, Orthodox, Protestant, Jewish, Muslim and Buddhist communities, said the proposed measures risk exerting pressure on older people and those with illnesses or disabilities. Assisted suicide is legal in Switzerland and several US states. Euthanasia is currently legal in the Netherlands, Spain, Portugal, Canada, Australia, Colombia, Belgium and Luxembourg under certain conditions. In the UK, lawmakers are debating a bill to help terminally ill adults end their lives in England and Wales after giving it initial approval in November. Misinformation and online safety experts have praised Merseyside Police for swiftly sharing the details of the ethnicity and nationality of the man who has been arrested after a car ploughed into a crowd in central Liverpool. On Monday evening the police force said they had arrested a "53-year-old white British man from the Liverpool area." While police forces do not usually publish this much detail about a suspect who has been arrested, it comes after rumours began to circulate about the man's identity following the attack, which the force also quickly said was not being treated as a terrorist incident. Liverpool's mayor, Steve Rotheram, said the police had managed to "dampen down" the spread of misinformation by sharing such information rapidly. "The police, with their messaging, were able to stem and to dampen down some of that wild speculation," he told BBC Radio 5 Live, while acknowledging the existence of "nefarious groups that are only interested in stirring up hatred." The potential for hatred spreading will have been at the forefront of the force's mind following the riots that engulfed England last summer, driven by rampant misinformation and disinformation in the wake of the Southport attack in July, in which a 17-year-old murdered three young girls. Far-right activists, fake news websites and conspiracy theorists advanced falsehoods about the killer's identity, with some circulating a fake name and falsely claiming that he was Muslim and an asylum seeker. For legal reasons, the only details that Merseyside Police had initially released about the Southport suspect were that he was a Cardiff-born 17-year-old from the village of Banks in Lancashire. The UK has strict contempt of court laws, which limit which details can be published about suspects in criminal cases before trial. Suspects are not named by the press until they have been charged and under-18s are usually not named at all. A judge went on to allow the Southport killer, Axel Rudakubana, to be named, partly to correct the "misinformation" that had been spreading. Sander van der Linden, a professor of social psychology in society at Cambridge University and an expert on information ecosystems, told Euronews that plugging information gaps is crucial to halting the spread of misinformation. "Information voids are almost a gravitational force for conspiracy theorists. Whenever there's an information void, people will fill in the gaps themselves and aided by the virality that you see on social media, that often turns into speculation, rumour, unverified theories, and sometimes harmful misinformation," he said, adding that this had been the case with last year's riots, though he noted that the suspect's age had been a "complicating factor" in that case. Van der Linden has been in talks with police forces about the dangers of information voids. "I've been talking about how important it is to try to pre-bunk, rather than debunk, and pre-emptively release details, when they can, to make sure these kinds of rumours and speculations don't have time to accumulate." "In this case, it's good – they quickly released the information … There's an opportunity for bad actors to exploit the information void with ideologically motivated rumours that then get traction and go viral on social media and turn into offline violence." But he noted that it would not be possible to always release such details and recommended that police are transparent about this. Imran Ahmed, CEO of the Centre for Countering Digital Hate, also welcomed Merseyside Police's intervention. He told Euronews: "The police are having to react to a rapidly evolving information environment. Given what happened in Southport, it's sensible, proportionate and welcome, that they're trying things to ensure that disinformation is spiked before it can go viral." "That said, what they can't do is deal with the source of the problem – platforms' refusal to deal with disinformation on a systemic level." He noted that the platforms had increasingly slashed safety features and moderation. "Things have been getting worse for the last couple of years. We see platforms rolling back safety features, bad actors becoming more sophisticated, frequency of events. Part of the problem is we now have a much more complicated and unpredictable threat environment, in part caused by the way in which social media has become an incredibly dynamic breeding ground for new conspiracy theories, malignant ideologies and the mobilisation of people for violence." Ahmed said that while police had responded to "rapid speculation" about the ethnicity of the attacker in this case, he did not see it as setting a precedent. "I think it's an experiment, not a precedent. I expect to see police using different tools as the situation demands. Given that they did see rapid speculation about the ethnicity of the attacker, it makes complete sense – you don't need hard and fast rules when it comes to dealing with dynamic and unpredictable situations." "[The conspiracy theories] that go viral are not in the hands of the police, they're in the hands of platforms and their algorithms. They need to have a range of tools available that they can deploy depending on the situation."
