International General Insurance Holdings Ltd. (IGIC) Continued to Capitalize on Its Strength
Diamond Hill Capital, an investment management company, released its 'Small Cap Fund' first-quarter 2025 investor letter. A copy of the letter can be downloaded here. In Q1, markets were uneven due to the new presidential administration's activity, leading to concern about the future. The Russell 3000 Index fell by 4.7% in Q1, the first quarterly loss since Q3 2023. Diamond Hill Small Cap Fund returned -11.56% in Q1, trailing the Russell 2000 Index's -9.48% return. For more information on the fund's top picks in 2025, please check its top five holdings.
In its first-quarter 2025 investor letter, Diamond Hill Small Cap Fund highlighted stocks such as International General Insurance Holdings Ltd. (NASDAQ:IGIC). International General Insurance Holdings Ltd. (NASDAQ:IGIC) is a global provider of specialty insurance and reinsurance solutions. The one-month return of International General Insurance Holdings Ltd. (NASDAQ:IGIC) was 9.53%, and its shares gained 81.78% of their value over the last 52 weeks. On May 6, 2025, International General Insurance Holdings Ltd. (NASDAQ:IGIC) stock closed at $25.74 per share with a market capitalization of $1.16 billion.
Diamond Hill Small Cap Fund stated the following regarding International General Insurance Holdings Ltd. (NASDAQ:IGIC) in its Q1 2025 investor letter:
"Other top contributors included Taseko Mines, Insperity and International General Insurance Holdings Ltd. (NASDAQ:IGIC). Global specialty re-insurance provider International General continues capitalizing on its strengths — an emphasis on long-term results, an underwriting-first culture and shareholder-friendly capital allocation — to drive solid fundamentals, which the market is beginning to appropriately realize."
An engineer wearing protective equipment, inspecting a large construction project.
International General Insurance Holdings Ltd. (NASDAQ:IGIC) is not on our list of 30 Most Popular Stocks Among Hedge Funds. As per our database, 6 hedge fund portfolios held International General Insurance Holdings Ltd. (NASDAQ:IGIC) at the end of the fourth quarter, compared to 7 in the third quarter. While we acknowledge the potential of International General Insurance Holdings Ltd. (NASDAQ:IGIC) as an investment, our conviction lies in the belief that AI stocks hold greater promise for delivering higher returns, and doing so within a shorter timeframe. If you are looking for an AI stock that is as promising as NVIDIA but that trades at less than 5 times its earnings, check out our report about the cheapest AI stock.
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Axios
8 minutes ago
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Two years ago, Axios managing editor for tech Scott Rosenberg wrote a story, "AI's scariest mystery," saying it's common knowledge among AI developers that they can't always explain or predict their systems' behavior. And that's more true than ever. Yet there's no sign that the government or companies or general public will demand any deeper understanding — or scrutiny — of building a technology with capabilities beyond human understanding. They're convinced the race to beat China to the most advanced LLMs warrants the risk of the Great Unknown. The House, despite knowing so little about AI, tucked language into President Trump's "Big, Beautiful Bill" that would prohibit states and localities from any AI regulations for 10 years. The Senate is considering limitations on the provision. Neither the AI companies nor Congress understands the power of AI a year from now, much less a decade from now. The big picture: Our purpose with this column isn't to be alarmist or " doomers." It's to clinically explain why the inner workings of superhuman intelligence models are a black box, even to the technology's creators. We'll also show, in their own words, how CEOs and founders of the largest AI companies all agree it's a black box. Let's start with a basic overview of how LLMs work, to better explain the Great Unknown: LLMs — including Open AI's ChatGPT, Anthropic's Claude and Google's Gemini — aren't traditional software systems following clear, human-written instructions, like Microsoft Word. In the case of Word, it does precisely what it's engineered to do. Instead, LLMs are massive neural networks — like a brain — that ingest massive amounts of information (much of the internet) to learn to generate answers. The engineers know what they're setting in motion, and what data sources they draw on. 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Anthropic — which just released Claude 4, the latest model of its LLM, with great fanfare — admitted it was unsure why Claude, when given access to fictional emails during safety testing, threatened to blackmail an engineer over a supposed extramarital affair. This was part of responsible safety testing — but Anthropic can't fully explain the irresponsible action. Again, sit with that: The company doesn't know why its machine went rogue and malicious. And, in truth, the creators don't really know how smart or independent the LLMs could grow. Anthropic even said Claude 4 is powerful enough to pose a greater risk of being used to develop nuclear or chemical weapons. OpenAI's Sam Altman and others toss around the tame word of " interpretability" to describe the challenge. "We certainly have not solved interpretability," Altman told a summit in Geneva last year. What Altman and others mean is they can't interpret the why: Why are LLMs doing what they're doing? 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Business Wire
16 minutes ago
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Alnylam Receives European Commission Approval for AMVUTTRA® (vutrisiran) for the Treatment of ATTR Amyloidosis with Cardiomyopathy Share 'Estimates show approximately 100,000 people are affected by ATTR amyloidosis across Europe, most with cardiomyopathy, so this approval marks a critical step toward addressing this underserved patient population,' said Pushkal Garg, M.D., Chief Medical Officer at Alnylam. 'AMVUTTRA is supported by a well-established efficacy and safety profile, with over 6,000 patient-years of global experience in the treatment of hATTR with polyneuropathy. By delivering rapid and sustained knockdown of TTR through convenient, quarterly dosing, it offers a clinically differentiated approach with the potential to transform outcomes for patients living with this debilitating and potentially fatal disease. We now look forward to securing access to AMVUTTRA for eligible patients across the EU as quickly as possible.' 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'As a physician, it is a privilege to see the true impact on patients in the clinic. The trial enrolled a broad population reflective of real-world clinical practice, and that's what makes the results so meaningful. This is a milestone for patients, who now have a new treatment option that has the potential to significantly improve outcomes of this disease.' ATTR-CM is caused by the deposition of misfolded TTR fibrils, which drive progressive and irreversible cardiovascular damage and premature death. AMVUTTRA is an RNAi therapeutic that works upstream by delivering sustained knockdown of disease-causing TTR at its source. In the EU, it is administered as a subcutaneous injection once every three months, either by a healthcare professional, or self-administered by patients or their caregivers, offering flexibility in treatment delivery. 'Amyloidosis is a serious and progressive disease that significantly impacts not only patients' physical health, but also their quality of life and independence. I am thrilled by the news of a new therapy for people in the EU living with ATTR-CM who often face delayed diagnosis. Having a new treatment option available marks a welcome development for the amyloidosis community,' said Giovanni d'Alessio, President of the Amyloidosis Alliance. In May 2025, the European Medicines Agency's Committee for Orphan Medicinal Products (COMP) adopted a positive opinion on the maintenance of the EU Orphan Designation for AMVUTTRA in ATTR amyloidosis. AMVUTTRA was approved in March 2025 by the U.S. Food and Drug Administration (FDA) and the Brazilian Health Regulatory Agency (ANVISA) for the treatment of the cardiomyopathy of wild-type or hereditary ATTR amyloidosis in adults. Alnylam continues to pursue additional global submissions to bring vutrisiran to patients worldwide. Indications In the EU, AMVUTTRA ® (vutrisiran) is indicated for the treatment of: hereditary transthyretin amyloidosis in adult patients with stage 1 or stage 2 polyneuropathy (hATTR-PN). wild-type or hereditary transthyretin amyloidosis in adult patients with cardiomyopathy (ATTR-CM). Important Safety Information Reduced Serum Vitamin A Levels and Recommended Supplementation Vutrisiran treatment leads to a decrease in serum vitamin A levels. Supplementation of approximately, but not exceeding, 2500 IU to 3000 IU vitamin A per day is advised for patients taking vutrisiran. Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g., night blindness). Adverse Reactions Commonly reported adverse reactions with vutrisiran were injection site reactions and increase in blood alkaline phosphatase and alanine transaminase. For additional information about vutrisiran, please see the full Summary of Product Characteristics. About AMVUTTRA ® (vutrisiran) AMVUTTRA ® (vutrisiran) is an RNAi therapeutic that delivers rapid knockdown of variant and wild‑type transthyretin (TTR), addressing the underlying cause of transthyretin (ATTR) amyloidosis. Administered quarterly via subcutaneous injection, vutrisiran is approved and marketed in more than 15 countries for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults. It is also approved in the U.S. and Brazil for the treatment of wild-type or hereditary ATTR amyloidosis in adult patients with cardiomyopathy (ATTR-CM). In the EU, AMVUTTRA is administered once every three months, either by a healthcare professional or through self-administration by patients or their caregivers. About ATTR Transthyretin amyloidosis (ATTR) is an underdiagnosed, rapidly progressive, debilitating and fatal disease caused by misfolded transthyretin (TTR) proteins, which accumulate as amyloid deposits in various parts of the body, including the nerves, heart and gastrointestinal tract. Patients may present with polyneuropathy, cardiomyopathy or both manifestations of disease. There are two different forms of ATTR – hereditary ATTR (hATTR), which is caused by a TTR gene variant and affects approximately 50,000 people worldwide, and wild-type ATTR (wtATTR), which occurs without a TTR gene variant and impacts an estimated 200,000-300,000 people worldwide. 2-5 About RNAi RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. 6 Its discovery has been heralded as 'a major scientific breakthrough that happens once every decade or so,' and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. 7 By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines known as RNAi therapeutics is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of today's medicines by potently silencing messenger RNA (mRNA) – the genetic precursors that encode for disease-causing or disease pathway proteins – thus preventing them from being made. 6 This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases. About Alnylam Pharmaceuticals Alnylam (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and prevalent diseases with unmet need. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach yielding transformative medicines. Since its founding in 2002, Alnylam has led the RNAi Revolution and continues to deliver on a bold vision to turn scientific possibility into reality. Alnylam has a deep pipeline of investigational medicines, including multiple product candidates that are in late-stage development. Alnylam is executing on its ' Alnylam P 5 x25 ' strategy to deliver transformative medicines in both rare and common diseases benefiting patients around the world through sustainable innovation and exceptional financial performance, resulting in a leading biotech profile. Alnylam is headquartered in Cambridge, MA. Alnylam Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. All statements other than historical statements of fact regarding Alnylam's expectations, beliefs, goals, plans or prospects including, without limitation, Alnylam's expectations regarding the safety and efficacy of AMVUTTRA for the treatment of ATTR-CM; the potential for AMVUTTRA to be used as a first-line treatment for ATTR-CM; the potential for AMVUTTRA to address the underserved ATTR-CM patient population and to improve outcomes for ATTR-CM patients; and Alnylam's ability to secure access to AMVUTTRA for eligible patients across the EU and the timing of such access should be considered forward-looking statements. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation, risks and uncertainties relating to: Alnylam's ability to successfully execute on its ' Alnylam P 5 x25 ' strategy; Alnylam's ability to successfully demonstrate the efficacy and safety of its product candidates; the pre-clinical and clinical results for Alnylam's product candidates; actions or advice of regulatory agencies and Alnylam's ability to obtain regulatory approval for its product candidates, as well as favorable pricing and reimbursement; successfully launching, marketing and selling Alnylam's approved products globally; and any delays, interruptions or failures in the manufacture and supply of Alnylam's product candidates or its marketed products; as well as those risks more fully discussed in the 'Risk Factors' filed with Alnylam's 2024 Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC), as may be updated from time to time in Alnylam's subsequent Quarterly Reports on Form 10-Q and in its other SEC filings. In addition, any forward-looking statements represent Alnylam's views only as of today and should not be relied upon as representing its views as of any subsequent date. Alnylam explicitly disclaims any obligation, except to the extent required by law, to update any forward-looking statements.
CNBC
18 minutes ago
- CNBC
The way you program an AI is like the way you program a person, says Nvidia's Huang
Nvidia CEO Jensen Huang says artificial intelligence is the "great equalizer" because it lets anyone program using everyday language. Speaking at London Tech Week on Monday, Huang said that, historically, computing was hard and not available to everyone. "We had to learn programming languages. We had to architect it. We had to design these computers that are very complicated," he said on stage alongside U.K. Prime Minister Kier Starmer. "Now, all of a sudden ... there's a new programming language. This new programming language is called 'human.'" Conversational AI models were thrown into the spotlight in 2022 when OpenAI's ChatGPT exploded onto the scene. In February, the San Francisco-based tech company said it had 400 million weekly active users. Users can ask chatbots, such as ChatGPT, Google's Gemini or Microsoft's Copilot, questions and they respond in a conversational way that feels more like talking to another human than an AI system. CEO Huang, whose company engineers some of the world's most advanced semiconductors and AI chips, highlighted that this technology can now be used in programming. He highlighted that very few people know how to use programming languages like C++ or Python, but "everybody ... knows 'human'." "The way you program a computer today, to ask the computer to do something for you, even write a program, generate images, write a poem — just ask it nicely," he said. "And the thing that's really, really quite amazing is the way you program an AI is like the way you program a person." He gave the example of simply asking a computer to write a poem to describe the keynote speech at the London Tech Week event. "You say: You are an incredible poet ... And I would like you to write a poem to describe today's keynote. And without very much effort, this AI would help you generate such a wonderful poem," he said. "And when it answers ... you could say: I feel like you could do even better. And it would go off and think about it, and it'll come back and say, in fact, I I can do better, and it does do a better job." Huang's comments come as a growing number of companies — such as Shopify, Duolingo and Fiverr — encourage their employees to incorporate AI into their work. Indeed, last week OpenAI announced that it has 3 million paying business users. Huang regularly touts AI's ability to help workers do their jobs more efficiently and has encouraged workers to embrace the technology as they look to make themselves valuable employees — especially given the horror stories around AI's potential to replace jobs. "This way of interacting with computers, I think, is something that almost anybody can do, and I would just encourage everybody to engage it," Huang added on Monday. "Children are already doing that themselves naturally, and this is going to be transformative.
