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Weight loss jabs such as Ozempic could banish depression and make you happier, a study claims

Weight loss jabs such as Ozempic could banish depression and make you happier, a study claims

The Sun10-05-2025

WEIGHT loss jabs could banish blues as well as bellies, a study claims.
People taking the injections showed 'significantly improved' emotional wellbeing in trials.
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Experts at the University of Bern in Switzerland reviewed 36 studies on a total of 26,000 people to check the impact of the medication.
They found that drugs such as Ozempic, Wegovy and Mounjaro had 'beneficial effects' on depression and bipolar disorder and schizophrenia.
The study, presented at the European Congress on Obesity, found no link between the jabs and new mental health problems or thoughts about self-harm or suicide.
Study author Dr Sigrid Breit said they 'exert a positive effect on mental state and quality of life.'
Depression and other disorders have been linked to low-grade swelling in the brain, which the drugs may help to bring down.
Dr Breit said: 'They may have antidepressant and anti- anxiety effects due to their anti-inflammatory properties, which can help reduce inflammation in the brain.
'These results are particularly important for people with severe mental disorders, who are three times more likely to be living with obesity than the general population.
'Future studies should explore whether these medications might be useful for the direct treatment of mental health disorders.'
Dr Ed Beveridge, of the Royal College of Psychiatrists, said: 'We know that many people with mental illness have weight management issues.
'It is crucial that they are regarded as a priority group for access to this medication where appropriate.'

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Weight loss drugs linked to higher risk of eye damage in diabetic patients
Weight loss drugs linked to higher risk of eye damage in diabetic patients

The Guardian

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Weight loss drugs linked to higher risk of eye damage in diabetic patients

Weight loss drugs could at least double the risk of diabetic patients developing age-related macular degeneration, a large-scale study has found. Originally developed for diabetes patients, glucagon-like peptide-1 receptor agonist (GLP-1 RA) medicines have transformed how obesity is treated and there is growing evidence of wider health benefits. They help reduce blood sugar levels, slow digestion and reduce appetite. But a study by Canadian scientists published in Jama Ophthalmology has found that after six months of use GLP-1 RAs are associated with double the risk of older people with diabetes developing neovascular age-related macular degeneration compared with similar patients not taking the drugs. Academics at the University of Toronto examined medical data for more than 1 million Ontario residents with a diagnosis of diabetes and identified 46,334 patients with an average age of 66 who were prescribed GLP-1 RAs. Nearly all (97.5%) were taking semaglutide, while 2.5% were on lixisenatide. The study did not exclude any specific brand of drugs, but since Wegovy was only approved in Canada in November 2021, primarily for weight loss, it is likely the bulk of semaglutide users in the study were taking Ozempic, which is prescribed for diabetes. Each patient on semaglutide or lixisenatide was matched with two patients who also had diabetes but were not taking the drugs, who shared similar characteristics such as age, gender and health conditions. The researchers then compared how many patients developed neovascular age-related macular degeneration over three years. The study found that those who had been taking semaglutide or lixisenatide for at least six months had twice the risk of developing macular degeneration, compared with similar patients who were not taking the drugs. Patients who had been taking GLP-1s for more than 30 months had more than three times the risk. Diabetic patients who were older and/or had had a stroke had an even higher risk of developing macular degeneration if they were on these drugs, the authors found. Marko Popovic, a co-author of the study and physician in the department of ophthalmology and vision sciences at the University of Toronto, said: 'GLP-1 receptor agonists appear to have multiple effects on the eye, and in the case of neovascular age-related macular degeneration the overall impact may be harmful. 'Based on our data, I would advise exercising particular caution when prescribing GLP-1 receptor agonists to older [diabetic] patients or those with a history of stroke, as both groups were found to have an even higher risk of developing [the condition].' In an accompanying editorial, Brian VanderBeek, an associate professor of ophthalmology at the Hospital of the University of Pennsylvania, said the findings suggested that large numbers of patients could be affected. 'This suggests as many as one in 1,000 GLP-1 RA users could progress to new age-related macular degenaration over unexposed patients: if this risk was carried over millions of users, those affected could end up being a sizable group of patients,' he said. VanderBeek said work needed to be done to determine if this only affects patients with diabetes or if those taking these drugs for weight management or other indications are similarly at risk. 'While certainly not outweighing the good these medications offer, prescribing physicians need to keep in mind the real and serious ocular adverse events that may occur.' A spokesperson for Novo Nordisk, which manufactures Ozempic and Wegovy, said: 'Patient safety is our top priority and we take any report about an adverse event related to the use of our medicines very seriously. We work closely with authorities and regulatory bodies from around the world to continuously monitor the safety profile of our products. 'These medicines have been extensively examined in Novo Nordisk's robust clinical development programs, including randomised controlled trials, which to date have not shown any observable treatment difference compared to placebo for macular degeneration or age-related macular degeneration. Therefore, Novo Nordisk does not conclude a causal relationship between GLP-1 RA use, semaglutide and age-related macular degeneration at this time.' Dr Alison Cave, the chief safety officer of the MHRA, a UK watchdog, said: 'Macular degeneration is not currently listed as a potential side-effect of these medicines. However, we keep the safety of these medicines under close review, including emerging evidence from scientific publications, and will take appropriate action where necessary. On the basis of the current evidence, the benefits of GLP-1 RAs outweigh the potential risks when used for the licensed indications.'

How weight loss injections dey affect pregnancy and contraceptives?
How weight loss injections dey affect pregnancy and contraceptives?

BBC News

timean hour ago

  • BBC News

How weight loss injections dey affect pregnancy and contraceptives?

Di UK medicines regulator don warn women wey dey use weight loss injections say make dem find beta contraception use. Di Medicines and Healthcare products Regulatory Agency (MHRA) say e neva clear weda medicine like Wefgovy and Mounjaro fit affect belle. E also warn say dis injections wey you dey see so fit make di contraceptives to no work as e dey work for pipo wey dey overweight or obese. Fear dey say wit di way wey dis 'skinny jabs' dem dey trend, plenti women no dey use drugs safely or even get beta advice as to how dem go use am. Di thinking be say di side effects of dis medication wey be vomiting and diarrhoea and di fact say dem dey slow down di way belle dey take empty mean say di contraceptive medicine fit no enta bodi well. Di MHRA say women suppose use contraceptive togeda wit GLP-1 medicines and for a certain period afterwards before dem try to get belle - two months for Wegovy and Ozempic, and one month for Mounjaro. Dem also advice say pesin wey dey use Mounjaro and oral contraceptives get two options. Either dem go follow di contraception wit condoms for four weeks afta dem start di injection or else make dem change contraception go coil or implant. Advice for di use of contraception alreadi dey di leaflet wey dey follow di medicine but MHRA don issue dia own guidance join. Di drugs safety board say make pesin no take di weight-loss injections if: Dem suppose dey give women dis informate wen dem start to dey collect di injections, but worry dey say di warning no dey enta well. Natasha Major, 26, start to use Mounjaro to lose weight bifor she plan to born her third pikin in a few years. But e shock am as just six weeks later, she find out say, she don carry belle. She bin dey take contraceptive pill dat time. She tok say, "I get polycystic ovaries too, so I no dey quick-quick get belle like dat. So e even shock me pass say e easy to carry belle like dat, bicos e no make sense to me." She den start to dey worry about weda she go harm her pikin or weda di baby no go grow well. Natasha come follow her doctor tok for advice and na so dem tell am, make she stop di medicine. She say, "we don pass di first shock nand now dey very happy. Di last time wey I take di injection na just three hours bifor I find out say I don carry belle and I neva take am since dat time." Natasha add say, "I bin do early scan to make sure say di belle make sense and e dey okay, baby bin get small heartbeat and evritin dey good". Di MHRA and doctors and pharmacists dey worry say dem no dey use di popular GLP-1 medicine like Wegovy, Mounjaro, Saxenda, Victoza and Ozempic, safely. Dis prescription medicines dey licensed to treat obesity (and type 2 diabetes for Ozempic). E dey make pipo to feel full by acting as di hormone wey bodi dey release afta pesin don chop. Mounjaro dey also work wit anoda hormone wey dey linked to appetite and blood sugar control. Normally, na pipo wey get very high BMI, na im NHS dey give di drugs but pipo fit buy am for chemists. E don popular sotay dem don dey sell am illegally for social media and for beauty saons witout medical advice as sharp-sharp way to lose weight. Di MHRA dey advise pipo make dem follow di prescriber tok about di risks and benefits of taking dem, and understand di potential side-effects by talking to a doctor or pharmacist. E don act now because e don receive around 40 reports relating to pregnancy wey dem make to im Yellow Card scheme, wia di public fit report suspected side-effects of medicines. Some of dis be pregnancies wey hapun by mistake. Di chief safety officer for di MHRA, Dr Allison Cave tok say dem find evidence for animal studies say, "dis medicine dem fit harm unborn pikin. But we no know weda e go get di same effect for human beings, we need more data for dat one". Dem no use women wey dey child bearing age do dis clinical trial and na why safety information no dey for dem. Dr Cave say if pesin get belle and dem dey take di medicine, make dem follow dia doctor tok on how to stop am as soon as possible. Di vice chairwoman for di National Pharmacy Association, Sukhi Basra tok say make women go pharmacist for advice if dem dey confused as to wen dem suppose to stop to dey take di drugs. Dr Bassel Wattar wey be sabi pesin on pregnancy and consultant for Epsom and St Helier University Hospitals, say di implant or intrauterine coil na "more ogbonge contraception" dan oral combined contraceptive pill while pesin dey take di injections. For some women, to lose plenti weight fit help some women to get back dia natural ovulation and boost dia chance to get belle but e tok say dis kain tin, need planning safely wit specialist doctors "so di pregnancy go dey safe afta washout period of dis drugs". Di British Pregnancy Advisory Service, tok say women for UK, dey face ogbonge challenges wen dem dey try access dia contraceptive method of choice. Lack of appointments, long waiting lists and high costs na just some of di kasala dem dey face, according to di BPAS. Dis na as dem dey ask for beta plan to provide dis choices dem for women.

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