NICU Admissions Higher in Pregestational Diabetes
Neonatal intensive care unit (NICU) admission rates were significantly higher among infants born to mothers with pregestational diabetes than among those born to mothers with gestational diabetes (GD).
METHODOLOGY:
This Irish study compared risks for NICU admission across maternal diabetes subtypes (type 1 diabetes [T1D], type 2 diabetes [T2D], and GD) to refine counselling and neonatal care.
Researchers conducted a retrospective analysis of 25,238 births (January 2018 to December 2020) and identified 3905 neonates born ≥ 34 weeks to mothers with diabetes, including those with T1D (n = 67), T2D (n = 60), and GD (n = 3712).
Data on gestational age, birth weight, mode of delivery, and maternal age were extracted from the registry. NICU admission details (indications, hypoglycaemia, and respiratory support) and maternal characteristics (body mass index [BMI] > 30 and preeclampsia) were obtained via electronic records.
The analysis was performed using quasi-Poisson regression for assessing NICU admission risk ratios (RRs), analysis of variance for comparing gestational age/birth weight, and chi-square tests for comparing categorical variables.
The primary outcome was the NICU admission rate; secondary outcomes included respiratory distress, severe hypoglycaemia, and maternal discharge timing.
TAKEAWAY:
Neonates born to mothers with T1D and T2D had a admission rate of 41.8% (RR, 3.32) and 31.1% (RR, 3.89), respectively, with both significantly higher than that in those born to mothers with GD (12.5%; RR, 0.133; P ≤ .001); the hospital baseline admission rate was 11.5%.
≤ .001); the hospital baseline admission rate was 11.5%. Neonates of mothers with T1D were born earlier (mean, 37 + 1 weeks) than those of mothers with T2D (mean, 38 + 1 weeks; P = .0019) and GD (mean, 39 weeks; P ≤ .001).
= .0019) and GD (mean, 39 weeks; ≤ .001). Moreover, they showed significantly higher birth weight centiles than those of mothers with T2D and GD at 25th (T1D vs T2D, P = .0042; T1D vs GD, P ≤ .001), median ( P ≤ .0001 for both), and 75th centiles (T1D vs T2D, P ≤ .0001; T1D vs GD, P = .0009).
= .0042; T1D vs GD, ≤ .001), median ( ≤ .0001 for both), and 75th centiles (T1D vs T2D, ≤ .0001; T1D vs GD, = .0009). Respiratory distress dominated T1D admissions (36.7%), while hypoglycaemia was primary in T2D (73.7%).
Mothers with pregestational diabetes were more frequently discharged before their infants (T1D, 42.9%; T2D, 31.5%) than those with GD (21.2%).
IN PRACTICE:
"It is important to counsel mothers on risks and expectations for the newborn period," the authors of the study wrote. "The aim of our study is to describe how the type of maternal diabetes impacts admission to NICU and to provide up-to-date, local data to support healthcare professionals when counselling patients with diabetes in pregnancy," they added.
SOURCE:
This study was led by Dearbhla Hillick, Rotunda Hospital, Dublin, Ireland. It was published online on May 22, 2025, in the European Journal of Pediatrics .
LIMITATIONS:
This study was limited by the dataset being unbalanced, with most neonates born to mothers with GD. Neonates of mothers without diabetes requiring NICU admission were not included. Factors such as maternal smoking, raised BMI, or preeclampsia possibly confounded the NICU admission risk.
DISCLOSURES:
Open access funding was provided by the IReL Consortium. The authors reported having no relevant conflicts of interest.
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Fox News
2 hours ago
- Fox News
Woman declared dead by coroner, moved to coffin, turns out to be alive
A woman declared dead by the coroner after her husband found her unresponsive in bed was being placed in a coffin when morticians made a startling discovery — she was very much alive. The horrifying tale from the Czech Republic unfolded when an 88-year-old woman, who was thought to be dead, showed signs of life in her coffin. According to the husband of the woman thought to be deceased called the Pilsen emergency services to potentially help his wife. The husband told the emergency dispatch that "she didn't move, she didn't breathe," according to the report. When paramedics arrived, they confirmed the woman's death and the coroners were dispatched to the apartment. The coroner also confirmed the woman's death and undertakers were called to move the body into the coffin. The husband also told Blesk that "the workers transferred her to the coffin, and when they were right here in the apartment in the hallway by the door, they found out she was alive." An ambulance arrived shortly after, and the woman was transported to the hospital. While this may seem like something out of a horror story, this rare medical occurrence has happened before. According to the Cleveland Clinic, it's known as the Lazarus Effect. Named after the biblical story of Jesus raising Lazarus back from the dead, this usually occurs after CPR ends. Typically, this happens after a cardiac arrest occurs and CPR is administered to the patient. This medical phenomenon occurs after the patient is clinically pronounced dead. Some time later, the patient will begin to show signs of life and must continue to show these signs for more than a few seconds. According to the National Institutes of Health, there have been 74 confirmed cases in the U.S. from 1982-2022. It is still unknown how or why the Lazarus Effect happens.
Gizmodo
2 hours ago
- Gizmodo
Cillian Murphy's Role in the '28 Years Later' Trilogy Is Coming Later Than We Hoped
Director and writer Danny Boyle teased the Oscar winner will appear to set up a third movie, if the first two do well. Cillian Murphy is set to make his eventual return to the world of 28 Days Later within the upcoming trilogy that 28 Years Later will kick off this summer, but there are a few catches. Director Danny Boyle (Trainspotting) revealed vague details about the Oscar-winning Oppenheimer actor's involvement to IGN. The upcoming trilogy expands on the world Boyle and Alex Garland (Civil War) started with 28 Days Later and its star Cillian Murphy, with a new set of interconnected stories. However, Murphy will not appear in the first film as it introduces a new central character: Spike, a 12-year-old boy portrayed by Alfie Williams whose family (led by Jodie Comer and Aaron Taylor-Johnson) finds itself in the thick of the post-apocalyptic zombie outbreak. 'Although each story completes itself, there's a handover section to the next film as well. So it's very ambitious. We haven't got the money for the third one yet. It will depend how the first one does, I guess,' Boyle shared and explained that Murphy's return is contingent on how the first two movies do. 'But hopefully if we do ok, they'll give us the go-ahead for the money and for the third one. Everybody's standing by for that, really. Including Cillian,' the director confirmed regarding Murphy's participation. Currently it's planned that he will make an appearance at the end of the Nia DaCosta (Candyman)-directed follow-up 28 Years Later: The Bone Temple, which picks up on the immediate continuation of events from Boyle's upcoming reboot sequel and is slated to open in theaters next January. 'He is in the second one,' Boyle revealed, 'I shouldn't give away too much. I'll get killed.' But we can guess that his appearance will only tease the potential of the third film, which Sony has yet to confirm. Boyle continued, 'You know that thing about sequels, you want to push it on and take huge risks.' 'I have to say fair play to [studio Sony Pictures]. They did allow us to take great liberties with [28 Years Later]. They could have said, 'Oh no, it needs to be more sequel-y. You need to rely on some of the ideas that are in the original. And what do you mean Cillian's not going to appear in the first one? I thought you said Cillian was going to be in it.' We said, 'Yeah, Cillian is going to be in it, but not quite the first one.' So fair play to them. They've put up with a lot.' 28 Years Later opens June 20.
Bloomberg
3 hours ago
- Bloomberg
UK Could Miss 2030 Clean Power Goal, Parliament Committee Warns
The UK's goal of a clean power grid by 2030 is in danger of slipping out of reach as planning delays and infrastructure bottlenecks challenge the government. The ambition requires 'building more energy generation and network infrastructure at a faster pace than Great Britain has managed in recent years,' according to a report from the House of Lords Industry and Regulators Committee published on Wednesday.
