
Crescita Therapeutics Announces Mutual Termination of Licensing Agreement with Croma Pharma GmbH for Pliaglis ®
LAVAL, Quebec--(BUSINESS WIRE)--Crescita Therapeutics Inc. (TSX: CTX and OTC US: CRRTF) (' Crescita ' or the ' Company '), a growth-oriented, innovation-driven Canadian commercial dermatology company with in-house R&D and manufacturing capabilities, today announced that it has, by mutual agreement, terminated its commercialization and development license agreement with CROMA Pharma GmbH ('Croma'), that granted Croma exclusive rights to market Pliaglis ® in Germany, the United Kingdom, Ireland, Switzerland, Brazil, Romania, Belgium, the Netherlands and Luxembourg (the 'Territories').
Following a strategic business review, Croma decided to rationalize its product portfolio and realign its business priorities. Under the terms of the termination agreement, Crescita will regain all development and commercialization rights for Pliaglis in the Territories, and Croma will pay the Company €575,000 (approximately CAD$900,000). Crescita plans to explore potential new partnerships to commercialize Pliaglis in the Territories.
About Crescita Therapeutics Inc.
Crescita (TSX: CTX and OTC US: CRRTF) is a growth-oriented, innovation-driven Canadian commercial dermatology company with in-house R&D and manufacturing capabilities. The Company offers a portfolio of high-quality, science-based non-prescription skincare products and early to commercial stage prescription products. We also own multiple proprietary transdermal delivery platforms that support the development of patented formulations to facilitate the delivery of active ingredients into or through the skin. For more information visit, www.crescitatherapeutics.com.
Forward-looking Information
Certain statements in this press release constitute forward-looking statements and/or forward-looking information (collectively 'forward-looking information') within the meaning of applicable securities laws. All information in this press release, other than statements of current and historical fact, represents forward-looking information and is qualified by this cautionary note.
Forward-looking information may relate to the Company's future financial outlook and anticipated events or results and may include information regarding the Company's financial position, business strategy, growth strategies, addressable markets, budgets, operations, financial results, taxes, dividend policy, plans, objectives, and expectations. Such information is provided for the purpose of presenting information about management's current expectations and plans relating to the future and allowing investors and others to get a better understanding of the Company's anticipated financial position, results of operations and operating environment. Readers are cautioned that such information may not be appropriate for other purposes.
Often, but not always, forward-looking information can be identified by the use of forward-looking terminology such as: 'outlook', 'objective', 'anticipate', 'intend', 'plan', 'goal', 'seek', 'believe', 'aim', 'project', 'estimate', 'expect', 'strategy', 'future', 'likely', 'may', 'should', 'will', 'growth strategy', 'future', 'prospects', 'continue', and similar references to future periods or suggesting future outcomes or events. In addition, any statements that refer to expectations, intentions, projections or other characterizations of future events or circumstances contain forward-looking information.
Examples of forward-looking information include, but are not limited to, statements made in this press release under the heading 'Financial Highlights', including statements regarding the Company's objectives, plans, goals, strategies, growth, performance, operating results, financial condition, business prospects, opportunities and industry trends, and similar statements concerning anticipated future events, results, circumstances, performance or expectations.
Forward-looking information is neither historical fact nor assurance of future performance. Instead, it reflects management's current beliefs, expectations and assumptions and is based only on information currently available to us. Forward-looking information is necessarily based on a number of estimates and assumptions that, while considered reasonable by the management of the Company as of the date of this press release, are inherently subject to significant business, economic, and competitive uncertainties and contingencies that are difficult to predict and many of which are outside of our control.
The Company's estimates, beliefs and assumptions, which may prove to be incorrect, include various assumptions regarding, among other things: the Company's future growth potential, results of operations, future prospects and opportunities; the Company's ability to retain and recruit, as applicable, customers, members of management and key personnel; industry trends; legislative or regulatory matters, including expected changes to laws and regulations and the effects of such changes; future levels of indebtedness; availability of capital; the Company's ability to secure additional capital and source and complete acquisitions; the Company's ability to maintain and expand its market presence and geographic scope; economic and market conditions, including the imposition of and adverse changes to tariffs and other trade protection measures; the impact of currency exchange and interest rates; the Company's ability to maintain existing financing and insurance on acceptable terms; the Company's ability to execute on, and the impact of, its environmental, social and governance initiatives; the impact of competition; and the Company's ability to respond to changes to its industry and the global economy.
Forward-looking information involves risks and uncertainties that could cause Crescita's actual results and financial condition to differ materially from those contemplated by such forward-looking information. Important factors that could cause such differences include, among others:
economic and market conditions, including factors impacting global supply chains such as pandemics, geopolitical conflicts and tensions, and trade protection measures, like the imposition of tariffs and retaliatory tariffs by the United States and Canada;
the impact of inflation and fluctuating interest rates;
the Company's ability to execute its growth strategies;
the degree or lack of market acceptance of the Company's products;
reliance on third parties for marketing, distribution and commercialization, and clinical trials;
the impact of variations in the values of the Canadian dollar in relation to the U.S. dollar and Euro;
the impact of the volatility in financial markets;
the Company's ability to retain members of its management team and key personnel;
the impact of changing conditions in the regulatory environment and product development processes;
manufacturing and supply risks;
increasing competition in the industries in which the Company operates;
the Company's ability to meet its contractual obligations;
the impact of product liability matters;
the impact of litigation involving the Company and/or its products;
the impact of changes in relationships with customers and suppliers;
the degree of intellectual property protection of the Company's products;
developments and changes in applicable laws and regulations, and;
other risk factors described from time to time in the reports and disclosure documents filed by Crescita with Canadian securities regulatory agencies and commissions, including the sections entitled 'Risk Factors' in the Company's most recent annual MD&A and AIF.
If any risks or uncertainties with respect to the above materialize, or if the opinions, estimates or assumptions underlying the forward-looking information prove incorrect, actual results or future events might vary materially from those anticipated in the forward-looking information. This list is not exhaustive of the factors that may impact the Company's forward-looking information. Although management has attempted to identify important risk factors that could cause actual results to differ materially from those contained in forward-looking information, there may be other risk factors not presently known or that management believes are not material that could also cause actual results or future events to differ materially from those expressed in such forward-looking information. There can be no assurance that such information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such information.
Accordingly, investors should not place undue reliance on forward-looking information, which speaks only as of the date provided, and is subject to change after such date. Except as required by applicable securities laws, the Company undertakes no obligation to publicly update any forward-looking information, whether written or oral, that may be provided from time to time, whether as a result of new information, future developments or otherwise.

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We want to extend our sincere thanks to the mining crews, the engineering teams and our long-term contractors for their extraordinary efforts in restoring pumping capacity and restarting operations, all without any lost time injuries. "The resilience of our team and the strength of our operations reflect the extraordinary nature of this world-class copper district-and the future it holds for generations to come." Figure 1. Outline of the Kakula and Kakula West orebody, overlaid with the underground development since mining commenced in 2021. A significant portion of the original Kakula deposit remains unmined as of May 2025. To view an enhanced version of this graphic, please visit: Notes: Existing underground development as at May 2025. Illustration is based on the 2023 Kamoa-Kakula IDP showing the estimated average grade of each vertical stack of blocks above a 2% total copper cut-off. A minimum 3-metre thickness is applied. Underground water levels in Kakula Mine have stabilized; underground mining recommences on the western side of Kakula Although water inflow rates into the Kakula Mine modestly increased following the initial seismic activity, they have since stabilized at approximately 4,000 litres per second. With existing underground pumping infrastructure impacted by the seismic activity, a total of approximately 4,400 litres per second of additional underground pumping capacity was installed, stabilizing underground water levels. The new pump stations feed into the existing central pumping infrastructure, where the water is then pumped to surface at four locations near the bottom of the north and south twin declines, as shown in Figure 2. With water levels stabilized, mining in the western side of the Kakula Mine has restarted. Mobile equipment and mining crews, which were evacuated from the mine on May 18, 2025, are returning underground, with the first blast having occurred on June 7, 2025. 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Preliminary findings indicate that the seismic activity originated in an area within the eastern side of the Kakula Mine with a mature percentage of extraction. Current thinking postulates that blocks of ore, earmarked for secondary extraction, started to yield in a cascading fashion, which resulted in stress redistribution onto regional pillars. As a consequence, the regional pillars became over-stressed and started to yield. The backfill, placed in mined-out stopes, was not capable of preventing the stress redistribution onto regional support pillars, but may have been a mitigant. The possibility that adverse regional geological features may have exacerbated the yielding of regional pillars cannot be excluded at this time. Pillars are sections of untouched ore or rock left in place to support the roof of the mine, while stopes are mined-out areas. Backfill is the process whereby mined-out stopes are filled with a mixture of concentrator tailings and cement, which cures to achieve a targeted strength. The geotechnical assessment has not yet been finalized as it relies on physical access to the eastern section of the Kakula Mine once dewatering is completed. The preliminary findings recommend modifying the short-term mine plans to increase pillar widths for additional structural support. The findings also advise changes to the mining sequence to improve stress distribution and overall stability. Furthermore, enhanced geotechnical monitoring will be installed throughout the mine. Kamoa-Kakula's management, together with Beck Engineering, Open House and other technical consultants, are evaluating any changes to the short-, medium- and long-term mine plans in light of these preliminary geotechnical findings. Work on an updated life-of-mine integrated development plan, which was underway before the seismic activity occurred, has been paused until Ivanhoe Mines' engineering team and its panel of technical experts have reviewed and agreed on any updated assumptions. Ivanhoe Mines will provide a timing update on the delivery of an updated IDP once work recommences. Members of Kamoa-Kakula's mining crew, (L-R) Kalume Malidja, Mining Foreman and Morné Du Plooy, Mining Superintendent To view an enhanced version of this graphic, please visit: Phase 1 and 2 concentrators operating at reduced capacity and set to ramp up as mining restarts on western side of the Kakula Mine; Phase 3 concentrator continues to outperform Crews recommenced mining on the western side of Kakula on June 7, 2025. Mining from this section will commence safely and conservatively, with planned ramp-up to an annualized mining rate of 3.6 million tonnes during the third quarter. This rate is sufficient for the Phase 1 and 2 concentrators to operate at a throughput of more than 80% of their combined design capacity of 9.2 million tonnes per annum, supplemented by ore from surface stockpiles and ore trucked from the Kamoa mines. Run-of-mine grade from the western side of Kakula, including development, is expected to range between 3.0% and 4.0% copper for the remainder of the year. The Phase 1 and 2 concentrators continue to operate at approximately 50% of their combined capacity, processing ore from surface stockpiles since underground operations ceased on May 18, 2025. The Phase 3 concentrator, located adjacent to the Kamoa mines area as shown in Figure 3, has continued to outperform operationally since the start of the year. The concentrator is operating at an average annualized milling rate of approximately 6.5 million tonnes per annum, which is 30% higher than the concentrator's design capacity of 5 million tonnes per annum. Year-to-date, ore processed by the Phase 3 concentrator has an average feed grade of 2.84% copper. Mining from the Kamoa and Kansoko mines, have ramped up over the past 2 months to a combined rate of over 6.8 million tonnes per annum on an annualized basis. Short-term mine plans for the Kamoa and Kansoko mines have findings been updated to include the recommendations from the preliminary geotechnical assessment. Longer-term mine plans will be also be reviewed alongside Kakula. Figure 3. Overview of the Kamoa-Kakula Copper Complex To view an enhanced version of this graphic, please visit: Revised 2025 production guidance Kamoa-Kakula's updated 2025 production guidance is based on several assumptions and estimates as of June 10, 2025. The guidance provided involves estimates of known and unknown risks, uncertainties, and other factors that may cause the actual results to differ materially. The revised 2025 production guidance takes into account the probable effect of recent seismic activity and associated interruptions in mining operations at the Kakula Mine. Although mining in the western side of the Kakula Mine has restarted risk factors remain, including; it is too early to accurately predict potential disruption caused by further unexpected seismic activity, the integrity of underground infrastructure, the ability to ramp up underground operations, the ability to complete dewatering activities and the time required to access the new mining areas. The updated 2025 production guidance is based on an assessment of these factors that management believes are reasonable at this time, given all available information. A waterfall diagram shown in Figure 4 details a breakdown of the revised production guidance. Revised 2025 Production Guidance Kamoa-Kakula 370,000 - 420,000 Contained copper in concentrate (tonnes) All figures are on a 100%-project basis and metal reported in concentrate is before refining losses or payability deductions associated with smelter terms. Figure 4. Waterfall breakdown of original to revised 2025 production guidance, approximated by category ('000's tonnes of copper) with percentage change shown in boxes To view an enhanced version of this graphic, please visit: The 2026 target of approximately 600,000 tonnes of copper production is withdrawn pending further review. Ivanhoe Mines will provide a timely update on the 2026 target production rate when more information becomes available. Ivanhoe Mines will provide updated 2025 C1 cash cost (C1) per pound of payable copper in the second quarter of 2025 financial results. On-site direct-to-blister smelter to start up in third quarter Kamoa-Kakula's senior management has confirmed that the start-up of the on-site direct-to-blister copper smelter will commence in early September 2025, with first anode expected in October. The smelter can operate at a minimum operating capacity of 50%, or approximately 250,000 tonnes of copper on an annualized basis. As at May 31, 2025, unsold concentrate stockpiles consisted of 33,000 tonnes of copper. In preparation for the first feed of concentrate, approximately four to six weeks after start-up commences, it is expected that total unsold concentrate stockpiles will be approximately 35,000 tonnes of copper in concentrate. In addition, Kamoa-Kakula's senior management anticipates the commissioning of the 178-megawatt Turbine #5 at the Inga II hydroelectric dam in October 2025, further boosting domestically generated hydroelectricity supplied to the Kamoa-Kakula Copper Complex. Ivanhoe Mines to host a conference call for investors on June 12, 2025 The company will hold an investor conference call to discuss the operational update at Kamoa-Kakula before the market opens on June 12, 2025, at 8:00 a.m. Eastern time / 5:00 a.m. Pacific time. The conference call will conclude with a question-and-answer (Q&A) session. Media are invited to attend on a listen-only basis. To view the webcast, use the link: Audience Phone Number: (+1) 647 951 0841 (Toll, for international callers)(+1) 888 985 7261 (Toll-Free North America) An audio webcast recording of the conference call, together with supporting presentation slides, will be available on Ivanhoe Mines' website at Disclosure of Technical Information Disclosures of a scientific or technical nature in this news release, other than the preliminary geotechnical findings and the technical information in Figure 1, have been reviewed and approved by Steve Amos, who is considered, by virtue of his education, experience, and professional association, a Qualified Person under the terms of NI 43-101. Mr. Amos is not considered independent under NI 43-101 as he is Ivanhoe Mines' Executive Vice President, Projects. Mr. Amos has verified the technical data disclosed in this news release. Disclosures of a scientific or technical nature regarding the preliminary geotechnical findings in this news release have been reviewed and approved by Koos Bosman, who is considered, by virtue of his education, experience, and professional association, a Qualified Person under the terms of NI 43-101. Mr. Bosman is considered independent of the company for purposes of NI 43-101 as he is Managing Director of Open House. Mr. Bosman has verified the technical data regarding the preliminary geotechnical findings disclosed in this news release. Disclosures of a scientific or technical nature in Figure 1 of this news release have been reviewed and approved by Joshua Chitambala, who is considered, by virtue of his education, experience, and professional association, a Qualified Person under the terms of NI 43-101. Mr. Chitambala is not considered independent under NI 43-101 as he is the Resource Manager for Ivanhoe Mines. Mr. Chitambala has verified the other technical data regarding the surface stockpiles disclosed in this news release. About Ivanhoe Mines Ivanhoe Mines is a Canadian mining company focused on advancing its three principal projects in Southern Africa; the expansion of the Kamoa-Kakula Copper Complex in the DRC, the ramp-up of the ultra-high-grade Kipushi zinc-copper-germanium-silver mine, also in the DRC; and the phased development of the tier-one Platreef platinum-palladium-nickel-rhodium-gold-copper Mine in South Africa. Ivanhoe Mines is exploring for copper in its highly prospective, 54-100% owned exploration licences in the Western Forelands, covering an area over six times larger than the adjacent Kamoa-Kakula Copper Complex, including the high-grade discoveries in the Makoko District. Ivanhoe is also exploring for new sedimentary copper discoveries in new horizons including Angola, Kazakhstan, and Zambia. Follow Robert Friedland (@robert_ivanhoe) and Ivanhoe Mines (@IvanhoeMines_) on X. Information contact Investors Vancouver: Matthew Keevil +1.604.558.1034 London: Tommy Horton +44 7866 913 207 MediaTanya Todd +1.604.331.9834 Forward-Looking Statements Certain statements in this news release constitute "forward-looking statements" or "forward-looking information" within the meaning of applicable securities laws. Such statements and information involve known and unknown risks, uncertainties, and other factors that may cause the actual results, performance, or achievements of the company, its projects, or industry results to be materially different from any future results, performance, or achievements expressed or implied by such forward-looking statements or information. Such statements can be identified using words such as "may", "would", "could", "will", "intend", "expect", "believe", "plan", "anticipate", "estimate", "scheduled", "forecast", "predict" and other similar terminology, or state that certain actions, events, or results "may", "could", "would", "might" or "will" be taken, occur or be achieved. These statements reflect the company's current expectations regarding future events, performance, and results and speak only as of the date of this news release. Such statements include, without limitation: (i) statements that development from existing underground infrastructure toward a new mining area in the eastern side of the Kakula is expected to commence imminently, and that this development will be isolated from the dewatering activities; (ii) statements that dewatering of the eastern side of the Kakula Mine is expected to commence by the end of August 2025 and be complete during the fourth quarter; (iii) statements that the processing rate of the concentrators will ramp up throughout the remainder of 2025, as mining on the western side of the Kakula Mine increases, supplemented by feed from ore stockpiles; (iv) statements that, with necessary copper concentrate expected to be available, the on-site copper smelter is expected to start up in the third quarter, with first anode expected in October; (v) statements that Kamoa-Kakula's mining crews aim to ramp up mining from the western side of the Kakula Mine to approximately 300,000 tonnes per month (3.6 million tonnes per year on an annualized basis) during the second half of 2025, subject to underground conditions; (vi) statements that for the remainder of 2025, Kakula's underground mining crews will focus on the following three activities: ramping up mining on the western side of the Kakula Mine, developing a new mining area on the eastern side of the Kakula Mine and ramping up production from the Kamoa mining area; (vii) statements that the new box cut at Kansoko will enable increased production from Kansoko, providing an additional source of ore for the Phase 1 and Phase 2 concentrators; (viii) statements that development of a new mining area on eastern side of the Kakula Mine will commence imminently; (ix) statements that development of the new mining area is expected to be conducted in a mix of ore and waste and be completed in the second quarter of 2026; (x) statements that following the completion of dewatering activities on the eastern side of Kakula, a physical geotechnical inspection of the mine's existing workings will be conducted, concluding the full assessment by the geotechnical experts; (xi) statements regarding additional pumps being ordered as part of the long-term pumping infrastructure plan and such pumps being deployed in pairs; (xii) statements that delivery, installation, and commissioning of the surface dewatering infrastructure is expected by mid-September; (xiii) statements regarding the impact of the preliminary assessment on the mine plan at Kakula, Kamoa and Kansoko; (xiii) production guidance for Kamoa Kakula for 2025; (xiv) statements that ore from the western side of Kakula is expected to deliver a head grade ranging between 3.0% and 4.0% copper; (xv) statements that the smelter's minimum operating capacity is 50%, or approximately 250,000 tonnes of copper on an annualized basis; (xvi) statements that Kamoa-Kakula's senior management anticipates the commissioning of the 178-megawatt Turbine #5 at the Inga II hydroelectric dam in September, further boosting domestically generated hydroelectricity to the Kamoa-Kakula Copper Complex; and (xv) statements regarding the locations where the "Stage Two" dewatering surface pumping infrastructure will be installed to dewater the eastern side of the Kakula Mine and that water will be discharged into existing surface water channels. Forward-looking statements and information involve significant risks and uncertainties, should not be read as guarantees of future performance or results, and will not necessarily be accurate indicators of whether such results will be achieved. Many factors could cause actual results to differ materially from the results discussed in the forward-looking statements or information, including, but not limited to: (i) uncertainty around the rate of water ingress into underground workings; (ii) the ability, and speed with which, additional equipment can be secured; (iii) the continuation of seismic activity; (iv) the state of underground infrastructure; (v) uncertainty around when future underground access can be secured; (vi) the fact that future mine stability cannot be guaranteed; (vii) the fact that future mining methods, may differ the impact on Kakula operations; and (viii) the ultimate conclusion of the assessment of the cause of the seismic activity at Kakula and the impact of same on the mining plan at the Kamoa Kakula Copper Complex. Additional factors also include those discussed above and under the "Risk Factors" section in the company's MD&A for the three months ended March 31, 2025, and its current annual information form, and elsewhere in this news release, as well as unexpected changes in laws, rules or regulations, or their enforcement by applicable authorities; changes in the rate of water ingress into underground workings; the continuation of seismic activity; the state of underground infrastructure; delays in securing underground access; changes to the mining methods required in the future; the failure of parties to contracts with the company to perform as agreed; social or labour unrest; changes in commodity prices; and the failure of exploration programs or studies to deliver anticipated results or results that would justify and support continued exploration, studies, development or operations. Although the forward-looking statements contained in this news release are based upon what management of the company believes are reasonable assumptions, the company cannot assure investors that actual results will be consistent with these forward-looking statements. These forward-looking statements are made as of the date of this news release and are expressly qualified in their entirety by this cautionary statement. Subject to applicable securities laws, the company does not assume any obligation to update or revise the forward-looking statements contained herein to reflect events or circumstances occurring after the date of this news release. The company's actual results could differ materially from those anticipated in these forward-looking statements as a result of the factors outlined in the "Risk Factors" section in the company's MD&A for the three months ended March 31, 2025, and its current annual information form. To view the source version of this press release, please visit