
Deadly listeria outbreak linked to shakes used at nursing homes, hospitals. Florida impact
A nationwide recall has been issued for frozen nutritional shakes linked to a deadly listeria outbreak, according to the Food and Drug Administration.
The shakes were sold to hospitals and long-term care institutions, including nursing homes.
As of Feb. 24, the FDA reported 38 people had been infected in 21 states, including Florida. Twelve have died.
On Feb. 22, Magnus LLC initiated a recall of 4 oz. Lyons ReadyCare and Sysco Imperial Frozen Supplemental Shakes.
The shakes came in a variety of flavors, including vanilla, chocolate, strawberry and strawberry banana.
Best buy dates were Feb. 21, 2025, through Feb. 21, 2026.
The frozen supplemental shakes were manufactured by Prairie Farms Dairy Inc. — Prairie Farms — in Fort Wayne, Indiana, under brands Lyons ReadyCare and Sysco Imperial.
The FDA is investigating the multistate outbreak of listeria in frozen supplement shakes.
As of Feb. 24, a total of 38 people have been infected with the outbreak strain in 21 states, including Florida.
Of the 38 people for whom information is available, 37 people have been hospitalized, and 12 deaths have been reported, the FDA reported.
"The true number of sick people in this outbreak is likely higher than the number reported, and the outbreak may not be limited to the states with known illnesses," the CDC said.
"This is because some people recover without medical care and are not tested for listeria. In addition, recent illnesses may not yet be reported as it usually takes 3 to 4 weeks to determine if a sick person is part of an outbreak."
According to the Centers for Disease Control, the deaths associated with the outbreak occurred in:
California
Illinois
Indiana
Michigan
Minnesota
North Carolina
New York
Tennessee
Texas
Washington
The shakes were sold nationwide to institutional settings, such as long-term care facilities, including hospitals, the FDA said.
Of the 38 people for whom information is available, 34 — 89% — reported living in long-term care facilities or were hospitalized prior to becoming sick.
Records reviewed from facilities indicated nutritional shakes were available to residents, the FDA said.
Those infected during the outbreak ranged in age from 43 to 101, with a median age of 78, according to the CDC.
There are 21 states with known listeria outbreaks related to the recall, as of Feb. 24, according to the FDA. States with cases include:
Alabama
California
Colorado
Connecticut
Florida
Illinois
Indiana
Maryland
Michigan
Minnesota
Missouri
North Carolina
Nevada
New York
Ohio
Oklahoma
Pennsylvania
Tennessee
Texas
Washington
West Virginia
The Centers for Disease Control had previously begun tracking the same outbreak in 2018, with 20 cases cropping up throughout 2024 and 2025.
"Sick people were residents in long-term care facilities and nursing homes and the likely source was a food served in those types of institutions, but there was not enough information to identify a specific food," the CDC said.
"In February 2025, after traceback identified a product of interest, the outbreak strain was found in environmental samples from Prairie Farms."
"Distributors and foodservice customers, including hospitals and long-term care facilities who purchased or received recalled Lyons ReadyCare and Sysco Imperial Frozen Supplemental Shakes should not sell or serve these products," the FDA said.
"Carefully clean and sanitize any surfaces or containers that they touched and follow FDA's safe handling and cleaning advice to reduce the risk of cross-contamination. Listeria can survive in refrigerated temperatures and can easily spread to other foods and surfaces."
Listeria are bacteria that can contaminate many foods, the CDC said. People who eat contaminated food can get infected with the bacteria.
"The disease-causing bacteria can be found in many places, including soil, water, sewage, rotting vegetation, and animals," the FDA said.
Signs and symptoms of listeriosis depend on the person infected, and the body part affected, according to the Centers for Disease Control.
"Listeriaare most likely to harm pregnant women, newborns, older adults, and people with weakened immune systems."
According to the Mayo Clinic, if you develop a listeria infection, symptoms could include:
Fever
Chills
Muscle aches
Nausea
Diarrhea
"Symptoms might begin a few days after you've eaten contaminated food, but it can take 30 days or more before the first signs and symptoms of infection begin," the Mayo Clinic said.
If the listeria infection spreads to your nervous system, signs and symptoms can include:
Headache
Stiff neck
Confusion or changes in alertness
Loss of balance
Convulsions
Especially for those in high-risk groups, the CDC offers the following suggestions to avoid the listeria bacteria found in food. Do not eat:
Unpasteurized soft cheeses, such as queso fresco and brie.
Unheated cheeses sliced at a deli.
Unheated deli meat, cold cuts, hot dogs, and fermented or dry sausages.
Premade deli salads, such as coleslaw and potato, tuna, or chicken salad.
Refrigerated pâté or meat spreads.
Refrigerated smoked fish.
Raw or lightly cooked sprouts.
Cut melon left out for more than 2 hours. One hour if it's exposed to temperatures hotter than 90 degrees.
Cut melon in refrigerator for more than a week.
Raw (unpasteurized) milk, yogurt, and ice cream.
This article originally appeared on Florida Times-Union: Listeria causes FDA recall in supplement shakes at hospitals

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The trial met its primary endpoint with a statistically significant and clinically meaningful benefit in radiographic progression-free survival (rPFS) with a positive trend in overall survival (OS) in patients with prostate-specific membrane antigen (PSMA)-positive metastatic hormone-sensitive prostate cancer (mHSPC) treated with radioligand therapy (RLT), Pluvicto™ (lutetium (177Lu) vipivotide tetraxetan), in combination with standard of care (SoC) versus SoC alone1. In PSMAddition, the SoC is a combination of androgen receptor pathway inhibitor (ARPI) therapy and androgen deprivation therapy (ADT)3. Almost all mHSPC patients ultimately progress to metastatic castration-resistant prostate cancer (mCRPC)4. There is a need for additional treatment options with novel mechanisms of action that further delay progression, prolong OS and improve disease control compared to the current SoC, while showing a favorable safety and tolerability profile. 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Results from PSMAddition in mHSPC show potential for treatment in an earlier setting with Pluvicto, which was recently granted US Food and Drug Administration (FDA) approval for earlier use in mCRPC, based on results from PSMAfore1,2. Novartis is harnessing the innovation of world-class scientists, strategic partnerships and one of the industry's most competitive pipelines to explore the potential of new, targeted therapies and precision medicine platforms to address the greatest unmet needs in prostate cancer. Data will be presented at an upcoming medical meeting and, based on FDA feedback, will be submitted for regulatory review in the second half of the year. About PSMAddition studyPSMAddition (NCT04720157) is a Phase III, open-label, prospective, 1:1 randomized study comparing the efficacy and safety of Pluvicto in combination with SoC (ARPI + ADT) vs. SoC alone in adult patients with PSMA-positive mHSPC3. Patients randomized to the SoC alone arm are allowed to crossover to receive Pluvicto, upon confirmation of radiographic progression by blinded independent review committee (BIRC) and per the discretion of the treating physician3. The primary endpoint is rPFS, defined as the time to radiographic progression by PCWG3-modified RECIST V1.1 (as assessed by BIRC) or death3. The key secondary endpoint of OS is defined as time to death due to any cause3. About Pluvicto™ (INN: lutetium (177Lu) vipivotide tetraxetan)Pluvicto is an intravenous RLT that combines a targeting compound (a ligand) with a therapeutic radionuclide (a radioactive particle, in this case lutetium-177)5,7. After administration into the bloodstream, Pluvicto binds to PSMA-expressing target cells, including prostate cancer cells that express PSMA, a transmembrane protein5,7. 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Novartis is investigating a broad portfolio of RLTs, exploring new isotopes, ligands and combination therapies to look beyond gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and prostate cancer and into breast, colon, lung and pancreatic cancer. Novartis has established global expertise, with specialized supply chain and manufacturing capabilities across its network of RLT production sites. To support growing demand for RLTs, we have expanded production capabilities in Millburn (NJ), Zaragoza (Spain), Ivrea (Italy) and a state-of-the-art facility in Indianapolis (IN). In Carlsbad (CA), Novartis is establishing its third US-based RLT manufacturing site to support expanded use of RLTs, create resiliency in its manufacturing network and optimize the delivery of medicines to patients on the West Coast. DisclaimerThis press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as 'potential,' 'can,' 'will,' 'may,' 'could,' 'trend,' 'potentially,' 'upcoming,' 'progression,' 'progress,' 'investigating,' 'investing,' 'look beyond,' or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for Pluvicto, or regarding potential future revenues from Pluvicto. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that Pluvicto will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that Pluvicto will be commercially successful in the future. In particular, our expectations regarding Pluvicto could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise. About Novartis Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people's lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach nearly 300 million people worldwide. Reimagine medicine with us: Visit us at and connect with us on LinkedIn, Facebook, X/Twitter and Instagram. References Data on file. Pluvicto [prescribing information]. Millburn, NJ: Advanced Accelerator Applications USA, Inc.; 2025. An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With SoC, Versus SoC Alone, in Adult Male Patients With mHSPC (PSMAddition). identifier: NCT04720157. Updated March 5, 2025. Accessed June 2, 2025. Oing C, Bristow RG. Systemic treatment of metastatic hormone-sensitive prostate cancer—upfront triplet versus doublet combination therapy. ESMO Open 2023l doi: 10.1016/ Sartor O, J. de Bono KN, Chi K, et al. Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. NEJM 2021; doi: 10.1056/NEJMoa2107322. Morris M, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial. The Lancet 2024; doi: 10.1016/S0140-6736(24)01653-2. University of Chicago Medicine. Lutetium-177 PSMA Therapy for Prostate Cancer (Pluvicto). Accessed June 18, 2024. Jadvar H. Targeted Radionuclide Therapy: An Evolution Toward Precision Cancer Treatment [published correction appears in AJR Am J Roentgenol. 2017 Oct;209(4):949. doi: 10.2214/AJR.17.18875]. AJR Am J Roentgenol. 2017;209(2):277-288. doi:10.2214/AJR.17.18264 Jurcic JG, Wong JYC, Knoc SJ, et al. Targeted radionuclide therapy. In: Tepper JE, Foote RE, Michalski JM, eds. Gunderson & Tepper's Clinical Radiation Oncology. 5th ed. Elsevier, Inc. 2021;71(3):209-249 # # # Novartis Media RelationsE-mail: Novartis Investor RelationsCentral investor relations line: +41 61 324 7944E-mail: in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data