
Doomsday Clock is closest its ever been to human extinction, but University of Chicago scientists remain optimistic
It was a small change, but a frightening one. Last month, the "Doomsday Clock" was moved up to 89 seconds, the closest the world has ever been to total annihilation.
The Bulletin of Atomic Scientists, based at the University of Chicago, uses the clock as a metaphor to show how close the planet is to reaching human extinction.
Believe it or not, the goal of the Doomsday Clock isn't to scare you. It's to make you take action.
Despite the grim message the clock currently conveys, one of the people behind it is actually optimistic about humanity's future.
University of Chicago professor Daniel Holz is one of the people who moved the Doomsday Clock forward last month. He's the current chair of the Science and Security Board at the Bulletin of Atomic Scientists, which has been tracking the risk of world destruction since atomic weapons were invented.
"It's a symbolic thing. We're trying to capture the urgency of the moment," he said. "We're at a moment of incredible danger. Everyone is freaked out. What are we doing? We need to turn the clock back."
At this moment, Holz said humanity is threatened by nuclear weapons…
"We're building more weapons, we're modernizing the arsenal. Even though we have plenty of weapons to wipe out civilization many times over ... we want even more and even better weapons. You can ask why, but we're doing it, China's doing it, Russia is doing it, the treaties are all going away," he said.
Climate change...
"Climate change is happening. We just came off the hottest year on record. There are fires, there was floods, there's extreme drought. There are extreme storms. It's all happening. I don't think anyone paying any attention has any doubt at this point that climate change is happening, and it's getting worse," Holz said.
Biohazards like pandemics...
"Because of travel, because of modern life as we know it, pandemics have a tendency to go much faster, and we saw that with COVID, and no place is safe," Holz said.
And even artificial intelligence...
"If an AI hallucinates and ends civilization, that would be a bummer," Holz said.
But the clock isn't meant to depress you. It's designed to inspire you.
"We're hoping that, by bringing attention to this, people will react accordingly, and the clock will be turned back," Holz said.
The clock did turn back in 2010.
So, what would make Holz and the Bulletin move the clock in the right direction again?
"Heads of state saying, 'Whoa, we do have to talk. Let's not just demonize each other, but let's sit down and try to make a deal. Let's try to work something out.' That is progress," he said.
Holz said there are already positive signs on climate change.
"The world is increasingly aware; and citizens, people on the streets are increasingly aware. We need that to kind of trickle up, as it were, to leadership," Holz said. "To be on this board to work with the Doomsday Clock is a fundamentally optimistic endeavor. If we were convinced it was hopeless, there's no point in spending one's time doing this."
The furthest from midnight the Doomsday Clock has ever been was 17 minutes to midnight in 1991, after the Cold War ended and a new arms treaty between the U.S. and the Soviet Union greatly reduced the number of nuclear weapons in their arsenals.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
18 hours ago
- Yahoo
New coronavirus discovered in China ‘only small step' from infecting humans
A new coronavirus discovered in China is only a small step from mutating and causing another global pandemic, experts have warned. Scientists believe the variant, called HKU5-CoV-2, may infect a broader range of animals than Covid-19 – which caused millions of deaths – and may have more potential for jumping between species. US researchers fear that HKU5-CoV-2, found in China, in February, could also infect humans, leading to a widespread outbreak. The new study, published in Nature Communications, looked at a lesser-known group of coronaviruses called merbecoviruses, which includes HKU5 and MERS-CoV, which is responsible for the deadly Middle East Respiratory Syndrome. The team from Washington State University looked at how the new pathogen interacts with human cells. They found that a small change in the virus's spike protein could allow it to attach to human ACE2 cells in people's throats, mouths and noses. HKU5-CoV-2 can infect and replicate inside human cells in both the airways and gut. According to the World Health Organisation, about 35 per cent of people infected with Middle East Respiratory Syndrome die. Since 2012, some 27 countries have reported cases, leading to 858 known deaths due to the infection, which spread from camels. But when HKU5 was discovered in February, scientists warned against exaggerating the risks because it does not enter human cells as readily as Sars-CoV-2, which caused Covid-19. HKU5 was first detected in bats by scientists from the Chinese laboratory where some say Covid originated in 2019. Prof Michael Letko, a virologist who co-led the study, said: 'HKU5 viruses in particular really hadn't been looked at much, but our study shows how these viruses infect cells. 'What we also found is HKU5 viruses may be only a small step away from being able to spill over into humans.' When Covid-19 emerged it was widely blamed on markets in China where different breeds of wild animal are kept caged and often slaughtered close to other animals. Meat is sold at the open-air stalls. Critics said the markets were the perfect breeding ground for new zoonotic diseases – those that spread to humans – to emerge. The scientists, whose experiments studied how the new pathogen interacts with human cells, believe the virus would have to carry certain mutations if it were to infect humans. 'These viruses are closely related to MERS, so we have to be concerned if they ever infect humans,' Prof Letko said. 'While there's no evidence they've crossed into people yet, the potential is there and that makes them worth watching.'


Politico
a day ago
- Politico
AI, the disruptor-in-chief
FORWARD THINKING Artificial intelligence is upending how industries function and it's coming for scientific research next. Rene Caissie, an adjunct professor at Stanford University, wants AI to conduct research. In 2021, he started a company, that lets public health departments, researchers and life sciences companies pose research questions and receive answers immediately. And, unlike many AI systems, Caissie told Ruth, the AI explains those answers by showing the data its results are based on. 'It used to be hard to do research,' he said, explaining that it takes a lot of time for researchers to get access to and organize data in order to answer basic scientific questions. Manual data analysis can also take months. The company is now partnering with HealthVerity, a provider of real-world health data, to build up its data sources. In turn, HealthVerity will offer Medeloop's research platform to its clients. The company has worked with the Food and Drug Administration, the National Institutes of Health, and the Centers for Disease Control and Prevention in the past. Caissie says the New York City Department of Health and Mental Hygiene is already using Medeloop's AI to run public health analyses. Why it matters: Public health departments receive huge amounts of data on human health from a variety of sources. But prepping that information and analyzing it can be onerous. Having access to a research platform like Medeloop could give public health departments and academic medical centers much faster insight into trends and in turn enable them to respond more quickly. How it works: Medeloop's AI is designed to think like a researcher. In a demo, Medeloop strategist John Ayers asked the bot how many people received a first-time autism diagnosis, broken down by age, race and sex, and what trends were visible with that data. He wanted the AI to only include people who had had interactions with a doctor for at least two years prior to diagnosis. The platform returned a refined query to improve results and a suggestion for what medical codes to use to identify the right patients for inclusion in the study. It delivered a trial design that looked at a cohort of 799,560 patients with new autism diagnoses between January 2015 and December 2024. Medeloop's AI showed that 70 percent of new autism diagnoses were for males. A monthly trends report found that, outside of a dip during the Covid-19 pandemic, new autism diagnoses have been on the rise, particularly among 5-11 year olds since 2019. Though Medeloop doesn't determine the cause of autism, the ease with which users can obtain answers could help speed up the pace of research. One of the platform's key innovations is its use of a federated network of data. Medeloop's new deal with HealthVerity will raise the platform's de-identified and secure patient records to 200 million. Notably, the data never leaves the health system, which increases security. Instead, Medeloop sends its AI to wherever the data is stored, analyzes it there and then returns the results to the platform. WELCOME TO FUTURE PULSE This is where we explore the ideas and innovators shaping health care. Scientists are making cover art and figures for research papers using artificial intelligence. Now illustrators are calling them out, Nature's Kamal Nahas reports. Share any thoughts, news, tips and feedback with Danny Nguyen at dnguyen@ Carmen Paun at cpaun@ Ruth Reader at rreader@ or Erin Schumaker at eschumaker@ Want to share a tip securely? Message us on Signal: Dannyn516.70, CarmenP.82, RuthReader.02 or ErinSchumaker.01. TECH MAZE Large language models like ChatGPT and Claude generate inferior mental health care treatment when presented with data about a patient's race, according to a study published this week in npj Digital Medicine. The findings: Researchers from Cedars-Sinai, Stanford University and the Jonathan Jaques Children's Cancer Institute tested how artificial intelligence would produce diagnoses for psychiatric patient cases under three conditions: race neutral, race implied and race explicitly stated using four models. They included the commercially available large language models ChatGPT, Claude and Gemini, as well as NewMes-15, a local model that can run on personal devices without cloud services. The researchers then asked clinical and social psychologists to evaluate the findings for bias. Most LLMs recommended dramatically different treatments for African American patients compared with others, even when they had the same psychiatric disorder and patient profile outside of race. The LLMs also proposed inferior treatments when they were made aware of a patient's race, either explicitly or implicitly. The biases likely come from the way LLMs are trained, the researchers wrote, and it's unclear how developers can mitigate those biases because 'traditional bias mitigation strategies that are standard practice, such as adversarial training, explainable AI methods, data augmentation and resampling may not be enough,' the researchers wrote. Why it matters: The study is one of the first evaluations of racial bias on psychiatric diagnoses across multiple LLMs. It comes as people increasingly turn to chatbots like ChatGPT for mental health advice and medical diagnoses. The results underscore the nascent technology's flaws. What's next: The study was small — only 10 cases were examined — which might not fully capture the consistency or extent of bias. The authors suggest that future studies could focus on a single condition with more cases for deeper analysis.


Indianapolis Star
a day ago
- Indianapolis Star
Moderna Announces Update on Investigational Pandemic Influenza Program
Phase 1/2 H5 avian flu vaccine study shows positive interim results Company has been notified that HHS will terminate Moderna's award for late-stage development of pre-pandemic influenza vaccines CAMBRIDGE, MA / ACCESS Newswire Moderna, Inc. (NASDAQ:MRNA) today announced positive interim data from a Phase 1/2 clinical study (NCT05972174) evaluating the safety and immunogenicity of its investigational pandemic influenza vaccine, mRNA-1018, in approximately 300 healthy adults aged 18 years and older. The interim results focus on a vaccine candidate targeting the H5 avian influenza virus subtype. The Company had previously expected to advance the program to late-stage development with the U.S. Department of Health and Human Services (HHS); however, today Moderna received notice that HHS will terminate the award for the late-stage development and right to purchase pre-pandemic influenza vaccines. 'While the termination of funding from HHS adds uncertainty, we are pleased by the robust immune response and safety profile observed in this interim analysis of the Phase 1/2 study of our H5 avian flu vaccine and we will explore alternative paths forward for the program,' said Stéphane Bancel, Chief Executive Officer of Moderna. 'These clinical data in pandemic influenza underscore the critical role mRNA technology has played as a countermeasure to emerging health threats.' The Phase 1/2 study evaluated a two-dose regimen of Moderna's investigational avian influenza vaccine. mRNA-1018 demonstrated a rapid, potent and durable immune response. At baseline, pre-existing immunity was minimal, with only 2.1% of participants showing hemagglutination inhibition (HAI) antibody titers ≥1:40, an HAI titer considered to correlate with protection. At Day 43, three weeks after the second vaccination, 97.8% of participants achieved titers ≥1:40 with a 44.5-fold increase of titers from baseline. The investigational vaccine was generally well-tolerated, with no dose-limiting tolerability concerns observed. Most solicited adverse reactions were Grade 1 or 2 and did not increase significantly with number of doses or between first and second doses. Further data is expected to be submitted for presentation at an upcoming scientific meeting. Moderna will explore alternatives for late-stage development and manufacturing of the H5 program consistent with the Company's strategic commitment to pandemic preparedness. About Moderna Moderna is a leader in the creation of the field of mRNA medicine. Through the advancement of mRNA technology, Moderna is reimagining how medicines are made and transforming how we treat and prevent disease for everyone. By working at the intersection of science, technology and health for more than a decade, the company has developed medicines at unprecedented speed and efficiency, including one of the earliest and most effective COVID-19 vaccines. Moderna's mRNA platform has enabled the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and autoimmune diseases. With a unique culture and a global team driven by the Moderna values and mindsets to responsibly change the future of human health, Moderna strives to deliver the greatest possible impact to people through mRNA medicines. For more information about Moderna, please visit and connect with us on X (formerly Twitter), Facebook, Instagram, YouTube and LinkedIn. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including statements regarding: the clinical development of mRNA-1018, the safety and immunogenicity data from the Phase 1/2 study; the cancellation of the development contract for Moderna's pandemic flu program by the U.S. Department of Health and Human Services; and the exploration of alternative paths for development of the vaccine program. The forward-looking statements in this press release are neither promises nor guarantees, and you should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, many of which are beyond Moderna's control and which could cause actual results to differ materially from those expressed or implied by these forward-looking statements. These risks, uncertainties, and other factors include, among others, those risks and uncertainties described under the heading 'Risk Factors' in Moderna's Annual Report on Form 10-K for the fiscal year ended December 31, 2024, and in subsequent filings made by Moderna with the U.S. Securities and Exchange Commission, which are available on the SEC's website at Except as required by law, Moderna disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this press release in the event of new information, future developments or otherwise. These forward-looking statements are based on Moderna's current expectations and speak only as of the date of this press release. Moderna Contacts Investors: Lavina Talukdar Senior Vice President & Head of Investor Relations +1 617-209-5834 SOURCE: Moderna, Inc. View the original press release on ACCESS Newswire