[Latest] Global Neoantigen Cancer Vaccine Market Size/Share Worth USD 1.98 Billion by 2034 at a 15.2% CAGR: Custom Market Insights (Analysis, Outlook, Leaders, Report, Trends, Forecast, Segmentation, Growth Rate, Value, SWOT Analysis)

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[220+ Pages Latest Report] According to a market research study published by Custom Market Insights, the demand analysis of Global Neoantigen Cancer Vaccine Market size & share revenue was valued at approximately USD 0.49 Billion in 2024 and is expected to reach USD 0.55 Billion in 2025 and is expected to reach around USD 1.98 Billion by 2034, at a CAGR of 15.2% between 2025 and 2034. The key market players listed in the report with their sales, revenues and strategies are OSE Immunotherapeutics SA, Gritstone bio Inc., BioNTech SE, Hoffmann-La Roche Ltd., Pfizer Inc., Merck & Co. Inc., Moderna Inc., Avidea Technologies Inc., Eli Lilly and Company, Vaccibody AS, Agenus Inc., Novogene Co. Ltd., ZIOPHARM Oncology Inc., ISA Pharmaceuticals B.V., BrightPath Biotherapeutics Co. Ltd., Vaximm AG, Medigene AG, Genocea Biosciences Inc., Advaxis Inc, and others.
Austin, TX, USA, June 10, 2025 (GLOBE NEWSWIRE) -- Custom Market Insights has published a new research report titled 'Neoantigen Cancer Vaccine Market Size, Trends and Insights By Product (Personalised antigen vaccine, Off-the-shelf neoantigen vaccine), By Neoantigen Type (Synthetic Long Peptide, Nucleic acid, Dendritic cell, Tumour cell), By Route of Administration (Intravenous, Intramuscular, Transdermal), and By Region - Global Industry Overview, Statistical Data, Competitive Analysis, Share, Outlook, and Forecast 2025–2034' in its research database.
'According to the latest research study, the demand of global Neoantigen Cancer Vaccine Market size & share was valued at approximately USD 0.49 Billion in 2024 and is expected to reach USD 0.55 Billion in 2025 and is expected to reach a value of around USD 1.98 Billion by 2034, at a compound annual growth rate (CAGR) of about 15.2% during the forecast period 2025 to 2034.'
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Neoantigen Cancer Vaccine Market Overview
As per the industry experts at CMI, the Neoantigen Cancer Vaccine Market is quickly growing as a result of the significance placed on personalized cancer therapies. The leading companies include OSE Immunotherapeutic SA, Gritstone Bio Inc., BioNTech SE, Hoffmann-La Roche Ltd and Pfizer Inc., all of whom are developing individualized cancer vaccines targeting patient-specific tumor neoantigens to enhance the immune response. Various malignancies are receiving these vaccines to enhance their outcomes.
Governments are supporting clinical trials and exploring fast-track CRA regulatory approvals to help accelerate the process and innovations. The pharma, biotechnology, and research community continue driving collaborations to advance cancer vaccines. Investment funding is increasing in the neoantigen cancer vaccine products globally—North America, Europe and Asia- pacific are the top three regions. This experience will add a new wave of molecularly-targeted and precisely effective cancer immunotherapies to the suite of effective pharmaceutical therapies worldwide.
Neoantigen Cancer Vaccine Market Growth Factors and Dynamics
Increasing incidence of cancer: The increasing incidence of cancer worldwide is a driving force behind the growth of the neoantigen cancer vaccine market. The increasing incidence of cancer creates a large demand for innovative, personalized therapies. Neoantigen vaccines designed to target mutations unique to an individual's tumor provide a breaking point in addressing multiple cancers effectively. The recent, notable positive Phase 2 results by BioNTech for its mRNA immunotherapy candidate BNT111 in patients with advanced melanoma in 2024 illustrate a greater focus on personalized cancer therapies. Furthermore, the increasing incidence of cancer diagnoses shown by the U.S. National Cancer Institute provides a pertinent need for advanced therapies like neoantigen vaccines.
Advances in delivery systems: Advances in delivery systems for vaccines, such as lipid nanoparticles and viral vectors, have provided stability, targeting, and greater efficacy regarding neoantigen vaccines, in addition to improving clinical response and efficacy in personalized cancer therapies. Again, the international Phase 3 'Artemia' trial, which was launched by OSE Immunotherapeutics in 2024, is noteworthy. This Phase 3 trial is for Tedopi, an 'off-the-shelf' neo-epitope-based cancer vaccine for HLA-A2-positive patients with metastatic non-small cell lung cancer (NSCLC) and lethargy who developed secondary resistance to immune checkpoint inhibitors. This pivotal trial aims to gain regulatory approval for Tedopi. This is a meaningful advancement in the neoantigen vaccine delivery system and cancer treatment.
Increased cancer incidence: The incidence of cancer worldwide is one of the major factors propelling growth of the neoantigen cancer vaccine market. As pointed out by the World Health Organization (WHO), cancer is one of the leading causes of death worldwide, with approximately 20 million new cases and 10 million deaths every year. The increasing rates of cancer demand new, more effective, and targeted treatments other than the traditional ones of chemotherapy and radiation. Neoantigen cancer vaccines are unique and extremely specific personalized therapies that stimulate the immune system to identify and attack cancer cells 'with laser precision', without employing belated-acting toxic treatments like chemotherapy and radiation on healthy tissue. The increasing rates of difficult to treat cancers such as melanoma, non-small cell lung cancer, and particularly glioblastoma hold potential for these types of precision-based immunotherapy.
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Advancements in Immunotherapy: Recent breakthroughs in immunotherapy have significantly contributed to the emergence and expansion of the neoantigen cancer vaccine market. Immunotherapy has revolutionized oncology by offering treatments that harness the body's immune system to target and eliminate cancer cells. Among these, neoantigen vaccines represent a cutting-edge class of therapies that are personalized based on tumor-specific mutations, making them uniquely suited for individualized treatment strategies. Innovations such as checkpoint inhibitors, CAR-T cells, and adoptive T-cell therapies have validated the immune system's potential in combating cancer, laying the groundwork for further development of neoantigen approaches. Additionally, the integration of advanced computational biology and next-generation sequencing technologies enables rapid identification and synthesis of neoantigens, accelerating vaccine production timelines and improving therapeutic outcomes. These technological advancements are critical in transforming experimental treatments into viable commercial products.
Report Scope
Feature of the Report
Details
Market Size in 2025
USD 0.55 Billion
Projected Market Size in 2034
USD 1.98 Billion
Market Size in 2024
USD 0.49 Billion
CAGR Growth Rate
15.2% CAGR
Base Year
2024
Forecast Period
2025-2034
Key Segment
By Product, Neoantigen Type, Route of Administration and Region
Report Coverage
Revenue Estimation and Forecast, Company Profile, Competitive Landscape, Growth Factors and Recent Trends
Regional Scope
North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America
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Neoantigen Cancer Vaccine Market SWOT Analysis
Strengths: Neoantigen cancer vaccines offer a significant degree of personalization in treatment as they target the specific mutations that can be found in each patient's tumors, which promotes precision in treatment. They have demonstrated great potential in treating cancers not otherwise treatable with standard therapies. In addition, the advances of both genomic sequencing and mRNA and its abbreviated immunogenicity promise, neoantigen cancer vaccines have the potential to show equally enhanced immunogenicity. Growing investment from major biotech firms and government agencies supports rapid R&D. Regulatory agencies like the FDA and EMA are offering fast-track approvals. Early clinical trials, especially in melanoma and NSCLC, have demonstrated promising results.
Weaknesses: High development costs and complex production processes limit scalability and accessibility. The need for advanced genomic sequencing and bioinformatics infrastructure creates technical bottlenecks. Turnaround time for creating personalized vaccines can be lengthy. Reimbursement challenges exist due to the novel nature of the therapy. Limited long-term efficacy data in many cancer types also restricts broader adoption. Workforce and supply chain challenges can delay progress, as seen in recent clinical trial halts.
Opportunities: Some developing markets such as India, Brazil, and South Africa present new opportunities for clinical expansion. Off-the-shelf vaccine approaches may provide the opportunity for scalability and reduced cost. Improved AI and bioinformatics technology may increase neoantigen prediction accuracy and ease of vaccine design. Biotech and healthcare companies are entering into strategic collaborative agreements, which are improving access. Governments and organizations are interested in funding initiatives in personalized cancer care. Increasing global incidence of cancer is increasing demand for new therapies.
Threats: As immunotherapies increase competition from other immunotherapies such as checkpoint inhibitors and CAR-T cells, this will cannibalize market share. Regulatory challenges and lack of standards in approvals may increase timeframes. Investor confidence may be challenged due to late-stage clinical trial failures potentially demonstrated by Gritstone Bio, which affect confidence in further investment into the new treatment that is a neoantigen cancer vaccine. The type of information shared digitally is related to genomic data and presents cybersecurity challenges. There may also be pricing barriers for access within the healthcare systems due to potential sensitivity towards the cost of the intervention. Similarly, I believe that we can expect frequent patent disputes and IP threats associated with the emergence of personalised cancer therapy.
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Market Share, Size & Forecast by Revenue | 2025−2034
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Competitive Landscape – Top Key Vendors and Other Prominent Vendors
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Neoantigen Cancer Vaccine Market Regional Perspective
The Neoantigen Cancer Vaccine Market can be divided across different regions such as North America, Europe, Asia-Pacific, and LAMEA. This is a cursory overview of each region:
North America: In the US, substantial advances have been made in neoantigen cancer vaccine research. For example, a Phase I trial at the Dana-Farber Cancer Institute showed results from a personalized neoantigen vaccine for advanced kidney cancer, with all nine patients being cancer-free after a median follow-up of 35 months with no serious adverse events. Mount Sinai researchers showed that a multi-peptide neoantigen cancer vaccine induced strong immune responses across multiple cancers in a Phase I trial. Moreover, Memorial Sloan Kettering Cancer Center shared an early-phase clinical trial, which demonstrated an investigational mRNA vaccine can induce sustained immune activity in pancreatic cancer patients.
Europe: European organizations are also making incremental research advances in neoantigen vaccines. At the 2024 American Association for Cancer Research (AACR) Annual Meeting, researchers from Institut Curie in Paris presented findings of a therapeutic cancer vaccine developed for each individual tumor. The therapeutic cancer vaccine showed strong immune responses when applied in a head and neck squamous cell carcinoma patient cohort. Transgene and NEC Corporation presented follow-up data from their Phase I trial of their individualized cancer vaccine, TG4050, in a cohort of head and neck cancer patients and will be commencing a randomized Phase II extension of the trial. The UK-based National Health Service (NHS) started trials.
Asia-Pacific: In the Asia-Pacific region, collaborative efforts have been made to advance neoantigen vaccine development. In March 2024, Boston Gene, NEC, and Transgene joined forces to advance their Phase I/II clinical trial for the neoantigen cancer vaccine TG4050, aiming to harness personalized medicine to combat cancer. Additionally, Everest Medicines announced financial results highlighting their efforts in developing a vaccine designed to encode dozens of tumor neoantigens using a lipid nanoparticle delivery system for efficient delivery of neoantigen-encoded mRNA.
LAMEA: The Relative scarcity of reporting on advances being made in developing neoantigen cancer vaccines in LAMEA has also resulted in much less excitement about the field. Still, LAMEA is witnessing increasing interest in cancer immunotherapy. Many collaborations and clinical trials are expanding to include populations outside the continent and share genetic backgrounds to better understand the efficacy and safety of these personalized cancer therapies. These types of moves in LAMEA will be critical for the global usability of neoantigen vaccines, and there is a great deal of support for these undertakings via global partnerships, as well as, development in the health infrastructure related to very early stage research.
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List of the prominent players in the Neoantigen Cancer Vaccine Market:
OSE Immunotherapeutics SA
Gritstone bio Inc.
BioNTech SE
Hoffmann-La Roche Ltd.
Pfizer Inc.
Merck & Co. Inc.
Moderna Inc.
Avidea Technologies Inc.
Eli Lilly and Company
Vaccibody AS
Agenus Inc.
Novogene Co. Ltd.
ZIOPHARM Oncology Inc.
ISA Pharmaceuticals B.V.
BrightPath Biotherapeutics Co. Ltd.
Vaximm AG
Medigene AG
Genocea Biosciences Inc.
Advaxis Inc.
Others
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The Neoantigen Cancer Vaccine Market is segmented as follows:
By Product
Personalised neo-antigen vaccine
Off-the-shelf neoantigen vaccine
By Neoantigen Type
Synthetic Long Peptide
Nucleic acid
Dendritic cell
Tumour cell
By Route of Administration
Intravenous
Intramuscular
Transdermal
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Regional Coverage:
North America
U.S.
Canada
Mexico
Rest of North America
Europe
Germany
France
U.K.
Russia
Italy
Spain
Netherlands
Rest of Europe
Asia Pacific
China
Japan
India
New Zealand
Australia
South Korea
Taiwan
Rest of Asia Pacific
The Middle East & Africa
Saudi Arabia
UAE
Egypt
Kuwait
South Africa
Rest of the Middle East & Africa
Latin America
Brazil
Argentina
Rest of Latin America
This Neoantigen Cancer Vaccine Market Research/Analysis Report Contains Answers to the following Questions.
Which Trends Are Causing These Developments?
Who Are the Global Key Players in This Neoantigen Cancer Vaccine Market? What are Their Company Profile, Product Information, and Contact Information?
What Was the Global Market Status of the Neoantigen Cancer Vaccine Market? What Was the Capacity, Production Value, Cost and PROFIT of the Neoantigen Cancer Vaccine Market?
What Is the Current Market Status of the Neoantigen Cancer Vaccine Industry? What's Market Competition in This Industry, Both Company and Country Wise? What's Market Analysis of Neoantigen Cancer Vaccine Market by Considering Applications and Types?
What Are Projections of the Global Neoantigen Cancer Vaccine Industry Considering Capacity, Production and Production Value? What Will Be the Estimation of Cost and Profit? What Will Be Market Share, Supply and Consumption? What about imports and exports?
What Is Neoantigen Cancer Vaccine Market Chain Analysis by Upstream Raw Materials and Downstream Industry?
What Is the Economic Impact On Neoantigen Cancer Vaccine Industry? What are Global Macroeconomic Environment Analysis Results? What Are Global Macroeconomic Environment Development Trends?
What Are Market Dynamics of Neoantigen Cancer Vaccine Market? What Are Challenges and Opportunities?
What Should Be Entry Strategies, Countermeasures to Economic Impact, and Marketing Channels for Neoantigen Cancer Vaccine Industry?
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Reasons to Purchase Neoantigen Cancer Vaccine Market Report
Neoantigen Cancer Vaccine Market Report provides qualitative and quantitative analysis of the market based on segmentation involving economic and non-economic factors.
Neoantigen Cancer Vaccine Market report outlines market value (USD) data for each segment and sub-segment.
This report indicates the region and segment expected to witness the fastest growth and dominate the market.
Neoantigen Cancer Vaccine Market Analysis by geography highlights the consumption of the product/service in the region and indicates the factors affecting the market within each region.
The competitive landscape incorporates the market ranking of the major players, along with new service/product launches, partnerships, business expansions, and acquisitions in the past five years of companies profiled.
Extensive company profiles comprising company overview, company insights, product benchmarking, and SWOT analysis for the major market players.
The Industry's current and future market outlook concerning recent developments (which involve growth opportunities and drivers as well as challenges and restraints of both emerging and developed regions.
Neoantigen Cancer Vaccine Market Includes in-depth market analysis from various perspectives through Porter's five forces analysis and provides insight into the market through Value Chain.
Reasons for the Research Report
The study provides a thorough overview of the global Neoantigen Cancer Vaccine market. Compare your performance to that of the market as a whole.
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What does the report include?
Drivers, restrictions, and opportunities are among the qualitative elements covered in the worldwide Neoantigen Cancer Vaccine market analysis.
The competitive environment of current and potential participants in the Neoantigen Cancer Vaccine market is covered in the report, as well as those companies' strategic product development ambitions.
According to the component, application, and industry vertical, this study analyzes the market qualitatively and quantitatively. Additionally, the report offers comparable data for the important regions.
For each segment mentioned above, actual market sizes and forecasts have been given.
Who should buy this report?
Participants and stakeholders worldwide Neoantigen Cancer Vaccine market should find this report useful. The research will be useful to all market participants in the Neoantigen Cancer Vaccine industry.
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