TGA approves Eli Lilly drug Kisunla in boost for dementia patients
The Therapeutic Goods Administration has approved a new drug tipped to revolutionise the treatment of hundreds of thousands of Australians suffering through early-stage Alzheimer's disease.
The breakthrough therapy called Kisunla, also known as donanemab, is designed to slow cognitive decline in patients by clearing amyloid plaques from the brain.
Frank Freschi, 77, from Melbourne, took the treatment as part of a clinical trial and said he hoped the drug could give him more time to enjoy with his grandchildren.
'I used to be able to remember lots of things, now I can remember what I did 40 years ago but not what I did 40 hours ago,' he said.
'Accessing an amyloid targeting therapy has meant holding onto the hope that I'm a little bit in control of my life, of what's happening to me.
'I'm also hoping that one day I will have helped medical science to produce a drug that will work for many people.
'And, selfishly, that I too may be able to get some more time out of it to enjoy with my family and my six grandkids.'
The TGA approved the drug, produced by US pharmaceutical behemoth Eli Lilly, on Wednesday, marking the first new treatment for early Alzheimer's disease in 25 years.
Alzheimer's is a fatal neurodegenerative disease and the most common cause of dementia, which impacts about 600,000 Australians directly and a further 1.7 million carers.
The economic impact of dementia from Alzheimer's was calculated at $8.1bn in 2024, with the figure expected to double by 2050.
The excessive build-up of amyloid plaques in the brain disrupts the brain's neurons and prevents messages from travelling normally, leading to memory and thinking issues.
Professor Peter Gonski, a Sydney-based geriatrician and Alzheimer's specialist, told NewsWire the treatment could potentially give two years back to patients.
'For those starting to deteriorate, it will give them an extra couple of years in benefit in those that do well on it,' he said.
'You're getting a better start in your dementia history.'
Professor Gonski stressed, however, the treatment could slow decline but would not cure the disease.
'When it gets to moderate or severe, it's not going to make a lot of difference, except that you have had that extra time when you were better,' he said.
Patients receive an intravenous injection of the drug once every four weeks.
Dementia Australia chief executive Tanya Buchanan said the TGA's approval marked a 'step forward' in dementia treatment, but the treatment would only impact a select profile of patients.
'With dementia the second leading cause of death of Australians and the leading cause of death of Australian women, we welcome any steps taken towards improving the lives of people living with dementia, their families and carers,' Professor Buchanan said.
'It is important to note that donanemab does come with possible side effects that needs to be carefully communicated to patients so they can make an informed choice and the treatment needs to be monitored by health professionals.
'We also need to ensure people understand that donanemab is not a cure and is only suitable for people in the early stages of Alzheimer's disease with a defined genetic profile, which is why it is so important for people to receive a timely diagnosis.'
Eli Lilly, a $1 trillion company listed on the New York Stock Exchange, will apply for donanemab to be included on the Pharmaceutical Benefits Scheme, with an advisory committee hearing expected in July.
The private prescription price is about $4700 for each injection.
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ABC News
3 hours ago
- ABC News
Professor Richard Scolyer completes 250th Parkrun, a goal set after cancer diagnosis
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The Advertiser
3 hours ago
- The Advertiser
'The stress brought the cancer on': 64yo woman scammed out of $223,000
Six months before Jenny Egan was diagnosed with advanced lung cancer, she was scammed out of $223,000. Ms Egan, 64, was diagnosed on her birthday on May 7. She saw her doctor that day, who told her "there's a mass on your lung". "I was devastated," said Ms Egan, of Fishing Point in Lake Macquarie. She connected on social media with a man from the US last year. "He basically tricked her into investing money in cryptocurrency," Jenny's daughter Brittney Egan said. Brittney, 29, has set up a GoFundMe for her mum, titled "Jenny's lung cancer battle". "My mum means the world to me. She's not just a parent, she's also my best friend," she said. "She inspires me with her kindness and generosity. She's been knocked down many times and got back up. I believe she can do it again." Ms Egan shared her story to raise awareness to prevent others from being scammed. "He had my phone number and pressured me non-stop to add more money," she said. "I was suicidal when I realised I'd been scammed. I just think the stress has brought the cancer on." She was a smoker, but had never been in hospital before and felt healthy. Ms Egan reported the scam to police and the Australian Cyber Security Centre. The security centre's scam portal sends such reports to the police and/or the ACCC's ScamWatch. A National Anti-Scam Centre spokesperson said it had "referred the website to be assessed for takedown". "We encourage all Australians to report suspicious scam activity via the Scamwatch service to support the disruption of scam networks." A nurse for 20 years at Wyong Hospital and in aged care, Ms Egan now works in patient transport. She was diagnosed with lung cancer after suffering from "pains in the right side of my chest". "I thought I'd pulled a muscle," she said. A doctor referred her for a CT scan. "I had five days of pain and each day the pain got less and less and then went," she said. She considered cancelling, but went because it was free. Her doctor, based at Tuggerah where Brittney works as a nurse, phoned the next day. She was referred to a respiratory physician in Gosford. "I had to go to hospital for a biopsy and bronchoscopy," she said. "The doctor said if it's not too bad, he'd do a resection of my lung. "Unfortunately, it was bad. He rang me a week later with the results and said it's inoperable." The doctor confirmed a tumour on her lung had spread to an adrenal gland and was a stage four cancer. She will begin radiation on the adrenal gland at Gosford Hospital on Wednesday. She will then have chemotherapy and further radiation for her lung. "I'm a mess, but I'm trying to stay at work. That's the only thing that keeps me sane and stops me from falling in a heap. "I try to think about other people and my job, rather than myself. I don't want to upset my kids." Her children, including son Chad, want her to "stay mentally strong because they believe that helps". "I'm a fighter and I'm not giving up," she said. Lake Macquarie Police began investigating after Ms Egan reported she had been scammed from August to November 2024. "As inquiries into the incident continue, anyone with information is urged to contact Lake Macquarie Police or Crime Stoppers on 1800 333 000," a police statement said. "Police urge anyone observing suspicious online activity and unknown solicitation of investment opportunities to be cautious and consider fraud prevention advice." Six months before Jenny Egan was diagnosed with advanced lung cancer, she was scammed out of $223,000. Ms Egan, 64, was diagnosed on her birthday on May 7. She saw her doctor that day, who told her "there's a mass on your lung". "I was devastated," said Ms Egan, of Fishing Point in Lake Macquarie. She connected on social media with a man from the US last year. "He basically tricked her into investing money in cryptocurrency," Jenny's daughter Brittney Egan said. Brittney, 29, has set up a GoFundMe for her mum, titled "Jenny's lung cancer battle". "My mum means the world to me. She's not just a parent, she's also my best friend," she said. "She inspires me with her kindness and generosity. She's been knocked down many times and got back up. I believe she can do it again." Ms Egan shared her story to raise awareness to prevent others from being scammed. "He had my phone number and pressured me non-stop to add more money," she said. "I was suicidal when I realised I'd been scammed. I just think the stress has brought the cancer on." She was a smoker, but had never been in hospital before and felt healthy. Ms Egan reported the scam to police and the Australian Cyber Security Centre. The security centre's scam portal sends such reports to the police and/or the ACCC's ScamWatch. A National Anti-Scam Centre spokesperson said it had "referred the website to be assessed for takedown". "We encourage all Australians to report suspicious scam activity via the Scamwatch service to support the disruption of scam networks." A nurse for 20 years at Wyong Hospital and in aged care, Ms Egan now works in patient transport. She was diagnosed with lung cancer after suffering from "pains in the right side of my chest". "I thought I'd pulled a muscle," she said. A doctor referred her for a CT scan. "I had five days of pain and each day the pain got less and less and then went," she said. She considered cancelling, but went because it was free. Her doctor, based at Tuggerah where Brittney works as a nurse, phoned the next day. She was referred to a respiratory physician in Gosford. "I had to go to hospital for a biopsy and bronchoscopy," she said. "The doctor said if it's not too bad, he'd do a resection of my lung. "Unfortunately, it was bad. He rang me a week later with the results and said it's inoperable." The doctor confirmed a tumour on her lung had spread to an adrenal gland and was a stage four cancer. She will begin radiation on the adrenal gland at Gosford Hospital on Wednesday. She will then have chemotherapy and further radiation for her lung. "I'm a mess, but I'm trying to stay at work. That's the only thing that keeps me sane and stops me from falling in a heap. "I try to think about other people and my job, rather than myself. I don't want to upset my kids." Her children, including son Chad, want her to "stay mentally strong because they believe that helps". "I'm a fighter and I'm not giving up," she said. Lake Macquarie Police began investigating after Ms Egan reported she had been scammed from August to November 2024. "As inquiries into the incident continue, anyone with information is urged to contact Lake Macquarie Police or Crime Stoppers on 1800 333 000," a police statement said. "Police urge anyone observing suspicious online activity and unknown solicitation of investment opportunities to be cautious and consider fraud prevention advice." Six months before Jenny Egan was diagnosed with advanced lung cancer, she was scammed out of $223,000. Ms Egan, 64, was diagnosed on her birthday on May 7. She saw her doctor that day, who told her "there's a mass on your lung". "I was devastated," said Ms Egan, of Fishing Point in Lake Macquarie. She connected on social media with a man from the US last year. "He basically tricked her into investing money in cryptocurrency," Jenny's daughter Brittney Egan said. Brittney, 29, has set up a GoFundMe for her mum, titled "Jenny's lung cancer battle". "My mum means the world to me. She's not just a parent, she's also my best friend," she said. "She inspires me with her kindness and generosity. She's been knocked down many times and got back up. I believe she can do it again." Ms Egan shared her story to raise awareness to prevent others from being scammed. "He had my phone number and pressured me non-stop to add more money," she said. "I was suicidal when I realised I'd been scammed. I just think the stress has brought the cancer on." She was a smoker, but had never been in hospital before and felt healthy. Ms Egan reported the scam to police and the Australian Cyber Security Centre. The security centre's scam portal sends such reports to the police and/or the ACCC's ScamWatch. A National Anti-Scam Centre spokesperson said it had "referred the website to be assessed for takedown". "We encourage all Australians to report suspicious scam activity via the Scamwatch service to support the disruption of scam networks." A nurse for 20 years at Wyong Hospital and in aged care, Ms Egan now works in patient transport. She was diagnosed with lung cancer after suffering from "pains in the right side of my chest". "I thought I'd pulled a muscle," she said. A doctor referred her for a CT scan. "I had five days of pain and each day the pain got less and less and then went," she said. She considered cancelling, but went because it was free. Her doctor, based at Tuggerah where Brittney works as a nurse, phoned the next day. She was referred to a respiratory physician in Gosford. "I had to go to hospital for a biopsy and bronchoscopy," she said. "The doctor said if it's not too bad, he'd do a resection of my lung. "Unfortunately, it was bad. He rang me a week later with the results and said it's inoperable." The doctor confirmed a tumour on her lung had spread to an adrenal gland and was a stage four cancer. She will begin radiation on the adrenal gland at Gosford Hospital on Wednesday. She will then have chemotherapy and further radiation for her lung. "I'm a mess, but I'm trying to stay at work. That's the only thing that keeps me sane and stops me from falling in a heap. "I try to think about other people and my job, rather than myself. I don't want to upset my kids." Her children, including son Chad, want her to "stay mentally strong because they believe that helps". "I'm a fighter and I'm not giving up," she said. Lake Macquarie Police began investigating after Ms Egan reported she had been scammed from August to November 2024. "As inquiries into the incident continue, anyone with information is urged to contact Lake Macquarie Police or Crime Stoppers on 1800 333 000," a police statement said. "Police urge anyone observing suspicious online activity and unknown solicitation of investment opportunities to be cautious and consider fraud prevention advice." Six months before Jenny Egan was diagnosed with advanced lung cancer, she was scammed out of $223,000. Ms Egan, 64, was diagnosed on her birthday on May 7. She saw her doctor that day, who told her "there's a mass on your lung". "I was devastated," said Ms Egan, of Fishing Point in Lake Macquarie. She connected on social media with a man from the US last year. "He basically tricked her into investing money in cryptocurrency," Jenny's daughter Brittney Egan said. Brittney, 29, has set up a GoFundMe for her mum, titled "Jenny's lung cancer battle". "My mum means the world to me. She's not just a parent, she's also my best friend," she said. "She inspires me with her kindness and generosity. She's been knocked down many times and got back up. I believe she can do it again." Ms Egan shared her story to raise awareness to prevent others from being scammed. "He had my phone number and pressured me non-stop to add more money," she said. "I was suicidal when I realised I'd been scammed. I just think the stress has brought the cancer on." She was a smoker, but had never been in hospital before and felt healthy. Ms Egan reported the scam to police and the Australian Cyber Security Centre. The security centre's scam portal sends such reports to the police and/or the ACCC's ScamWatch. A National Anti-Scam Centre spokesperson said it had "referred the website to be assessed for takedown". "We encourage all Australians to report suspicious scam activity via the Scamwatch service to support the disruption of scam networks." A nurse for 20 years at Wyong Hospital and in aged care, Ms Egan now works in patient transport. She was diagnosed with lung cancer after suffering from "pains in the right side of my chest". "I thought I'd pulled a muscle," she said. A doctor referred her for a CT scan. "I had five days of pain and each day the pain got less and less and then went," she said. She considered cancelling, but went because it was free. Her doctor, based at Tuggerah where Brittney works as a nurse, phoned the next day. She was referred to a respiratory physician in Gosford. "I had to go to hospital for a biopsy and bronchoscopy," she said. "The doctor said if it's not too bad, he'd do a resection of my lung. "Unfortunately, it was bad. He rang me a week later with the results and said it's inoperable." The doctor confirmed a tumour on her lung had spread to an adrenal gland and was a stage four cancer. She will begin radiation on the adrenal gland at Gosford Hospital on Wednesday. She will then have chemotherapy and further radiation for her lung. "I'm a mess, but I'm trying to stay at work. That's the only thing that keeps me sane and stops me from falling in a heap. "I try to think about other people and my job, rather than myself. I don't want to upset my kids." Her children, including son Chad, want her to "stay mentally strong because they believe that helps". "I'm a fighter and I'm not giving up," she said. Lake Macquarie Police began investigating after Ms Egan reported she had been scammed from August to November 2024. "As inquiries into the incident continue, anyone with information is urged to contact Lake Macquarie Police or Crime Stoppers on 1800 333 000," a police statement said. "Police urge anyone observing suspicious online activity and unknown solicitation of investment opportunities to be cautious and consider fraud prevention advice."
The Advertiser
4 hours ago
- The Advertiser
PTSD in our elderly is a lesser-known side effect of extreme weather events
A forgotten side effect of extreme weather events, debilitating our elderly, is finally being brought into the light in a push for older Australians to be better cared for. Post Traumatic Stress Disorder and social isolation due to displacement and homelessness is not often talked about in mainstream media reports of such events like the Lismore floods or Cyclone Alfred. But the trauma can be intense and long-lasting for older Australians, according to a team from Griffith University and Anglicare Southern Queensland. Read more from The Senior: During a public webinar on June 12, aged care expert Victoria Cain spoke of an Anglicare aged care resident living with dementia who now has severe PTSD "superimposed on his dementia" because of the Lismore floods of 2022. "It's directly related to the floods because of the homelessness, so that alone is quite distressing ... many [aged care] residents have PTSD because of previous storm or flood events," said Ms Cain, Anglicare's Southern Queensland Clinical Lead, Specialist Dementia Care Program. "You then have an increase of isolation for residents who can't actually get out of their rooms or out of the floors. So it leads to isolation, it leads to increased depression, it leads to increased lack of mobility." In another instance, Ms Cain spoke of a recent stay in a hotel in Hervey Bay following Cyclone Alfred where the lifts had been inoperable since March and wouldn't be fixed for another 12 weeks. For some people this may be seen as an inconvenience, but for the elderly woman she met living on the top floor she would be heavily impacted by climbing up and down five flights of stairs every day - almost cut off from the world. Associate Professor Patricia Lee of Griffith University said whether it's bushfires, floods, cyclones or extreme heatwaves they all can have disruptive and harmful consequences on the elderly who need "continuous high care". The university is currently working with Anglicare on a research project investigating climate-change vulnerability on aged care residents and associated health impacts, while also looking at adaption strategies. "Older people are particularly vulnerable due to their age-related health conditions - chronic diseases, the climate vulnerabilities," Professor Lee said. "It can be isolating for people with underlying healthy conditions and also it reduces their mobility and increase social isolation - especially for those who are living alone." The research project will focus on two Queensland regional centres, Toowoomba and Hervey Bay. Share your thoughts in the comments below, or send a Letter to the Editor by CLICKING HERE. A forgotten side effect of extreme weather events, debilitating our elderly, is finally being brought into the light in a push for older Australians to be better cared for. Post Traumatic Stress Disorder and social isolation due to displacement and homelessness is not often talked about in mainstream media reports of such events like the Lismore floods or Cyclone Alfred. But the trauma can be intense and long-lasting for older Australians, according to a team from Griffith University and Anglicare Southern Queensland. Read more from The Senior: During a public webinar on June 12, aged care expert Victoria Cain spoke of an Anglicare aged care resident living with dementia who now has severe PTSD "superimposed on his dementia" because of the Lismore floods of 2022. "It's directly related to the floods because of the homelessness, so that alone is quite distressing ... many [aged care] residents have PTSD because of previous storm or flood events," said Ms Cain, Anglicare's Southern Queensland Clinical Lead, Specialist Dementia Care Program. "You then have an increase of isolation for residents who can't actually get out of their rooms or out of the floors. So it leads to isolation, it leads to increased depression, it leads to increased lack of mobility." In another instance, Ms Cain spoke of a recent stay in a hotel in Hervey Bay following Cyclone Alfred where the lifts had been inoperable since March and wouldn't be fixed for another 12 weeks. For some people this may be seen as an inconvenience, but for the elderly woman she met living on the top floor she would be heavily impacted by climbing up and down five flights of stairs every day - almost cut off from the world. Associate Professor Patricia Lee of Griffith University said whether it's bushfires, floods, cyclones or extreme heatwaves they all can have disruptive and harmful consequences on the elderly who need "continuous high care". The university is currently working with Anglicare on a research project investigating climate-change vulnerability on aged care residents and associated health impacts, while also looking at adaption strategies. "Older people are particularly vulnerable due to their age-related health conditions - chronic diseases, the climate vulnerabilities," Professor Lee said. "It can be isolating for people with underlying healthy conditions and also it reduces their mobility and increase social isolation - especially for those who are living alone." The research project will focus on two Queensland regional centres, Toowoomba and Hervey Bay. Share your thoughts in the comments below, or send a Letter to the Editor by CLICKING HERE. A forgotten side effect of extreme weather events, debilitating our elderly, is finally being brought into the light in a push for older Australians to be better cared for. Post Traumatic Stress Disorder and social isolation due to displacement and homelessness is not often talked about in mainstream media reports of such events like the Lismore floods or Cyclone Alfred. But the trauma can be intense and long-lasting for older Australians, according to a team from Griffith University and Anglicare Southern Queensland. Read more from The Senior: During a public webinar on June 12, aged care expert Victoria Cain spoke of an Anglicare aged care resident living with dementia who now has severe PTSD "superimposed on his dementia" because of the Lismore floods of 2022. "It's directly related to the floods because of the homelessness, so that alone is quite distressing ... many [aged care] residents have PTSD because of previous storm or flood events," said Ms Cain, Anglicare's Southern Queensland Clinical Lead, Specialist Dementia Care Program. "You then have an increase of isolation for residents who can't actually get out of their rooms or out of the floors. So it leads to isolation, it leads to increased depression, it leads to increased lack of mobility." In another instance, Ms Cain spoke of a recent stay in a hotel in Hervey Bay following Cyclone Alfred where the lifts had been inoperable since March and wouldn't be fixed for another 12 weeks. For some people this may be seen as an inconvenience, but for the elderly woman she met living on the top floor she would be heavily impacted by climbing up and down five flights of stairs every day - almost cut off from the world. Associate Professor Patricia Lee of Griffith University said whether it's bushfires, floods, cyclones or extreme heatwaves they all can have disruptive and harmful consequences on the elderly who need "continuous high care". The university is currently working with Anglicare on a research project investigating climate-change vulnerability on aged care residents and associated health impacts, while also looking at adaption strategies. "Older people are particularly vulnerable due to their age-related health conditions - chronic diseases, the climate vulnerabilities," Professor Lee said. "It can be isolating for people with underlying healthy conditions and also it reduces their mobility and increase social isolation - especially for those who are living alone." The research project will focus on two Queensland regional centres, Toowoomba and Hervey Bay. Share your thoughts in the comments below, or send a Letter to the Editor by CLICKING HERE. A forgotten side effect of extreme weather events, debilitating our elderly, is finally being brought into the light in a push for older Australians to be better cared for. Post Traumatic Stress Disorder and social isolation due to displacement and homelessness is not often talked about in mainstream media reports of such events like the Lismore floods or Cyclone Alfred. But the trauma can be intense and long-lasting for older Australians, according to a team from Griffith University and Anglicare Southern Queensland. Read more from The Senior: During a public webinar on June 12, aged care expert Victoria Cain spoke of an Anglicare aged care resident living with dementia who now has severe PTSD "superimposed on his dementia" because of the Lismore floods of 2022. "It's directly related to the floods because of the homelessness, so that alone is quite distressing ... many [aged care] residents have PTSD because of previous storm or flood events," said Ms Cain, Anglicare's Southern Queensland Clinical Lead, Specialist Dementia Care Program. "You then have an increase of isolation for residents who can't actually get out of their rooms or out of the floors. So it leads to isolation, it leads to increased depression, it leads to increased lack of mobility." In another instance, Ms Cain spoke of a recent stay in a hotel in Hervey Bay following Cyclone Alfred where the lifts had been inoperable since March and wouldn't be fixed for another 12 weeks. For some people this may be seen as an inconvenience, but for the elderly woman she met living on the top floor she would be heavily impacted by climbing up and down five flights of stairs every day - almost cut off from the world. Associate Professor Patricia Lee of Griffith University said whether it's bushfires, floods, cyclones or extreme heatwaves they all can have disruptive and harmful consequences on the elderly who need "continuous high care". The university is currently working with Anglicare on a research project investigating climate-change vulnerability on aged care residents and associated health impacts, while also looking at adaption strategies. "Older people are particularly vulnerable due to their age-related health conditions - chronic diseases, the climate vulnerabilities," Professor Lee said. "It can be isolating for people with underlying healthy conditions and also it reduces their mobility and increase social isolation - especially for those who are living alone." The research project will focus on two Queensland regional centres, Toowoomba and Hervey Bay. Share your thoughts in the comments below, or send a Letter to the Editor by CLICKING HERE.
