
National Hero John Davidson Hits the Road Once Again to Honour His Son and Push for a Cure for Duchenne Muscular Dystrophy
LONDON, ON, June 2, 2025 /CNW/ - Thirty years ago, John Davidson and his 15-year-old son Jesse captured the hearts of Canadians when John pushed Jesse across Ontario in his wheelchair to raise awareness for Duchenne muscular dystrophy. Three years later, he made the massive journey across the country.
Now, approaching his 80th birthday, John is lacing up once again.
On June 10, 2025, John will walk 30 kilometres from St. Thomas to London, Ontario, a symbolic route he once walked with Jesse, to commemorate 30 years since the journey that inspired the creation of Jesse's Journey (now Defeat Duchenne Canada). This special anniversary walk honours Jesse's legacy and the more than 1 in 5,000 boys affected by Duchenne, a rare and fatal genetic disorder with no cure.
" When Jesse and I set out to cross Ontario in 1995, we had no idea what was ahead. But we had extreme resolve," says John. "Thirty years later, that same resolve remains solidly in place. Quitting is not an option. Everyone should try to make a difference."
Since 1995, Defeat Duchenne Canada has invested nearly $19 million in 63 research projects in Canada and around the world, funding promising advancements in diagnosis, treatment, and the search for a cure. This year, the organization aims to cross a significant milestone: committing its $20 millionth dollar to Duchenne research.
"What you'll see on June 10 is a dad - nearing 80 - doing his best to make a difference," John adds. "I'll be walking for Jesse, and for all the boys still waiting. I hope I see you along the road. The journey continues."
Canadians across the country are invited to be part of this historic moment.
Whether cheering on John along the route, donating, or sharing a message of encouragement, your support fuels hope.
Learn more at www.jessesjourney.com.
About Defeat Duchenne Canada:
Defeat Duchenne Canada (formerly Jesse's Journey) is the country's only national charity dedicated to ending Duchenne muscular dystrophy.
Our goal is to provide leadership in research, advocacy, and support to ensure our boys can live long and active lives.
About Duchenne muscular dystrophy:
One in every 5,000 boys is born with Duchenne muscular dystrophy, the most common fatal form of muscular dystrophy diagnosed in children.
The disease is relentless. It slowly weakens the body's muscles, deteriorating the function of vital organs and ultimately shortens their life. Although there are medical treatments that may help slow its progression, there is currently no cure and life expectancy hovers in the early thirties
Social media:
Facebook - @defeatduchenne
Twitter - @defeatduchenne
Instagram - @defeatduchenne
LinkedIn - /company/defeatduchenne
YouTube - /defeatduchenne
SOURCE Defeat Duchenne Canada

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Cision Canada
43 minutes ago
- Cision Canada
ERA Congress: Long-term data show sustained efficacy and safety of zigakibart in patients with IgA nephropathy
VIENNA, June 4, 2025 /CNW/ -- New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented today at the 62 nd ERA Congress demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile. IgAN is the most common form of glomerular disease worldwide and a frequent cause of chronic kidney disease. Its pathogenesis is marked by inflammation and progressive kidney damage, which can lead to kidney failure. Many patients are unaware they have the condition until significant kidney damage has occurred, and 50% of IgAN patients will ultimately develop kidney failure. By targeting the APRIL pathway and reducing production of pathogenic galactose-debecause ofgA1), zigakibart addresses a key driver of disease progression. "Zigakibart is designed to intercept the initiating factor in IgAN pathogenesis, offering a new approach that may halt or significantly delay progression", explained lead investigator Professor Jonathan Barratt. The ADU-CL-19 trial included 40 adults with biopsy-confirmed IgAN and persistent proteinuria despite stable supportive therapy. Patients received zigakibart every two weeks via intravenous infusion or subcutaneous injection, in addition to maximally tolerated renin–angiotensin system inhibitors (RASi) unless RASi-intolerant – demonstrating efficacy beyond standard care. At Week 100, proteinuria was reduced by 60% from baseline. Over half of patients (55%) reached <500 mg/24 h, and 31% achieved <300 mg/24 h, indicating deeper remission. Estimated glomerular filtration rate (eGFR) remained stable across subgroups. "The consistency of eGFR stabilisation over 100 weeks, even across proteinuria response groups, is particularly encouraging," said Prof. Barratt. Treatment also led to sustained reductions in serum immunoglobulins, including a 74% drop in IgA and pathogenic Gd-IgA1, consistent with APRIL pathway inhibition. Zigakibart was well tolerated throughout. Most adverse events were mild or moderate, with no treatment-related serious infections or discontinuations. Infections were the most common AEs; the study coincided with a high prevalence of COVID-19. This is the longest duration of eGFR stabilisation reported for an anti-APRIL agent in IgAN. "These long-term results build confidence in zigakibart as a potential cornerstone therapy for IgAN," said Prof. Barratt. "We're excited to see how the upcoming Phase 3 trials will further define its role." The global Phase 3 BEYOND study is now evaluating zigakibart in a broader population, with primary proteinuria endpoints at 40 weeks and long-term kidney function through 104 weeks.

Montreal Gazette
an hour ago
- Montreal Gazette
Campaign to distribute smoke detectors in 16 First Nations communities kicks off in Kahnawake
By KAHNAWAKE — Indigenous Peoples living on reserves are 10 times more likely to die in a house fire than non-Indigenous Canadians, according to the National Indigenous Fire Safety Council. An initiative launched Wednesday in Kahnawake aims to change that. The campaign will distribute 6,000 smoke detectors across 16 First Nations communities, including Kahnawake — devices that local firefighters say are more crucial than fire engines when it comes to saving lives. 'Fire departments don't save lives. They save structures,' said Kahnawake Fire Brigade captain Karonhi:io Curotte. Fatal fires tend to spread too fast for fire departments to respond on time, he said. The life-and-death question is not how fast the fire is extinguished, but how quickly people get out. 'A fire grows so fast,' said Arnold Lazare, the former Kahnawake fire chief who is now spearheading the campaign in his capacity as Indigenous Fire Marshall of Canada at the National Indigenous Fire Safety Council. Even 'if the department gets there within three minutes (after the fire starts) ... the smoke is at a level where it's fatal already.' Smoke detectors alert people to fires quickly, improving their odds of getting out on time. In Kahnawake, many homes have smoke detectors, but the devices are often too old to function, fire chief Wihse Stacey said. 'I don't think people are hesitant to put smoke alarms in their homes.' A recent distribution of smoke detectors saw the supply of more than 100 of the devices run out in a matter of minutes, he said. 'The problem is that they don't understand that smoke alarms have a shelf life.' With most calls to the fire department concerning smaller issues, such as suspicious odours, Stacey said firefighters will talk to people they meet about installing smoke alarms. 'Public education' is key to fighting fires, he said. 'Telling them is one thing. Teaching them why is a whole different story.' The detectors, donated by Kidde, a U.S. smoke detector distributor, will be installed by fire departments in homes to prevent improper installation. The detectors are designed to last 10 years without requiring a new battery, said Kidde communications officer Ivanette Bonilla. A May 27 house fire in Kahnawake was the third in about a month, Curotte said. 'The house was fully engulfed,' said Stacey, with the family losing their home. But that frequency is not the norm, Curotte said, with public safety campaigns having successfully reduced the number of fires over recent decades. When he became a firefighter 32 years ago, Curotte said the department would expect a major fire every month. 'People didn't have smoke detectors,' he said. 'We've had people die.' Fire detector awareness has significantly improved in the community, he said, making Kahnawake less susceptible to fatal house fires than some of the other communities included in the campaign. Many Indigenous communities are without fire departments, he said. And many don't receive the necessary funding to pay their firefighters. Kahnawake has 15 paid staff, including firefighters, office personnel and ambulance drivers. 'It's the only fire department in all of Quebec where you see red and white ambulances,' Curotte said.


Cision Canada
3 hours ago
- Cision Canada
SGS Acquires H2Safety to Optimize Emergency Management and Operational Safety for North American Industrial Sectors
CALGARY, AB, June 4, 2025 /CNW/ - SGS, the world's leading testing, inspection and certification company announces the acquisition of H 2 Safety Services Inc. (H 2 Safety), a North American market leader in emergency response management, Health Safety and Environment (HSE), training and emergency software services. Founded in 2004, H 2 Safety serves a wide range of industrial sectors including oil and gas, mining, transportation, utilities, renewables and government. With a unique focus on public consultation and regulatory compliance, H 2 Safety also excels in Indigenous relations and government relations. "Our approach to safeguarding critical infrastructure, communities, employees and natural environments is rooted in building authentic relationships and addressing community concerns transparently," said James Harasen, CEO and Chairman of H 2 Safety. "We are excited about joining SGS to expand our emergency management footprint while also leveraging SGS's proven expertise in delivering comprehensive HSE solutions across various industries." H 2 Safety's H2CommandCentre® platform is a robust emergency management application that empowers organizations with rapid and holistic incident management response capabilities. It activates emergency response teams including GIS and ICS experts, delivers rapid notifications, offers real-time check-ins, uses real-time maps to identify hazard zones while also generating lists of critical residents and stakeholders. With over 15,000 users, the platform is supporting organizations with achieving their operational safety objectives and business continuity, while also protecting people and the environment. "Operational integrity is at the core of SGS's corporate culture, since our customers entrust us with their quality assurance and operational fluidity needs in a wide range of industrial environments. Whether it's delivering inspections to monitor the integrity of oil pipelines or deterring wildlife from landing in hazardous substances, HSE is at the core of what we do. We also have a strong HSE record within our own operations, so we really walk the talk when it comes to protecting assets, employees and the environment," said Patrick Beck, Head of Industrial Services at SGS in North America. H 2 Safety contributes to achieving SGS's Strategy 27, which includes responding to megatrends driving growth in the TIC industry. One of these megatrends is innovation in digital capabilities and new technologies. Organizations in the industrial sector are investing more in digital transformation solutions to remain competitive and to increase market share. An end-to-end emergency management platform serves as a powerful digital tool to strengthen digital transformation when it comes to operational safety and compliance. Another megatrend driving growth in the TIC industry is ESG regulation and societal expectations. Optimizing HSE and emergency management, with a focus on Indigenous and community relations, positively contributes to achieving corporate environmental and social development objectives. With this acquisition, SGS is also building towards achieving the company's objective of doubling North American sales between 2023 to 2027. For media inquiries, please contact: ABOUT SGS SGS is the world's leading Testing, Inspection and Certification company. We operate a network of over 2,500 laboratories and business facilities across 115 countries, supported by a team of 99,500 dedicated professionals. With over 145 years of service excellence, we combine the precision and accuracy that define Swiss companies to help organizations achieve the highest standards of quality, compliance and sustainability. Our brand promise – when you need to be sure – underscores our commitment to trust, integrity and reliability, enabling businesses to thrive with confidence. We proudly deliver our expert services through the SGS name and trusted specialized brands, including Brightsight, Bluesign, Maine Pointe and Nutrasource. SGS is publicly traded on the SIX Swiss Exchange under the ticker symbol SGSN (ISIN CH1256740924, Reuters SGSN.S, Bloomberg SGSN:SW).