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Arialief Fake Reviews Investigated: What to Know Before Buying (Official Website Statement)

Arialief Fake Reviews Investigated: What to Know Before Buying (Official Website Statement)

Yahoo13-05-2025

A Deep Dive Into the Science, Real Customer Experiences, and the Truth Behind Arialief's Neuropathy Relief Claims—Official Ingredient Breakdown, Results Timeline & Buyer Protections Revealed
Mobile, May 13, 2025 (GLOBE NEWSWIRE) --
In This Article, You'll Discover:
What Arialief nerve health supplement is and how it works from the inside out
The full list of Arialief ingredients including Magnesium Glycinate, Alpha Lipoic Acid, Turmeric, and more
How Arialief supports neuropathy relief, nerve pain, and sciatic discomfort naturally
A breakdown of how each ingredient contributes to nerve repair, inflammation reduction, and circulation
Real user testimonials and reported results from those using Arialief for nerve discomfort
A detailed look at Arialief pricing, bundle options, and free wellness bonuses
What makes Arialief different from traditional painkillers, creams, or generic supplements
A transparent discussion on safety, quality standards, and money-back guarantee
Whether Arialief is the right fit for seniors, adults with long-term nerve issues, or those seeking daily nerve support
A legally sound disclaimer and affiliate disclosure for readers' protection
TL;DR – Arialief Nerve Health Supplement Review Summary
Arialief, a science-backed and plant-supported nerve health supplement, is designed to alleviate discomfort associated with neuropathy, sciatic nerve pain, tingling, burning sensations, and overall nerve inflammation. With a blend of proven ingredients like Magnesium Glycinate, Alpha Lipoic Acid, Butcher's Broom, L-Carnitine, Turmeric, and CoQ10, Arialief works from the inside to calm nerve tension, support circulation, restore cellular energy, and protect against oxidative damage.
It requires just one capsule per day, is made in the USA in a cGMP-certified facility, and comes with a 180-day money-back guarantee, ensuring your satisfaction. Many users report noticeable improvements within weeks, including reduced tingling, better sleep, and greater mobility. With tiered pricing, free bonuses, and no known harsh side effects, Arialief presents a practical, natural solution for individuals seeking long-term support for nerve-related discomfort.
This review offers a complete look at the benefits, science, results, pricing, and safety of Arialief to help readers decide whether it's the right step toward daily nerve relief and improved quality of life.
Introduction
If you've ever dealt with burning feet, tingling legs, or that strange crawling feeling in your arms you know how hard nerve discomfort can hit.
Some days, it's a dull ache that makes you tired. Other days, it's like tiny needles stabbing your skin or electric jolts out of nowhere. And the worst part? It can mess with everything: your sleep, your mood, your ability to enjoy time with your family or take a simple walk outside.
Doctors may run tests. You might try painkillers, creams, or expensive treatments. But deep down, you start wondering: 'Is this how it's going to be from now on?' That fear of losing control over your body, of never feeling 'normal' again it's real. And for many, it leads to quiet suffering.
But here's the truth nobody tells you. Nerve problems don't always start on the surface. They often begin inside with weak nerve signals, poor blood flow, too much inflammation, and tired cells that can't keep up.That's why a new kind of support is needed. In this Arialief review, we'll explore how this supplement could be the relief your nerves have been waiting for.
Arialief Overview
Product Name: Arialief
Formulation: Capsules
Primary Ingredients:
Magnesium (as Magnesium Glycinate from proprietary blend): 80 mg (19% DV)
Proprietary Blend: 575 mg (* Daily Value not established)
Magnesium Glycinate
Alpha Lipoic Acid
Butcher's Broom (Ruscus aculeatus) Root Extract
L-Carnitine
Turmeric (Curcuma longa) Rhizome Extract 95% Curcuminoids
Coenzyme Q10 (as Ubiquinone)
Other Ingredients: Hypromellose (Vegetable Capsule), Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Silicon Dioxide.
Bottle Contents: 30 Capsules per bottle (Serving Size: 1 Capsule)
Guarantee: 180-Day Money-Back Guarantee.
Cost:
2 Bottle (60 Day Supply): $79 + $9.99
3 Bottles (90 Day Supply): $207($69 each) + 2 Free eBooks + Free Shipping
6 Bottles (180 Day Supply): $294($49 each) + 2 Free eBooks + Free Shipping
Category: Nerve Health Support.
Working Mechanism:
Core Concept: Provides nutritional support for nerve health to alleviate neuropathy pain and discomfort.
Action: Uses a blend of ingredients known for supporting nerve function, reducing inflammation, improving circulation, and providing antioxidant protection. Magnesium Glycinate for nerve function/muscle relaxation; ALA as an antioxidant; Butcher's Broom for circulation/inflammation; L-Carnitine for cellular energy/nerve regeneration; Turmeric for anti-inflammatory effects; CoQ10 for cellular energy and nerve function restoration.
Goal: To offer ultimate relief and support for neuropathy pain, promote long-term nerve health, reduce nerve tension and inflammation, and allow users to live discomfort-free.
Target Audience: Individuals struggling with neuropathy nerve discomfort, sciatic discomfort, nerve tension, and inflammation. Those seeking natural, long-lasting relief and support for nerve health.
Manufacturing & Quality:
Natural and Safe Ingredients
Meticulously crafted formula
Manufactured in the USA
FDA approved, cGMP certified
Offers & Bonuses:
Tiered pricing with increasing discounts.
Free Shipping & Handling on 3 and 6 bottle orders.
Bonus #1: "THE FOREVER YOUNG" eBook by Dr. Sven (RRP: $49.95, Free with 3 or 6 bottle purchase).
Bonus #2: "BULLETPROOF HEALTH FOR SENIORS" eBook (RRP: $49.95, Free with 3 or 6 bottle purchase).
Shipping: $9.99 Shipping & Handling for the 2-bottle order. Free Shipping & Handling for 3 and 6 bottle orders.
Let today be the day you stop tolerating nerve pain and start treating it right. Arialief gives your nerves the nutrients they need to heal and thrive.
What Is Arialief?
Arialief is a daily nerve support supplement made for one purpose: to help people feel like themselves again. It's not a band-aid. It's not a trendy "miracle" pill. It's a carefully designed blend of nutrients and plant-based ingredients that work together to ease nerve discomfort, reduce tension, and support long-term nerve health.
Each capsule combines some of the most respected natural compounds for nerve support like Magnesium Glycinate for calming muscles and nerves, Alpha Lipoic Acid to fight oxidative stress, and Turmeric to soothe inflammation at the root. Added to this are CoQ10, Butcher's Broom, and L-Carnitine, all of which support energy, circulation, and cellular repair key when your nerves are screaming for relief.
But what really makes it stand out, something you'll see repeated across Arialief reviews is its simplicity. Just one capsule a day. No complicated regimens. No scary side effects. No filler ingredients. Just a science-inspired, plant-supported way to give your nerves the support they've been silently begging for.
And that simplicity is important especially when your nerves are already under pressure. Because when discomfort becomes part of your everyday life, even small changes can feel overwhelming. Arialief was designed to make one thing easier: feeling good again.
How Arialief Works Inside the Body- Supporting Nerves Where It Matters Most:
When your nerves are irritated, inflamed, or simply not functioning as they should, the discomfort can show up in countless ways. Pins and needles. Burning. Stiffness. Random zaps of pain. But the real issue is often deeper than just where it hurts; it's what's happening on the inside.
That's where Arialief's approach is different. Instead of covering up the discomfort, it focuses on nourishing and protecting the fragile nerve pathways that help your body communicate and move. The formula is built to reach three key goals: calm nerve tension, restore cellular balance, and support long-term nerve repair.
For example, Alpha Lipoic Acid is known for its role in protecting nerve cells from damage caused by oxidative stress. At the same time, Coenzyme Q10 helps recharge the energy within those cells which is vital, especially when nerves are under constant strain.
Magnesium Glycinate steps in to relax muscles and reduce nerve excitability, helping your body unwind and your nerves to rest. And then there's Butcher's Broom, a little-known root extract that promotes healthy circulation crucial for carrying oxygen and nutrients to stressed nerve endings.
Together, these ingredients don't just work in the same direction they work in harmony, like pieces of a puzzle. Each one supports a specific part of your nervous system's health, helping you feel more in control of your body again.
So while Arialief doesn't promise overnight magic, it does offer something far more meaningful: a gentle, daily routine that helps your body do what it was designed to do: feel safe, steady, and strong.
Live on your terms again with Arialief's comprehensive nerve health formula. One capsule a day. Zero hassle. Real, gradual results.
The Science Behind the Arialief Ingredients
Each capsule of Arialief is thoughtfully crafted to support your nerve health from multiple angles gently, consistently, and without any unnecessary additives. Here's how each key ingredient contributes:
Magnesium Glycinate
Role: Calms overactive nerves and relaxes muscles
Why It Matters: Many people with nerve tension are low in magnesium. This form is gentle on the stomach and helps reduce muscle tightness, cramps, and sensitivity often linked with nerve discomfort.
Alpha Lipoic Acid (ALA)
Role: Antioxidant support and nerve protection
Why It Matters: ALA helps protect nerve cells from oxidative stress, the same internal damage that contributes to burning, tingling, and numbness. It also helps improve blood sugar balance, which is closely tied to nerve health.
L-Carnitine
Role: Nerve regeneration and cellular energy
Why It Matters: This nutrient helps nerves recover by improving energy production at the cellular level. It supports the repair of damaged nerve fibers and helps ease sensations like sharp pain or pins and needles.
Butcher's Broom Root Extract
Role: Improves circulation and reduces inflammation
Why It Matters: Better circulation means your nerves get the oxygen and nutrients they need to heal. This plant extract also helps ease swelling and pressure around irritated nerves, especially in the legs.
Turmeric Extract (95% Curcuminoids)
Role: Natural inflammation relief
Why It Matters: Turmeric helps soothe chronic inflammation that puts stress on your nerves. It's one of the most respected herbs for long-term joint and nerve comfort.
Coenzyme Q10 (CoQ10)
Role: Supports energy production in nerve cells
Why It Matters: CoQ10 helps power the healing process. It restores energy inside cells especially important for nerves that are damaged or under stress. Over time, this may support better function and less discomfort.
What Results Can You Expect? Here's How Arialief Supports Everyday Comfort
Arialief isn't magic, and it's not a quick fix. But for many people, that's exactly why it works. It doesn't promise to numb the pain and call it a day. It supports your body's own ability to restore balance and calm which means the relief can actually last.
So what does that look like in real life?
For some users, the first changes are subtle. They might notice their legs don't feel as restless at night. Or that strange buzzing sensation in their toes doesn't show up as often. Maybe they're finally sleeping a bit deeper, or waking up without that morning stiffness in their lower back.
Others say the discomfort fades slowly, like a background noise that gets quieter over time. Instead of sudden jolts of pain, they feel a steady calm. Instead of daily tension in their neck or shoulders, they notice a looser, more relaxed feeling.
Here are a few more shifts users have reported:
Easier walking or standing for longer periods
Fewer 'zaps' of nerve pain during rest
Less tingling or coldness in the feet
Better sleep from reduced nerve agitation
Improved focus and energy during the day
Of course, how fast you notice results depends on your body. Some people feel better after a few weeks. For others, especially those with long-standing issues, it may take a few months. That's why the makers of Arialief suggest giving it a fair chance, usually 3 to 6 months for full results to take hold.
Because when your nerves have been under stress for years, they don't just bounce back overnight. But when they're finally supported properly, the difference can be life-changing.
Relief doesn't have to be complicated. Just one capsule a day with Arialief can help ease nerve pain and support mobility—naturally and effectively.
Who Is Arialief For?
Arialief wasn't created for athletes or bodybuilders. It wasn't made for people looking for a trendy detox or a flashy wellness fad. It was made for the everyday person who's quietly struggling with something they can't always explain nerve discomfort that just won't go away.
If any of the following feels familiar, Arialief may be worth considering:
You feel tingling, burning, or numbness in your hands or feet
You experience shooting pain down your legs, especially from the lower back
You struggle with sciatic discomfort that flares up without warning
You've noticed your nerves feel 'on edge' or overly sensitive to pressure
You're tired of taking painkillers that wear off too quickly or leave you groggy
You want a more natural, daily approach to support your nerve health over time
You're over 40 and just want to age with more comfort and mobility
Arialief is especially helpful for people dealing with neuropathy, sciatic nerve irritation, or long-term inflammation. These aren't always easy conditions to live with; they can interrupt your sleep, limit your mobility, and quietly drain your energy.
What makes this formula different is that it meets you where you are. It doesn't force your body into an artificial state of relief. It works with your body, gently and gradually, helping you rebuild a stronger, calmer nervous system over time.
How to Take Arialief : How Long Before You Feel the Difference
One of the best things about Arialief is how easy it is to add to your routine. No complicated instructions, no mixing powders or timing it around meals. You take one capsule a day, preferably with water and a meal.
That's it. Because the formula is gentle and designed for long-term support, most people find it easy to tolerate even those who've had bad experiences with other supplements. And since it only requires one capsule a day, it fits into even the busiest lifestyle without adding stress.
From tingling toes to sciatic flare-ups, Arialief is designed to soothe nerve stress where it starts—inside your cells. Experience a new kind of relief.
When Will You Start Noticing Results?
Here's a general guide based on user feedback and the way the ingredients work:
Week 1-2: Many people report subtle shifts less nerve 'buzz,' a bit more calm at night, or slightly easier movement during the day.
Week 3-6: This is where most people start to notice real change. The edge is taken off the discomfort. Sleep gets better. That constant nerve tension begins to loosen.
Month 3 and beyond: For deeper or long-term nerve issues, this is where lasting benefits often appear. The nerves feel more stable, less reactive. Energy improves. And that nagging sense of 'something's not right' starts to fade.
The makers of Arialief recommend giving the formula at least 3 months ideally 6 to support full nerve repair. After all, if the damage has taken years to build, the healing deserves a little time too.
Consistency is everything. Think of Arialief like brushing your teeth; it only works if you stick with it.
Is Arialief Safe? Here's What You Should Know About Quality and Trust
When it comes to supplements, especially for something as delicate as nerve health, quality matters. You're not just looking for a quick fix, you're trusting a product to support your body every single day. That's why Arialief was built with high standards right from the start.
First, let's talk about where it's made. Arialief is manufactured in the USA, in a facility that follows cGMP guidelines short for current Good Manufacturing Practices. These are strict quality control rules enforced by the FDA to make sure every capsule is pure, consistent, and made in clean, safe conditions.
The formula itself is simple and clean. No sugar, no gluten, and no artificial preservatives. Just carefully chosen nutrients and plant compounds that are tested for purity and potency before they ever make it into a bottle.
You'll also find that Arialief uses vegetable-based capsules, making it a gentle option even for those with sensitive stomachs or dietary concerns. There's no fluff here, no weird fillers or complicated ingredient lists.
And the best part? It comes with a 180-day money-back guarantee. That's six full months to try it risk-free. If it doesn't work for you, even if the bottles are empty, you can ask for a full refund. No questions. No pressure.
So if you're the kind of person who likes to double-check everything before trying something new, that's okay in fact, it's smart. And Arialief was designed to meet that standard.
When nothing else seems to work, try something that's actually built for nerve repair. Arialief delivers real support with no prescriptions, no gimmicks—just results.
How Much Does Arialief Cost? And Which Option Makes the Most Sense?
When you're dealing with nerve discomfort, it's easy to feel like your options are either expensive prescriptions, endless painkillers, or just learning to 'deal with it.' But that's exactly why Arialief was priced to be different, affordable, fair, and built for the long haul.
You've got a few choices, depending on how ready you are to commit:
2 Bottles (60-Day Supply)
Price: $79 + $9.99 shipping
Perfect for a short-term test drive. If you're just starting to feel nerve discomfort or want to try Arialief without a big commitment, this is a solid place to begin.
3 Bottles (90-Day Supply)
Price: $207 ($69 per bottle) Free Shipping + 2 Bonus eBooks
This plan is ideal if your symptoms are moderate or have been building over time. It gives your body enough time to respond, and you save money compared to buying two bottles at a time.
6 Bottles (180-Day Supply)
Price: $294 ($49 per bottle) Best Deal
Includes Free Shipping + 2 Bonus eBooks
This is the most cost-effective option especially for people with long-term nerve concerns. It gives you six full months of support (the suggested window for best results), the biggest savings per bottle, and the most bonuses.
Free Bonuses with 3 & 6 Bottle Orders:
Bonus #1:'The Forever Young' eBook wellness strategies to age with strength and mobility
Bonus #2:'Bulletproof Health for Seniors' tips to protect your body and brain as you age
These extras were created to give you even more tools to support your health because Arialief isn't just about one capsule, it's about a lifestyle that helps you feel better long-term.
And remember, no matter which option you choose, it's all backed by a 180-day guarantee. That means you can try Arialief with zero pressure and if it doesn't help, you get your money back.
Real Arialief Reviews: What Are People Saying About It ?
Sometimes, the most powerful proof isn't in the ingredients, it's in the stories. Here's what real users have shared about their experience with Arialief:
'My sciatic pain used to control my schedule. Not anymore.'
'I planned my day around where I could sit or stretch. If I stood too long, it felt like lightning down my leg. Arialief didn't fix it overnight, but after the first month, I noticed the flare-ups weren't as sharp. By month three, I stopped reaching for the heating pad every night. That freedom is huge.'
— Melissa J., 54, Seattle, WA
'It's the first time I've felt normal in years.'
'I tried creams, patches, yoga… everything. But nothing made my legs feel truly at ease. With Arialief, it wasn't dramatic, just a slow, steady calm. The stiffness melted away, my sleep improved, and I even started walking longer distances without pain. I finally feel like myself again.'
— Harold M., 70, Chicago, IL
Find your way back to comfort with Arialief's gentle daily nerve support. Backed by a 180-day guarantee and trusted by those who've tried everything else.
Frequently Asked Questions About Arialief
Q1: Will Arialief work for all types of nerve discomfort?
Arialief was made to support general nerve health, so it may help with a range of issues including tingling, burning, numbness, or sciatic irritation. While everyone's body is different, the ingredients are chosen to help calm nerve stress, support circulation, and reduce inflammation. That said, results may vary depending on the cause and severity of your discomfort.
Q2: How long should I take Arialief to see results?
Most people begin to notice small improvements in 2-4 weeks, but deeper, lasting relief often shows up after 3-6 months of consistent use. Think of it as giving your body the time and tools it needs to heal from within.
Q4: Can I take Arialief if I'm over 60?
Yes, absolutely. In fact, many users are older adults looking for more comfort and mobility. The formula is designed to be gentle yet effective, making it a smart option for anyone looking to support aging nerves without harsh chemicals.
Q5: Is there anything I should avoid while taking Arialief?
While you don't need to make big lifestyle changes, small habits can help like staying active, eating whole foods, and avoiding too much sugar or alcohol, which can stress your nerves. Arialief works best when it's part of a healthy routine.
Q7: Can Arialief help with sleep or mood?
Some users report sleeping better and feeling calmer after a few weeks. That's likely because when nerve discomfort fades, the body naturally feels more at ease which can have a positive effect on rest and emotional well-being.
Final Thoughts - Is Arialief the Right Next Step for You?
Living with nerve discomfort can be incredibly isolating. It's the kind of pain that doesn't always show on the outside but it's there. In the background. At night. During long walks. While tying your shoes. And slowly, it chips away at your energy, your sleep, and even your confidence.
That's why Arialief was created. Not to mask the discomfort. Not to promise overnight fixes. But to finally support your nerves in the way they've needed all along gently, naturally, and consistently.
If you've tried other options and still feel like something's missing. If you're tired of feeling limited by your body. If you want to feel more ease, more control, and more comfort each day.
If this Arialief review has you thinking twice, consider this: you don't have to guess or commit forever. You just have to start. And with a 180-day money-back guarantee even if the bottles are empty. There's no real risk, just the potential for real relief.
Because sometimes the smallest decision one capsule a day can open the door to a much bigger change.
Ready to stop just 'dealing with' nerve pain? Start your journey to long-lasting relief and greater mobility today with Arialief—your nerves will thank you with every capsule.
Contact: Arialief
Address: 19655 E 35th Drive Suite 100 Aurora, CO 80011 USA
Phone: (302) 200-3480
Email: support@arialief.com
Disclaimer and Affiliate Disclosure
The information provided in this review is for general educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. The content is based on independent research, free from any external influence, and personal opinions and should not be interpreted as professional medical guidance. Readers are advised to consult a qualified healthcare provider before beginning any new supplement regimen, especially if they have pre-existing conditions, are pregnant or nursing, or are taking prescribed medications.
Results mentioned in this review are not guaranteed and may vary from person to person. Individual outcomes depend on various biological and lifestyle factors. This review does not claim to treat, cure, or prevent any disease or health condition.
The Food and Drug Administration (FDA) has not evaluated the product Arialief or its associated statements. Arialief is a dietary supplement, not a pharmaceutical drug.
This article may contain affiliate links. If a reader clicks on a link and makes a purchase, a commission may be earned at no additional cost to the buyer. These commissions help support the maintenance and continued publication of health and wellness reviews. However, they do not influence the content or recommendations presented in the review.
The publisher of this article is committed to providing accurate, up-to-date, and unbiased information. However, errors, inaccuracies, or omissions may inadvertently occur. No liability is assumed for any reliance placed on the information contained herein. Syndication partners and distribution platforms are not responsible for the content, claims, or purchase decisions made by readers as a result of this publication.
All trademarks and product names are the property of their respective owners. Use of these names does not imply any affiliation with or endorsement by them.
CONTACT: Contact: Arialief Address: 19655 E 35th Drive Suite 100 Aurora, CO 80011 USA Phone: (302) 200-3480 Email: support@arialief.comSign in to access your portfolio

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— The all-oral chemotherapy-free combination of savolitinib plus osimertinib demonstrated significant PFS benefit with a favorable safety profile in the SACHI Phase III China study — — Webcast to be held at 8:30 am HKT on Tuesday, June 3 to discuss the data presented — HONG KONG and SHANGHAI and FLORHAM PARK, N.J., June 02, 2025 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited ('HUTCHMED') (Nasdaq/AIM:​HCM; HKEX:​13) announces primary results from the interim analysis of the SACHI Phase III study. These results were presented in a late-breaking oral presentation on Sunday, June 1, 2025, during the American Society of Clinical Oncology ('ASCO') Annual Meeting in Chicago, USA. SACHI is a Phase III study of the savolitinib and osimertinib combination for the treatment of patients with locally advanced or metastatic epidermal growth factor receptor ('EGFR') mutation-positive non-small cell lung cancer ('NSCLC') with MET amplification after disease progression on first-line EGFR inhibitor therapy ( identifier NCT05015608). Title: Savolitinib combined with osimertinib versus chemotherapy in EGFR-mutant and MET-amplification advanced NSCLC after disease progression on EGFR tyrosine kinase inhibitor: Results from a randomized Phase III SACHI study Lead Author: Shun Lu, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Session: Oral Abstract Session: Lung Cancer - Non-Small Cell Metastatic Abstract Number: LBA8505 Date & Time: Sunday, June 1, 2025, 8:00 AM Central Daylight Time Location: Arie Crown Theater Prof. Shun Lu, Chief of the Shanghai Lung Cancer Center at Shanghai Chest Hospital, School of Medicine, Shanghai Jiaotong University, and Principal Investigator of the SACHI study, said, 'The results from the SACHI Phase III study represent a significant advancement in the treatment of EGFR mutation-positive NSCLC with MET amplification. The savolitinib and osimertinib combination demonstrates promising efficacy in patients who have progressed on prior EGFR inhibitor therapy. These findings highlight the potential of this novel, chemotherapy-free combination to enable a continued oral regimen, offering a convenient and well-tolerated treatment option that addresses critical unmet needs for patients with this challenging disease.' The event will be held in English and can be accessed via A replay will also be available on the website shortly after the event. As of the interim analysis data cut-off of August 30, 2024, a total of 211 patients were randomized to receive the savolitinib and osimertinib combination or chemotherapy. In the intention to treat (ITT) population, the median progression-free survival ('PFS') assessed by investigator was 8.2 months with savolitinib plus osimertinib, compared to 4.5 months with chemotherapy (hazard ratio ['HR'] 0.34; 95% confidence interval ['CI'] 0.23-0.49; p < 0.0001). The independent review committee ('IRC') assessed median PFS was 7.2 months vs 4.2 months, respectively (HR 0.40; 95% CI 0.28-0.59; p < 0.0001). The investigator-assessed objective response rate (ORR) was 58% in the savolitinib plus osimertinib group compared to 34% for patients in the chemotherapy group. The disease control rate (DCR) was 89% vs 67% and the median duration of response (DoR) was 8.4 months vs 3.2 months, respectively. Overall survival was not mature at the time of the interim analysis. Efficacy outcomes in the third-generation EGFR tyrosine kinase inhibitor ('TKI')–treated patients were comparable with those in the intention-to-treat and third-generation EGFR-TKI–naïve populations. In the third generation EGFR-TKI–treated subgroup, the investigator-assessed and IRC-assessed median PFS were highly consistent, both at 6.9 vs 3.0 months (HR 0.32; p < 0.0001). The safety profile of the savolitinib and osimertinib combination was tolerable and no new safety signals were observed. Treatment-emergent adverse events of Grade 3 or above occurred in 57% of patients in the savolitinib plus osimertinib group compared to 57% for patients in the chemotherapy group, suggesting a favorable safety profile. In January 2025, the Independent Data Monitoring Committee (IDMC) of SACHI has considered that the study has met the pre-defined primary endpoint of PFS in a planned interim analysis and as a result, enrollment into the study has concluded. Supported by data from SACHI, a New Drug Application (NDA) for the combination of savolitinib and osimertinib for the treatment of patients with locally advanced or metastatic EGFR mutation-positive NSCLC with MET amplification after disease progression on first-line EGFR inhibitor therapy has been accepted and granted priority review by the China National Medical Products Administration (NMPA). About Savolitinib Savolitinib is an oral, potent, and highly selective MET TKI that has demonstrated clinical activity in advanced solid tumors. MET is a tyrosine kinase receptor that has an essential role in normal cell development. Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene amplification or protein overexpression. MET overexpression and/or amplification can lead to tumor growth and the metastatic progression of cancer cells, and is a known mechanism of acquired resistance to EGFR TKIs. The prevalence of MET depends on the sample type, detection method and assay cut-off used. Savolitinib is approved in China and is marketed under the brand name ORPATHYS® by our partner, AstraZeneca, for the treatment of adult patients with locally advanced or metastatic NSCLC with MET exon 14 skipping alteration, representing the first selective MET inhibitor approved in China. It has been included in the National Reimbursement Drug List of China (NRDL) since March 2023. It is currently under clinical development for multiple tumor types, including lung, kidney, and gastric cancers as a single treatment and in combination with other medicines. About HUTCHMED HUTCHMED (Nasdaq/AIM:​HCM; HKEX:​13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: or follow us on press release contains forward-looking statements within the meaning of the 'safe harbor' provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect HUTCHMED's current expectations regarding future events, including but not limited to its expectations regarding the therapeutic potential of savolitinib, the further clinical development for savolitinib, its expectations as to whether any studies on savolitinib would meet their primary or secondary endpoints, and its expectations as to the timing of the completion and the release of results from such studies. Such risks and uncertainties include, among other things, assumptions regarding enrollment rates and the timing and availability of subjects meeting a study's inclusion and exclusion criteria; changes to clinical protocols or regulatory requirements; unexpected adverse events or safety issues; the ability of savolitinib, including as combination therapies, to meet the primary or secondary endpoint of a study, to obtain regulatory approval in different jurisdictions and to gain commercial acceptance after obtaining regulatory approval; the potential markets of savolitinib for a targeted indication, and the sufficiency of funding. In addition, as certain studies rely on the use of other drug products such as osimertinib as combination therapeutics, such risks and uncertainties include assumptions regarding their safety, efficacy, supply and continued regulatory approval. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. For further discussion of these and other risks, see HUTCHMED's filings with the US Securities and Exchange Commission, The Stock Exchange of Hong Kong Limited and on AIM. HUTCHMED undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development. CONTACTS Investor Enquiries +852 2121 8200 / ir@ Media Enquiries FTI Consulting – +44 20 3727 1030 / HUTCHMED@ Ben Atwell / Alex Shaw +44 7771 913 902 (Mobile) / +44 7779 545 055 (Mobile) Brunswick – Zhou Yi +852 9783 6894 (Mobile) / HUTCHMED@ Panmure Liberum Nominated Advisor and Joint Broker Atholl Tweedie / Freddy Crossley / Rupert Dearden +44 20 7886 2500 HSBC Joint Broker Simon Alexander / Alina Vaskina / Arnav Kapoor +44 20 7991 8888 Cavendish Joint Broker Geoff Nash / Nigel Birks +44 20 7220 0500

New Resource from NYC Medical Malpractice Attorney Jonathan C. Reiter Now Available
New Resource from NYC Medical Malpractice Attorney Jonathan C. Reiter Now Available

Business Upturn

time12 hours ago

  • Business Upturn

New Resource from NYC Medical Malpractice Attorney Jonathan C. Reiter Now Available

New York City, NY, June 01, 2025 (GLOBE NEWSWIRE) — In a healthcare system where medical errors rank as the third leading cause of death in America, acclaimed NYC trial attorney Jonathan C. Reiter is jolting listeners from passive acceptance to active vigilance with his groundbreaking new podcast series, 'Understanding Medical Malpractice and Its Impact.' The podcast transforms listeners' mental state from relaxed inattention to focused engagement, delivering critical insights for patients navigating the aftermath of medical negligence – from recognizing when standards of care have been breached to understanding the complex legal landscape of pursuing justice. 'Most patients don't realize they're victims of malpractice until it's almost too late to take action,' says Reiter, whose decades of experience have secured millions in compensation for victims of medical negligence. 'This podcast bridges the knowledge gap that exists between medical professionals and the patients they serve.' The debut episode explores the shocking prevalence of preventable medical errors, including surgical mistakes, misdiagnosis, birth injuries, and medication errors. Reiter provides listeners with a comprehensive framework for identifying potential malpractice and outlines the critical steps patients should take immediately following suspected negligence. 'Understanding the statute of limitations is crucial,' Reiter emphasizes. 'In New York, patients typically have just 2.5 years from the date of malpractice to file a lawsuit, but many victims spend much of that time simply trying to understand what happened to them.' Future episodes will feature interviews with medical experts, patient advocates, and survivors of medical negligence, creating a multifaceted resource for patients and their families. The podcast also examines the broader impact of medical malpractice on the healthcare system and explores potential reforms. With his characteristic clarity and compassion, Reiter transforms complex legal concepts into accessible guidance for listeners. The podcast serves as a natural extension of his commitment to patient advocacy and healthcare accountability. 'Understanding Medical Malpractice and Its Impact' is available now on the website here. About Jonathan C. Reiter Jonathan C. Reiter Law Firm – Top NYC Medical Malpractice Lawyer, Releases New Legal Resource Jonathan C. Reiter is a prominent New York City medical malpractice and personal injury attorney. With over 30 years of experience, he has established himself as one of NYC's premier legal advocates for victims of medical negligence. His firm, the Jonathan C. Reiter Law Firm, PLLC, has secured substantial verdicts and settlements for clients affected by medical errors, helping them rebuild their lives after devastating injuries. Media Contact: Jonathan C. Reiter Law Firm, PLLC T: 212-736-0979 Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.

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