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Presgera Under Review: Yellow Vitamin Neuropathy Support Supplement for Nerve Pain Tingling & Burning Relief

Presgera Under Review: Yellow Vitamin Neuropathy Support Supplement for Nerve Pain Tingling & Burning Relief

Business Upturn16-05-2025

Denver, May 15, 2025 (GLOBE NEWSWIRE) —
In This Article, You'll Discover: The real-life struggles individuals face when living with nerve pain, tingling, and burning sensations
What causes peripheral neuropathy symptoms and why may they worsen over time
Why many over-the-counter nerve relief products fall short in providing long-term support
How Presgera Yellow Vitamin Neuropathy Support Supplement differs with its research-backed formula
A detailed breakdown of the ingredients, including Alpha-Lipoic Acid, Magnesium Glycinate, and Turmeric
How this natural nerve support supplement may assist in promoting healthy nerve function
Honest reviews and results shared by real users who experienced noticeable improvements
Business details: pricing tiers, money-back guarantee, and ordering information directly from the official website
The importance of managing expectations and incorporating professional medical guidance when needed
TL;DR – Presgera Yellow Vitamin Neuropathy Support Supplement Reviewed
This article provides a comprehensive, research-informed review of Presgera Yellow Vitamin, an advanced neuropathy support supplement created for individuals struggling with nerve pain, tingling, and burning sensations. Readers will learn about the real-world symptoms of peripheral neuropathy, the biological causes behind nerve discomfort, and how Presgera's proprietary blend of ingredients—such as Alpha-Lipoic Acid, Coenzyme Q10, and Magnesium Glycinate—is formulated to nutritionally support nerve health.
Unlike typical over-the-counter options, Presgera delivers a non-GMO, gluten-free formula that targets inflammation and oxidative stress without making medical claims. The article includes real user testimonials, scientific research references, usage guidelines, and a breakdown of Presgera's pricing, shipping, and return policy. With a 180-day money-back guarantee, this long-form review highlights what makes Presgera a top-rated solution for those seeking natural and lasting support for neuropathy relief—all while encouraging responsible supplement use and consulting with a healthcare provider.
Disclaimer: This product is not intended to diagnose, treat, cure, or prevent any disease. Prices mentioned are subject to change. Always refer to the official website for the latest information.
Understanding the Daily Struggle of Neuropathy
What Living With Nerve Pain Feels Like
For millions of individuals, the invisible pain of neuropathy becomes an everyday battle. It's not always something you can see, but it's definitely something you can feel—every step, every brush of fabric against your skin, every moment of restlessness during the night. Tingling in your toes. Burning in your fingers. A persistent ache that travels up your legs. These aren't just random discomforts. They are clear signs that something's off within the body's nervous system.
These symptoms often build up quietly, sometimes worsening over time until they affect daily function—walking, sleeping, even holding objects. When the nerves are damaged or not functioning properly, the result is often pain, numbness, and a quality of life that feels increasingly restricted.
The Widespread Reach of Neuropathy Discomfort
Peripheral neuropathy doesn't discriminate. It can affect men and women alike, whether caused by diabetes, aging, injury, or even unknown triggers. According to recent surveys, millions of people over the age of 40 report some form of nerve discomfort ranging from mild tingling to severe burning sensations.
While there are many causes, the root issue is often inflammation, oxidative stress, and insufficient nutrient delivery to nerves. Over time, this leads to weakened nerve signals and discomfort that refuses to subside on its own.
Why Many People Feel Stuck and Undiagnosed
One of the biggest challenges of neuropathy is that it often goes underdiagnosed or mismanaged. Many people chalk it up to 'just getting older' or 'poor circulation.' Traditional options may include pain medications or creams that offer surface-level comfort but no lasting solution.
That's where a growing number of people are seeking neuropathy support supplements as a holistic, non-prescription path. But not all supplements are equal. That's why Presgera, a yellow vitamin complex designed for nerve health, is earning attention.
Disclaimer: Always consult a healthcare provider before starting any supplement program, especially if you are managing a medical condition.
A New Approach to Lasting Support
Presgera is part of a new class of natural nerve support formulas—offering non-GMO, gluten-free, and bioavailable ingredients in a once-daily capsule. Designed to work from within, it supports the body's natural processes involved in nerve health, inflammation reduction, and cellular repair without relying on synthetic ingredients.
Why You May Be Experiencing Neuropathy Symptoms
The Hidden Triggers Behind Nerve Discomfort
Neuropathy, often described as tingling, burning, or numbness in the hands and feet, isn't just a random inconvenience. It's typically the result of nerve damage or dysfunction within the peripheral nervous system. But the question most people ask is: why is this happening to me?
The answer varies by person, but common triggers include: Long-term blood sugar imbalances (including diabetes or prediabetes)
Chronic inflammation
Vitamin and mineral deficiencies
Poor circulation
Oxidative stress damaging nerve cells
Side effects of medications or past chemotherapy
Autoimmune conditions or injury-related nerve compression
When these factors remain unaddressed, the nerves can gradually lose their ability to send and receive clear signals, resulting in sensations that are uncomfortable or even debilitating. And while not everyone will receive a formal diagnosis, many silently experience symptoms without realizing they could be associated with peripheral neuropathy.
When Simple Symptoms Signal a Bigger Issue
What starts as occasional tingling can become daily discomfort. Many individuals report waking up with stiffness, a burning feeling in their feet, or even sensitivity to light touch. These aren't merely signs of aging—they're red flags that your nerves may be under stress.
It's important to understand that nerve pain, tingling, and burning sensations are often progressive. Without proper support, these symptoms may intensify over time, limiting mobility and reducing your quality of life.
This is why many individuals are turning to neuropathy support supplements as a natural way to address these symptoms before they worsen. The goal isn't to replace medical treatment but to support nerve function and overall wellness through targeted nutrition and anti-inflammatory compounds.
Disclaimer: If you are experiencing persistent or worsening symptoms, always consult with a healthcare provider. Supplements may provide supportive benefits but are not intended to replace medical evaluation or treatment.
Why Nutritional Gaps Can Make Nerve Pain Worse
Nerves rely on a steady supply of vitamins, minerals, and antioxidants to function properly. Unfortunately, many people over the age of 40 begin experiencing nutritional gaps due to diet, stress, or declining absorption efficiency. This is particularly true for nutrients like: Magnesium Glycinate – essential for calming overactive nerve impulses
– essential for calming overactive nerve impulses Alpha-Lipoic Acid – helps protect nerves from oxidative damage
– helps protect nerves from oxidative damage Vitamin-like compounds such as Coenzyme Q10 – support mitochondrial energy in nerve cells
When these nutrients are lacking, your nerves can suffer. That's why choosing a supplement that targets these deficiencies with bioavailable, clinically-informed ingredients can be a smart step forward.
Understanding Neuropathy Without Fear
The goal here isn't to create alarm—but to bring awareness. Neuropathy is more common than many realize, and with early intervention and nutritional support, it's possible to manage discomfort and regain a better sense of control over your body. A properly formulated natural nerve support supplement like Presgera Yellow Vitamin may play a meaningful role in that journey.
Take control of nerve discomfort today—order Presgera now and experience targeted support with a risk-free 180-day money-back guarantee!
Why Over-the-Counter Neuropathy Relief Products Often Fall Short
The Frustration of Temporary Fixes
For many individuals living with neuropathy discomfort, the first instinct is to reach for over-the-counter solutions—creams, patches, or general painkillers. These products may provide short-term surface relief, but they often fail to address the internal causes of nerve discomfort.
The reason? Most of these options don't target nerve regeneration, oxidative stress, or inflammatory markers. Instead, they act as temporary numbing agents or analgesics, offering relief that fades as quickly as it arrives. Without a supportive mechanism to nourish and restore nerve function, the underlying issues persist.
Why Most Nerve Supplements Disappoint
Even in the growing supplement category, many nerve pain support supplements rely on generic blends that lack clinical dosing, proper ingredient absorption, or proven bioavailability. It's not uncommon to find: Ineffective dosages far below therapeutic thresholds
Missing key compounds like Alpha-Lipoic Acid or Magnesium Glycinate
Use of synthetic fillers or harsh binders
Poor manufacturing quality or lack of third-party testing
Additionally, supplements that rely on 'trendy' but unsupported ingredients can mislead consumers with flashy marketing but little science to back up their claims.
This leaves customers disillusioned—and still in pain.
What to Look For Instead
The most effective neuropathy support supplement is one that: Uses clinically studied ingredients in therapeutic ranges
Prioritizes bioavailability so the body can absorb and utilize the nutrients effectively
Includes anti-inflammatory and antioxidant support
Is free from gluten, GMOs, and artificial additives
Offers full transparency on sourcing and formulation
Presgera meets these benchmarks with a thoughtfully designed formula targeting both the cause and discomfort of nerve-related issues. With its foundation built on nerve cell nourishment, circulation support, and cellular energy restoration, Presgera sets itself apart from most conventional options.
Disclaimer: While individual results will vary, using a quality supplement formulated for nerve support may help promote a healthier nervous system over time. Always speak to a licensed professional before changing your routine.
Bridging the Gap Between Ineffective and Supportive
The market may be saturated with empty promises—but that doesn't mean hope is lost. Presgera aims to fill the gap between gimmicks and genuine support, providing ingredients that work together to support nerve comfort, mobility, and long-term wellness in a safe, daily-use formula.
Ingredient Deep Dive: What Makes Presgera's Formula Unique
A standout feature of Presgera Yellow Vitamin Neuropathy Support Supplement is its strategic combination of clinically-informed, bioavailable ingredients chosen specifically to support nerve function, manage oxidative stress, and enhance circulation. Below is a breakdown of each core component in the formula and how it contributes to this complete nerve health support supplement.
Magnesium Glycinate
Calm Overactive Nerve Responses and Muscle Tension
Magnesium plays a vital role in over 300 biochemical processes in the human body, including nerve transmission and muscle relaxation. However, not all forms of magnesium are created equal.
Magnesium Glycinate is a chelated form that boasts superior bioavailability and is known for its gentle impact on the digestive system. It helps calm nerve excitability, which is often associated with tingling, twitching, or nerve sensitivity. For individuals dealing with burning and aching nerve sensations, magnesium glycinate can help maintain electrical stability in nerve cells and reduce unnecessary firing.
Alpha-Lipoic Acid (ALA)
Combat Oxidative Stress Affecting Nerve Health
Alpha-Lipoic Acid is a well-researched antioxidant compound that helps fight free radicals and reduce oxidative stress—key contributors to nerve cell damage. ALA is both water- and fat-soluble, allowing it to penetrate deep into cells, including nerve cells.
Clinical studies have explored ALA's benefits in supporting individuals with neuropathy-related symptoms, especially when oxidative damage and inflammation are present. Its inclusion in the Presgera yellow vitamin complex provides a foundation for ongoing nerve cell protection and improved blood sugar metabolism.
Butcher's Broom (Ruscus aculeatus)
Support Healthy Circulation to Nerve Endings
Butcher's Broom is a natural plant extract traditionally used to support vascular tone and improve circulation—particularly in small blood vessels.
For those experiencing neuropathy symptoms, poor blood flow can contribute to a lack of oxygen and nutrient delivery to peripheral nerves.Butcher's Broom supports better microvascular function, which may assist in delivering oxygen-rich blood to the areas most affected by discomfort, such as the hands and feet.
L-Carnitine
Energize Nerve Cells and Promote Functional Regeneration
L-Carnitine is an amino acid compound that facilitates the transport of fatty acids into mitochondria—the energy production centers of your cells. Nerve cells, like all cells, require energy to function, communicate, and regenerate.
In cases of nerve damage or inflammation, cellular energy output may decline. L-Carnitine supports recovery by ensuring efficient fuel metabolism within nerve cells. Studies have shown it may help reduce nerve tension and discomfort, especially when taken consistently over time.
Turmeric (Curcuma longa)
Reduce Inflammation That Affects Nerve Health
Turmeric, and specifically its active compound curcumin, is known for its potent anti-inflammatory and antioxidant properties. Chronic inflammation is a major contributing factor to nerve damage and ongoing discomfort in neuropathy.
The turmeric extract used in Presgera is included to help reduce inflammation in and around nerve fibers, support tissue healing, and maintain overall nerve function. Because curcumin also has poor natural absorption, Presgera includes it in a concentrated, optimized form to enhance effectiveness.
Coenzyme Q10 (Ubiquinone)
Revitalize Mitochondria and Reboot Damaged Nerve Function
CoQ10 is a vitamin-like nutrient critical for mitochondrial energy production. It helps convert food into usable energy, especially in high-demand cells like those in the heart, brain, and nervous system.
In the context of neuropathy, Coenzyme Q10 supports the restoration of damaged nerves by fueling the cellular processes required for communication and repair. Studies have explored its use in individuals with diabetes and neurodegenerative concerns, making it a smart addition for any nerve-focused formula.
Why This Combination Works
Each ingredient in Presgera has been carefully selected to perform a specific role: Calm overactive or inflamed nerves
Provide antioxidant protection against free radicals
Support circulation to peripheral areas
Restore cellular energy for nerve regeneration
Promote daily comfort and mobility
Unlike supplements that rely on just one or two active ingredients, Presgera brings together a multi-targeted approach for those seeking real support—not just symptom masking.
This formula aligns with what experts are now recognizing: nerve health is best supported with a comprehensive, multi-nutrient strategy rather than a single quick fix.
Nerve pain holding you back? Get the support you deserve with Presgera's proven formula—buy now and enjoy lasting comfort with no subscriptions!
How Presgera Works With Your Body to Support Nerve Health
A Multi-Pathway Strategy for Lasting Support
Presgera isn't designed to mask symptoms or act as a fast-acting numbing agent. Instead, it's formulated to work with your body'sown biological processes to promote the foundations of healthy nerve function. It does this through three distinct support pathways: Nutritional replenishment for nerve cell nourishment Inflammation reduction through botanical compounds Mitochondrial energy support to restore cellular communication
Each of these is critical to how Presgera functions as a neuropathy support supplement for individuals dealing with daily nerve-related discomfort.
Step 1: Replenishing Key Nutrients for Nerve Communication
The nerves rely on a steady supply of vitamins, minerals, and antioxidants to perform their functions effectively. When nutrient levels drop—due to aging, stress, illness, or poor absorption—the nerve cells struggle to communicate with muscles, skin, and the brain.
Presgera Yellow Vitamin includes ingredients like Magnesium Glycinate and L-Carnitine to replenish these gaps, contributing to: Reduced nerve misfiring
More stable nerve signaling
Muscle relaxation and tension relief
These nutrients do not alter the nervous system like medications do, but rather provide nutritional support to maintain balance and function.
Step 2: Addressing the Role of Chronic Inflammation
Nerve pain often coincides with low-grade chronic inflammation around nerve fibers. This can create a cycle of swelling, pressure, and pain that intensifies over time.
Presgera incorporates Turmeric (curcumin) and Alpha-Lipoic Acid (ALA) to address this concern. Both ingredients are known for their antioxidant effects and are used to help the body manage oxidative stress, which plays a role in nerve irritation.
Disclaimer: While turmeric and ALA are widely studied for their antioxidant and anti-inflammatory properties, individual results may vary. These nutrients are not a substitute for medical treatment and should be used as part of a broader wellness strategy.
Step 3: Supporting Cellular Energy for Repair and Recovery
Damaged or weakened nerves require energy to heal. The mitochondria within nerve cells need fuel to restore optimal communication and functional pathways.
That's where Coenzyme Q10 and L-Carnitine come into play. These ingredients help support: Energy conversion within nerve cells
Regeneration of communication pathways
Enhanced endurance at the cellular level
Together, they create an internal environment that supports long-term nerve health, rather than offering a short-lived fix.
Why a Synergistic Formula Matters
Presgera stands apart by combining these ingredients into a unified system. Many nerve support products on the market isolate just one or two of these categories—like ALA alone or magnesium alone. But nerve function is complex, and supporting it effectively requires a well-rounded blend.
Presgera delivers: A comprehensive yellow vitamin complex
Non-GMO and gluten-free formulation
formulation A transparent label with therapeutic ingredient doses
A once-daily capsule routine that's easy to follow
Note: This product is intended to support general wellness and healthy nerve function. It is not a treatment for any diagnosed condition. Always discuss supplement use with your healthcare provider, especially if taking prescription medications or managing a chronic illness.
Don't wait for symptoms to worsen—start nourishing your nerves now with Presgera Yellow Vitamin. Safe, natural, and satisfaction guaranteed!
Who Presgera Is Designed For
A Targeted Solution for Those Living With Daily Nerve Discomfort
Presgera Yellow Vitamin Neuropathy Support Supplement is formulated for individuals who experience persistent nerve-related symptoms—especially those who are not getting the relief they need from conventional options. Whether discomfort stems from aging, lifestyle, or chronic health conditions, Presgera was developed to meet the needs of people seeking nutritional support for nerve wellness.
It is particularly well-suited for adults who experience: Tingling or burning sensations in the hands or feet
Numbness or nerve sensitivity interfering with sleep
Occasional shooting or radiating discomfort in the limbs
Muscle tension associated with nerve irritation
Slow nerve recovery following strain, inflammation, or circulatory issues
This supplement is not intended to treat or cure neuropathy, but instead offers a non-prescription nerve support solution for individuals who wish to proactively support their neurological function through nutritional means.
Ideal for Adults Over 40 and Those Managing Neurological Health
As we age, nutrient absorption slows, oxidative stress increases, and the nervous system becomes more vulnerable. Individuals over 40 are especially prone to experiencing symptoms related to nerve degeneration, inflammation, or circulatory deficiencies that contribute to daily discomfort.
Presgera was designed with this group in mind—those who need natural, long-term support for nerve health without relying on synthetic ingredients or harsh medications.
It's also relevant for individuals recovering from: Stress-related nerve fatigue
Long periods of inactivity or poor circulation
Lifestyle-related nerve sensitivity (such as extended sitting or standing)
Certain medication side effects that may impact nerve function
Disclaimer: Always speak with your physician if you have a medical condition, are undergoing treatment, or are concerned about interactions. Supplements like Presgera are intended to support overall well-being and should not replace professional medical advice.
Safe for Daily Use and Long-Term Wellness Routines
Presgera uses a clean-label formulation that's: Free from GMOs and gluten
Made in the USA under certified manufacturing standards
Designed for consistent, once-daily use
Non-addictive and non-habit-forming
There are no auto-ship programs or forced subscriptions. You buy what you need, when you need it, with a 180-day satisfaction guarantee behind each order.
A Natural Alternative for Health-Conscious Individuals
Presgera appeals to those who value science-backed, natural solutions. It's a smart choice for individuals seeking: A plant-powered formula with antioxidant support
A bioavailable nerve support complex
The flexibility to use alongside healthy diet, mobility, and stress-reducing habits
Confidence in transparency and customer satisfaction
Whether you're looking to improve comfort, restore confidence in your body, or support your nervous system through a targeted supplement, Presgera Yellow Vitamin is crafted to help you feel more in control—naturally and consistently.
Say goodbye to frustrating nerve pain—Presgera delivers premium support with clean ingredients and a 180-day guarantee. Try it risk-free today!
Real User Experiences and Testimonials
Hearing From Those Who've Tried Presgera
When it comes to managing nerve pain, tingling, and burning sensations, real-life experience often speaks louder than marketing claims. While clinical support and ingredient science are important, the voices of actual users reveal how a supplement performs in the real world.
Thousands of individuals have turned to Presgera Yellow Vitamin Neuropathy Support Supplement in search of a more natural, non-invasive solution to daily nerve discomfort. The overwhelming sentiment? Relief, consistency, and greater comfort throughout the day.
Below are testimonials from verified customers, as featured on the official website.
Michael, New York
'For years, I suffered from neuropathy discomfort, especially in the evenings. After just a few days of using Presgera, I noticed a real difference. The burning sensations faded, and I could move around without that constant discomfort. This product has made my daily life much easier.'
Emily, Los Angeles
'I was skeptical at first. I've tried creams, patches, and several nerve supplements that didn't really work for me. Presgera has exceeded all my expectations. The tension in my back and legs has eased up dramatically. I feel like my old self again, and that's priceless.'
John, Chicago
'After trying countless products and getting nowhere, I finally found Presgera. It's been the only thing that gave me consistent relief. I have less discomfort now, and I'm able to get through my day with more energy and less distraction. I'm grateful for that.'
Sarah, Miami
'I never thought a supplement could be so helpful. Presgera has genuinely made a difference in how I feel. The tingling has decreased, and I'm sleeping better. I'm so thankful I found it, and I've already recommended it to a few friends.'
Disclaimer: These reviews reflect individual experiences and are not intended to suggest typical results. Presgera is a dietary supplement designed to support nerve health and comfort, not to treat or cure any disease.
What Users Appreciate Most
Across thousands of positive reviews, a few themes consistently emerge: Users value the clean, non-GMO and gluten-free formula
Many experience relief without needing multiple doses per day
Customers report improvements in mobility, comfort, and sleep
The 180-day money-back guarantee provides peace of mind during the trial period
With a user rating of 4.92/5 based on over 39,000 reviews, Presgera has developed a strong reputation among individuals looking for natural nerve support that fits into a consistent, everyday routine.
Feel like yourself again—order Presgera Yellow Vitamin and get science-backed nerve support shipped fast with zero auto-billing or gimmicks!
Scientific Support for Presgera Ingredients
Evidence-Based Formulation With Clinical Backing
The ingredients in Presgera Yellow Vitamin Neuropathy Support Supplement are not chosen at random—they are backed by research and have been studied for their roles in nerve health, inflammation support, antioxidant protection, and circulation enhancement. While Presgera itself has not undergone clinical trials as a whole product, many of its individual components are supported by data from peer-reviewed medical journals.
Disclaimer: The research presented here references individual ingredients and their general health-supportive roles. This information is for educational purposes and does not imply treatment or cure of any condition.
Alpha-Lipoic Acid: Antioxidant Powerhouse for Nerve Cells
Several clinical studies suggest Alpha-Lipoic Acid (ALA) may play a role in reducing oxidative stress and supporting individuals experiencing neuropathy-related symptoms. A review published in Diabetes & Metabolism Research and Reviews found that ALA improved symptoms such as burning pain, numbness, and tingling in individuals with diabetic neuropathy.
found that ALA improved symptoms such as in individuals with diabetic neuropathy. ALA's dual solubility in water and fat allows it to penetrate deep into nerve cells, where it combats free radical damage.
Source: PubMed: 998735
Magnesium Glycinate: Calming Nerve Excitability
Magnesium is vital for proper nerve signaling. Among its many forms, magnesium glycinate is considered both highly bioavailable and well-tolerated by the digestive system. Studies have shown that magnesium can modulate calcium channels in neurons, reducing overactive nerve impulses linked with discomfort.
linked with discomfort. Magnesium deficiencies have been linked to nerve irritability, muscle spasms, and neuropathic pain.
Source: PubMed: 30712095
Coenzyme Q10: Energy for Repair and Recovery
CoQ10 plays a central role in mitochondrial energy production. It also acts as an antioxidant, supporting cellular regeneration, including within nerve tissue. Research shows CoQ10 can help enhance nerve conduction and cell recovery in individuals with oxidative stress-related damage.
in individuals with oxidative stress-related damage. It has also been explored in the context of neurodegenerative conditions and aging-related cellular decline.
Source: PubMed: 31490017
Curcumin (Turmeric Extract): Inflammation Modulation
Curcumin, the active compound in turmeric, is recognized for its ability to influence inflammation pathways and reduce cellular stress. A clinical study in Neurochemistry International noted curcumin's neuroprotective effects, including anti-inflammatory activity and support for neural repair.
noted curcumin's neuroprotective effects, including anti-inflammatory activity and support for neural repair. It's often used in natural supplements for nerve inflammation, joint pain, and cognitive function.
Source: PubMed: 34337067
L-Carnitine: Fuel for Nerve Regeneration
L-Carnitine facilitates the conversion of fatty acids into energy, which is essential for nerve cell repair and communication. Studies show L-Carnitine supplementation may support neuropathic pain reduction , especially in individuals with diabetes or undergoing chemotherapy.
, especially in individuals with diabetes or undergoing chemotherapy. It'sparticularly useful when energy output at the cellular level is compromised.
Source: PubMed: 27220803
Butcher's Broom: Circulation Enhancer
Traditional use and clinical observation point to Butcher's Broom extract as a microcirculation enhancer. While not as heavily studied as other ingredients, Butcher's Broom has demonstrated venotonic effects—meaning it supports vascular tone and blood flow.
effects—meaning it supports vascular tone and blood flow. Improved circulation helps deliver oxygen and nutrients to nerve endings, where damage often occurs.
Source: PubMed: 31423848
A Science-Led, Nutrient-Specific Approach
By combining these ingredients into a single, comprehensive neuropathy support supplement, Presgera positions itself as a scientifically aligned alternative for those seeking daily nerve health assistance. The goal is not to cure—but to provide daily nutritional support through ingredients that have been studied and vetted for their specific roles in nerve protection, inflammation modulation, and energy production.
Tingling or burning sensations? Presgera offers real support—not a band-aid. Act now and reclaim daily comfort naturally and effectively!
How to Use Presgera Effectively
Simplicity and Consistency Are Key
Presgera was formulated with ease and compliance in mind. Unlike some supplements that require complicated dosing schedules or multiple capsules per day, Presgera Yellow Vitamin Neuropathy Support Supplement is designed to fit effortlessly into your daily wellness routine.
Recommended Use:
Take one capsule daily with a full glass of water, preferably at the same time each day. It can be taken in the morning or evening—whichever best fits your schedule. For individuals with sensitive stomachs, it is recommended to take Presgera with a small meal.
Disclaimer: Always follow the dosing instructions on the product label, and consult a healthcare provider before beginning any new supplement, especially if you are pregnant, nursing, or taking medications.
When Will You See Results?
While individual experiences vary, many users report noticing positive changes within the first 2 to 4 weeks of consistent use. However, because nerve function and cellular regeneration take time, the most profound benefits often emerge after 60 to 90 days of daily use.
According to thousands of verified users, results may include: A reduction in tingling and burning sensations
Greater comfort during rest or physical activity
Improved mobility and reduced stiffness
Enhanced ability to sleep without nerve-related interruptions
Again, it's important to remember: this supplement is not a quick fix or a replacement for professional treatment. It works best when incorporated into a broader strategy that includes a healthy lifestyle, balanced diet, regular movement, and stress reduction.
How Long Should You Take Presgera?
Most people seeking natural nerve support continue supplementation for at least 90 days to give the nutrients time to build up in the body and produce noticeable results. Long-term users often choose the 180-day supply option, which offers the lowest per-bottle pricing and includes two digital wellness bonuses.
Presgera can be used continuously without cycling on and off, as it contains non-habit-forming, non-stimulant ingredients.
Pairing Presgera With Lifestyle Habits
While Presgera is designed to stand alone as a neuropathy support supplement, it can work even more effectively when combined with supportive habits: Staying hydrated to maintain circulation
Engaging in light exercise or stretching to reduce pressure on nerves
Managing blood sugar levels where applicable
Reducing inflammation through a clean, nutrient-dense diet
Supporting restful sleep
These actions help create the internal environment necessary for nerve recovery and comfort.
Accessibility and Ease of Use
Presgera comes in a standard-size capsule that is easy to swallow, free from gluten, and manufactured under GMP-certified conditions in the United States. Each bottle contains a 30-day supply, and there is no subscription required—only the support you choose.
Experience a natural path to nerve wellness—Presgera's antioxidant-rich formula is trusted by thousands. Shop now and feel the difference!
What Makes Presgera the Standout Solution?
Not Just Another Nerve Supplement
In a saturated marketplace of quick fixes and underwhelming formulas, Presgera Yellow Vitamin Neuropathy Support Supplement distinguishes itself with a carefully engineered design, built from the ground up to support long-term nerve health. It's more than a blend of trendy ingredients—it's a strategic formulation grounded in clinical research, customer feedback, and nutritional science.
Many competing products offer vague promises, incomplete ingredient transparency, or proprietary blends that hide actual dosages. Presgera, by contrast, publishes its full label, uses therapeutic dosing, and skips artificial additives entirely.
Designed to Address the Root Contributors to Discomfort
Presgera supports the nutritional foundations that contribute to nerve wellness in three key ways: Calming overactive nerve responses through ingredients like Magnesium Glycinate
through ingredients like Combating oxidative stress with powerful antioxidants such as Alpha-Lipoic Acid and Turmeric
with powerful antioxidants such as Rebuilding mitochondrial energy and cell communication with L-Carnitine and Coenzyme Q10
This combination targets not just one, but multiple biological pathways involved in nerve discomfort—making it a more complete support solution.
Clean, Transparent, and Reliable
Every capsule of Presgera is: Manufactured in the USA under GMP-certified practices
Free from GMOs, gluten, artificial colors, and common allergens
Delivered in a once-daily capsule that supports absorption and consistency
that supports absorption and consistency Backed by a 180-day money-back guarantee—a standout policy in the supplement world
This kind of clean-label transparency matters. Consumers increasingly seek products they can trust, verify, and use long-term without worrying about harsh ingredients or gimmicks.
Trusted by Thousands and Reviewed for Real Results
Presgera has quickly built a reputation as one of the top-rated nerve support supplements available online. With over 39,000 verified reviews and an average rating of 4.92 out of 5, it's clear this formula resonates with individuals looking for a real, daily-use solution to their ongoing discomfort.
Across reviews, users frequently mention: Less tingling or burning in hands and feet
Improved mobility and quality of sleep
Feeling more like themselves again after months or years of nerve sensitivity
Disclaimer: Presgera is not a medication and is not intended to treat, diagnose, or cure any disease. It is a dietary supplement designed to support healthy nerve function as part of a balanced lifestyle.
Summary: Why Presgera Leads the Pack
If you're comparing options for neuropathy support supplements, here's why Presgera continues to stand out: Full-spectrum ingredient support for nerve health, inflammation, circulation, and energy
Transparent labeling with therapeutic doses
High consumer satisfaction and a risk-free 180-day return policy
No forced subscriptions or recurring billing
Real-world results supported by scientific evidence and actual user experience
Presgera provides a balanced, credible option for those seeking a daily nerve health supplement grounded in both evidence and ethical practices.
Pricing, Discounts, and Where to Buy
Choose the Presgera Package That Fits Your Goals
Presgera is available exclusively through the official website to ensure product authenticity, best pricing, and access to the 180-day money-back guarantee. There are no third-party retailers, recurring subscriptions, or hidden charges.
Customers can choose from three package tiers, each designed to offer increasing savings based on supply length and usage commitment:
Basic – 2 Bottles 60-day supply
Priced at $79 per bottle
Total cost: $158
Ideal for first-time users seeking to evaluate results over a two-month period
Bundle – 3 Bottles + 2 FREE Bonuses 90-day supply
Priced at $69 per bottle
Total cost: $207
Includes: Bonus #1: The Forever Young (Digital eBook) – Regular Price $49.95 Bonus #2: Bulletproof Health for Seniors (Digital eBook) – Regular Price $49.95
Excellent for those seeking continued support over the full recommended usage window
Most Popular – 6 Bottles + 2 FREE Bonuses + Free Shipping 180-day supply
Priced at $49 per bottle
Total cost: $294
Includes: Bonus #1: The Forever Young Bonus #2: Bulletproof Health for Seniors Free U.S. shipping
Recommended for those committed to long-term support and maximum savings (over $780 saved)
Pricing Disclaimer: Prices and promotions are accurate as of the time of writing but are subject to change without notice. Always refer to the official Presgera website for current pricing, availability, and bonus eligibility.
Free Bonuses That Add Real Value
When purchasing the 3- or 6-bottle bundles, customers receive instant access to two digital resources focused on overall wellness and aging well: The Forever Young – Learn the science-backed rituals that may help reduce signs of aging, improve skin elasticity, and maintain brain sharpness.
– Learn the science-backed rituals that may help reduce signs of aging, improve skin elasticity, and maintain brain sharpness. Bulletproof Health for Seniors – A wellness guide filled with natural recipes designed to support immunity, cardiovascular health, and restful sleep.
These bonuses are designed to complement the goals of Presgera—offering additional insights for those seeking comprehensive support.
180-Day Satisfaction Guarantee
Every order of Presgera is backed by a 180-day money-back guarantee, meaning you have up to six full months to decide if the product is right for you. If you're not satisfied, you can contact customer service for a full refund—no questions asked.
Guarantee applies only to purchases made directly from the official website. Refund terms are clearly outlined on the checkout page and confirmation email.
No Subscriptions. No Auto-Billing.
Unlike some supplement brands, Presgera does not enroll you in auto-ship programs or recurring billing cycles. You choose the supply package you want, and that's it. Reorders can be placed as needed with complete control.
Presgera combines product quality with customer-focused policies that make it one of the most trusted neuropathy support supplements available today. Whether you're just beginning your journey or ready to commit to long-term support, the flexible purchase options and ironclad refund policy give you everything you need to try it risk-free.
Satisfaction Guarantee and Customer Service
Peace of Mind With Every Purchase
Presgera is backed by a 100% satisfaction guarantee, designed to remove any hesitation from trying the product. The company understands that every individual's experience with nerve health is unique—and supplement support should reflect that flexibility.
With Presgera, you're not just purchasing a neuropathy support supplement—you're investing in a product backed by a risk-free promise.
The 180-Day Money-Back Guarantee Explained
Every order, whether for 2, 3, or 6 bottles, is protected by a 180-day money-back guarantee. This gives users up to six full months to evaluate the product and its impact.
If at any point within 180 days you decide Presgera is not right for you, you can: Request a refund for your entire purchase
Keep your bonuses (if included)
Return your bottles—even if they're empty
There are no questions asked, no hoops to jump through, and no restocking fees. It's a straightforward policy based on customer-first principles.
Note: Refunds are available only on purchases made through the official website. Orders made elsewhere or outside the guarantee window may not qualify.
Safe and Secure Ordering
When placing your order on the official Presgera website, you can rest assured: Transactions are protected by SSL encryption
Your credit card data is never stored or shared
Checkout is processed through BuyGoods, a trusted U.S.-based retail platform
You will receive: A confirmation email upon purchase
A receipt detailing your order and shipping status
Access to your digital bonus materials (when eligible)
Contact details in case you need support
Customer Support That's There When You Need It
If you have questions about the product, your order, the refund process, or anything else, the Presgera team is easy to reach: Customer Support Email: [email protected]
[email protected] Fulfillment Partner: BuyGoods
BuyGoods Mailing Address: 1201 N Orange Street, Suite #7223, Wilmington, DE, 19801, USA
Responses are typically sent within 24 to 48 hours during business days.
No Hidden Programs or Auto-Deliveries
There are no forced subscriptions. When you order Presgera, you're making a one-time purchase with no recurring charges. You can reorder at your convenience, and the brand's goal is to earn repeat customers through satisfaction—not through automated billing tactics.
This level of transparency is what has helped Presgera earn a strong reputation among users seeking natural support for nerve discomfort.
End the cycle of disappointment—Presgera gives your body the nutrients it needs to support lasting nerve comfort. Order now, thank yourself later!
Final Thoughts: Should You Try Presgera?
Living with nerve pain, tingling, or burning sensations can be exhausting—both physically and emotionally. For many, the journey toward relief involves trial and error, doctor visits, and countless remedies that promise more than they deliver.
Presgera does not claim to be a miracle cure. Instead, it presents itself as a thoughtfully crafted, research-aligned neuropathy support supplement built on nutritional science and transparency. Its ingredients were selected to support the body's natural processes—reducing oxidative stress, nourishing damaged nerves, improving circulation, and enhancing cellular energy production.
Who Benefits Most From Presgera?
Presgera is ideal for individuals who: Want to support nerve health without relying solely on pharmaceuticals
Are tired of superficial creams or ineffective supplements
Prefer a clean-label, non-GMO, gluten-free supplement
Seek a multi-ingredient formula with bioavailable nutrients
Appreciate a brand that stands behind its product with a 180-day money-back guarantee
It's especially well-suited for adults over 40, those with sedentary lifestyles, or individuals managing lifestyle-related challenges like blood sugar concerns or stress-induced inflammation.
A Low-Risk Opportunity to Reclaim Daily Comfort
With zero subscriptions, straightforward dosing, and clear communication on ingredients and results, Presgera offers a responsible approach to supporting nerve wellness. Whether you choose a 2-, 3-, or 6-bottle package, you're protected by a long refund window and responsive customer service.
Thousands of users have already added Presgera Yellow Vitamin to their routines—and based on the 39,000+ verified reviews, the majority report greater day-to-day ease and improved quality of life.
Disclaimer: This supplement is not intended to diagnose, treat, cure, or prevent any medical condition. It is a dietary product intended to support general wellness. As always, consult your physician before beginning any new regimen.
Final Ordering Note
Always refer to the official Presgera website for the most current pricing and package details. Offers, discounts, and bonuses are subject to change at any time.
Presgera has carved out its place as a top-rated neuropathy support supplement, not because of hype—but because of results. If you're ready to explore a targeted, well-formulated approach to nerve support, it may be time to see what Presgera can do for you.
Support nerve health from within—Presgera helps calm, restore, and protect with just one capsule a day. Start your journey to relief now!
Frequently Asked Questions About Presgera Yellow Vitamin Neuropathy Support Supplement
What is Presgera, and how does it support nerve health?
Presgera is a research-informed neuropathy support supplement designed to assist individuals experiencing nerve pain, tingling, and burning sensations. It combines clinically aligned ingredients like Alpha-Lipoic Acid, Magnesium Glycinate, Coenzyme Q10, and Turmeric to support nerve function, reduce oxidative stress, and promote circulation—without relying on synthetic additives or pharmaceuticals.
How is Presgera different from other nerve pain supplements?
Unlike generic over-the-counter products, Presgera is a yellow vitamin complex formulated with therapeutic doses of proven nutrients. It targets the root contributors to nerve discomfort—oxidative damage, nutrient deficiencies, and mitochondrial dysfunction—making it a comprehensive natural nerve health supplement rather than a temporary fix.
Who should use Presgera Yellow Vitamin?
Presgera is ideal for adults seeking nutritional support for: Tingling or burning in the hands and feet
Occasional nerve discomfort or numbness
Muscle tension linked to nerve irritation
Circulation issues impacting nerve endings
It's especially beneficial for individuals over 40, those with sedentary lifestyles, or anyone looking for a non-GMO, gluten-free nerve support formula to complement their wellness regimen.
How does Alpha-Lipoic Acid in Presgera help with neuropathy?
Alpha-Lipoic Acid (ALA) is a powerful antioxidant known for its ability to neutralize free radicals and reduce inflammation around nerve tissues. In the context of neuropathy support, ALA helps protect nerve cells from oxidative stress and has been studied for its role in improving symptoms of burning, tingling, and nerve sensitivity.
What makes Magnesium Glycinate effective for nerve pain?
Magnesium Glycinate is one of the most bioavailable and well-tolerated forms of magnesium. It supports proper nerve signaling and helps calm overactive nerve responses, making it essential for those seeking magnesium for nerve support in managing discomfort.
What role does Coenzyme Q10 play in nerve regeneration?
CoQ10 supports cellular energy production, particularly in mitochondria—the 'engines' of nerve cells. By enhancing energy availability, CoQ10 aids in nerve regeneration and cellular repair, making it a valuable ingredient for long-term nerve function support.
Is Presgera safe to take daily?
Yes. Presgera is a non-addictive, stimulant-free dietary supplement designed for consistent daily use. It contains no GMOs, gluten, or artificial additives. However, if you are pregnant, nursing, or taking medications, consult with your healthcare provider before starting.
How long before I see results?
Many users report noticeable improvement within the first 2 to 4 weeks, with the most significant results emerging after 60 to 90 days of daily use. For best outcomes, consistent use over time is recommended. The 3- and 6-bottle packages are structured around this optimal support window.
Will I be enrolled in a subscription program?
No. Presgera is a one-time purchase only. There are no auto-ship programs, subscriptions, or hidden charges. You retain full control over future reorders.
Is Presgera made in the USA?
Yes. Presgera is manufactured in a GMP-certified facility in the United States, under strict quality standards and with premium raw materials.
Is there a money-back guarantee?
Yes. Presgera is backed by a 180-day money-back guarantee. If you're not satisfied with your results, you can request a full refund—no questions asked.
Always refer to the official website for updated pricing, bonuses, and refund terms. Prices and promotions are subject to change.
Need relief that actually supports nerve function? Presgera is clean, proven, and backed by a full refund if you're not thrilled. Try it now! Company : Presgera
: Presgera Address : 19655 E 35th Dr., Suite 100, Aurora, CO 80011 USA
: 19655 E 35th Dr., Suite 100, Aurora, CO 80011 USA Email : [email protected]
: [email protected] Phone Support: +1 (719) 824-2781
Disclaimer
General Disclaimer and Affiliate Disclosure
The information presented in this article is for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment of any kind. The content is based on research, publicly available references, and anecdotal consumer experiences. Readers should not interpret any statement made herein as a substitute for consultation with a qualified healthcare provider or licensed medical professional. Always consult with your physician or other licensed health provider before starting any dietary supplement, especially if you are pregnant, nursing, have a medical condition, or are taking prescription medications.
This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary and are not guaranteed. Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration (FDA). This content may contain general references to ingredients or health outcomes that are supported by third-party studies, which are cited for informational purposes only.
While every effort has been made to ensure the accuracy and completeness of the content at the time of publication, no guarantee is given that the information provided is error-free or up to date. This includes, but is not limited to, details about ingredients, product specifications, pricing, shipping policies, bonus offers, or contact information. The publisher, contributors, editors, and any associated syndication partners are not responsible for any typographical errors, omissions, or inaccuracies that may appear within the content or as a result of changes made after publication.
Any links to the official website(s) within this article may be affiliate links. If a reader clicks on such a link and makes a purchase, the publisher or its designated partners may receive a commission at no additional cost to the reader. This compensation does not influence the editorial integrity of the content, which is based on independent research and public information. The presence of an affiliate relationship does not constitute an endorsement or sponsorship of the product by the publisher or the editorial team.
By reading this article and interacting with the linked content, readers acknowledge and agree that neither the publisher nor any content distributor shall be held liable for any direct or indirect loss or damage arising from reliance on the information provided. Use of any product referenced in this article is undertaken at the sole risk of the reader.
For the most accurate, up-to-date product details, including current pricing, terms, and refund policies, please visit the official product website.
Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same.

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HUTCHMED Highlights SACHI Phase III Study Data Presented at the 2025 ASCO Annual Meeting
HUTCHMED Highlights SACHI Phase III Study Data Presented at the 2025 ASCO Annual Meeting

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HUTCHMED Highlights SACHI Phase III Study Data Presented at the 2025 ASCO Annual Meeting

— The all-oral chemotherapy-free combination of savolitinib plus osimertinib demonstrated significant PFS benefit with a favorable safety profile in the SACHI Phase III China study — — Webcast to be held at 8:30 am HKT on Tuesday, June 3 to discuss the data presented — HONG KONG and SHANGHAI and FLORHAM PARK, N.J., June 02, 2025 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited ('HUTCHMED') (Nasdaq/AIM:​HCM; HKEX:​13) announces primary results from the interim analysis of the SACHI Phase III study. These results were presented in a late-breaking oral presentation on Sunday, June 1, 2025, during the American Society of Clinical Oncology ('ASCO') Annual Meeting in Chicago, USA. SACHI is a Phase III study of the savolitinib and osimertinib combination for the treatment of patients with locally advanced or metastatic epidermal growth factor receptor ('EGFR') mutation-positive non-small cell lung cancer ('NSCLC') with MET amplification after disease progression on first-line EGFR inhibitor therapy ( identifier NCT05015608). Title: Savolitinib combined with osimertinib versus chemotherapy in EGFR-mutant and MET-amplification advanced NSCLC after disease progression on EGFR tyrosine kinase inhibitor: Results from a randomized Phase III SACHI study Lead Author: Shun Lu, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Session: Oral Abstract Session: Lung Cancer - Non-Small Cell Metastatic Abstract Number: LBA8505 Date & Time: Sunday, June 1, 2025, 8:00 AM Central Daylight Time Location: Arie Crown Theater Prof. Shun Lu, Chief of the Shanghai Lung Cancer Center at Shanghai Chest Hospital, School of Medicine, Shanghai Jiaotong University, and Principal Investigator of the SACHI study, said, 'The results from the SACHI Phase III study represent a significant advancement in the treatment of EGFR mutation-positive NSCLC with MET amplification. The savolitinib and osimertinib combination demonstrates promising efficacy in patients who have progressed on prior EGFR inhibitor therapy. These findings highlight the potential of this novel, chemotherapy-free combination to enable a continued oral regimen, offering a convenient and well-tolerated treatment option that addresses critical unmet needs for patients with this challenging disease.' The event will be held in English and can be accessed via A replay will also be available on the website shortly after the event. As of the interim analysis data cut-off of August 30, 2024, a total of 211 patients were randomized to receive the savolitinib and osimertinib combination or chemotherapy. In the intention to treat (ITT) population, the median progression-free survival ('PFS') assessed by investigator was 8.2 months with savolitinib plus osimertinib, compared to 4.5 months with chemotherapy (hazard ratio ['HR'] 0.34; 95% confidence interval ['CI'] 0.23-0.49; p < 0.0001). The independent review committee ('IRC') assessed median PFS was 7.2 months vs 4.2 months, respectively (HR 0.40; 95% CI 0.28-0.59; p < 0.0001). The investigator-assessed objective response rate (ORR) was 58% in the savolitinib plus osimertinib group compared to 34% for patients in the chemotherapy group. The disease control rate (DCR) was 89% vs 67% and the median duration of response (DoR) was 8.4 months vs 3.2 months, respectively. Overall survival was not mature at the time of the interim analysis. Efficacy outcomes in the third-generation EGFR tyrosine kinase inhibitor ('TKI')–treated patients were comparable with those in the intention-to-treat and third-generation EGFR-TKI–naïve populations. In the third generation EGFR-TKI–treated subgroup, the investigator-assessed and IRC-assessed median PFS were highly consistent, both at 6.9 vs 3.0 months (HR 0.32; p < 0.0001). The safety profile of the savolitinib and osimertinib combination was tolerable and no new safety signals were observed. Treatment-emergent adverse events of Grade 3 or above occurred in 57% of patients in the savolitinib plus osimertinib group compared to 57% for patients in the chemotherapy group, suggesting a favorable safety profile. In January 2025, the Independent Data Monitoring Committee (IDMC) of SACHI has considered that the study has met the pre-defined primary endpoint of PFS in a planned interim analysis and as a result, enrollment into the study has concluded. Supported by data from SACHI, a New Drug Application (NDA) for the combination of savolitinib and osimertinib for the treatment of patients with locally advanced or metastatic EGFR mutation-positive NSCLC with MET amplification after disease progression on first-line EGFR inhibitor therapy has been accepted and granted priority review by the China National Medical Products Administration (NMPA). About Savolitinib Savolitinib is an oral, potent, and highly selective MET TKI that has demonstrated clinical activity in advanced solid tumors. MET is a tyrosine kinase receptor that has an essential role in normal cell development. Savolitinib blocks atypical activation of the MET receptor tyrosine kinase pathway that occurs because of mutations (such as exon 14 skipping alterations or other point mutations), gene amplification or protein overexpression. MET overexpression and/or amplification can lead to tumor growth and the metastatic progression of cancer cells, and is a known mechanism of acquired resistance to EGFR TKIs. The prevalence of MET depends on the sample type, detection method and assay cut-off used. Savolitinib is approved in China and is marketed under the brand name ORPATHYS® by our partner, AstraZeneca, for the treatment of adult patients with locally advanced or metastatic NSCLC with MET exon 14 skipping alteration, representing the first selective MET inhibitor approved in China. It has been included in the National Reimbursement Drug List of China (NRDL) since March 2023. It is currently under clinical development for multiple tumor types, including lung, kidney, and gastric cancers as a single treatment and in combination with other medicines. About HUTCHMED HUTCHMED (Nasdaq/AIM:​HCM; HKEX:​13) is an innovative, commercial-stage, biopharmaceutical company. It is committed to the discovery and global development and commercialization of targeted therapies and immunotherapies for the treatment of cancer and immunological diseases. Since inception it has focused on bringing drug candidates from in-house discovery to patients around the world, with its first three medicines marketed in China, the first of which is also approved around the world including in the US, Europe and Japan. For more information, please visit: or follow us on press release contains forward-looking statements within the meaning of the 'safe harbor' provisions of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements reflect HUTCHMED's current expectations regarding future events, including but not limited to its expectations regarding the therapeutic potential of savolitinib, the further clinical development for savolitinib, its expectations as to whether any studies on savolitinib would meet their primary or secondary endpoints, and its expectations as to the timing of the completion and the release of results from such studies. Such risks and uncertainties include, among other things, assumptions regarding enrollment rates and the timing and availability of subjects meeting a study's inclusion and exclusion criteria; changes to clinical protocols or regulatory requirements; unexpected adverse events or safety issues; the ability of savolitinib, including as combination therapies, to meet the primary or secondary endpoint of a study, to obtain regulatory approval in different jurisdictions and to gain commercial acceptance after obtaining regulatory approval; the potential markets of savolitinib for a targeted indication, and the sufficiency of funding. In addition, as certain studies rely on the use of other drug products such as osimertinib as combination therapeutics, such risks and uncertainties include assumptions regarding their safety, efficacy, supply and continued regulatory approval. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. For further discussion of these and other risks, see HUTCHMED's filings with the US Securities and Exchange Commission, The Stock Exchange of Hong Kong Limited and on AIM. HUTCHMED undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development. CONTACTS Investor Enquiries +852 2121 8200 / ir@ Media Enquiries FTI Consulting – +44 20 3727 1030 / HUTCHMED@ Ben Atwell / Alex Shaw +44 7771 913 902 (Mobile) / +44 7779 545 055 (Mobile) Brunswick – Zhou Yi +852 9783 6894 (Mobile) / HUTCHMED@ Panmure Liberum Nominated Advisor and Joint Broker Atholl Tweedie / Freddy Crossley / Rupert Dearden +44 20 7886 2500 HSBC Joint Broker Simon Alexander / Alina Vaskina / Arnav Kapoor +44 20 7991 8888 Cavendish Joint Broker Geoff Nash / Nigel Birks +44 20 7220 0500

New Resource from NYC Medical Malpractice Attorney Jonathan C. Reiter Now Available
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New Resource from NYC Medical Malpractice Attorney Jonathan C. Reiter Now Available

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Allogene Therapeutics Provides Updated Phase 1 Data Highlighting Durable Responses with ALLO-316 in Heavily Pretreated Advanced Renal Cell Carcinoma at ASCO
Allogene Therapeutics Provides Updated Phase 1 Data Highlighting Durable Responses with ALLO-316 in Heavily Pretreated Advanced Renal Cell Carcinoma at ASCO

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Allogene Therapeutics Provides Updated Phase 1 Data Highlighting Durable Responses with ALLO-316 in Heavily Pretreated Advanced Renal Cell Carcinoma at ASCO

Data Highlights Transformative Promise of CAR T in Solid Tumors Phase 1 Trial with ALLO-316 Demonstrated Potential to Provide Meaningful Clinical Benefit in Patients with CD70 TPS ≥ 50% Advanced or Metastatic RCC A Single Dose of ALLO-316 Achieved a 31% Confirmed Response Rate Four of Five Confirmed Responders Remain in Response Including One Ongoing Remission Over 12 Months Robust Expansion, Persistence, and Tumor Infiltration of ALLO-316 Seen with Standard Lymphodepletion, Showcasing Dagger® Technology as a Next-Generation Allogeneic Platform Phase 1 Safety Profile was Manageable; Proactive Diagnostic and Management Strategies Proved Effective in Mitigating IEC-HS While Preserving Efficacy SOUTH SAN FRANCISCO, Calif., June 01, 2025 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) products for cancer and autoimmune disease, presented updated data from the Phase 1 TRAVERSE study of ALLO-316 in renal cell carcinoma (RCC) during an oral presentation at the 2025 ASCO Annual Meeting. The Phase 1 TRAVERSE trial enrolled patients with advanced or metastatic renal cell RCC. Leveraging the proprietary Dagger® technology to enable robust CAR T cell expansion, it stands as the first and only allogeneic CAR T product to show promise in treating solid tumors. The presentation focused on the Phase 1b expansion cohort from the Phase 1 TRAVERSE study in which patients were treated with a standard regimen of cyclophosphamide and fludarabine followed by a single dose of 80 million AlloCAR T™ cells. 'ALLO-316 is showing clear evidence of targeted antitumor activity in patients who had failed most or all approved therapies for advanced or metastatic renal cell carcinoma,' said Zachary Roberts, M.D., Ph.D., EVP, Research and Development and Chief Medical Officer at Allogene. 'Our proprietary Dagger technology allows the use of a standard cyclophosphamide and fludarabine-based lymphodepletion regimen with a single dose of ALLO-316. Strong CAR T-cell kinetics and extensive infiltration of tumor tissue by CAR T cells are combining to generate deep and durable remissions. These are results that were previously considered out of reach for patients with advanced solid tumors.' 'Patients diagnosed with advanced or metastatic renal cell carcinoma often face a median survival in months after exhausting standard therapies,' said Samer A. Srour, MB ChB, MS, Associate Professor of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center and lead investigator of the TRAVERSE trial. 'These updated results from a larger cohort of patients with confirmed CD70 positive tumors provide compelling evidence that treatment with ALLO-316 can reduce tumor burden, control disease, and in some cases deliver durable responses. These findings underscore the clinical promise of an allogeneic CAR T to address the significant unmet needs in solid tumors and offer hope to patients who have exhausted other options.' In the Phase 1b expansion cohort, 22 patients whose tumors had progressed on multiple prior therapies were treated with lymphodepletion and 20 were treated with ALLO-316. All patients had tumors resistant to immune checkpoint blockers and at least one tyrosine kinase inhibitor (TKI), 82% had ≥2+ prior TKI, and 41% had prior belzutifan. Sixteen of the ALLO-316 treated patients had a high CD70 Tumor Proportion Score (TPS >50%). The Phase 1b expansion cohort evaluated the safety and efficacy of ALLO-316 at DL2 (80M CAR T cells) following a standard FC lymphodepletion regimen (fludarabine (30 mg/m2/day) and cyclophosphamide (500 mg/m2/day) for 3 days). The median time from enrollment to the start of therapy was four days. A single dose of ALLO-316 stabilized or reversed disease progression in the majority of patients. In the 16 patients with CD70 TPS ≥50%, the trial demonstrated a Confirmed Overall Response Rate (ORR) of 31% with 44% achieving a minimum of 30% reduction in tumor burden. Of the five confirmed responders, four maintain ongoing responses, with one in sustained remission for over 12 months. The median duration of response (mDOR) has not yet been reached, indicating the potential for long-term disease control. CD70+ patients Phase 1b(N=20) ORR (confirmed CR or PR per RECIST v1.1), n/N (%) 5/20 (25) CD70 TPS ≥50%CD70 TPS <50% 5/16 (31)0/4 (0) RECIST v1.1, Response Evaluation Criteria in Solid Tumors, version 1.1; TPS, tumor proportion score The safety profile of ALLO-316 was manageable and consistent with lymphodepletion and an active CAR T product. The most frequent Grade ≥3 events were hematologic and there were no treatment-related Grade 5 events. The most common all-grade adverse events were cytokine release syndrome (CRS) (68%; with no grade ≥3), neutropenia (68%), decreased white blood cell count (68%), anemia (59%), and thrombocytopenia (55%). Immune effector cell-associated neurotoxicity syndrome (ICANS) was 18% (with no grade ≥3) and no graft-versus-host disease (GvHD) occurred. Improved recognition of IEC-HS symptoms led to diagnosis in 36% of patients with 2 patients (9%) experiencing a short-term Grade 3 (one) or Grade 4 (one patient) event. Newly implemented diagnostic and management algorithms significantly mitigated IEC-HS, with no associated Grade 5 events. TEAEs ≥20% incidence in Phase 1b, n (%) Phase 1b (N=22a) All Grades Grade ≥3 Neutropenia 15 (68) 15 (68) White blood cell count decreased 15 (68) 15 (68) Anemia 13 (59) 9 (41) Thrombocytopenia 12 (55) 6 (27) Nausea 8 (36) 0 ALT increased 7 (32) 2 (9) Peripheral edema 7 (32) 0 Pyrexia 7 (32) 0 Arthralgia 6 (27) 0 AST increased 6 (27) 2 (9) Fatigue 5 (23) 0 Headache 5 (23) 0 AEs of Special Interest Any Grade Grade ≥3 CRS 15 (68) 0 Infection 10 (45) 8 (36) IEC-HS 8 (36) 2 (9)b ICANS 4 (18) 0 Graft-versus-host disease 0 0 IEC-HS includes the preferred terms immune effector cell-associated HLH-like syndrome and Hemophagocytic lymphohistiocytosis. a Includes 2 patients who received LD but did not receive ALLO-316 b One patient experienced G4 IEC-HS based on GI bleeding with subsequent improvement and 1 patient experienced G3 IEC-HS based on hypotension managed without pressors with subsequent improvement. About ALLO-316 (TRAVERSE)ALLO-316 is an AlloCAR T™ investigational product targeting CD70, which is highly expressed in renal cell carcinoma (RCC). CD70 is also selectively expressed in several cancers, creating the potential for ALLO-316 to be developed across a variety of both hematologic malignancies and solid tumors. The ongoing Phase 1 TRAVERSE trial is designed to evaluate the safety, tolerability, and activity of ALLO-316 in patients with advanced or metastatic clear cell RCC. In October 2024 the U.S. Food and Drug Administration (FDA) granted Regenerative Medicine Advanced Therapy (RMAT) designation based on the potential of ALLO-316 to address the unmet need for patients with advanced or metastatic RCC. The FDA previously granted Fast Track Designation (FTD) to ALLO-316 in March 2023. In April 2024, the Company announced an award from the California Institute for Regenerative Medicine (CIRM) to support the ongoing TRAVERSE trial with ALLO-316 in RCC. About Allogene TherapeuticsAllogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) products for cancer and autoimmune disease. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of 'off-the-shelf' CAR T cell product candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit and follow @AllogeneTx on X and LinkedIn. Cautionary Note on Forward-Looking Statements for Allogene This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. This press release may, in some cases, use terms such as 'develop,' 'potential,' 'expect,' 'can,' 'enable,' 'showing,' 'generate,' 'may,' 'could,' 'designed to,' 'promise,' 'hope,' 'ongoing,' 'indicating,' 'mitigate,' 'evaluate,' 'pioneer,' 'goal' or 'will,' including alternative forms thereof, or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the potential of ALLO-316 to treat patients with advanced or metastatic RCC or to provide meaningful clinical benefit in patients with advanced RCC; the potential for ALLO-316 to be developed across a variety of both hematologic malignancies and solid tumors and to generate deep and durable remissions; the potential that ALLO-316 can reduce tumor burden, control disease, and deliver durable responses; the design and potential benefits of our Dagger technology; whether the Dagger® technology will become the next-generation allogeneic platform; ALLO-316 and the Dagger technology's ability to enable robust CAR T cell expansion and persistence and tumor infiltration; the potential of ALLO-316 to address the unmet need in solid tumors or offer hope to patients who have exhausted other options; the transformative potential of our AlloCAR T™ in solid tumors; the potential advantages of the RMAT and Fast Track designation; and our ability to deliver cell therapy on-demand, more reliably, and at greater scale to more patients. Various factors may cause material differences between Allogene's expectations and actual results, including, risks and uncertainties related to: the limited nature of our Phase 1 data from our clinical trials and the extent to which such data may or may not be validated in any future clinical trials; the extent to which the Food and Drug Administration disagrees with our clinical or regulatory plans or the import of our clinical results, which could cause future delays to our clinical trials or require additional clinical trials; we may encounter difficulties enrolling patients in our clinical trials; we may not be able to demonstrate the safety and efficacy of our product candidates in our clinical trials, which could prevent or delay regulatory approval and commercialization; RMAT and Fast Track designations may not lead to a faster development or regulatory review or approval process and it does not increase the likelihood that our product candidates will receive marketing approval and the designations can be revoked if the criteria for eligibility cease to be met; and challenges with manufacturing or optimizing manufacturing of our product candidates. These and other risks are discussed in greater detail in Allogene's filings with the Securities and Exchange Commission (SEC), including without limitation under the 'Risk Factors' heading in its Quarterly Report on Form 10-Q for the year ended March 31, 2025. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release. AlloCAR T™ and Dagger® are trademarks of Allogene Therapeutics, Inc. Allogene's investigational AlloCAR T™ oncology products utilize Cellectis technologies. The anti-CD70 AlloCAR T program is licensed exclusively from Cellectis by Allogene and Allogene holds global development and commercial rights to this AlloCAR T™ program. Allogene Media/Investor Contact:Christine CassianoEVP, Chief Corporate Affairs & Brand Strategy while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data

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