This Workout Supplement May Help With Alzheimer's-New Pilot Study
A popular workout supplement could lead to better outcomes for Alzheimer's patients, according to the findings of a new study.
Creatine is a popular fitness supplement that many people use to help build muscle. However, a new study published in the journal Alzheimer's & Dementia Translational Research & Clinical Interventions discovered it could also boost brain cognition in Alzheimer's patients.
In the United States, roughly 7.2 million Americans aged 65 and older are living with Alzheimer's in 2025, according to the Alzheimer's Association.
The chronic neurodegenerative disease can affect memory, thinking and behavior and is currently the most common form of dementia worldwide.
In the study, patients with Alzheimer's disease took 20 grams of creatine monohydrate for eight weeks.
They improved on cognitive function, scoring higher in sorting, reading and attention tests after the full eight weeks were over.
Researchers said the study laid the groundwork of "preliminary evidence" to conduct further research.
"We decided to do this study because there were a couple of recent studies in mice suggesting that, in a mouse model of Alzheimer's, creatine monohydrate supplementation may be beneficial," study co-author Matthew Taylor, Ph.D, RD, assistant professor and director of the KU Brain Nutrition Laboratory at University of Kansas Medical Center, told Women's Health.
"Prior to this study, no work had been done in humans with Alzheimer's, so it was the right time to start looking at it as a potentially beneficial supplement for Alzheimer's."
Since creatine helps create adenosine triphosphate (ATP), a primary energy source for the brain, researchers speculate that creatine is able to improve overall cognition in Alzheimer's patients.
Creatine also may be able to reduce inflammation, improving the symptoms of Alzheimer's disease.
Matthew Taylor, assistant professor and director of the KU Brain Nutrition Laboratory at University of Kansas Medical Center, told Women's Health: "The brain requires a lot of energy, but in Alzheimer's, brain energy metabolism drastically declines. Creatine is a very important substance for transporting energy produced by our mitochondria and increasing creatine levels may even encourage mitochondria to produce more energy."
Further research is likely needed to understand the full impact of creatine on the body as well as the potential implications for Alzheimer's disease.
"I would not advise the use of creatine with the goal of improving cognition," Amit Sachdev, MD, medical director in the Department of Neurology at Michigan State University told Women's Health, adding there's not "well-established data to support this use."
Taylor echoed this sentiment.
"Our study is far from a definitive study," he said. "Well-designed, placebo-controlled clinical trials are needed to determine whether creatine is beneficial for Alzheimer's. I would suggest Alzheimer's patients and their families discuss taking any supplement with their neurologist."
Related Articles
The Good Life: A Tough, but Promising Path Ahead for College Grads'Important' Alzheimer's Treatment Breakthrough Gets FDA Approval'Remarkable' ALS Drug May Also Work on Alzheimer'sOzempic May Lower Risk of Alzheimer's and Dementia
2025 NEWSWEEK DIGITAL LLC.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Business Insider
3 hours ago
- Business Insider
Moderna announces FDA approved mNEXSPIKE, new vaccine against COVID-19
Moderna (MRNA) announced that the U.S. Food and Drug Administration, FDA, has approved mNEXSPIKE, a new vaccine against COVID-19, for use in all adults 65 and older, as well as individuals aged 12-64 years with at least one or more underlying risk factor as defined by the Centers for Disease Control and Prevention. 'The FDA approval of our third product, mNEXSPIKE, adds an important new tool to help protect people at high risk of severe disease from COVID-19,' said Stephane Bancel, Chief Executive Officer of Moderna. 'COVID-19 remains a serious public health threat, with more than 47,000 Americans dying from the virus last year alone. We appreciate the FDA's timely review and thank the entire Moderna team for their hard work and continued commitment to public health.' Confident Investing Starts Here:
Yahoo
9 hours ago
- Yahoo
Can adults grow new brain cells?
When you buy through links on our articles, Future and its syndication partners may earn a commission. The developing human brain gains billions of neurons while in the womb, and tacks on some more during childhood. For most of the 20th century, the conventional wisdom was that the brain cells grown before adulthood would be the only ones we would have for the rest of our lives. But over the past few decades, more and more research is challenging that belief. So is it actually possible for adults to grow neurons? While some experts believe there's strong evidence that we can gain brain cells after childhood, others are still skeptical of this notion. The process of creating new brain cells is called neurogenesis. Researchers first observed neurogenesis after birth in lab animals of various ages, including mice, rats and songbirds. In adult mice, they found new neurons growing in parts of the brain collectively called the subventricular zone, an area closely linked with sense of smell, as well as in the hippocampus, a structure that's central to memory. Researchers think that neurogenesis in these brain regions is important for plasticity, or the brain's ability to adapt and change over time. Plasticity underlies the ability to learn and form memories, for instance. In mice, it's clear that lifestyle factors such as living in a stimulating environment and exercising can promote the growth of new neurons. Conversely, in mouse models of diseases like Alzheimer's, neurogenesis is hampered. What's still up for debate is whether these findings extend beyond mice and other lab animals. "Most of our knowledge about adult neurogenesis came from studies in animal models," Hongjun Song, a professor of neuroscience at the University of Pennsylvania Perelman School of Medicine, told Live Science in an email. "Whether such knowledge can be directly translated to human studies is a challenge." That's because many of the studies that have established the existence of adult neurogenesis in animals used methods that aren't possible in human studies, such as injecting radioactive tracer molecules into the brain. These methods enable scientists to visualize if and where new neurons are growing, but the tracers themselves can be toxic. These methods also require dissecting the brain after the animal has been euthanized. "Unfortunately, there is no way to measure neurogenesis in the living person yet," Gerd Kempermann, a professor of genomics of regeneration at the Center for Regenerative Therapies in Dresden, Germany, told Live Science in an email. Related: Is there really a difference between male and female brains? Emerging science is revealing the answer. There are, however, some rare cases in which scientists have been able to apply similar methods to track neurogenesis in humans. For example, the radioactive tracer molecules used in animal neurogenesis studies are also sometimes used by doctors to track tumor growth in patients with brain cancer. While these radioactive tracer molecules are too toxic to give to healthy people, their benefits outweigh their risks in patients who already have cancer. Scientists behind a 1998 study published in the journal Nature Medicine used this approach and analyzed the brains of cancer patients after their deaths. They reported that, in addition to flagging cancer cells, the tracer molecules had marked new neurons in the hippocampus. This finding suggested that humans could grow new neurons well into adulthood, given the patients were 57 to 72 years old. Later, a 2013 study in the journal Cell used a form of radiocarbon dating to look for new neurons in humans. Radiocarbon dating usually determines the age of a sample by comparing the relative proportion of two different forms of carbon, or carbon isotopes, called carbon-14 and carbon-12. But to study neurogenesis in humans, scientists instead looked at carbon-14 concentrations inside the DNA of cells. Their approach took advantage of the fact that there was a spike in carbon-14 levels in the atmosphere caused by nuclear bomb tests in the 1950s and 1960s. People's bodies absorbed this carbon-14 via their diets, and it became incorporated into their DNA. The amount of carbon-14 in a given cell corresponds to the isotope's concentrations in the atmosphere at the time the cell formed, making it possible to roughly pinpoint the "birthday" of that cell — and determine whether it formed after its owner's birth. By analyzing postmortem brain tissue from people ages 19 to 92, this radiocarbon study identified newborn neurons in the adult hippocampus. But while compelling, the study's methods were so complex that the results have never been replicated. That said, there are also more indirect markers of neurogenesis, such as certain proteins that are only present in growing neurons. Using these methods, both Kempermann and other research groups have uncovered additional evidence of newborn neurons in the adult human brain. "There are many different markers that are more or less specific for adult neurogenesis," Kempermann said. "In tissue sections, one can study these markers under the microscope and look for patterns that are consistent with neuronal development." But some researchers aren't convinced by this evidence. Arturo Alvarez-Buylla, a professor of neurological surgery at the University of California, San Francisco, has spent his career studying the growth of new neurons. While he's observed new neurons being formed in children and adolescents, he's found little evidence to support the notion of neurogenesis in adults. Alvarez-Buylla believes there are a number of issues that may lead other researchers to find signs of neurogenesis in adult humans. For example, the chemical markers that some labs use to track new neurons may also show up in other cell types, such as glia, which are cells in the brain that support neurons' function in various ways. This may make it appear that new neurons are growing when they're actually not. He's also skeptical of the use of carbon-14 dating for this purpose, calling it "creative" but arguing that researchers can't confirm that the new cells are neurons, or if there could be other potential reasons for varying carbon-14 levels in cells. But Alvarez-Buylla isn't ruling out the possibility of human adult neurogenesis; he's only saying that — so far — the evidence hasn't convinced him. "I would say that is a rare phenomenon," said Alvarez-Buylla. "If it happens, it's very, very few cells." Kempermann, on the other hand, is a firm believer that people can grow new neurons well into adulthood. "The positive reports outnumber the critical papers by far, their take is much wider, and their quality is overall higher." The researchers said that understanding whether adult neurogenesis exists will continue to be a key question for the field of neuroscience. RELATED STORIES —Could we ever retrieve memories from a dead person's brain? —What happens in your brain while you sleep? —How much of your brain do you need to survive? "The question about whether adults can grow new neurons has tremendous implications for the plasticity of the adult brain," Song said. If new neurons can be grown and integrated into the brain, he explained, those mechanisms could form the basis for new therapies for a variety of conditions, including brain injuries and neurodegenerative disorders. Alvarez-Buylla said that even if he doesn't believe neurogenesis happens frequently in adults, it may nonetheless be possible to harness the mechanisms used by animals to grow new neurons for human therapies. "The whole idea that it can happen opens a huge door for repair," he said. "I hope that we can keep our plasticity open to things going either way."
Yahoo
11 hours ago
- Yahoo
The Best Time to Take Vitamin D for Maximum Absorption, According to Health Experts
Reviewed by Dietitian Sarah Pflugradt, Ph.D., RDN, CSCSIt can be challenging to meet your vitamin D needs through diet alone. It doesn't matter whether you take vitamin D in the morning or evening. Take vitamin D with a meal or snack containing fat to enhance it comes to the supplement aisle, multivitamins, omega-3s and probiotics might score the most real estate on the shelf. However, if that multi doesn't come with a dose of vitamin D, your doctor might recommend adding another pill to your routine. Known as the "sunshine vitamin," vitamin D is something most of us aren't getting enough of, and if you're wondering what time of day you should take it, we're here with the answer. Roxana Ehsani, M.S., RD, CSSD, explains that vitamin D is one of four fat-soluble vitamins (A, E and K are the others). Our bodies make vitamin D after being exposed to the sun, and we can also get it through our diet. It plays 'many important roles in our body,' adds Ehsani. These include supporting your immune system, muscle and nerve function, your body's ability to absorb calcium and more. Even though vitamin D is critical for overall health, research suggests that an estimated 25% of Americans are deficient in it. This could be because there are few food sources of vitamin D, and many people don't see sunshine during winter, live in regions with limited sunlight, and/or keep their skin covered while al fresco. The average older adult's recommended Daily Value of vitamin D is 20 micrograms, which is equal to 800 international units (IU). For reference, one egg and a 3-ounce can of tuna each have above 1 mcg, 3 ounces of sockeye salmon delivers around 12 mcg, and 3 ounces of trout offers around 14 mcg. Unless you're taking a spoonful of cod liver oil (34 mcg) or eating salmon or trout daily, it can be challenging to meet that mark through food alone, since most food sources of vitamin D offer small amounts. In the U.S., people get most of their dietary vitamin D from fortified milk, which contains around 100 IU per 8-ounce serving. But you'd need to drink a quart or more of milk daily to reach the DV—and milk consumption has been declining in recent years, a factor that some experts cite when discussing increased vitamin D deficiency. That's why many people take a vitamin D supplement. However, you want to make sure not only that you're taking the right amount but also that your body is absorbing it properly. Read along to learn when to take your vitamin D supplement and what factors you should consider. We'll cut to the chase: According to the current scientific consensus, our experts agree that it doesn't matter what time of the day you take your vitamin D supplement. Many people find it handy to take supplements in the morning before the day sweeps them away. Others like to store them in a drawer near the kitchen cleaning supplies to pop after tidying up after dinner. It shouldn't make a substantial difference in absorption rates whether you swing to one side or the other, although it's easiest to remember if you pick one time and stick with it. There are many factors to consider when taking any supplement, not just a vitamin D supplement; here's what you should keep in mind. First, several conditions can influence an individual's vitamin D levels (or needs). These include osteoporosis or osteopenia, depression, kidney or liver disease and having a family history of neurological conditions, to name a few. According to David Davidson, M.D., it's especially important for 'people with absorption issues, like inflammatory bowel disease or post-gastric bypass surgery' to work with their doctors to dial in their dose and receive personalized guidance about when to take vitamin D. Body size can also alter absorbency and dosing, so be sure to ask your doctor for an individual recommendation before you set off to shop for supplements. If you notice any nausea, constipation, noticeable appetite shifts or other adverse symptoms after taking your supplement, be sure to chat with your doctor. Regardless of why you're including a vitamin D supplement in your regimen, it's important to consider your routine. It's difficult to reap the health benefits of vitamin D if you forget to take it most of the time. Many people do well with 'habit stacking' or pairing the routine of taking vitamin D with something else they do daily on autopilot. Keep this in mind as you consider when to take your supplements. Ehsani shows how to put this into practice: 'If you always brush your teeth in the morning after breakfast, for instance, can you place your vitamin D supplements next to your toothbrush to remind you to take it each day?' As with any new medication or supplement, it's important to check with a health care professional to determine the best time for you. As a general rule, though, 'the 'best' time is what works best for you,' Ehsani says. 'The timing of when to take the vitamin D supplement shouldn't matter, but it should be taken with food,' Davidson says. 'Because it's a fat-soluble vitamin, food, specifically healthy fats, will help with the absorption of vitamin D.' For example, if you tend to have almond-butter toast each morning, 'consider taking it with that meal, as almond butter contains healthy fats,' Ehsani advises. Or, if you like to serve dinner with a side salad topped with a handful of walnuts and drizzled with a vinaigrette, take your vitamin D before you sit down to dig in. You could also choose to take your vitamin D with a glass of whole milk or a yogurt drink—you'll get the addition of calcium from the dairy and the vitamin D will help your body absorb the calcium. 'It may be impractical for you to take it with meals if you eat a majority of your meals away from home and can't realistically carry the vitamin D supplement with you everywhere you go,' Ehsani acknowledges. So, if that's not a realistic proposition, tell a health care professional about your schedule and when you think it might better fit, and ask for their runner-up recommendation. There are two types of vitamin D: D2 and D3. UV-grown plants, fungi and fortified foods deliver D2, while we get D3 from sunlight and animal-based ingredients. While both are important and beneficial, vitamin D3 is more bioavailable than vitamin D2. This means that your body uses vitamin D3 more efficiently, so you might need a higher dose of vitamin D2 to achieve the same effects as you might with a supplement that includes just D3. Before starting any new supplement regimen, talk to a health care professional about the best form of vitamin D for you. And if you already take a vitamin D supplement, confirm with them that you're taking the right form. Related: 7 Things You Should Look for When Buying a Supplement, According to Dietitians The best time to take a vitamin D supplement is when it fits well into your day—and when you can remember to take it. When choosing a vitamin D supplement, consider opting for vitamin D3 over D2 so your body can use it more efficiently. Additionally, Ehsani and Davidson confirm that, ideally, you should take your vitamin D supplement with a meal that contains fat to help with absorption. For instance, if you like to take vitamin D first thing in the morning, well before you typically eat breakfast, or prefer to pop your supplements just before bed, think about doing so with a handful of nuts or a spoonful of nut butter, Ehsani says. That way, you'll enjoy two wellness wins in one: better vitamin D absorption and all the health benefits of nuts. Related: 5 Supplements You Shouldn't Be Taking, According to a Dietitian Read the original article on EATINGWELL
