ASCO 2025: Reshaping the Landscape in Endometrial Cancer
Reflecting on data delivered at ASCO 2025, Ursula A. Matulonis, MD, reports that there has been remarkable progress in the treatment landscape for endometrial cancer, particularly for patients with advanced or recurrent disease. Immune checkpoint inhibitors like pembrolizumab, dostarlimab, and durvalumab are now available, with some approved in combination with chemotherapy for mismatch repair-deficient or all-comer advanced disease.
ASCO and other recent meetings have highlighted the urgent need to address more aggressive endometrial cancer subtypes — such as serous, clear cell, and carcinosarcomas — with targeted therapies including WEE1 and CDK2 inhibitors, as well as antibody-drug conjugates. Promising new data, including the use of abemaciclib with letrozole and metformin for ER-positive, low-grade cancers, underscores the growing momentum in precision therapy and the importance of ongoing clinical trial participation.
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