Giants vs. Guardians Prediction, Odds, Picks
Data Skrive
Slade Cecconi will start for the Cleveland Guardians looking to slow down Jung Hoo Lee and the San Francisco Giants on Tuesday at 9:45 p.m. ET. The favored Giants have -164 moneyline odds to win against the underdog Guardians, who are listed at +138. San Francisco is the run-line favorite (-1.5). The total is 7.5 runs for the contest.
Take a look at everything you need to know from a betting perspective on the Giants-Guardians game, regarding the run line, moneyline and total, plus expert picks.
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Check out the best moments between the Atlanta Braves and the San Francisco Giants! Giants vs. Guardians Game Information & Odds When: Tuesday, June 17, 2025 at 9:45 p.m. ET
Where: Oracle Park in San Francisco, California
How to watch on TV: NBCS-BA and CLEG Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Giants -164 +138 7.5 +100 -122 -1.5 +128 -154 Giants vs. Guardians Prediction Score Prediction: Giants 4, Guardians 3
Total Prediction: Under 7.5 runs
Win Probabilities: Giants 57%, Guardians 43% Giants vs. Guardians Betting Insights The Giants have been favorites in 43 games this season and won 26 (60.5%) of those contests.
San Francisco has a record of 7-5 in games when bookmakers favor them by at least -164 on the moneyline.
The implied probability of a win from the Giants, based on the moneyline, is 62.1%.
The Guardians have won in 19, or 44.2%, of the 43 contests they have been named as odds-on underdogs this year.
This season, Cleveland has been victorious four times in 13 chances when named as an underdog of at least +138 or longer on the moneyline.
Sportsbooks have implied with the moneyline set for this matchup that the Guardians have a 42% chance of pulling out a win. Giants Recent Betting Performance The Giants have a 4-1 record from the five games they were moneyline favorites over their last 10 matchups.
Over their last 10 outings, the Giants and their opponents combined to go over the run total five times (all 10 of the games had set totals).
The Giants are 6-4-0 against the spread over their past 10 games. Giants Recent Stats Stat Avg/Total Record 7-3 Runs Per Game 5.3 HR 11 ERA 4.59 K/9 8.1 Giants Player Insights Lee has 17 doubles, five triples, six home runs and 24 walks while hitting .265.
Among all hitters in baseball, Lee is 148th in home runs and 67th in RBI.
Heliot Ramos is batting .286 to lead his team.
Ramos is 43rd in home runs in MLB, and 55th in RBI.
Wilmer Flores has a team-high 51 runs batted in.
Mike Yastrzemski is hitting .248 with 12 doubles, a triple, five home runs and 32 walks.
Yastrzemski is riding a six-game hitting streak into this one. In his last 10 games he is hitting .308 with three doubles, five walks and seven RBIs. Guardians Recent Betting Performance In seven games as underdogs over the last 10 matchups, the Guardians have a record of 1-6.
In their last 10 games with a total, the Guardians and their opponents are 4-5-1 when it comes to hitting the over.
The Guardians have four wins against the spread in their last 10 chances. Guardians Recent Stats Stat Avg/Total Record 2-8 Runs Per Game 2.9 HR 9 ERA 4.03 K/9 7.0 Guardians Player Insights Jose Ramirez leads the Guardians with 13 home runs and 34 runs batted in, while posting a team-high batting average of .324.
In all of the big leagues, Ramirez is 23rd in homers and 67th in RBI.
Steven Kwan is batting .300 with 14 doubles, six home runs and 23 walks.
Kwan ranks 148th in homers and 157th in RBI among all MLB batters this season.
Carlos Santana paces the Guardians with 34 runs batted in.
Kyle Manzardo has eight doubles, two triples, 11 home runs and 23 walks while batting .208.
Check out the best moments between the Atlanta Braves and the San Francisco Giants!
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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