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LeanBiome Under Review: Best Microbiome Support Supplement by Lean for Good BIOME

LeanBiome Under Review: Best Microbiome Support Supplement by Lean for Good BIOME

Business Upturn29-04-2025

New York, April 29, 2025 (GLOBE NEWSWIRE) —
In This Article, You'll Discover: Why gut health plays a critical role in weight management, stubborn belly fat, and persistent food cravings.
How Biome (LeanBiome) by Lean for Good® helps restore gut balance to support sustainable weight loss naturally.
helps restore gut balance to support sustainable weight loss naturally. A complete breakdown of Biome's ingredients, including nine specific lean bacteria strains, Inulin, Greenselect Phytosome®, and key botanical extracts.
The five-step mechanism through which Biome promotes fat burning, reduces hunger, and improves metabolism.
Real customer testimonials and before-and-after LeanBiome reviews highlighting success stories from long-term users.
Potential side effects of Biome and how its plant-based, non-GMO formulation minimizes risks.
Full Biome pricing options, discounts, bonuses, and details on the 180-day 'Empty Bottle' Money-Back Guarantee.
Who Biome is best suited for, including individuals struggling with slow metabolism, cravings, and stubborn weight gain.
Best practices for maximizing results using Biome alongside simple lifestyle enhancements.
A final verdict on whether Biome is a legitimate, effective solution for sustainable fat loss and long-term gut health restoration.
TL;DR Summary:
If you have been struggling with stubborn belly fat, slow metabolism, and constant food cravings despite your best efforts, poor gut health could be the hidden cause. Biome (LeanBiome) by Lean for Good® offers a science-backed solution, restoring your gut microbiome with nine lean bacteria strains, prebiotic fiber, and natural fat-burning botanicals to support healthy weight loss naturally. In this complete LeanBiome review, we uncover how Biome works, the specific ingredients it uses, the benefits you can expect, and why rebalancing your gut may be the missing key to sustainable fat loss and long-term health. Supported by real user testimonials, clean manufacturing standards, a 180-day money-back guarantee, and transparent pricing, Biome stands out as a trusted, legitimate option for those ready to address belly fat and weight management at the root cause.
Introduction
If you've been battling stubborn belly fat, creeping weight gain, or constant hunger despite doing everything you thought was 'right,' it's not your fault. You try to eat healthier, you watch your portions, you even push yourself to exercise more. And yet, the scale barely moves. Clothes start feeling tighter. Energy levels dip. Worst of all, the cravings for sweets, bread, and snacks seem to grow stronger, not weaker. It's exhausting, physically and emotionally.
Deep down, many people start wondering if something inside them is broken. They silently blame themselves for 'lack of willpower' or 'getting older.' They try harder, eat less, and still get nowhere. It's a frustrating, lonely cycle. Maybe you've felt it too, staring at your reflection, grabbing at your waistline, and wondering what more you can possibly do. The fear creeps in that maybe this is just how life is going to be now: a slow, painful drift into more weight gain and less control.
But the truth is, the real problem often runs much deeper than calories or exercise routines. New research shows that when your gut microbiome, the delicate balance of bacteria inside your digestive system gets thrown off, it can silently sabotage every effort you make to lose weight. A damaged gut doesn't just slow your metabolism; it ramps up your hunger hormones, locks your body into fat-storage mode, and even triggers intense cravings for the very foods you're trying to avoid.
In other words, when your gut is out of balance, your body isn't fighting with you, it's fighting against you. That's why traditional diets and workout plans so often fail. They don't address the root cause: the unhealthy shift happening deep inside your gut. And until that swamp-like environment is drained and replaced with the right 'lean bacteria,' true, lasting weight loss remains frustratingly out of reach.
This is exactly where Biome (or LeanBiome) by Lean for Good® steps in. Instead of blaming your willpower, it helps you fix what's broken inside, starting with the hidden ecosystem in your gut that could be the real reason behind your stubborn belly fat, slow metabolism, and constant cravings. We'll explore everything about it in this LeanBiome review.
Biome (by Lean for Good®) Overview Product Name: LeanBiome
LeanBiome Formulation: Capsules
Capsules Primary Ingredients: Lactobacillus gasseri: 25 mg (10 Billion CFU) Lactobacillus rhamnosus: 10 mg (5 Billion CFU) Proprietary Blend (10 mg / 5 Billion CFU): Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus plantarum, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium breve. Inulin (from Chicory Root) Greenselect Phytosome® Sphaeranthus indicus Garcinia mangostan
Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide, gellan gum.
Hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide, gellan gum. Bottle Contents: 60 Capsules (Servings Per Container: 30, Serving Size: 2 Capsules. Based on suggested use, this is a 30-day supply).
60 Capsules (Servings Per Container: 30, Serving Size: 2 Capsules. Based on suggested use, this is a 30-day supply). Guarantee: 180-Day 'Empty Bottle' Money-Back Guarantee.
180-Day 'Empty Bottle' Money-Back Guarantee. Cost: 1 Bottle (30-Day Supply): $59 3 Bottles (90-Day Supply): $49 6 Bottles (180-Day Supply): $39 + Free US Shipping.
Category: Weight Management Support.
Weight Management Support. Developer/Creator: Lean for Good® (Distributed by: Lean for Good, 285 Northeast Ave. Tallmadge, OH 44278. Contact: 800-763-1979, leanforgood.com ).
Lean for Good® (Distributed by: Lean for Good, 285 Northeast Ave. Tallmadge, OH 44278. Contact: 800-763-1979, ). Biome (or LeanBiome) Is Best For: Individuals struggling with belly fat, unexplained weight gain, slow metabolism, persistent hunger and cravings. Those who believe gut health is linked to weight and haven't succeeded with other weight loss methods.
Individuals struggling with belly fat, unexplained weight gain, slow metabolism, persistent hunger and cravings. Those who believe gut health is linked to weight and haven't succeeded with other weight loss methods. Key Benefits: Supports healthy weight loss. Helps become 'naturally lean.' Suppresses hunger & dampens cravings. Fires up the metabolism. Reduces fat storage. Rebalances the gut microbiome ('drains the swamp').
Manufacturing & Quality: Produced in a state-of-the-art, FDA-inspected, cGMP Certified facility. Made in the USA. Vegan-friendly. Free From: Gluten, Dairy, Soy, Nuts, Crustaceans, Sugar, GMOs, BPAs.
Offers & Bonuses: Tiered pricing discounts for 3 and 6-bottle purchases. Free eBook ('21 Gut-Friendly Smoothie Recipes' – Value $29.95) with 3 or 6 bottle orders. Free US Shipping on 6-bottle orders.
Shipping: Ships within 5-7 business days (US), 1-2 weeks (International).
Ships within 5-7 business days (US), 1-2 weeks (International). Dosage: Take two (2) capsules per day with a sip of water, preferably in the morning before breakfast.
What Is LeanBiome And How Can It Help You Finally Lose Belly Fat?
Biome by Lean for Good® isn't just another diet pill or quick-fix supplement. It's a science-backed formula designed to help fix one of the biggest hidden causes of stubborn weight gain: an unhealthy gut microbiome. Instead of trying to force your body to lose weight through willpower alone, Biome (or LeanBiome) focuses on healing the internal imbalance that's been working against you from the start. It helps restore the good bacteria your body needs to naturally burn fat, control cravings, and fire up a healthy metabolism again.
Inside each capsule of Biome, you'll find a carefully selected mix of nine specific 'lean bacteria' species. These are the good guys, friendly bacteria that, according to research, are linked to better fat metabolism, reduced belly fat, fewer hunger cravings, and a naturally leaner body type. But Biome doesn't stop there. It also includes a unique prebiotic fiber (inulin) to feed these good bacteria, a patented green tea extract to support gut health even further, and natural plant extracts that may help your body burn fat more efficiently.
What's even smarter about Biome is how it delivers these powerful ingredients. It uses special delayed-release capsules (called DRcaps®) that protect the live bacteria from getting destroyed by stomach acid. That way, more of the probiotics survive the journey and actually reach your intestines where they can get to work rebalancing your gut and turning your body into a place where fat has a harder time sticking around.
In short, Biome isn't about fighting your body harder. It's about helping your body finally work the way it was meant to naturally, steadily, and with less struggle. And once your gut is back in balance, everything else can start falling into place: fewer cravings, better digestion, a faster metabolism, and yes, real, lasting weight loss.
Ready to support your gut health and naturally encourage healthy weight loss? Order Biome today and start experiencing the benefits from the inside out.
How Does Biome (or LeanBiome) Work? Step-by-Step Mechanism
Biome isn't about forcing your body to lose weight through extreme dieting or endless workouts. Instead, it takes a smarter, gentler approach — by going straight to the hidden root of stubborn weight gain: your gut microbiome. Here's how Biome quietly but powerfully helps turn things around inside your body.
Step 1: Protect and Deliver the Good Bacteria Where They're Needed Most
When you swallow a capsule of Biome, it doesn't just dissolve in your stomach and disappear. Thanks to special DRcaps® delayed-release technology, the probiotics are shielded from harsh stomach acids and carried safely to your intestines — the real headquarters of your gut health. That way, the good bacteria arrive alive and ready to do their job, instead of getting destroyed before they even start.
Step 2: Rebuild a Stronger, Leaner Gut Microbiome
Once inside your intestines, the nine 'lean bacteria' strains in Biome get to work. They help rebalance your gut environment by outnumbering the harmful bacteria that promote fat storage, sugar cravings, and sluggish digestion. It's like sending reinforcements into a battlefield — tipping the odds back in your favor, one microscopic ally at a time.
Step 3: Feed the Good Bacteria to Strengthen Their Impact
To help the lean bacteria thrive and multiply, Biome includes Inulin, a natural prebiotic fiber. Inulin acts like food for the probiotics, encouraging them to grow stronger and create a healthier, more balanced gut ecosystem. A better-fed microbiome can mean fewer food cravings, a smoother digestive process, and better control over your appetite.
Step 4: Support Fat Burning and Reduce Belly Fat
Alongside the probiotics, Biome also unleashes the power of Greenselect Phytosome® and the herbal duo of Sphaeranthus indicus and Garcinia mangostana. Together, these ingredients help fire up your metabolism, encourage fat loss especially around the belly area and shift your body away from fat storage mode. It's a steady, natural support system that helps your body burn fat more efficiently over time.
Step 5: Help You Feel Fuller, Longer and Cut Down on Cravings
With a healthier gut and more balanced hunger hormones, you'll likely start to notice something surprising: you're not as hungry all the time. Those intense cravings for sugar, bread, and snacks start to fade. Instead of fighting your body at every meal, you begin to feel more in control, making better food choices feel easier, not forced.
Biome's goal isn't just temporary weight loss. It's to help restore a gut environment that naturally supports a healthier metabolism, a slimmer waistline, and more energy for the long run.
What's Inside Biome (or LeanBiome): The Ingredients
Biome isn't just a random mix of probiotics and herbs thrown together. Every single ingredient was handpicked to target the real reasons behind stubborn fat gain, especially the ones most people don't even know exist. The formula focuses on three key areas: restoring a healthy gut microbiome, feeding the good bacteria to help them grow stronger, and encouraging the body to burn fat more efficiently.
Here's a closer look at what makes Biome different, and why these ingredients could finally make weight loss feel natural again.
Lactobacillus gasseri
This powerful probiotic strain has been linked in studies to noticeable reductions in belly fat. It's known for helping calm down inflammation in the gut and encouraging the body to shed stubborn fat more easily. For people struggling with midsection weight that just won't move, L. gasseri could be a real game changer.
Lactobacillus rhamnosus
Another 'lean bacteria' superstar, L. rhamnosus has been shown to support overall fat loss and better weight management. Some research suggests it can even help people lose more fat compared to those who don't have enough of this bacteria in their gut. It's like adding a powerful teammate to your fat-fighting squad.
Lactobacillus fermentum
Studies point to L. fermentum's ability to promote reductions in body fat percentages meaning not just weight loss, but actual fat burning. It's also believed to strengthen gut health overall, creating a stronger, more resilient digestive system that works for you, not against you.
Other Lean Bacteria: Lactobacillus plantarum, Lactobacillus paracasei, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium breve
Together, these additional strains make up a well-rounded team of good bacteria. They work to crowd out bad bacteria, promote better digestion, reduce bloating, and help reset the gut's natural fat-burning rhythm.
Inulin (from Chicory Root)
Inulin is a natural fiber that acts as food for the probiotics. It helps the good bacteria thrive and multiply once inside your gut. A healthier, more balanced gut means fewer cravings, better metabolism, and a stronger foundation for long-term weight management.
Greenselect Phytosome® (Caffeine-Free Green Tea Extract)
Unlike regular green tea, Greenselect uses a special technology that makes it easier for your body to absorb. It's been linked to significantly greater weight loss results in people who combined it with simple diet changes. Plus, it supports gut health and metabolism without any jittery caffeine side effects.
Sphaeranthus indicus & Garcinia mangostana
These two botanical extracts work in synergy to help reduce stubborn belly fat. Clinical studies suggest that when taken together, they can support both fat burning and a decrease in overall body weight. They act like an extra push, helping your body shift away from fat storage and toward a naturally leaner state.
Each ingredient inside Biome has been selected with care, not just for weight loss, but for restoring a healthy, fat-fighting environment inside your body where true transformation can happen.
Stop struggling against your body and start working with it. Choose Biome now and begin your journey toward sustainable fat loss and lasting energy.
Real Benefits of Using Biome (or LeanBiome)
Biome isn't about chasing quick wins or temporary results. It's about rebuilding your body's natural ability to stay lean, healthy, and energized — starting deep within your gut. As your microbiome gets stronger and healthier, the changes don't just show up on the scale; they ripple into every part of your life. Here's what you can truly expect from using Biome consistently. Supports Healthy, Long-Term Weight Loss
Biome helps restore the natural balance of gut bacteria that's often missing in people who struggle with stubborn fat, especially around the belly. By reinforcing your gut with nine strains of 'lean bacteria,' it encourages your body to burn fat more efficiently instead of clinging onto it. This isn't about dropping a few pounds only to gain them back later — it's about resetting your body's inner systems so that losing weight feels steady, natural, and sustainable. Reduces Persistent Hunger and Uncontrollable Cravings
One of the most frustrating parts of weight struggles is the constant mental battle with cravings. It's exhausting to feel like you're always fighting your own appetite. Biome helps by supporting better hunger hormone balance. As your gut health improves, many people notice they feel fuller longer, experience fewer blood sugar crashes, and find it easier to walk away from that bag of chips or that late-night dessert. It's like finally being able to breathe again after years of feeling trapped by food urges. Fires Up a Sluggish Metabolism
When your gut is unhealthy, your metabolism tends to slow down — no matter how much you diet or exercise. Biome helps by giving your metabolism the internal support it needs to wake up and start working properly again. A healthier microbiome means your body is better able to convert food into energy instead of fat. Over time, you might find yourself feeling more energetic, more active, and more alive — without having to over-caffeinate or crash midday. Helps Flatten Belly Fat and Support a Leaner Body Shape
Because Biome is specially formulated to target the gut issues connected to fat storage, many users notice a visible reduction in belly fat first. The stubborn bulge that refused to move despite years of effort can start to soften, slim down, and shift. Clothes may begin to fit better. Confidence slowly starts to return. Rebalances Your Gut for Better Digestion and Overall Health
Good digestion isn't just about avoiding bloating or gas. A healthy gut influences everything from your mood and immunity to how your body processes nutrients. Biome's ingredients help clean up the 'swamp' inside your gut, making digestion smoother, nutrient absorption better, and reducing that heavy, sluggish feeling after meals. A better gut often means a better you — not just physically, but emotionally too.
Biome isn't about punishing your body into weight loss. It's about healing your body into a naturally lean, vibrant, and healthier state, starting from the inside out.
Affordability, Bonuses & Guarantee
Pricing: 1 Bottle (30-Day Supply) – $59
– $59 3 Bottles (90-Day Supply) – $49 per bottle ($147 total)
– $49 per bottle ($147 total) 6 Bottles (180-Day Supply) – $39 per bottle ($234 total) + FREE US Shipping
Considering what most people spend monthly on quick fixes that don't last from pricey supplements to diet programs. Biome feels like an investment in real change, not just another short-lived promise.
If you're serious about flattening stubborn belly fat and regaining your energy, Biome is ready to help. Visit the official website and claim your bottles today.
And here's the best part, Biome is backed by a 180-Day 'Empty Bottle' Money-Back Guarantee.
Exclusive Bonus With Multi-Bottle Orders: #Bonus: 21 Gut-Friendly Smoothie Recipes (Value: $29.95)A practical, delicious guide filled with easy smoothies designed to nourish your gut, stabilize your blood sugar, and support your fat-loss goals. These smoothies aren't just tasty, they're part of the bigger healing journey Biome helps you start.
With everything combined, powerful ingredients, real gut healing, deep fat-loss support, risk-free guarantee, and valuable bonuses. Biome makes saying 'yes' to your health easier and smarter than ever.
FAQs About Biome (or LeanBiome)
How is Biome different from regular diet pills or probiotics?
Biome is different because it combines nine specific 'lean bacteria' strains with gut-nourishing ingredients that help rebalance your metabolism naturally. It's designed not just for digestion, but for real weight and belly fat support from the inside out.
When will I start seeing results with Biome?
Everyone's body is different, but most people start noticing changes in their digestion, energy, or cravings within the first few weeks. For the best results, giving Biome at least 60 to 90 days is recommended. Remember, it's about real, lasting change, not just a quick fix.
Is Biome safe to take daily?
Yes, Biome is made with naturally sourced ingredients, carefully formulated in an FDA-inspected, GMP-certified facility in the USA. It's vegan-friendly, free from gluten, dairy, soy, nuts, sugar, and GMOs. Most users tolerate it very well without any issues. As always, if you have specific health conditions or are pregnant or nursing, it's a smart idea to check with your doctor first.
Can Biome help if I've struggled with weight for years?
Absolutely. In fact, Biome is made for people who feel like nothing else has worked. If you've been stuck in a cycle of diets, workouts, and frustration, the root cause might have been your gut health all along. Biome aims to fix that foundation so that losing weight can finally become easier and more natural — even if you've been struggling for years.
Do I have to change my diet while using Biome?
While Biome supports gut health on its own, simple healthy habits can definitely speed things up. Eating more fiber-rich foods, drinking plenty of water, moving your body regularly, and cutting back on processed junk will all help your lean bacteria thrive faster. Think of Biome as your inside helper — and your everyday habits as its teammates.
Is Biome suitable for both men and women?
Yes, Biome works for both men and women. Weight struggles connected to gut imbalance don't discriminate. Whether you're male or female, 30 or 70, if you're dealing with stubborn belly fat, cravings, or slow metabolism, Biome is designed to support your journey toward a healthier, leaner body.
Real LeanBiome Review: Before & After Testimonials
'I honestly thought I was broken. I'd tried every diet you can name keto, fasting, low-carb and nothing seemed to stick. I'd lose a little, gain it right back. It was exhausting. Then I found Biome. It felt different from the start. Within a few weeks, my cravings calmed down. I wasn't constantly thinking about food anymore. And the stubborn belly fat that haunted me for years? It's finally starting to shrink. I feel like I have control over my body again.'
— Priyanka, 42, New Jersey
'The thing no one tells you about weight struggles is how much it messes with your confidence. I used to avoid mirrors and pictures at all costs. Biome didn't just help my digestion or flatten my stomach — it helped me feel proud of my body again. I wake up with more energy, my jeans fit better, and for the first time in years, I feel excited to get dressed in the morning.'
— Marcus, 51, Texas
'I was skeptical at first. I mean, how could gut bacteria have anything to do with my cravings? But after trying Biome for about six weeks, I noticed I wasn't raiding the pantry at midnight anymore. I wasn't even thinking about sweets all the time. It's like my body's hunger signals finally calmed down. And the bonus? I'm seeing my waistline come back without starving myself. I only wish I'd found this sooner.'
— Leah, 36, California
Final Verdict: The LeanBiome Review
If you're tired of fighting your own body, exhausted from endless dieting, cravings, frustration, and self-blame. If you know deep down that something inside isn't working the way it should then Biome could be the missing piece you've been searching for.
It doesn't promise overnight miracles. It doesn't offer a magic wand. What it offers is healing, starting with the real root of weight struggles: your gut.
Biome gives your body the chance to reset, to rebuild, and to return to a naturally lean, energetic, healthier version of yourself. Not through punishing diets. Not through shortcuts. But through science-backed support that helps your body do what it was always designed to do.
And with the 180-day money-back guarantee, there's nothing to fear and everything to gain. Either you start seeing the transformation you deserve, or you get every penny back.
Biome is designed to address the root cause of stubborn weight gain — your gut. Order your supply today and experience the difference better gut health can make. Company : Lean for Good Biome/LeanBiome
: Lean for Good Biome/LeanBiome Address : 315 Deaderick St., Suite 1550, Nashville, TN 37235.
: 315 Deaderick St., Suite 1550, Nashville, TN 37235. Email : [email protected]
: [email protected] Order Phone Support: (800) 763-1979
Disclaimers and Disclosures
This article is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. The content presented herein is based on publicly available research, product information, and subjective opinions at the time of writing. It is not intended to replace professional medical consultation, diagnosis, or treatment from a licensed healthcare provider.
Readers are strongly encouraged to consult with a qualified physician or healthcare professional before beginning any new dietary supplement, wellness regimen, or weight loss program, including Biome (LeanBiome) by Lean for Good®. Individual results may vary, and no specific outcome is guaranteed. Factors such as age, gender, health status, lifestyle habits, medication use, and genetic background can significantly influence outcomes.
The statements made regarding dietary supplements discussed in this article have not been evaluated by the Food and Drug Administration (FDA). Products mentioned are not intended to diagnose, treat, cure, or prevent any disease. Any testimonials, case studies, or examples are illustrative and do not represent typical results. They are not intended to guarantee that any individual will achieve the same or similar results.
While every effort has been made to ensure the accuracy, completeness, and timeliness of the information contained herein, no representations or warranties, express or implied, are made regarding the accuracy, reliability, validity, or completeness of the information. Typographical errors, omissions, and inaccuracies are possible. The publisher, authors, editorial contributors, and syndication partners expressly disclaim any and all liability for any direct, indirect, incidental, consequential, or punitive damages arising from any errors, inaccuracies, omissions, reliance on information provided, or actions taken based on the contents of this article.
This article may contain affiliate links. If a reader clicks on an affiliate link and subsequently makes a purchase, a commission may be earned at no additional cost to the purchaser. Such affiliate relationships do not influence editorial integrity, content presentation, or product evaluations presented in this article.
The publisher, authors, editors, and syndication partners assume no responsibility for any loss, injury, claim, liability, or damage of any kind resulting from the use of any product, program, information, or instructions contained in this article. All readers agree to access and use this information at their own risk.
All product details, including but not limited to prices, promotions, guarantees, ingredients, manufacturing processes, and shipping policies, are subject to change without notice. Readers are advised to verify all product information independently by visiting the official product website before making any purchase decision.
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SOLVE FSHD and Modalis Announce Strategic Collaboration to Develop an Innovative CRISPR-Based Epigenome Editing Treatment for Facioscapulohumeral Muscular Dystrophy

VANCOUVER, British Columbia & TOKYO & WALTHAM, Mass.--(BUSINESS WIRE)-- SOLVE FSHD, a venture philanthropy organization dedicated to accelerating treatments for facioscapulohumeral muscular dystrophy (FSHD), and Modalis Therapeutics Corporation (TSE 4883; 'Modalis'), a CRISPR-based epigenome editing therapeutics company focused on rare genetic diseases, today announced a strategic collaboration to develop an innovative therapy for FSHD, a debilitating muscular disorder affecting approximately 1 million individuals worldwide. The novel therapy leverages Modalis's proprietary CRISPR-GNDM ® (Guide Nucleotide-Directed Modulation) technology, which can dynamically modulate gene expression without introducing double-strand DNA breaks. SOLVE FSHD will provide strategic funding to support the development of Modalis's MDL-103 program. MDL-103 is an innovative therapeutic solution that continuously suppresses the expression of the DUX4 gene, the toxic disease-causing gene for FSHD, which becomes abnormally activated due to epigenetic changes in the D4Z4 repeat region on chromosome 4. MDL-103 is designed to have durable activity over long periods of time under the control of a strong, muscle-specific promoter, and is delivered to the muscles of patients using a muscle-tropic AAV delivery system. Modalis's CRISPR-GNDM ® technology has the potential to transform the treatment of FSHD by epigenetically silencing the expression of DUX4. 'SOLVE FSHD is pleased to partner with Modalis and to add them to our diverse portfolio of collaborators that are advancing potential therapies for FSHD,' stated Eva Chin, Executive Director of SOLVE FSHD. 'SOLVE FSHD identified Modalis as a company committed to finding a cure for this debilitating condition. We were impressed by their unique approach to targeting the epigenetic cause of FSHD, using a platform technology that has shown promise in other neuromuscular diseases. We believe that the support from SOLVE FSHD will allow Modalis to accelerate the advancement of MDL-103 into clinical trials.' 'We are delighted to be working in partnership with SOLVE FSHD and greatly appreciate the invaluable support for the development of MDL-103,' said Haru Morita, CEO of Modalis. 'This strategic collaboration is a strong validation of Modalis's CRISPR-GNDM ® technology and our MDL-103 program. As a pioneer in this technology, we have demonstrated promising long-term drug efficacy in mouse models, shown durable target engagement and safety in non-human primates, and exhibited excellent biodistribution in neuromuscular disorders. We believe that MDL-103, which incorporates CRISPR-GNDM ® technology with a muscle tropic AAV delivery system, has significant potential as a breakthrough treatment for FSHD.' About SOLVE FSHD SOLVE FSHD is a venture philanthropic organization established to catalyze innovation and accelerate key research in finding a cure for FSHD. Established by renowned Canadian entrepreneur and philanthropist, Chip Wilson, the Wilson family has committed $100 million to kick-start funding into projects that support the organizations' mission to solve FSHD by 2027. The goal of SOLVE FSHD is to find a solution that can slow down or stop muscle degeneration, increase muscle regeneration and strength, and improve the quality of life for those living with FSHD, visit Modalis was founded in 2016 and conducts research and development activities in Massachusetts, USA. Modalis is a pioneering leader in the field of epigenetic medicine. Modalis develops therapeutics for patients suffering from serious genetic disorders such as neuromuscular diseases, CNS diseases, and cardiomyopathies. Modalis's proprietary CRISPR-GNDM ® technology is capable of specifically up or down modulating the expression of disease-relevant genes without introducing double-strand DNA breaks. For more information, visit

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