ImmunoGenesis doses first subject in Phase I/II trial of hypoxia reversal agent
ImmunoGenesis has initiated the first subject dosing in a multicentre Phase I/II trial of IMGS-101 (evofosfamide), the hypoxia reversal agent, in conjunction with Balstilimab and Zalifrelimab, for treating adults with certain cancer types.
The subject was dosed at the University of Texas MD Anderson Cancer Center in Houston, US.
The open-label trial will focus on adults with locally advanced or metastatic castration-resistant prostate cancer, human papillomavirus-(HPV) negative squamous cell carcinoma of the head and neck (SCCHN), and pancreatic cancer.
It comprises a dose escalation and expansion part to assess the pharmacokinetics, efficacy, anti-tumour activity, and safety of the combination.
ImmunoGenesis Clinical Development senior vice-president Dr Charles Schweizer said: 'This trial marks an exciting step forward in addressing one of the key challenges in cancer immunotherapy. Hypoxia limits T-cell infiltration and suppresses immune responses, especially in prostate, pancreatic, and head and neck cancers.
'By reversing hypoxia, IMGS-101 may restore T-cell access to tumours, enhancing the effectiveness of checkpoint inhibitors and potentially transforming outcomes in these hard-to-treat cancers.'
Also referred to as Evofosfamide, IMGS-101 is stated to be a 2-nitroimidazole prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) that was initially developed as a hypoxia-activated prodrug.
Dr Michael Curran of MD Anderson and the founder of ImmunoGenesis demonstrated in his lab that IMGS-101 has a unique ability to overcome one of the most significant immunosuppressive barriers by reversing hypoxia.
The therapy is claimed to have 'restored' the function of T-cells in pre-clinical models and during a Phase I study, highlighting the early signs of synergy with checkpoint inhibitors.
IMGS-101 is being developed as a hypoxia-reversal agent aimed at conditioning tumours to respond to checkpoint inhibition.
Balstilimab and Zalifrelimab, both developed by the immuno-oncology company Agenus, are a fully human monoclonal immunoglobulin G1 targeting programmed cell death protein 1 (PD-1) and a cytotoxic T-lymphocyte associated antigen 4 (CTLA-4), respectively.
"ImmunoGenesis doses first subject in Phase I/II trial of hypoxia reversal agent" was originally created and published by Clinical Trials Arena, a GlobalData owned brand.
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'Many rashes can be mistaken for callus or dry skin of the feet, which may need prescription treatment,' Moghaddam said. HuffPost and its publishing partners may receive a commission from some purchases made via links on this page. Every item is independently curated by the HuffPost Shopping team. Prices and availability are subject to change. Amazon Gold Bond is loved for affordable moisturizing products and this foot cream is especially popular. It's made with three key vitamins: vitamin E (which can help to lock in moisture), vitamin B (which helps with the appearance of skin) and vitamin C (which can protect against environmental stressors).Promising review: 'Having very rough heels and wearing sandals was embarrassing. This keeps my feet looking very nice.' — Genie 2-pack: $19 at Amazon 4-ounce tube: $6 Amazon Think your cracked heels are beyond hope? Give this Eucerin foot cream a try and your feet will be transformed. 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My feet, for the first time in at least 10 years, are soft, callus-free and look healthy. I put it on every morning before I put my socks on to help it soak in and it has been a complete transformation for my feet. I will buy this stuff for the rest of my life! I can't recommend it enough!' — DeEtta S. $9 at Amazon Amazon Made with shea butter, coconut oil and jojoba oil, this foot cream is formulated to gently exfoliate the skin, making removing dry calluses easier while simultaneously locking in review: 'This cream has made my cracked heels so soft! I've been using it only at night before bed, and the heel cracks have about disappeared, even though I'm still in and out of the pool and walking barefoot around the place all the time. Wow, the 40% urea really made a difference for those callouses. No knock on Kerasal, which works the same; it just takes longer to heal those bad cracks because of its lower concentration of active thick, sticky cream dries to a powdery matte finish (the Kerasal is in a petrolatum base and stays greasier). I put socks on over the product but only to hold in the moisture a little more; once it's dry, the cream doesn't leave grease stains. Don't be put off by the texture of the cream, which acts a bit like white glue while you're applying it. Just spread a nice layer over those callouses, rub the rest into your cuticles, let dry a couple minutes and you're done! The urea softens and draws moisture into your skin, while the salicylic acid helps exfoliate that thick dry layer on top. No more heel cracks, nor rough cuticles. I am thrilled with my newly soft, soft skin.' — Goat girl $16 at Amazon $16 at Walmart Amazon Technically an ointment and not a cream, this foot product is a best seller (it has more than 53,000 ratings) and it's easy to see why: You simply massage a few drops into your feet and let it work its magic. You'll notice your heels soften as you go about your day thanks to the combo of petrolatum and salicylic review: 'I have tested countless foot care products, but Kerasal Intensive Foot Repair Ointment is an exceptional solution for cracked heels and dry feet. My own feet were suffering from severe dryness and painful cracks. Upon applying the ointment just once, I noticed a remarkable difference. The formula immediately soothed and hydrated my skin, alleviating the a few days, my feet underwent a dramatic transformation. The cracks began to heal and the skin regained its softness and suppleness. I could finally walk comfortably again without the agonizing pain that had plagued me. This ointment contains a potent blend of active ingredients, including ceramides, shea butter and lanolin, which work synergistically to repair damaged skin, seal in moisture, and prevent future dryness. The thick, creamy texture adheres well to the skin, ensuring prolonged hydration. Kerasal Intensive Foot Repair Ointment is a must-have for anyone with cracked heels or dry feet. Its effectiveness and ease of use make it a lifesaver for summer feet. I highly recommend this product to anyone seeking a solution to foot care woes.' — Lisa G. $8 at Amazon $9 at Walmart Amazon Made with salicylic acid, shea butter, tea tree oil and vitamin E, this thick foot cream will turn any rough patches silky smooth. The salicylic acid serves as a gentle exfoliant while the tea tree oil calms inflammation and the shea butter and vitamin E moisturize. Promising review: 'I've had monster calluses and cracked heels for years. I tried a lot of products. This one works for me. I noticed a huge improvement in just four days. Two weeks and the cracks were gone. Calluses are no longer a problem. It has a light, neutral scent and nice texture. It sinks right in.' — Springhop $19 at Amazon Amazon Urea is a common ingredient in foot cream because it helps remove dead skin cells while binding to water, helping keep skin moisturized. It's the primary ingredient in this popular review: 'I have no idea how I did not know about this product until now. I was watching a dermatologist recommend urea creams on her channel and I decided to give it a try. I suffer from very dry skin but I decided to give it a shot since body oil and generic lotions just never do the trick for as long as I would like. I put this cream all over my feet after a warm shower…really focusing on my heels and then I immediately put on socks and went to bed. I was shocked with the results the next morning. My rough heels were soft and it looked like I just got a pedicure. It's three days later and my dry heels have only slightly returned.I will definitely do this trick at least once a week. I personally do not recommend putting this on the body unless you just got out of a warm shower and your skin is still damp. I did notice that when I put it on my dry body, that I must have used too much product and therefore was left with a sticky feeling and slight build up. I am extremely satisfied with the price because other urea creams can be pretty expensive. I definitely will continue to use this product for my feet. Please give it a try so you can feel confident being barefoot or wearing sandals and heels.' — Catie Schooley $10 at Amazon Amazon Dr. Scholl's is a big name in the foot game and this foot cream is made to undo the dryness that you may be experiencing in your feet. Made with urea, essential oils and Epsom salt, it'll keep your feet soft for 24 hours. The peppermint, lavender and eucalyptus scent will have your feet smelling great too! Promising review: 'I haven't had feet this soft since I was in my 20s. This stuff really worked for me. I put it on every morning before I put my socks and shoes on and go to work. At the end of the day, my feet look great and are soft.' — Veronica $6 at Amazon $9 at CVS $6 at Target Amazon If you're an athlete or work out a lot, you should especially show your feet some love and using this tea tree oil-based foot cream is a great way to do it. Not only does it smell amazing, according to reviewers, but it also helps prevent athlete's foot — particularly helpful if you shower at the review: 'This foot cream is the only product that has helped my feet. They stay hydrated, they don't crack, burn or feel painfully tired at the end of the day. I use it morning and night. I hope it stays around because it is a permanent part of my daily life now.' — Crystlmalice $8 at Amazon Amazon Unlike some thick lotions, this heel cream is absorbed quickly. 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It has just enough of a 'mild peppermint scent' to it, according to one reviewer, and hydrates skin without feeling too review: 'In the winter, I use this lotion with socks on after I shower and it works wonders on my feet. They are no longer dry or cracked.' — Momof4 $5 at Target Target If you've developed thick calluses on your feet, this dermatologist-recommended foot cream will help soften them right up thanks to the active ingredient, lactic acid. It helps repair splits and cracks quickly, yet review: 'This foot cream works like a charm - put it on at night with socks for about a week and you will be amazed at the transformation in your feet' — Carol $12 at Target $12 at Amazon Walmart The coconut oil in this foot cream moisturizes while rosemary extract helps calm inflamed skin. Bonus: one reviewer said it smells 'amazing.'Promising review: 'I'm really happy I came across this product. My feet were in bad shape, very dry and so badly cracked that it hurt to walk but thanks to Burt's Bees they are on their way to recovery. The only thing I dislike is that it's a little messy, but if it completely heals my heels I don't care.' — 550123 $9 at Walmart $10 at CVS $9 at Amazon Walmart Who doesn't love a multitasking beauty product? Heal calluses and cracks while preventing the growth of fungi under your toenails — a must if you shower at the gym. Even though you're hard on your feet, they'll still look cute!Promising review: 'It is great stuff. You should know not to put it on your whole foot, just the parts with problems. Be sure to always put lotion on after putting on the aura. Next morning wash it off and more lotion. It got rid of my ugly crack heels in one week. I will use this once a month to keep my heels smooth. Thanks for this great product.' — Becky $16 at Walmart $16 at Amazon These Terry Cotton Insoles Really 'Keep Smelly Feet At Bay' — And They're Under $20 Reviewers Swear These Shoes Are Perfect For Swollen And Sensitive Feet If You Hate Sweaty Feet, You'll Love These Breathable Walking Shoes
