Wishes Can't Wait Telethon phone lines are OPEN!
ALABAMA (WHNT) — News 19 and Make-A-Wish Alabama are partnering up for the Wishes Can't Wait telethon TODAY!
Phone lines open at 6 a.m. and will close at 7 p.m. To donate by phone, you can call (256) 319-1371.
More than 70 children in North Alabama are waiting for Make-A-Wish Alabama to grant their wishes.
That's why News 19 is partnering with Make-A-Wish Alabama to help fulfill these wishes, because Wishes Can't Wait!
The children who are waiting for their wishes to be granted are all living with a critical illness. Some of those children have spent most of their lives in and out of doctors' offices, hospitals and treatments.
Make-A-Wish helps those children live a life outside of their medical complications by offering them a joyful moment amidst an otherwise difficult time. Whether it's meeting a celebrity, asking for a gift, or planning the trip of a lifetime, Make-A-Wish wants to give every child their dream.
Those wishes make a big impact. Last year, Make-A-Wish surveyed over 3,000 wish alumni, wish parents and medical professionals about the impact of granted wishes. Here's what they found:
Nine out of 10 wish kids reported that the wish experience relieved them from traumatic stress
Nine out of 10 wish parents saw their child's emotional well-being improve with a wish
Nine out of 10 medical providers say a wish increased compliance with treatment
Nine out of 10 medical providers observed that the wish experience has a positive impact on a child's physical well-being and overall quality of life
Eight out of 10 wish kids reported that their wish gave them the strength to fight their critical illness.
The problem is that wishes are expensive. The average wish costs $10,000, and Make-A-Wish relies on donors to grant every single one. 245 children are waiting throughout Alabama, and 78 of them are in North Alabama. Any of those children could be your neighbors, co-workers' kids, or classmates of your own children.
Anyone can donate, including businesses! We encourage business owners in the area to consider Wishes Can't Wait as part of their philanthropy efforts.
We know our viewers have a heart for service, and you prove it over and over again.
The best part is you know your money is staying right here in the state. 100% of the proceeds go to children in our backyard, fighting these unimaginable medical battles.
We are accepting donations right now! If you'd like to donate online, you can donate here. You can also text WISHES to 44834.
Make-A-Wish Alabama has granted over 1,700 wishes since the chapter's founding in 2012.
Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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13 hours ago
- Yahoo
BioNTech Announces Strategic Transaction to Acquire CureVac in Public Exchange Offer
Acquisition will strengthen the research, development, manufacturing and commercialization of mRNA-based cancer immunotherapy candidates, marking BioNTech's next key milestone in the execution of its oncology strategy Acquisition of CureVac will complement BioNTech's capabilities and proprietary technologies in mRNA design, delivery formulations, and mRNA manufacturing Public exchange offer for all shares of CureVac where each share of CureVac will be exchanged for approx. $5.46 in BioNTech American Depositary Shares ('ADSs'), representing a premium of 55% to CureVac's three-month volume weighted average price of approx. $3.53 as of June 11, 2025 All-stock acquisition has potential to create long-term value for both companies' shareholders given their complementary capabilities, focus on mRNA innovation, and shared vision Transaction is supported by CureVac's major shareholder dievini Hopp BioTech holding GmbH & Co. KG and certain of its affiliates and expected to close in 2025 MAINZ and TÜBINGEN, Germany, June 12, 2025 (GLOBE NEWSWIRE) -- BioNTech SE (Nasdaq: BNTX, 'BioNTech') and CureVac N.V. (Nasdaq: CVAC, 'CureVac') today announced that they have entered into a definitive Purchase Agreement pursuant to which BioNTech intends to acquire all of the shares of CureVac, a clinical-stage biotech company developing a novel class of transformative medicines in oncology and infectious diseases based on messenger ribonucleic acid ('mRNA'). The all-stock transaction will bring together two highly complementary companies based in Germany and will build on BioNTech's proven track record and established position in the global mRNA industry. With the acquisition, BioNTech aims to strengthen the research, development, manufacturing, and commercialization of investigational mRNA-based cancer immunotherapy. The strategic transaction will complement BioNTech's capabilities and proprietary technologies in mRNA design, delivery formulations, and mRNA manufacturing. For BioNTech, this transaction marks the next milestone in the execution of its oncology strategy which focuses on two pan-tumor programs, mRNA-based cancer immunotherapy candidates, and BNT327, a PD-L1xVEGF-A bispecific antibody candidate. Under the terms of the Purchase Agreement, each CureVac share will be exchanged for approx. $5.46 in BioNTech ADSs, resulting in an implied aggregate equity value for CureVac of approx. $1.25 billion (subject to the adjustments described below). The consideration is subject to a collar mechanism, such that if the 10-day volume weighted average price of the BioNTech ADSs ending on the fifth business day prior to the closing of the offer ('VWAP') exceeds $126.55, the exchange ratio would be 0.04318, and if the VWAP is lower than $84.37, the exchange ratio would be 0.06476. Upon closing of the transaction, CureVac shareholders are expected to own between 4% and 6% of BioNTech. 'This transaction is another building block in BioNTech's oncology strategy and an investment in the future of cancer medicine,' said Prof. Ugur Sahin, M.D., CEO and Co-Founder of BioNTech. 'We intend to bring together complementary capabilities and leverage technologies with the goal of advancing the development of innovative and transformative cancer treatments and establishing new standards of care for various types of cancer in the coming years.' 'To me, this transaction is more than a business decision, it represents a shared commitment to leverage the full potential of mRNA as a disruptive technology to develop transformative therapies with greater scale and speed,' said Dr. Alexander Zehnder, CEO of CureVac. 'For more than two decades, both companies have operated with related ambitions, often tackling challenges from different angles. This transaction aims at combining complementary scientific capabilities, proprietary technologies, and manufacturing expertise in the mRNA field under one roof.' BioNTech will start preparing an integration plan in alignment with BioNTech's ongoing group-wide transformation. Following the closing of the transaction, CureVac's operating subsidiary will become a wholly owned subsidiary of BioNTech. As part of this plan, BioNTech will integrate CureVac's state-of-the-art research and manufacturing site in Tübingen. BioNTech's all-stock acquisition of CureVac is expected to create long-term value for shareholders of both companies, building on BioNTech's proven track record in mRNA research, development, manufacturing, and commercialization, in particular the COVID-19 vaccine, which was developed in collaboration with Pfizer Inc. and marked the first approved mRNA product in the history of medicine. Based on BioNTech's strong financial position with €15.9 billion in cash, cash equivalents and security investments as of March 31, 2025, its global presence, late-stage clinical pipeline, and sustained investment in mRNA research across a broad range of solid tumor types, the acquisition positions the company to accelerate and broaden the development of mRNA-based medicines for patients in need. Following the closing of the exchange offer BioNTech and CureVac will effectuate a corporate reorganization of CureVac and its subsidiaries, resulting in BioNTech owning 100% of CureVac's business and interests in CureVac and its subsidiaries. As part of this corporate reorganization, CureVac shareholders who do not tender their shares in the exchange offer will receive the same consideration received for each CureVac share tendered in the exchange offer (without interest and subject to applicable withholding taxes). An extraordinary general meeting of CureVac's shareholders will be convened in connection with the exchange offer to adopt, among other things, certain resolutions relating to the transaction. The transaction was unanimously approved by both BioNTech's and CureVac's management and supervisory boards. The transaction, which is expected to close in 2025, is subject to the satisfaction of customary closing conditions, including a minimum acceptance threshold of at least 80% of CureVac's shares (which threshold may be reduced to 75% unilaterally by BioNTech under certain circumstances) and required regulatory approvals. Certain shareholders of CureVac representing 36.76% of CureVac's shares, including dievini Hopp BioTech holding GmbH & Co. KG and certain of its affiliates and all members of CureVac's management and supervisory boards, have entered into tender and support agreements, pursuant to which they have agreed, among other things, and subject to the terms and conditions of such agreements, to tender their shares in the exchange offer and to vote in favor of the resolutions relating to the transaction at the CureVac extraordinary general meeting to be held in connection with the transaction. In addition, the German Federal government has confirmed to generally have a positive view on the transaction. BioNTech therefore assumes that Kreditanstalt für Wiederaufbau – which holds 13.32% of the shares in CureVac on behalf of the Federal Republic of Germany – will support the transaction by tendering its shares in CureVac. As a result, BioNTech expects to have contractual commitments to support the transaction from shareholders of CureVac representing a total of 50.08% of CureVac shares towards the 80% minimum condition required under the exchange offer. Covington & Burling LLP, Hengeler Mueller Partnerschaft von Rechtsanwälten mbB and Loyens & Loeff N.V. served as legal counsel to BioNTech. Skadden, Arps, Slate, Meagher & Flom LLP and NautaDutilh N.V. served as legal counsel to CureVac. PJT Partners served as exclusive financial advisor to BioNTech. Goldman Sachs Bank Europe SE served as exclusive financial advisor to CureVac. About BioNTechBiopharmaceutical New Technologies (BioNTech) is a global next generation immunotherapy company pioneering novel investigative therapies for cancer and other serious diseases. BioNTech exploits a wide array of computational discovery and therapeutic modalities with the intent of rapid development of novel biopharmaceuticals. Its diversified portfolio of oncology product candidates aiming to address the full continuum of cancer includes mRNA cancer immunotherapies, next-generation immunomodulators and targeted therapies such as antibody-drug conjugates (ADCs) and innovative chimeric antigen receptor (CAR) T cell therapies. Based on its deep expertise in mRNA development and in-house manufacturing capabilities, BioNTech and its collaborators are researching and developing multiple mRNA vaccine candidates for a range of infectious diseases alongside its diverse oncology pipeline. BioNTech has established a broad set of relationships with multiple global and specialized pharmaceutical collaborators, including Bristol Myers Squibb, Duality Biologics, Fosun Pharma, Genentech, a member of the Roche Group, Genevant, Genmab, MediLink, OncoC4, Pfizer and more information, please visit About CureVacCureVac (Nasdaq: CVAC) is a pioneering multinational biotech company founded in 2000 to advance the field of messenger RNA (mRNA) technology for application in human medicine. CureVac's mRNA platform incorporates a series of novel technologies, designed to improve the efficacy, safety and cost-effectiveness of mRNA therapeutics aimed at resulting in enhanced immune responses at lower doses. Additionally, CureVac has developed LNPs, which have been optimized for indication specific use across infectious diseases and oncology. CureVac is leveraging mRNA technology, combined with advanced omics and computational tools, to design and develop off-the-shelf and personalized cancer vaccine product candidates. It also develops programs in prophylactic vaccines and in treatments that aim to enable the human body to produce its own therapeutic proteins. Headquartered in Tübingen, Germany, CureVac also operates sites in the Netherlands, Belgium, Switzerland, and the U.S. Further information can be found at Cautionary Statement Regarding Forward-Looking Statements This document includes 'forward-looking statements,' within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as 'potential,' 'can,' 'will,' 'plan,' 'may,' 'could,' 'would,' 'expect,' 'look forward,' 'investigational,' 'pipeline,' 'to acquire,' 'development,' 'to include,' 'commitment,' or similar terms. Such forward-looking statements include, but are not limited to, statements relating to the ability of BioNTech and CureVac to complete the transactions contemplated by the Purchase Agreement (including the parties' ability to satisfy the conditions to the consummation of the exchange offer contemplated thereby and the other conditions set forth in the Purchase Agreement), the expected timetable for completing the transactions, the benefits sought to be achieved in the proposed transactions, the potential and capacity of BioNTech following the transaction and the potential effects of the proposed transactions on BioNTech and CureVac. Many of these risks and uncertainties are beyond the control of BioNTech or CureVac. Investors are cautioned that any such forward-looking statements are based on BioNTech's or CureVac's current beliefs and expectations regarding future events and are not guarantees of future performance and involve risks and uncertainties. There can be no guarantees that the conditions to the closing of the transactions will be satisfied on the expected timetable or at all. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. You should not place undue reliance on these statements. Risks and uncertainties include, but are not limited to, uncertainties as to the timing of the exchange offer and the subsequent corporate reorganization of CureVac; uncertainties as to how many of CureVac's shareholders will tender their shares in the exchange offer; the risk that competing offers or acquisition proposals will be made; the possibility that various conditions to the consummation of the exchange offer and the transactions contemplated by the Purchase Agreement may not be satisfied or waived; the possibility of a termination of the Purchase Agreement; the ability to obtain necessary regulatory approvals or to obtain them on acceptable terms or within expected timing; the effects of disruption from the transactions contemplated by the Purchase Agreement and the impact of the announcement and pendency of the transactions on BioNTech's and/or CureVac's business, including their relationships with employees, business partners or governmental entities; the risk that the exchange offer or the other transactions contemplated by the Purchase Agreement may be more expensive to complete than anticipated; the risk that litigation in connection with the exchange offer or the other transactions contemplated by the Purchase Agreement may result in significant costs of defense, indemnification and liability; a diversion of management's attention from ongoing business operations and opportunities as a result of the exchange offer, the other transactions contemplated by the Purchase Agreement or otherwise; general industry conditions and competition; general political, economic and business conditions, including interest rate, inflation, tariff and currency exchange rate fluctuations, and the ongoing Russia-Ukraine and Middle East conflicts; the impact of regulatory developments and changes in the United States, Europe and countries outside of Europe, including with respect to tax matters; the impact of pharmaceutical industry regulation and health care legislation in the United States, Europe and elsewhere; the particular prescribing preferences of physicians and patients; competition from other products; challenges and uncertainties inherent in new product development; ability to obtain or maintain proprietary intellectual property protection; safety, quality, data integrity or manufacturing issues; and potential or actual data security and data privacy breaches. Neither BioNTech nor CureVac undertakes any obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise, except to the extent required by law. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in BioNTech's and CureVac's respective Annual Report on Form 20-F for the year ended December 31, 2024, in each case as amended by any subsequent filings made with the U.S. Securities and Exchange Commission (the 'SEC'), available on the SEC's website at Notice to Investors and Security HoldersThis document is for information purposes only and does not constitute an offer to sell or the solicitation of an offer to buy any securities nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. In connection with the proposed transactions, BioNTech intends to file a Registration Statement on Form F-4 (the 'Registration Statement') with the U.S. Securities and Exchange Commission (the 'SEC'), including an offer to exchange/prospectus to register, under the Securities Act of 1933, as amended, the issuance of BioNTech's American Depositary Shares ('ADSs') pursuant to the exchange offer. In addition, BioNTech intends to file a Tender Offer Statement on Schedule TO (the 'Schedule TO'), which will include, as exhibits, the offer to exchange/prospectus, a form of letter of transmittal and other customary ancillary documents, with the SEC and soon thereafter CureVac intends to file a Solicitation/Recommendation Statement on Schedule 14D-9 (the 'Schedule 14D-9') with respect to the exchange offer. The exchange offer for the common shares of CureVac referred to in this document has not yet commenced. The solicitation and offer to purchase CureVac's common shares will only be made pursuant to the Schedule TO and related exchange offer/prospectus. This material is not a substitute for the offer to exchange/prospectus, the Schedule TO, the Schedule 14D-9, the Registration Statement or for any other document that BioNTech or CureVac may file with the SEC and send to CureVac's shareholders in connection with the proposed transactions. With respect to the public offering of BioNTech ADSs to CureVac shareholders in Germany and in any other member state of the European Economic Area, this document is an advertisement for the purposes of the prospectus regulation EU 2017/1129, as amended. It does not constitute an offer to purchase any BioNTech ADSs or shares in BioNTech and does not replace the securities prospectus which will be available free of charge, together with the relevant translation(s) of the summary, from BioNTech's website ( The approval of the securities prospectus by the German Federal Financial Supervisory Authority should not be understood as an endorsement of the investment in any BioNTech ADSs or shares in BioNTech. Investors in Germany and in any other member state of the European Economic Area should acquire BioNTech ADSs solely on the basis of the prospectus (including any supplements thereto, if any) relating to the ADSs and should read the prospectus which is yet to be published (including any supplements thereto, if any) before making an investment decision in order to fully understand the potential risks and rewards associated with the decision to invest in the BioNTech ADSs. Investment in BioNTech ADSs entails numerous risks, including a total loss of the initial investment. With respect to the public offering of BioNTech ADSs to CureVac shareholders in the United Kingdom (the 'UK'), BioNTech will publish a UK prospectus exemption document for the purposes of the prospectus regulation EU 2017/1129 as it forms part of UK domestic law by virtue of the European Union (Withdrawal) Act 2018, as amended. This document does not constitute an offer to purchase any BioNTech ADSs or shares in BioNTech and does not replace the UK prospectus exemption document which will be available free of charge from BioNTech's website ( Investors in the UK should acquire BioNTech ADSs solely on the basis of the UK prospectus exemption document (including any supplements thereto, if any) relating to the BioNTech's ADSs and should read the UK prospectus exemption document which is yet to be published (including any supplements thereto, if any) before making an investment decision in order to fully understand the potential risks and rewards associated with the decision to invest in the BioNTech ADSs. Investment in BioNTech ADSs entails numerous risks, including a total loss of the initial investment. BEFORE MAKING ANY INVESTMENT DECISION OR DECISION WITH RESPECT TO THE EXCHANGE OFFER, WE URGE INVESTORS OF CUREVAC TO READ THE REGISTRATION STATEMENT, EXCHANGE OFFER/PROSPECTUS, SCHEDULE TO (INCLUDING THE EXCHANGE OFFER, RELATED LETTER OF TRANSMITTAL AND OTHER OFFER DOCUMENTS) AND SCHEDULE 14D-9, AS EACH MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO TIME, AND OTHER RELEVANT DOCUMENTS CAREFULLY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT BIONTECH, CUREVAC AND THE PROPOSED TRANSACTIONS THAT HOLDERS SHOULD CONSIDER. Investors will be able to obtain free copies of the Registration Statement, exchange offer/prospectus, Schedule TO and Schedule 14D-9, as each may be amended from time to time, and other relevant documents filed by BioNTech and CureVac with the SEC (when they become available) at the SEC's website, or free of charge from BioNTech's website ( or by contacting BioNTech's Investor Relations Department at investors@ These documents are also available free of charge from CureVac's website ( or by contacting CureVac's Investor Relations Department at communications@ CONTACTS BioNTech: Investor RelationsDouglas Maffei, PhDInvestors@ Media RelationsJasmina AlatovicMedia@ CureVac: Media and Investor Relationscommunications@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
14 hours ago
- Yahoo
6 toilet habit changes you should always see a doctor about
No one enjoys talking about bowel movements. But ignoring the signs your body is trying to send you can mean putting off a diagnosis you really need to hear. Just ask TOWIE star Chloe Meadows. The reality TV regular recently shared on Dr Oscar Duke's Bedside Manners podcast that she'd spent a decade silently struggling with bleeding, stomach pain and extreme fatigue before finally getting a diagnosis: ulcerative colitis, a chronic condition that causes inflammation and ulcers in the colon. She lived with on-and-off symptoms for years, assuming they'd passed. It wasn't until age 26, when she became visibly unwell, that a blood test led her to A&E and finally, a diagnosis. Meadows' experience is an important reminder that when your toilet habits change – and stay changed – it's time to talk to your GP. Below, we break down six toilet-related red flags that experts say you should never ignore. And no, it's not just about your bowel movements; your wee, urgency levels, and even smells all matter, too. Whether you're suddenly constipated, dealing with constant diarrhoea, or noticing your stool looks different (narrower, paler or greasy), changes that last longer than a few weeks are worth investigating. The NHS advises that ongoing shifts in bowel habits could be linked to anything from diet and stress to Irritable Bowel Syndrome (IBS), coeliac disease or inflammatory bowel disease (IBD). In some cases, persistent symptoms could be a sign of bowel cancer, so don't brush them off. When to see your GP: If your usual routine has changed for more than two to three weeks, especially if it's paired with stomach pain, fatigue, or weight loss. It might be bright red or dark and tarry; either way, it's not something to ignore. Bright red blood can come from piles or small tears, but darker blood might mean there's bleeding higher up in the digestive system. When to see your GP: If you see blood in your poo. You may be offered a stool test, or in some cases, a referral for further checks. If anything feels amiss and suddenly starts to sting, burn or feel uncomfortable, you might assume it's a urinary tract infection (UTI). And often, that's true. But it can also be a sign of kidney stones or bladder issues. Blood in your urine should also be taken seriously, even if it only happens once. When to see your GP: If you have pain while urinating, see blood or feel the urge to go far more often than usual. Needing the loo more often than usual (especially at night), feeling like you can't wait, or leaking a little when you cough, sneeze or laugh could signal an overactive bladder, prostate issues (in men), or pelvic floor dysfunction. These symptoms might feel embarrassing, but they're generally common and manageable with the right support. When to see your GP: If bladder leaks or urgency interfere with your daily life, or if you notice a sudden change in how often you need to go. A little mucus in your stool isn't always a worry, but frequent slimy stools can be a sign of infection or inflammation in your gut. When to see your GP: If mucus appears regularly, especially if it comes with bloating, pain or a change in bowel movements. If going to the toilet has become uncomfortable, painful, or feels like hard work, that's your body waving a red flag. Regular straining can cause or worsen hemorrhoids, but it might also signal bowel issues or even neurological problems affecting your pelvic floor. When to see your GP: If you're straining often, feel like you're not fully emptying your bowels, or notice pain during or after a bowel movement. If you're unsure, remember that everyone has their own baseline of what's 'normal'. However, there are a few simple signs to watch for as a guide. According to the Bladder and Bowel Health Service, healthy bowel movements should be soft, smooth and easy to pass; ideally at least three times a week. You should also be able to urinate without pain or discomfort. If you also notice you're often bloated, tired, straining, or notice blood or mucus, it's time to speak to your GP. Changes might be harmless, but they're always worth checking. Read more on bowel habits: This Poop Chart Will Tell You If Your Bathroom Habits Are Actually Healthy Or If You Need To See A Doctor ASAP (Buzzfeed, 4-min read) How 'blowing bubbles' and 'mooing' can help ease constipation, according to NHS doctor (Yahoo Life UK, 4-min read) Bowel cancer cases in young people rising sharply in England, study finds (PA Media, 4-min read)
Yahoo
a day ago
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World Precision Instruments and SynVivo Launch Next-Generation Multiplexed TEER-on-a-Chip Platform for Real-Time Organ-on-a-Chip Cell Monitoring
SARASOTA, Fla. and HUNTSVILLE, Ala., June 11, 2025 /PRNewswire/ -- World Precision Instruments (WPI), a global leader in transepithelial electrical resistance (TEER) instrumentation, and SynVivo Inc., a pioneer in Organ-on-a-Chip (OOC) technology, today announced the commercial launch of a next-generation multiplexed TEER-on-a-Chip platform—a breakthrough solution enabling real-time, high-throughput measurement of barrier integrity in advanced Organ-on-a-Chip models. The co-developed platform integrates WPI's gold-standard EVOM™ measurement technology with SynVivo's SynTEER™ multiplexed OOC models with embedded electrodes, providing researchers with a seamless solution for performing TEER measurements directly within microfluidic chips. Initially validated on SynVivo's advanced SynBBB™ Blood-Brain Barrier model, this is the first in a planned series of Organ-on-a-Chip platforms powered by the new EVOM-Chip™ system from WPI. With electrodes embedded directly into SynVivo's SynTEER™ multiplexed OOC models researchers can now perform real-time TEER measurements across multiple channels—enabling continuous barrier monitoring, streamlined workflows, and improved reproducibility. The EVOM-Chip™ system allows for hands-free, simultaneous data collection, and remains fully compatible with live-cell imaging and physiologically relevant flow conditions. "This collaboration represents a major advancement in functional barrier modeling," said Gwen Fewell, President & CEO of SynVivo Inc. "Integrating TEER measurement directly into our chip enhances data fidelity, reduces variability, and streamlines experimental workflows—key to enabling more predictive, standardized and scalable in vitro models. By combining our vascularized OOC technology with WPI's industry-leading TEER measurement expertise, we're delivering a powerful solution for researchers tackling complex questions in CNS drug development, inflammation, and drug discovery." WPI's EVOM™ family of TEER instrumentation has set the standard for barrier function assessment for over 30 years. SynVivo's SynTEER™ platform builds on this legacy with pre-integrated, precisely aligned electrodes designed to optimize TEER signal fidelity across a range of Organ-on-a-Chip applications. As the OOC market rapidly grows, it continues to face challenges around standardization and automation, both of which are essential for mainstream adoption in pharmaceutical research. "A critical gap has been the ability to perform on-chip, non-destructive sensing—particularly TEER measurements—a need shared by the majority of OOC platforms but rarely implemented successfully or in a multiplex fashion," explains Mark Rutledge, CEO of WPI. "With EVOM™ Chip, researchers can monitor their OOC platforms from cell seeding through barrier formation, as well as before, during and after drug treatment, to get accurate and reproducible readouts, without affecting the health or well-being of the cells." The system's initial application on the SynBBB™ Blood-Brain Barrier platform has demonstrated a strong correlation between electrical resistance and functional barrier properties, supporting its use in CNS drug development, inflammation studies, and neurovascular research. See It Live at MPS World Summit – Brussels, June 10–13, 2025Visit WPI and SynVivo at the MPS World Summit to explore the EVOM-Chip™ and SynTEER-on-a-Chip systems in action and learn how integrated TEER-on-Chip technology can accelerate your research. WPI Booth #131 SynVivo Booth #404 ABOUT WORLD PRECISION INSTRUMENTS For over 55 years, World Precision Instruments (WPI) has been a leading global manufacturer and provider of innovative research equipment and laboratory supplies to the life sciences, pharmaceutical, health care, and industrial markets. Our proven technology supports complex model development, including preclinical models and organ-on-a-chip systems, providing researchers with the tools to identify and validate drugs to understand mechanism of action, dosage, administration, drug-drug interactions, patient-specific reactions, pharmacokinetics, pharmacodynamics, safety and efficacy. Our areas of innovation focus on tissue and cell biology, fluidics, animal physiology and electrophysiology. With an extensive global network and a passion for innovation, WPI provides novel solutions to customers' daily challenges. For more information, visit About SynVivoSynVivo is a pioneering organ-on-chip company developing physiologically relevant tissue models for drug discovery, disease research, and safety testing. Its advanced microfluidic platforms replicate human tissue microenvironments to enhance the predictive accuracy of in vitro testing. SynVivo is committed to bridging the gap between traditional preclinical models and human clinical outcomes, advancing a new standard in predictive, human-relevant drug development. View original content to download multimedia: SOURCE SynVivo and World Precision Instruments Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
