logo
Bottlenose dolphin born at Brookfield Zoo Chicago, takes its first breath on video

Bottlenose dolphin born at Brookfield Zoo Chicago, takes its first breath on video

Yahoo3 hours ago

A bottlenose dolphin safely delivered a calf early Saturday morning at Brookfield Zoo Chicago, a 'momentous occasion' that marks the first dolphin birth in more than a decade at the west suburban zoo.
Allie, a 38-year-old bottlenose dolphin and experienced mother of four, gave birth to the calf — which will be named later this summer — at 12:22 a.m., the zoo said in a news release. Veterinarians estimated that the calf weighs between 33 to 37 pounds and is 115 to 120 centimeters long.
'Every birth is a remarkable learning opportunity, and the scientific information we gain benefits marine conservation efforts,' said Dr. Mike Adkesson, the zoo's president and CEO. 'The birth offers a moment to celebrate the incredible work and dedication of our team to ensure the health and well-being of the animals in our care.'
Allie began showing signs of labor Friday morning when her body temperature dropped about a degree, the zoo said. By 11 p.m., the calf's flukes presented itself, and within less than an hour and a half the calf was born, the zoo's first since 2014. A video showed the calf swimming up to the water's surface for its first breath alongside Allie and Tapeko, another dolphin and an experienced mother.
https://www.chicagotribune.com/wp-content/uploads/2025/06/Brookfield-Zoo-Baby-Dolphin.mp4
'The calf came out very strong,' Dr. Jennifer Langan, senior veterinarian, said in the video one hour after the delivery. 'It has been breathing well, and it's developing new skills that dolphins have to develop really quickly. That includes learning how to surface to breathe, learning how to move its flukes.'
The calf reached other developmental milestones as well, including 'slipstreaming,' which is when a calf gets pulled along by its mother so that it doesn't have to work as hard to swim, the zoo said. The calf's dorsal fin and tail flukes are also pliable and lack firmness, but will gradually stiffen in a few days.
These milestones, which staff are monitoring 'around the clock,' are important because although calves are born fully developed after a 12-month gestation, they heavily rely on their mother for nutrition, navigation and to conserve energy. A calf's first year of life can be particularly precarious. In the wild, 1 in 5 calves born to first-time mothers don't survive their first year, the zoo said.
'The first 30 days are a critical time frame for Allie and her calf,' said Dr. Sathya Chinnadurai, the zoo's senior vice president of animal health, welfare and science. 'We're closely monitoring behaviors and milestones to gauge the calf's progress, like its first breath of air, bonding with its mother, growth and an increase in nursing efficiency.'
Staff will confirm which dolphin is the calf's father in the coming months, the zoo said.
Brookfield Zoo has a long history of dolphin care and research. In 1961, it opened the country's first inland dolphin aquarium. For over five decades, the zoo has also led the Sarasota Dolphin Research Program in Florida, the world's longest-running wild dolphin conservation program, which studies bottlenose dolphins as indicators of the overall health of the marine ecosystem, as well as the presence of diseases and toxins like contaminants, runoff, red tides and algal blooms.
The zoo's Seven Seas dolphin habitat is temporarily closed while the calf acclimates to the dolphin group.

Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Trump-Musk row fuels 'biggest crisis ever' at Nasa
Trump-Musk row fuels 'biggest crisis ever' at Nasa

Yahoo

timean hour ago

  • Yahoo

Trump-Musk row fuels 'biggest crisis ever' at Nasa

The row between Donald Trump and Elon Musk over a major spending bill has exacerbated uncertainty over the future of Nasa's budget, which is facing deep cuts. The space agency has published its budget request to Congress, which would see funding for science projects cut by nearly a half. Forty science missions, which are in development or in space already, are in line to be stood down. The president has threatened to withdraw federal contracts with Musk's company, Space X. Nasa relies on the firm's Falcon 9 rocket fleet to resupply the International Space Station with crew and supplies. The space agency also expects to use its Starship rocket to send astronauts to the Moon and eventually to Mars once it has been developed. Dr Simeon Barber, a space scientist at the Open University said that the uncertainty was having a "chilling impact" on the human space programme. "The astonishing exchanges, snap decisions and U turns we've witnessed in the last week undermine the very foundations that we build our ambitions on. "Space science and exploration relies upon long term planning and cooperation between government, companies and academic institutions." Aside from the feud between the President and Mr Musk, there is also concern about deep cuts requested by the White House to Nasa's budget. All sectors have been earmarked for savings, apart from an effort to send astronauts to Mars, which has received a $100m (£736,000) boost. According to Casey Dreier, chief of space policy for the Pasadena-based Planetary Society, which promotes space exploration, the potential cuts represent "the biggest crisis ever to face the US space programme". Nasa has said that its request to reduce its overall budget by nearly a quarter "aligns (its) science and technology portfolios to missions essential for the exploration of the Moon and Mars". Dr Adam Baker, a space analyst at Cranfield University told BBC News that if these proposals are approved by Congress, it would fundamentally shift the agency's focus. "President Trump is repurposing Nasa for two things: to land astronauts on the Moon before the Chinese and to have astronauts plant a US flag on Mars. Everything else is secondary." Those who back the proposals say the White House's budget has given Nasa a clear purpose, for the first time since the days of the Apollo Moon landings of the 1960s and 70s, when the aim was to beat the Soviet Union to the Moon. Nasa's critics say that since then the space agency has become a bloated, unfocussed bureaucracy which routinely goes massively over budget in its space missions and wastes taxpayer's money. One of the most egregious examples of this is Nasa's new rocket for its plans to return American astronauts to the Moon, the Space Launch System (SLS). Its development has been delayed, and costs have spiralled such that it costs $4.1bn (£3.3bn) for each and every launch. By contrast, SpaceX's equivalent rocket system, Starship, is estimated to cost around $100m (£80m) per launch because it is designed to be reusable. Jeff Bezos's Blue Origin space company promises similar savings for its proposed New Glenn rocket. To no one's surprise, SLS will be phased out under the White House proposals, in the hope that Starship and New Glenn can take its place. But the past three development launches of Starship have been unsuccessful, and Blue Origin has only recently begun to test its Moon rocket. "The worry is that Nasa may be jumping out of the frying pan, into the fire," says Dr Barber. "The development of these alternatives to SLS is being bankrolled by Elon Musk and Jeff Bezos. "If they lose their appetite for this endeavor and SpaceX or Blue Origin say they need more money to develop their systems, Congress will have to give it to them," says Dr Barber. Nasa needs saving from itself – but is this billionaire right for that job? Of greater concern, says Dr Barber, is the potential loss of 40 missions to explore other planets and to monitor the impact of climate change on Earth from space, many of which involve collaborations with international partners. "I think it is very sad that what has taken so long to build can be knocked down with a wrecking ball so quickly with no plan to rebuild it afterwards." The projects facing the axe include dozens of planetary missions already in space for which most of the development and launch costs have already been paid for, with relatively small savings proposed on their operating costs. Also under threat are two collaborations with the European Space Agency: An ambitious plan to bring martian rocks collected by Nasa's Perseverance Rover back to Earth and a mission to send Europe's Rosalind Franklin Rover to the red planet to search for signs of past life. Prof Sir Martin Sweeting, head of the UK space firm Surrey Satellite Technology Ltd, and co-author of a Royal Society report on the future of space says that while the development was "unwelcome", there may be an upside for Europe as it takes greater responsibility for its own space exploration programme. "Maybe we have been too reliant on Nasa the big player to carry a lot of the emphasis in space," he told BBC News. "It is an opportunity to think about how Europe wants to get a better balance in its space activities." But there is much more downside for Europe in the short term. As well as the return of Mars samples and its Rover, ESA risks reduced access to the International Space Station if it is wound down, and the budget cuts cancel Nasa's extensive contributions to its successor, the Lunar Gateway, a multinational space station planned for orbit around the Moon. In its recently published strategy ESA stated it "will be seeking to build a more autonomous space capability, and to continue being a reliable, strong and desirable partner with space agencies from around the globe," with the implication that it would do so with or without Nasa. Also facing cuts are numerous current and proposed Earth Observation programmes according to Dr Baker. "These Earth observation programmes are our canary in the coal mine," he told BBC News. "Our ability to predict the impact of climate change and mitigate against it could be drastically reduced. If we turn off this early warning system it is a frightening prospect". The budget proposals have yet to be approved by Congress. The planetary Society's Casey Dreier has told BBC News that many Republicans have told lobbyists privately that they are prepared to vote against the cuts. But, Mr Dreier worries that there is a strong possibility that political gridlock might mean that no budget will be agreed. It is likely that the reduced White House budget would be put in place as an interim measure, which could then not easily be reversed, because once space missions are turned off it is hard, if not impossible, to start them up again.

Dupixent® (dupilumab) Data at Revolutionizing Atopic Dermatitis (RAD) Conference Reinforce Use in Atopic Dermatitis Patients with Skin of Color
Dupixent® (dupilumab) Data at Revolutionizing Atopic Dermatitis (RAD) Conference Reinforce Use in Atopic Dermatitis Patients with Skin of Color

Yahoo

timean hour ago

  • Yahoo

Dupixent® (dupilumab) Data at Revolutionizing Atopic Dermatitis (RAD) Conference Reinforce Use in Atopic Dermatitis Patients with Skin of Color

Atopic dermatitis is a chronic disease that disproportionately impacts communities of color Dupixent achieved 75% or greater improvement in overall disease severity, the primary endpoint, in more than three-quarters of treated patients Patients experienced substantial reductions in hyperpigmentation, dry skin and itch from baseline Results support commitment to enhance clinical understanding of chronic diseases in communities of color TARRYTOWN, N.Y. and PARIS, June 07, 2025 (GLOBE NEWSWIRE) -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) and Sanofi today presented results from the DISCOVER Phase 4, single-arm, open-label trial assessing Dupixent® (dupilumab) in adults and adolescents with moderate-to-severe atopic dermatitis with skin of color. These are the first clinical trial results for Dupixent in a large population of patients with darker skin tones. The results, along with the Dupixent Phase 3 trials, demonstrated patients taking Dupixent experienced improvements in signs and symptoms of atopic dermatitis from baseline across many skin tones. The data were shared in an oral presentation at the 2025 Revolutionizing Atopic Dermatitis (RAD) Conference. 'Atopic dermatitis, a chronic disease with underlying type 2 inflammation, has a high prevalence and quality of life impact on patients with skin of color. Unique clinical features like darker patches of hyperpigmentation versus redness typically seen on lighter skin may lead to less accurate diagnoses and underestimation of disease severity,' said Andrew Alexis, M.D., M.P.H., Professor of Clinical Dermatology at Weill Cornell Medicine. 'The results from the DISCOVER trial showed that Dupixent patients with atopic dermatitis and darker skin not only experienced reduced disease severity and itch but also saw improvements in areas of particular concern including dyspigmentation and dry skin. These data deepen the clinical understanding of atopic dermatitis within this underserved population, including use of newly validated scales.' In the trial, 120 patients with atopic dermatitis and skin of color (82% Black, 11% Asian, 2% American Indian/Alaska Native, 5% Arab, Central American or other) were treated with Dupixent every two weeks using a weight-based dosing regimen. At 24 weeks: 76% achieved a ≥75% improvement in overall disease severity (EASI-75), the primary endpoint. Improvements were seen by some patients as early as two weeks. 53% achieved clinically meaningful improvement in itch (≥4-point reduction on the peak-pruritus numerical rating scale [PP-NRS]). Improvements were seen by some patients as early as two weeks. Patients experienced a 53% reduction from baseline in post-inflammatory hyperpigmentation, dropping from 5.1 points (moderate/marked) to 2.4 points (mild). 18% were very or extremely bothered by dry skin vs. 78% at baseline, based on patient reporting. The safety results in the DISCOVER trial were generally consistent with the known safety profile of Dupixent in its approved dermatological indications. The overall rate of adverse events (AEs; n=124) in the DISCOVER trial was 42%, with the most common (≥2%) AEs being headache (3%), upper respiratory tract infection (2%), eczema (2%), conjunctivitis (3%) and allergic conjunctivitis (2%). About Atopic Dermatitis in Skin of ColorAtopic dermatitis is a chronic skin disease with underlying type 2 inflammation that causes intense, persistent itch and skin lesions that cover much of the body, resulting in skin dryness, cracking, pain, crusting and oozing. In patients with skin of color, the type and location of the lesions can vary, and they are more likely to have hardened skin lesions and severe skin dryness, itch, dyspigmentation and greater disease severity than those with lighter skin. Additionally, redness that is observed on lighter skin typically appears as darkened, grey or violet on darker skin tones. Because the disease presents differently in people with skin of color, it can be misdiagnosed or the severity underestimated, which can contribute to higher levels of healthcare resource utilization. About the DISCOVER Clinical TrialThe DISCOVER Phase 4 open-label, single-arm trial evaluated the efficacy and safety of Dupixent in adults and adolescents aged 12 years and older with moderate-to-severe atopic dermatitis and skin of color, as defined by Fitzpatrick skin types IV-VI (those with high melanin; light brown to black). During the 24-week treatment period, all patients in the trial received Dupixent monotherapy every two weeks based on weight after a loading dose: patients weighing ≥30 to <60 kg received 200 mg and patients weighing ≥60 kg received 300 mg. The primary endpoint assessed the proportion of patients who achieved at least 75% improvement on the Eczema Area and Severity Index (EASI-75) at 24 weeks. Secondary endpoints included the proportion of patients who achieved ≥4-point improvement on the Peak-Pruritus Numerical Rating Scale (PP-NRS) at 24 weeks. Additional endpoints included pigmentary changes on the clinician-reported Post-Inflammatory Hyperpigmentation Severity Scale (PHSS; scale: 0-8) and skin dryness on the newly developed patient-reported Xerosis NRS (X-AD; scale: 0-10) at 24 weeks. About DupixentDupixent, which was invented using Regeneron's proprietary VelocImmune® technology, is a fully human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) pathways and is not an immunosuppressant. The Dupixent development program has shown significant clinical benefit and a decrease in type 2 inflammation in Phase 3 trials, establishing that IL-4 and IL-13 are two of the key and central drivers of the type 2 inflammation that plays a major role in multiple related and often co-morbid diseases. Dupixent has received regulatory approvals in more than 60 countries in one or more indications including certain patients with atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic esophagitis (EoE), prurigo nodularis, chronic spontaneous urticaria (CSU) and chronic obstructive pulmonary disease (COPD) in different age populations. More than 1,000,000 patients are being treated with Dupixent globally.1 About Regeneron's Technology Regeneron's VelocImmune technology utilizes a proprietary genetically engineered mouse platform endowed with a genetically humanized immune system to produce optimized fully human antibodies. When Regeneron's co-Founder, President and Chief Scientific Officer George D. Yancopoulos was a graduate student with his mentor Frederick W. Alt in 1985, they were the first to envision making such a genetically humanized mouse, and Regeneron has spent decades inventing and developing VelocImmune and related VelociSuite® technologies. Dr. Yancopoulos and his team have used VelocImmune technology to create a substantial proportion of all original, FDA-approved fully human monoclonal antibodies. This includes Dupixent® (dupilumab), Libtayo® (cemiplimab-rwlc), Praluent® (alirocumab), Kevzara® (sarilumab), Evkeeza® (evinacumab-dgnb), Inmazeb® (atoltivimab, maftivimab and odesivimab-ebgn) and Veopoz® (pozelimab-bbfg). In addition, REGEN-COV® (casirivimab and imdevimab) had been authorized by the FDA during the COVID-19 pandemic until 2024. Dupilumab Development Program Dupilumab is being jointly developed by Regeneron and Sanofi under a global collaboration agreement. To date, dupilumab has been studied across more than 60 clinical trials involving more than 10,000 patients with various chronic diseases driven in part by type 2 inflammation. In addition to the currently approved indications, Regeneron and Sanofi are studying dupilumab in a broad range of diseases driven by type 2 inflammation or other allergic processes in Phase 3 trials, including chronic pruritus of unknown origin, bullous pemphigoid, and lichen simplex chronicus. These potential uses of dupilumab are currently under clinical investigation, and the safety and efficacy in these conditions have not been fully evaluated by any regulatory authority. U.S. INDICATIONS DUPIXENT is a prescription medicine used: to treat adults and children 6 months of age and older with moderate-to-severe eczema (atopic dermatitis or AD) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age. with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age. with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults and children 12 years of age and older whose disease is not controlled. It is not known if DUPIXENT is safe and effective in children with chronic rhinosinusitis with nasal polyps under 12 years of age. to treat adults and children 1 year of age and older with eosinophilic esophagitis (EoE), who weigh at least 33 pounds (15 kg). It is not known if DUPIXENT is safe and effective in children with eosinophilic esophagitis under 1 year of age, or who weigh less than 33 pounds (15 kg). to treat adults with prurigo nodularis (PN). It is not known if DUPIXENT is safe and effective in children with prurigo nodularis under 18 years of age. with other medicines for the maintenance treatment of adults with inadequately controlled chronic obstructive pulmonary disease (COPD) and a high number of blood eosinophils (a type of white blood cell that may contribute to your COPD). DUPIXENT is used to reduce the number of flare-ups (the worsening of your COPD symptoms for several days) and can improve your breathing. It is not known if DUPIXENT is safe and effective in children with chronic obstructive pulmonary disease under 18 years of age. to treat adults and children 12 years of age and older with chronic spontaneous urticaria (CSU) who continue to have hives that are not controlled with H1 antihistamine treatment. It is not known if DUPIXENT is safe and effective in children with chronic spontaneous urticaria under 12 years of age, or who weigh less than 66 pounds (30 kg). DUPIXENT is not used to relieve sudden breathing problems and will not replace an inhaled rescue medicine. DUPIXENT is not used to treat any other forms of hives (urticaria). IMPORTANT SAFETY INFORMATION Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®. Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you: have eye problems. have a parasitic (helminth) infection. are scheduled to receive any vaccinations. You should not receive a 'live vaccine' right before and during treatment with DUPIXENT. are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby. A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines; have asthma and use an asthma medicine; or have atopic dermatitis, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, prurigo nodularis, chronic obstructive pulmonary disease, or chronic spontaneous urticaria, and also have asthma. Do not change or stop your other medicines, including corticosteroid medicine or other asthma medicine, without talking to your healthcare provider. This may cause other symptoms that were controlled by those medicines to come back. DUPIXENT can cause serious side effects, including: Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area. Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an exam if needed Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, brown or dark colored urine, persistent fever, or a feeling of pins and needles or numbness of your arms or legs. Psoriasis. This can happen in people with atopic dermatitis and asthma who receive DUPIXENT. Tell your healthcare provider about any new skin symptoms. Your healthcare provider may send you to a dermatologist for an examination if needed. Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms. The most common side effects include: Eczema: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, dry eye, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia). Asthma: injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections. Chronic Rhinosinusitis with Nasal Polyps: injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, high count of a certain white blood cell (eosinophilia), gastritis, joint pain (arthralgia), trouble sleeping (insomnia), and toothache. Eosinophilic Esophagitis: injection site reactions, upper respiratory tract infections, cold sores in your mouth or on your lips, and joint pain (arthralgia). Prurigo Nodularis: eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, herpes virus infections, common cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea. Chronic Obstructive Pulmonary Disease: injection site reactions, common cold symptoms (nasopharyngitis), high count of a certain white blood cell (eosinophilia), viral infection, back pain, inflammation inside the nose (rhinitis), diarrhea, gastritis, joint pain (arthralgia), toothache, headache, and urinary tract infection. Chronic Spontaneous Urticaria: injection site reactions. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088. Use DUPIXENT exactly as prescribed by your healthcare provider. It's an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it's recommended DUPIXENT be administered by or under supervision of an adult. In children 6 months to less than 12 years of age, DUPIXENT should be given by a caregiver. Please see accompanying full Prescribing Information including Patient Information. About RegeneronRegeneron (NASDAQ: REGN) is a leading biotechnology company that invents, develops and commercializes life-transforming medicines for people with serious diseases. Founded and led by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to numerous approved treatments and product candidates in development, most of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurological diseases, hematologic conditions, infectious diseases, and rare diseases. Regeneron pushes the boundaries of scientific discovery and accelerates drug development using our proprietary technologies, such as VelociSuite, which produces optimized fully human antibodies and new classes of bispecific antibodies. We are shaping the next frontier of medicine with data-powered insights from the Regeneron Genetics Center® and pioneering genetic medicine platforms, enabling us to identify innovative targets and complementary approaches to potentially treat or cure diseases. For more information, please visit or follow Regeneron on LinkedIn, Instagram, Facebook or X. About Sanofi Sanofi is an R&D driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. We apply our deep understanding of the immune system to invent medicines and vaccines that treat and protect millions of people around the world, with an innovative pipeline that could benefit millions more. Our team is guided by one purpose: we chase the miracles of science to improve people's lives; this inspires us to drive progress and deliver positive impact for our people and the communities we serve, by addressing the most urgent healthcare, environmental, and societal challenges of our time. Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY. Regeneron Forward-Looking Statements and Use of Digital Media This press release includes forward-looking statements that involve risks and uncertainties relating to future events and the future performance of Regeneron Pharmaceuticals, Inc. ('Regeneron' or the 'Company'), and actual events or results may differ materially from these forward-looking statements. Words such as 'anticipate,' 'expect,' 'intend,' 'plan,' 'believe,' 'seek,' 'estimate,' variations of such words, and similar expressions are intended to identify such forward-looking statements, although not all forward-looking statements contain these identifying words. These statements concern, and these risks and uncertainties include, among others, the nature, timing, and possible success and therapeutic applications of products marketed or otherwise commercialized by Regeneron and/or its collaborators or licensees (collectively, 'Regeneron's Products') and product candidates being developed by Regeneron and/or its collaborators or licensees (collectively, 'Regeneron's Product Candidates') and research and clinical programs now underway or planned, including without limitation Dupixent® (dupilumab); uncertainty of the utilization, market acceptance, and commercial success of Regeneron's Products and Regeneron's Product Candidates and the impact of studies (whether conducted by Regeneron or others and whether mandated or voluntary), including the studies discussed or referenced in this press release, on any of the foregoing; the likelihood, timing, and scope of possible regulatory approval and commercial launch of Regeneron's Product Candidates and new indications for Regeneron's Products, such as Dupixent for the treatment of chronic pruritus of unknown origin, bullous pemphigoid, lichen simplex chronicus, and other potential indications; the ability of Regeneron's collaborators, licensees, suppliers, or other third parties (as applicable) to perform manufacturing, filling, finishing, packaging, labeling, distribution, and other steps related to Regeneron's Products and Regeneron's Product Candidates; the ability of Regeneron to manage supply chains for multiple products and product candidates and risks associated with tariffs and other trade restrictions; safety issues resulting from the administration of Regeneron's Products (such as Dupixent) and Regeneron's Product Candidates in patients, including serious complications or side effects in connection with the use of Regeneron's Products and Regeneron's Product Candidates in clinical trials; determinations by regulatory and administrative governmental authorities which may delay or restrict Regeneron's ability to continue to develop or commercialize Regeneron's Products and Regeneron's Product Candidates; ongoing regulatory obligations and oversight impacting Regeneron's Products, research and clinical programs, and business, including those relating to patient privacy; the availability and extent of reimbursement or copay assistance for Regeneron's Products from third-party payors and other third parties, including private payor healthcare and insurance programs, health maintenance organizations, pharmacy benefit management companies, and government programs such as Medicare and Medicaid; coverage and reimbursement determinations by such payors and other third parties and new policies and procedures adopted by such payors and other third parties; changes in laws, regulations, and policies affecting the healthcare industry; competing drugs and product candidates that may be superior to, or more cost effective than, Regeneron's Products and Regeneron's Product Candidates (including biosimilar versions of Regeneron's Products); the extent to which the results from the research and development programs conducted by Regeneron and/or its collaborators or licensees may be replicated in other studies and/or lead to advancement of product candidates to clinical trials, therapeutic applications, or regulatory approval; unanticipated expenses; the costs of developing, producing, and selling products; the ability of Regeneron to meet any of its financial projections or guidance and changes to the assumptions underlying those projections or guidance; the potential for any license, collaboration, or supply agreement, including Regeneron's agreements with Sanofi and Bayer (or their respective affiliated companies, as applicable), to be cancelled or terminated; the impact of public health outbreaks, epidemics, or pandemics on Regeneron's business; and risks associated with litigation and other proceedings and government investigations relating to the Company and/or its operations (including the pending civil proceedings initiated or joined by the U.S. Department of Justice and the U.S. Attorney's Office for the District of Massachusetts), risks associated with intellectual property of other parties and pending or future litigation relating thereto (including without limitation the patent litigation and other related proceedings relating to EYLEA® (aflibercept) Injection), the ultimate outcome of any such proceedings and investigations, and the impact any of the foregoing may have on Regeneron's business, prospects, operating results, and financial condition. A more complete description of these and other material risks can be found in Regeneron's filings with the U.S. Securities and Exchange Commission, including its Form 10-K for the year ended December 31, 2024 and its Form 10-Q for the quarterly period ended March 31, 2025. Any forward-looking statements are made based on management's current beliefs and judgment, and the reader is cautioned not to rely on any forward-looking statements made by Regeneron. Regeneron does not undertake any obligation to update (publicly or otherwise) any forward-looking statement, including without limitation any financial projection or guidance, whether as a result of new information, future events, or otherwise. Regeneron uses its media and investor relations website and social media outlets to publish important information about the Company, including information that may be deemed material to investors. Financial and other information about Regeneron is routinely posted and is accessible on Regeneron's media and investor relations website ( and its LinkedIn page ( Sanofi Disclaimers or Forward-Looking Statements This media update contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates regarding the marketing and other potential of the product, or regarding potential future revenues from the product. Forward-looking statements are generally identified by the words 'expects', 'anticipates', 'believes', 'intends', 'estimates', 'plans', and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, unexpected regulatory actions or delays, or government regulation generally, that could affect the availability or commercial potential of the product, the fact that product may not be commercially successful, the uncertainties inherent in research and development, including future clinical data and analysis of existing clinical data relating to the product, including post marketing, unexpected safety, quality or manufacturing issues, competition in general, risks associated with intellectual property and any related future litigation and the ultimate outcome of such litigation, and volatile economic and market conditions, and the impact that global crises may have on us, our customers, suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global economy as a whole. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under 'Risk Factors' and 'Cautionary Statement Regarding Forward-Looking Statements' in Sanofi's annual report on Form 20-F for the year ended December 31, 2024. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements. All trademarks mentioned in this press release are the property of the Sanofi group except for VelociSuite and Regeneron Genetics Center. Regeneron Contacts:Media Relations Ilana YellenTel: +1 Contacts:Media RelationsSandrine GuendoulTel: +33 6 25 09 14 Evan BerlandTel: +1 Le BourhisTel: + 33 6 75 06 43 Victor RouaultTel: +33 6 70 93 71 GilbertTel: +1 UbaldiTel: +33 6 30 19 66 Investor Relations Mark HudsonTel: +1 914-847-3482 Investor RelationsThomas Kudsk LarsenTel: +44 7545 513 KaisserianTel: +33 6 47 04 12 Lauscher Tel: +1 Keita BrowneTel: +1 Pham Tel: +33 7 85 93 30 17 Elgoutni Tel: +1 617-710-3587 Châtelet Tel: +33 6 80 80 89 90 Li Tel: +33 6 84 00 90 72 1 Data on FileSign in to access your portfolio

What Would've Happened in the Canceled World War Z Movie Sequel?
What Would've Happened in the Canceled World War Z Movie Sequel?

Yahoo

timean hour ago

  • Yahoo

What Would've Happened in the Canceled World War Z Movie Sequel?

Not that Brad Pitt ever really needed the extra exposure, but World War Z was supposed to mark the beginning of a science fiction series that would have placed the perennial A-list actor at the hot-zone epicenter of his very own expanded zombie franchise. In the original 2013 movie (currently airing on SYFY — view the schedule here!), Pitt starred as Gerry Lane, dragged out of retirement and back to his former role as a U.N. investigator, all to stake out the cure for a global zombie disease. The film ended with the game-changing tease that the cure renders zombies unable to detect humans who haven't been infected yet, which in turn set up a possible second film in which society might have fought to reclaim a world already devastated by the zombie apocalypse. Marc Forster (Finding Neverland, Quantum of Solace) directed World War Z, and a similarly big directing name — David Fincher — was intended to be seated at the helm for Pitt's return in the planned (but never made) World War Z sequel. World War Z had been inspired by the same-named 2006 horror novel from author Max Brooks, and a 2012 Los Angeles Times feature flagged the first film as the opening salvo in what was meant to be a full-fledged zombie-themed movie trilogy that would feature Pitt in the ongoing leading role. Fincher's busy creative schedule, plus budget issues and a changing landscape of cultural standards at the international box office, all reportedly conspired to thwart the studio's attempts at getting a film followup to World War Z past the pre-production stage. By 2019, reports surfaced that plans for the sequel had officially been shelved. But in a more recent 2023 interview with GQ — fresh on the heels of the first TV season of post-apocalyptic creature drama The Last of Us — Fincher opened up about the direction his sequel collaboration with Pitt might have taken. 'It was a little like The Last of Us,' Fincher confided. 'I'm glad that we didn't do what we were doing, because The Last of Us has a lot more real estate to explore the same stuff. In our title sequence, we were going to use the little parasite… they used it in their title sequence, and in that wonderful opening with the Dick Cavett, David Frost-style talk show.' The Last of Us introduced its zombie-adjacent apocalypse of fungus-infected 'clickers' by showing, right from the start, the domino effect of societal panic that followed from the first reported cases of the disease's quickly-spreading pandemic among humans. Fincher's praise for the series' handling of similarly-themed material came with an additional revelation that his World Ward Z sequel likely would not have followed Brooks' book-based source material any more closely than the first film — but, he intriguingly added, 'there is some talk of doing that.' With no recent reports from the World War Z front, it's tough to know whether a sequel will ever materialize — or, for that matter, if the franchise might someday be rebooted under new creative direction and a new cast. That means the franchise remains quarantined to only a single movie for now... but at least it's a good one. Catch Pitt saving the planet from zombies in the original , airing this month on SYFY. Scope the full TV schedule !

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into the world of global news and events? Download our app today from your preferred app store and start exploring.
app-storeplay-store