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The Speed of Your Eyes Could Hide Objects in Plain Sight

The Speed of Your Eyes Could Hide Objects in Plain Sight

Yahoo21-05-2025

A gently lobbed baseball is easy to see. The same ball, however, can seem to vanish from the hand of a skilled pitcher, whizzing invisibly into the catcher's mitt.
Given enough acceleration, moving objects become too fast to see. Yet this visual speed limit isn't universal – some people are apparently better at seeing in high-speed.
According to a new study, the secret may lie in subtle eye movements known as saccades. These rapid motions of the eyes shift our focus between various points of interest, and are regarded as the most frequent movement the human body makes. By some calculations they occur two to three times every second, adding up to around 10,000 times every waking hour.
Saccades take place naturally constantly without our thought or even awareness, but they don't occur at the same speed in everybody. The quickness of each person's saccades may determine their visual speed limit, the authors report, enabling those with faster saccades to perceive faster motion.
The findings seem to demonstrate how our perception depends not just on the sensory limits of our eyes, but also on how our eyes behave as they observe. From bow hunters to baseball players, those with exceptional skills in fast visual tasks might be unwittingly capitalizing on speedy saccades.
"What parts of the physical world we can sense depends fundamentally on how good our sensors are," says lead author Martin Rolfs, a vision scientist at Humboldt University of Berlin.
Human eyes aren't sensitive to infrared light, for example, so we can't see it. This is an in-built limitation, illustrating how the mechanics of our sensory organs dictate our perception.
"In this paper, however, we show that the limits of seeing are not just defined by these biophysical constraints, but also by the actions and movements that impose changes on the sensory system," Rolfs says.
As we scan a scene or read text, our eyes naturally dart around to different focal points, briefly pausing on each before flitting to the next. While this helps our vision cover more territory, it risks disrupting the entire retinal image, effectively blinding our perception for fractions of a second at a time.
Fortunately our brain's visual system edits out this disrupted motion in real-time, providing us with a seamless visual input by selectively excluding the careening effect of saccades.
"Even though visual processing remains operational during saccades, this saccade-induced retinal motion is subjectively invisible during natural vision – a phenomenon referred to as saccadic omission," the researchers write.
Saccades occur with incredible speed, outpacing most ordinary moving stimuli. Yet when we do encounter unusually fast objects, those similar enough to our own saccade motions may be edited from our perception.
In the new study, Rolfs and his colleagues used high-speed video projections to display fast-moving objects that either matched or deviated from the motion of saccades. For each stimulus, observers performed perceptual tasks that were only possible if they'd seen the trajectory of motion.
Stimuli following the specific movement patterns of saccades became invisible to observers, the study found.
"So we are basically suggesting that the kinematics of our actions (here, saccades) fundamentally constrain a sensory system's access to the physical world around us," Rolfs says.
Considering how active our eyes are, this highlights the importance of factoring that movement into our understanding of the broader visual system.
"In simple terms, the properties of a sensory system such as the human visual system are best understood in the context of the kinematics of actions that drive its input," Rolfs says.
"Our visual system and motor system are finely tuned to each other, but this has long been ignored."
The study was published in Nature Communications.
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2 Day Virtual Device Makers and Drugmakers Supplier Management Qualification, Contracts and Audits Course
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Associated Press

time38 minutes ago

  • Associated Press

2 Day Virtual Device Makers and Drugmakers Supplier Management Qualification, Contracts and Audits Course

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Press Release: ASCO: new Sarclisa data support subcutaneous administration with on-body injector
Press Release: ASCO: new Sarclisa data support subcutaneous administration with on-body injector

Associated Press

time3 hours ago

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Press Release: ASCO: new Sarclisa data support subcutaneous administration with on-body injector

ASCO: new Sarclisa data support subcutaneous administration with on-body injector Paris, June 3, 2025. New data from two clinical studies of the investigational use of Sarclisa administered subcutaneously (SC) via an on-body injector (OBI) (also referred to as an on-body delivery system) in relapsed or refractory multiple myeloma (R/R MM) support the potential use of this innovative delivery method to advance patient care, while upholding Sarclisa's efficacy and safety profile. The results were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting and include full data from the IRAKLIA phase 3 study, the first to incorporate the use of an OBI in the treatment of MM, and demonstrate non-inferior efficacy and pharmacokinetics compared to Sarclisa intravenous (IV) infusion. Alyssa Johnsen, MD, PhD Global Therapeutic Area Head, Immunology and Oncology Development 'Our subcutaneous clinical program is rooted in our mission to address patient needs and reduce treatment burden in multiple myeloma. We believe the novel on-body injector represents a significant innovation thatcouldimprove and streamline the treatment process for both patients and providers. We are pleased to share thesedata, the first to evaluate an on-body injector with a multiple myeloma treatment, and look forwardtopotentiallybringing this formulation and administrationoptionto the multiple myeloma community.' The OBI offers the potential to improve the overall patient experience in MM treatment. 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The safety and efficacy of Sarclisa SC administered with the OBI or manual administration are investigational and have not been approved for use by any regulatory authority. IRAKLIA phase 3 study IRAKLIA is a global, randomized, open-label, pivotal phase 3 non-inferiority study comparing Sarclisa SC administered via an OBI and Sarclisa IV, both in combination with pomalidomide and dexamethasone (Pd) in adult patients with R/R MM who have received at least one prior line of treatment. At the data cut-off of November 6, 2024, and a median follow-up of 12 months, the study demonstrated: Primary endpoints Secondary endpoints The overall safety profile of Sarclisa SC-Pd observed in this study was consistent with the established safety profile of Sarclisa IV-Pd, but with a notably lower rate of systemic IRs. 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The secondary objective is patient preference for the OBI versus manual administration of Sarclisa SC. About Enable Injections Based in the US (Cincinnati, OH), Enable Injections is a global healthcare innovation company committed to improving the patient treatment experience through the development and manufacturing of enFuse. enFuse is an innovative wearable drug delivery platform that is designed to deliver large volumes of pharmaceutical and biologic therapeutics via subcutaneous administration, with the aim of improving convenience, supporting superior outcomes, and advancing healthcare system economics. For more information, visit About Sarclisa Sarclisa (isatuximab) is approved in more than 50 countries, including in the US, EU, Japan, and China, across multiple treatment lines for MM. Based on the ICARIA-MM phase 3 study, Sarclisa is approved in the US, EU and Japan in combination with Pd for the treatment of patients with R/R MM who have received ≥two prior therapies, including lenalidomide and a proteasome inhibitor and have relapsed on the last therapy; this combination is also approved in China for patients who have received at least one prior line of therapy, including lenalidomide and a proteasome inhibitor. Based on the IKEMA phase 3 study, Sarclisa is also approved in more than 50 countries in combination with carfilzomib and dexamethasone, including in the US for the treatment of patients with R/R MM who have received one to three prior lines of therapy and in the EU for patients with MM who have received at least one prior therapy. In the US, EU, UK, and China, Sarclisa is approved in combination with VRd as a front-line treatment option in transplant-ineligible NDMM patients, based on the IMROZ phase 3 study. In Japan, Sarclisa is approved in combination with VRd as a front-line treatment option regardless of transplant eligibility. At Sanofi, we are building on a long-standing commitment to oncology as we continue to chase the miracles of science to improve the lives of those living with cancer. We are committed to transforming cancer care by developing innovative, first and best-in-class immunological and targeted therapies for rare and difficult-to-treat cancers with high unmet need. For more information on Sarclisa clinical studies, please visit About Sanofi Sanofi is an R&D driven, AI-powered biopharma company committed to improving people's lives and creating compelling growth. We apply our deep understanding of the immune system to invent medicines and vaccines that treat and protect millions of people around the world, with an innovative pipeline that could benefit millions more. Our team is guided by one purpose: we chase the miracles of science to improve people's lives; this inspires us to drive progress and deliver positive impact for our people and the communities we serve, by addressing the most urgent healthcare, environmental, and societal challenges of our time. Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY Media Relations Sandrine Guendoul | +33 6 25 09 14 25 | [email protected] Evan Berland | +1 215 432 0234 | [email protected] Léo Le Bourhis | +33 6 75 06 43 81 | [email protected] Victor Rouault | +33 6 70 93 71 40 | [email protected] Timothy Gilbert | +1 516 521 2929 | [email protected] Investor Relations Thomas Kudsk Larsen |+44 7545 513 693 | [email protected] Alizé Kaisserian | +33 6 47 04 12 11 | [email protected] Felix Lauscher | +1 908 612 7239 | [email protected] Keita Browne | +1 781 249 1766 | [email protected] Nathalie Pham | +33 7 85 93 30 17 | [email protected] Tarik Elgoutni | +1 617 710 3587 | [email protected] Thibaud Châtelet | +33 6 80 80 89 90 | [email protected] Yun Li | +33 6 84 00 90 72 | [email protected] Sanofi forward-looking statements All trademarks mentioned in this press release are the property of the Sanofi group with the exception of enFuse. Attachment

Behind History's Icons II: Hitler's Jaw and Cold War Secrets
Behind History's Icons II: Hitler's Jaw and Cold War Secrets

Medscape

time7 hours ago

  • Medscape

Behind History's Icons II: Hitler's Jaw and Cold War Secrets

Ancient Egyptians believed that mummifying a king's body was key to his ascent into the realm of the gods. The preserved body, known as the Ach, a luminous spirit, was thought to begin this journey by entering the sarcophagus, seen as the womb of Nut, the mother goddess of the sky. The belief in the enduring power of human remains has been deep in global history. In the West, reverence for the relics of Christian saints took place early in the Church. Some of the most extraordinary examples include what was believed to be the foreskin of Jesus and the severed head of Saint John the Baptist. By the 19th century, European scientists had begun preserving and studying body parts of famous individuals — from Mohammed's beard and Buddha's teeth to Adolf Hitler's jaw. Following the Napoleon relics story, Part II probes Hitler's preserved jaws. Hitler's Final Days It was April 28, 1945. Hitler, 1889-1945, Germany's leader, paced furiously through the corridors of the Wolf's Lair, his secret headquarters near Rastenburg, close to Görlitz. He was furious, as his trusted deputy head of the Nazi Party's paramilitary force, Heinrich Himmler is believed to have been betrayed by Hitler for several months. He reportedly held secret talks with Western Allies to end the war. Shockingly, he is said to have offered to halt the Holocaust of Hungarian Jews if Americans — Germany's main enemy in the West — would ease their attacks. Hitler was reportedly stunned. In an effort to regain his composure, Hitler summons Hermann Fegelein — 1906-1945, his liaison to the Waffen Schutzstaffel, the Nazi Party's armed military unit responsible for combat operations. According to these reports, Hitler ordered their execution. Another report stated that he ordered his arrest and left the execution order to his subordinates. Himmler, in turn, expels Hitler from the Nazi Party and removes him from all party and state positions. However, in reality, Hitler was more composed than he appeared. As often in his life, even moments of lost composure serve a greater purpose. Historian and Himmler biographer Heinz Peter Longerich noted that just one week before his public outburst on April 22, 1945, Hitler privately declared that he would stop issuing orders. This was his way of signaling to his top officials that the war was lost. By this point, Hitler had effectively lost control over his army. Obergruppenführer Felix Steiner, 1896-1966, had earlier refused to carry out a relief attack ordered by Hitler during the Battle of Berlin, calling it impossible. To avoid being linked to inevitable and shameful defeat, Hitler allowed others to handle peace negotiations and then publicly expelled them from the Nazi Party. Historians widely agree that Hitler decided to take his own life on April 27, 1945, one day before his outburst. When news of Himmler's betrayal became known, Hitler acted quickly and decisively. He first expelled Himmler from the party and then, by proxy, took revenge on Fegelein. Just before midnight, Hitler hurriedly married his partner, Eva Braun in 1912-1945. He then dictated his political and personal will to his secretary, Traudl Junge in 1920-2002. On the morning of April 30, Hitler tested poison ampoules on his German shepherd and later gave a similar poison to his colleagues. At approximately 3:30 PM, he had Braun swallow cyanide before shooting. However, myths and uncertainties surround what occurred next. Corpse Odyssey Hitler's death did not end speculation. Conspiracy theories quickly surfaced, claiming that he had faked his death and fled abroad, possibly to Argentina or Japan, with the help of body doubles and plastic surgery. According to conspiracy theories, Hitler fired a double shot and burned his body beyond recognition before escaping the submarine to Argentina or Japan. These theories claim that his outbursts of rage, will, distribution of poison vials, and suicide were staged. Until recently, Hitler was said to have lived a privileged life abroad, even after undergoing surgical alterations. Local historian and biographer Harald Sandner calls this 'humbug.' He pointed out that Hitler's body was examined multiple times by experts and moved at least 10 times. According to the report, Hitler and Braun's bodies were carried into the Reich Chancellery Garden at approximately 3:50 PM on April 30, 1945. The individuals who carried the bodies into the garden included Hitler's valet Heinz Linge, Criminal Director Peter Högl, Hauptsturmführer Ewald Lindloff, and Obersturmführer Heinrich Josef Reiser. The bodies were then doused with gasoline and set on fire. Eyewitness accounts, including that of Rottenführer Hermann Karnau, mentioned that between 4 and 6:20 PM, the remains showed movement described as 'the flesh moved up and down,' which is consistent with the natural effects of burning human bodies and muscle contractions during cremation. On May 4, Soviet soldiers found the remains, initially unaware of their significance. The next day, the bodies were reburied and moved to Helios Hospital Berlin-Buch, where autopsies were performed on May 8. Fritz Echtmann, longtime assistant to Hitler's dentist Hugo Johannes Blaschke, 1881-1959, may be for propaganda reasons, confirmed the identity of Hitler's jaw remains as unclear. However, Soviet authorities promoted the narrative that Hitler had cowardly taken poison, rejecting the evidence that he had also shot himself, and confirmed the authenticity of the jaws. Soviet doctors later claimed Hitler had 'cowardly poisoned himself instead of heroically shooting himself.' On May 4, 1945, Soviet troops from the 3rd Shock Army discovered these bodies. Unaware that they belonged to Adolf and Eva Hitler, they wrapped them in blankets and buried them. On May 5, the next day, other Soviet soldiers found the bodies again and transported them in an ammunition box to the Pathological Institute at Helios Hospital Berlin-Buch. The bodies were autopsied between May 8 and May 10. Echtmann confirmed the authenticity of Hitler's jaw. For propaganda purposes, Soviet doctors later claimed that Hitler had 'cowardly poisoned himself instead of heroically shooting himself.' Even decades later, in 1968, the well-known Russian journalist and military history professor Lev Aleksandrovich Bezymensky in 1920-2007 wrote that Hitler's charred corpse smelled of bitter almonds. In the second half of May 1945, grave robbers opened Hitler's grave, searching for a rumored Nazi treasure said to be buried with him. Soviet soldiers protected the bodies and moved them again, in ammunition crates, to Finow, 38 km away, where they were reburied. On May 22, 1945, the body was exhumed and reburied for unknown reasons. Forensic Investigation On June 9, 1945, Marshal of the Soviet Union Georgy Konstantinovich Zhukov in 1896-1974 claimed that Hitler's death was uncertain. British historian Sir Richard John Evans suggested that the Soviet Union might have wanted to maintain the threat of Hitler's survival to justify a harsh occupation policy. Consequently, false information about Hitler's death is deliberately disseminated. This theory is supported by the fact that Hitler's suicide was reported in the Soviet newspaper Krasnaya Zvezda on May 10, 1945. As late as June 5, Soviet Army officers confirmed this to American officers. Probably on orders from Joseph Vissarionovich Stalin in 1878-1953 denials began just 4 days later. On June 7, 1945, the bodies of Adolf and Eva Hitler were reportedly brought to Rathenau in a 'half-rotten state.' Between December 8, 1945, and January 13, 1946, Soviet Colonel General Bogdan Zakharovich Kobulov ordered a new examination of Hitler's body. To prevent this investigation, other Soviet officials arranged for the bodies to move to Magdeburg, Germany. Once again, the bodies were buried in ammunition crates in a 2 m deep pit in the courtyard of Westendstraße 32 (now Klausenerstraße 32). On February 21, 1946, the bodies were autopsied. They were then buried in the courtyard of a Soviet military settlement beneath an 18 cm thick concrete slab. On April 5, 1970, the KGB, a highly centralized and secretive organization Chief Yuri Vladimirovich Andropov, 1914-1984, ordered the bodies to be destroyed. The military settlement was to be handed over to the East German authorities, and Andropov did not want to risk the bodies falling into their hands. Among historians, Sandner's accounts are valued but are not fully reliable. Sandner, who had never received formal training in history, did not provide detailed annotations in his books to clarify his reasoning. A publication by the French forensic scientist and pathologist Philippe Charlier in the European Journal of Internal Medicine is considered scientifically credible. Charlier reported that the Russian domestic intelligence service (Federal Security Service) allowed him and his team to examine Hitler's presumed skull and dentures, which had survived the final burning. Their investigation confirmed that the dentures belonged to Hitler. However, they were not 100% certain about the skull, which showed traces of a gunshot wound. These findings align with the report of German forensic biologist Mark Benecke, who was permitted to examine Hitler's alleged remains for a week in November 2001. Benecke wrote at the time: 'There is no doubt about the authenticity of the teeth. Hitler had a unique dental structure. He used a large metal bridge in 1944. Using old x-rays, I was able to clearly identify the teeth as Hitler's.' However, Benecke found no traces of poison or glass fragments in the ampoule. Surprised, he consulted Bezymensky. 'Bezymensky told me that the KGB had only allowed him to publish his book in 1986 on one condition: That he would support the poison theory,' Benecke wrote about his conversation with Bezymensky. Finally, the alleged fragment of Hitler's skull was stored in a plastic box, which was intended for computer disks. According to contemporary historian Joachim Fest in 1926-2006, Hitler's body was found 'slumped over,' with 'his head slightly bent forward…on the flowered sofa,' after he had shot a coin-sized hole in his temple with a pistol. If this description is correct, the skull fragment could not belong to Hitler. The entry and exit wounds suggest the shot came from below, most likely fired 'in the mouth.' To confirm identity, the remaining blood traces must be examined. However, Benecke stated that he would require comparative DNA from Hitler's relatives, such as his sister, who was buried near Munich. Exhumation is the only method to obtain genetic material. Conclusion Few other deaths are surrounded by myths similar to Hitler's death. The search for the truth about Hitler's death is complicated by the competing interests and the interests of those with partial knowledge. Historians now agree that Hitler died by suicide on April 30, 1945, either by shooting himself or by combining gunshots with poison. Scientific evidence confirms that Hitler's dentures are preserved and currently held by Russian domestic intelligence services. Whether the skull in the Russian State Archives belonged to him remains unclear.

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