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IN8bio Recognizes Achievement of 4-Years in Remission for Patient Treated with INB-200 in Glioblastoma Trial

Yahoo

a day ago

Yahoo

IN8bio Recognizes Achievement of 4-Years in Remission for Patient Treated with INB-200 in Glioblastoma Trial

Patient with a grade 4, IDH-mutant, MGMT-methylated glioma remains alive and progression-free for four years after receiving treatment with the INB-200 gamma-delta T cell therapy in glioblastoma trial NEW YORK, June 09, 2025 (GLOBE NEWSWIRE) -- IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta T cell therapies for cancer and autoimmune diseases, announced that Patient 009 in the Phase 1 trial of INB-200 for newly-diagnosed GBM has recently reached a significant clinical milestone. The patient, with a grade 4, IDH-mutant glioma, has been in remission and surviving for 4 years having been treated with INB-200. The patient is doing well, has returned to work and has a good quality of life post-treatment with INB-200. Patient 009's clinical progress and 4-year remission far surpasses progression-free outcomes observed in other clinical trials of IDH-mutant glioma patients. 'Surviving four years without progression in newly diagnosed astrocytoma WHO4 IDH mutated is a significant achievement demonstrating the potential activity of gamma-delta T cells,' said Dr. Burt Nabors, Principal Investigator of the INB-200 trial and Vice-Chair of Research of Neurology and Director for the UAB Division of Neuro-oncology. 'This outcome further highlights the potential impact of INB-200 in one of the most aggressive, difficult-to-treat and deadly cancers.' IN8bio recently presented updated Phase 1 data from the INB-200 trial at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. The results showed that repeated doses of INB-200 demonstrated an extended mPFS of 16.1 months, more than double the expected 6.9 months typically observed with the standard-of-care Stupp protocol in newly diagnosed GBM. INB-200 is the first genetically modified gamma-delta T cell therapy evaluated in GBM and has demonstrated a favorable safety profile and signals of long-term benefit. 'We are thrilled that our study participant has reached this incredible milestone,' said William Ho, CEO and co-founder, IN8bio. 'This type of long-term survival and life changing clinical impact is exactly what we strive to achieve at IN8bio. The current standard-of-care for newly diagnosed GBM has not advanced beyond an overall survival of 14-16 months in over two decades. This is a powerful testament to what's possible when we harness the unique biology of gamma-delta T cells.' About IN8bio IN8bio is a clinical-stage biopharmaceutical company developing γδ T cell-based immunotherapies for cancer and autoimmune diseases. Gamma-delta T cells are a specialized population of T cells that possess unique properties, including the ability to differentiate between healthy and diseased tissue. The company's lead program, INB-100, is focused on acute myeloid leukemia evaluating haplo-matched allogeneic γδ T cells given to patients following a hematopoietic stem cell transplant. The company is also evaluating autologous DeltEx DRI γδ T cells, in combination with standard of care, for glioblastoma in its INB-200 and 400 programs, and advancing novel γδ T cell engagers for potential oncology and autoimmune indications. For more information about IN8bio, visit FORWARD LOOKING STATEMENTS This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as 'aims,' 'anticipates,' 'believes,' 'could,' 'estimates,' 'expects,' 'forecasts,' 'goal,' 'intends,' 'may,' 'plans,' 'possible,' 'potential,' 'seeks,' 'will' and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding: the ability of repeated intracranial dosing of INB-200 to extend mPFS and improve mOS in patients with GBM, including those with chemotherapy-resistant tumors; INB-200's ability to continue to be well-tolerated and show no serious toxicities beyond those typically observed with chemotherapy; INB-200's ability to improve patient outcomes and allow patients to return to work; the ability of IN8bio's DRI technology to offer a new way to treat newly-diagnosed GBM; gamma-delta T cells' ability to eliminate chemo-resistant cancer and stem cells that often survive SOC treatment; INB-200's potential as a novel direction in therapy for the treatment of solid tumor cancers like GBM; INB-200's ability to improve outcomes in ways that enhance effectiveness of treatments without adding toxicity; IN8bio's ability to achieve anticipated milestones, including the advancement of clinical development plans and receipt of regulatory approvals; and other statements that are not historical fact. IN8bio may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: risks to site initiation, clinical trial commencement, patient enrollment and follow-up, as well as IN8bio's ability to meet anticipated deadlines and milestones; uncertainties inherent in the initiation and completion of preclinical studies and clinical trials and clinical development of IN8bio's product candidates; the risk that IN8bio may be unable to raise additional capital and could be forced to delay, further reduce or to explore other strategic options for certain of its development programs, or even terminate its operations; IN8bio's ability to continue to operate as a going concern; the risk that IN8bio may not realize the intended benefits of its γδ-TCE platform or DeltEx platform; the availability and timing of results from preclinical studies and clinical trials; whether the outcomes of preclinical studies will be predictive of clinical trial results; whether initial or interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; the risk that trials and studies may be delayed and may not have satisfactory outcomes; potential adverse effects arising from the testing or use of IN8bio's product candidates; the uncertainty of regulatory approvals to conduct trials or to market products; IN8bio's reliance on third parties, including licensors and clinical research organizations; and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, which are described in greater detail in the section entitled 'Risk Factors' in IN8bio's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on May 7, 2025, as well as in other filings IN8bio may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and IN8bio expressly disclaims any obligation to update any forward-looking statements contained herein, whether because of any new information, future events, changed circumstances or otherwise, except as otherwise required by law. Contacts: IN8bio, McCall646.933.5603pfmccall@ Media Contact:KKH AdvisorsKimberly in to access your portfolio

Weight stigma isn't just cruel — it makes losing weight harder

CNN

4 days ago

CNN

Weight stigma isn't just cruel — it makes losing weight harder

Maybe you have decided that the voice inside your head judging yourself or others for body size can be pretty mean, but at least it's encouraging weight loss, right? No, it's not, experts say. 'There has long been a misunderstanding … that if you shame people about their weight, then that will lead them to eat less or to eat more healthfully or to exercise more in order to lose weight,' said Dr. Rebecca Pearl, associate professor of clinical and health psychology at the University of Florida. 'What the research, though, has shown over and over again is that that is not true,' Pearl said. 'It actually has the opposite effect.' Stigma around weight and body size is everywhere: in US culture, messages from people around you and even at your doctor's office, Pearl said. One study found that after bariatric surgery, experiencing continued weight stigma was associated with higher risks of depression, anxiety and disordered eating such as binge eating. Those who experienced less weight stigma were more likely to continue losing weight and maintain weight loss, according to the study published Thursday in the journal Health Psychology. And not only are biases around weight damaging to mental health, they also are counterproductive if people want to lose weight or engage in more health-promoting behaviors, said first study author Dr. Larissa McGarrity, clinical psychologist in physical medicine and rehabilitation at University of Utah Health. Weight stigma centers around a pervasive public misconception: that what a person weighs is entirely within a person's control. 'As a result of that, people should just be able to eat healthy on their own, to lose weight on their own, to be physically active –– that's their personal responsibility to do that,' said Pearl, who was not involved in the study. When a person doesn't lose weight or comes up against barriers to that thin body ideal –– such as lack of access to nutritious and affordable foods, no place for physical activity, or their genetics –– the misconception says their body shape is a sign of a moral failing, said Dr. Alexis Conason, a psychologist and certified eating disorder specialist in New York City who also did not participate in the new research. Messages saying that a person has a responsibility to lose weight and is a worse person if they do not can come from images or storylines in television and social media, direct comments from people you know, and bullying or discrimination, Pearl said. It gets worse when a person absorbs those derogatory remarks from others about their body weight and applies it to themselves. 'Experiencing stigma from other people is harmful,' Pearl said. 'But for the individuals who really internalize that, that seems to be a really strong predictor of these negative eating and physical activity outcomes, but also kind of broader mental and physical health outcomes.' Physical activity is so important to many aspects of health, including healthy aging, management of depression, better sleep and lower cancer risk. People often have a hard time going to the gym or getting outside for exercise, because it can feel intimidating or overwhelming, said Dr. A. Janet Tomiyama, professor of psychology at the University of California Los Angeles who was not involved in the study. It is particularly hard if you know you will get comments, judgment or even just extra attention because of your weight, Conason added. Research has linked experiencing and internalizing weight stigma to less motivation and enjoyment of physical activity, less confidence about exercising, and less time spent exercising, Pearl said. 'A gym is a location where a lot of weight stigma and fat shaming can happen,' said Tomiyama. 'If you've been stigmatized for the way you look, the last thing you want to do is put on some tight clothes and go to a gym.' Being judged for your body can be distressing, which can impact food choices. 'When someone is teased or criticized, or even just feels like they're getting negative looks from other people around them, that is stressful,' Pearl said. 'We know that one of the very common ways that everybody copes with stress is by eating more and eating more unhealthy kinds of foods.' Stress eating isn't a behavior we need to shake our finger and shame people out of either, Tomiyama said. It is in our own biology as well as that of other animals, she added. Physical or psychological stress signals your body to release the hormone cortisol, Tomiyama said. 'One of the things that cortisol does, is it works on our brain to really activate reward processes that make high-sugar, high-salt, high-calorie food taste really, really good,' she added. 'And so, at a brain level, it's making these potentially health harming foods way harder to resist.' Cortisol also blocks the parts of your brain that help you make decisions that benefit you in the long term, Tomiyama said. Research has linked exposure to weight stigma and unhealthy, disordered eating behaviors such as binge eating, purging and unhealthy restriction –– all of which undermine health, Pearl said. Eating Disorder Resources US: National Eating Disorder Association The NEDA has a confidential, toll free helpline at 800-931-2237 as well as an online click-to-chat service. For 24/7 crisis support, text 'NEDA' to 741-741. The NEDA also has a list of recommended websites and free or low-cost resources. ANAD runs a helpline at 888-375-7767 from 9 a.m. to 9 p.m. CT and provides links to support groups and treatment providers. A call center at 800-334-673 and online chat run by the Butterfly Foundation is open 8 a.m. to midnight AET every day except public holidays. Helplines for England, Scotland, Wales and Northern Ireland are open 9 a.m. to midnight weekdays and 4 p.m. to midnight weekends, every day of the year. Unfortunately, weight stigma is pervasive, and it isn't something you can snap your fingers and rid yourself of, Conason said. One step the medical field can take is to de-emphasize body mass index, or BMI, as an important marker of health, especially because it often classifies healthy people as unhealthy and those with health issues as falling into a healthy weight class, Tomiyama said. When working with clients, Conason also focuses on creating resiliency, she said. 'We may not be able to change the entire culture, but we can try to understand that the problem is the culture, not our bodies,' Conason said. 'That can provide resiliency around moving through the world and experiencing weight stigma and trying not to internalize the stigma.' Conason does this by helping clients build greater self-compassion, educating them on the ways in which a culture of weight stigma has influenced them, and encouraging the practice of acceptance. If you notice an internalized weight stigma is affecting your behavior, contacting a disordered eating mental health counselor or a weight-inclusive dietitian may be a helpful first step.

CNN

4 days ago

CNN

Weight stigma isn't just cruel — it makes losing weight harder

Maybe you have decided that the voice inside your head judging yourself or others for body size can be pretty mean, but at least it's encouraging weight loss, right? No, it's not, experts say. 'There has long been a misunderstanding … that if you shame people about their weight, then that will lead them to eat less or to eat more healthfully or to exercise more in order to lose weight,' said Dr. Rebecca Pearl, associate professor of clinical and health psychology at the University of Florida. 'What the research, though, has shown over and over again is that that is not true,' Pearl said. 'It actually has the opposite effect.' Stigma around weight and body size is everywhere: in US culture, messages from people around you and even at your doctor's office, Pearl said. One study found that after bariatric surgery, experiencing continued weight stigma was associated with higher risks of depression, anxiety and disordered eating such as binge eating. Those who experienced less weight stigma were more likely to continue losing weight and maintain weight loss, according to the study published Thursday in the journal Health Psychology. And not only are biases around weight damaging to mental health, they also are counterproductive if people want to lose weight or engage in more health-promoting behaviors, said first study author Dr. Larissa McGarrity, clinical psychologist in physical medicine and rehabilitation at University of Utah Health. Weight stigma centers around a pervasive public misconception: that what a person weighs is entirely within a person's control. 'As a result of that, people should just be able to eat healthy on their own, to lose weight on their own, to be physically active –– that's their personal responsibility to do that,' said Pearl, who was not involved in the study. When a person doesn't lose weight or comes up against barriers to that thin body ideal –– such as lack of access to nutritious and affordable foods, no place for physical activity, or their genetics –– the misconception says their body shape is a sign of a moral failing, said Dr. Alexis Conason, a psychologist and certified eating disorder specialist in New York City who also did not participate in the new research. Messages saying that a person has a responsibility to lose weight and is a worse person if they do not can come from images or storylines in television and social media, direct comments from people you know, and bullying or discrimination, Pearl said. It gets worse when a person absorbs those derogatory remarks from others about their body weight and applies it to themselves. 'Experiencing stigma from other people is harmful,' Pearl said. 'But for the individuals who really internalize that, that seems to be a really strong predictor of these negative eating and physical activity outcomes, but also kind of broader mental and physical health outcomes.' Physical activity is so important to many aspects of health, including healthy aging, management of depression, better sleep and lower cancer risk. People often have a hard time going to the gym or getting outside for exercise, because it can feel intimidating or overwhelming, said Dr. A. Janet Tomiyama, professor of psychology at the University of California Los Angeles who was not involved in the study. It is particularly hard if you know you will get comments, judgment or even just extra attention because of your weight, Conason added. Research has linked experiencing and internalizing weight stigma to less motivation and enjoyment of physical activity, less confidence about exercising, and less time spent exercising, Pearl said. 'A gym is a location where a lot of weight stigma and fat shaming can happen,' said Tomiyama. 'If you've been stigmatized for the way you look, the last thing you want to do is put on some tight clothes and go to a gym.' Being judged for your body can be distressing, which can impact food choices. 'When someone is teased or criticized, or even just feels like they're getting negative looks from other people around them, that is stressful,' Pearl said. 'We know that one of the very common ways that everybody copes with stress is by eating more and eating more unhealthy kinds of foods.' Stress eating isn't a behavior we need to shake our finger and shame people out of either, Tomiyama said. It is in our own biology as well as that of other animals, she added. Physical or psychological stress signals your body to release the hormone cortisol, Tomiyama said. 'One of the things that cortisol does, is it works on our brain to really activate reward processes that make high-sugar, high-salt, high-calorie food taste really, really good,' she added. 'And so, at a brain level, it's making these potentially health harming foods way harder to resist.' Cortisol also blocks the parts of your brain that help you make decisions that benefit you in the long term, Tomiyama said. Research has linked exposure to weight stigma and unhealthy, disordered eating behaviors such as binge eating, purging and unhealthy restriction –– all of which undermine health, Pearl said. Eating Disorder Resources US: National Eating Disorder Association The NEDA has a confidential, toll free helpline at 800-931-2237 as well as an online click-to-chat service. For 24/7 crisis support, text 'NEDA' to 741-741. The NEDA also has a list of recommended websites and free or low-cost resources. ANAD runs a helpline at 888-375-7767 from 9 a.m. to 9 p.m. CT and provides links to support groups and treatment providers. A call center at 800-334-673 and online chat run by the Butterfly Foundation is open 8 a.m. to midnight AET every day except public holidays. Helplines for England, Scotland, Wales and Northern Ireland are open 9 a.m. to midnight weekdays and 4 p.m. to midnight weekends, every day of the year. Unfortunately, weight stigma is pervasive, and it isn't something you can snap your fingers and rid yourself of, Conason said. One step the medical field can take is to de-emphasize body mass index, or BMI, as an important marker of health, especially because it often classifies healthy people as unhealthy and those with health issues as falling into a healthy weight class, Tomiyama said. When working with clients, Conason also focuses on creating resiliency, she said. 'We may not be able to change the entire culture, but we can try to understand that the problem is the culture, not our bodies,' Conason said. 'That can provide resiliency around moving through the world and experiencing weight stigma and trying not to internalize the stigma.' Conason does this by helping clients build greater self-compassion, educating them on the ways in which a culture of weight stigma has influenced them, and encouraging the practice of acceptance. If you notice an internalized weight stigma is affecting your behavior, contacting a disordered eating mental health counselor or a weight-inclusive dietitian may be a helpful first step.

Nominations Open for the End Brain Cancer Initiative's 2025 National Patient Disease Education Initiative and HOPE Award

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IN8bio Recognizes Achievement of 4-Years in Remission for Patient Treated with INB-200 in Glioblastoma Trial

Weight stigma isn't just cruel — it makes losing weight harder

Weight stigma isn't just cruel — it makes losing weight harder

Nominations Open for the End Brain Cancer Initiative's 2025 National Patient Disease Education Initiative and HOPE Award

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Try Our AI Features

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Related Articles

IN8bio Recognizes Achievement of 4-Years in Remission for Patient Treated with INB-200 in Glioblastoma Trial

Weight stigma isn't just cruel — it makes losing weight harder

Weight stigma isn't just cruel — it makes losing weight harder

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