Novo Nordisk semaglutide data shows new health benefits across serious chronic diseases
Novo Nordisk A/S
Data across obesity, cardiovascular disease, MASH, type 2 diabetes, as well as advances in obesity-related care to be presented at ECO 2025 – covering burden, and the value of treatment and prevention
Analysis of the landmark SELECT trial to uncover new insights into the early cardiovascular benefits of semaglutide
Real-world studies reinforce value of semaglutide in obesity
Bagsværd, Denmark, 6 May 2025 – Novo Nordisk today announced that new data spanning the company's industry-leading portfolio across metabolic and cardiovascular health will be presented at the upcoming 32nd European Congress on Obesity (ECO), 11–14 May 2025. The data will further extend the wide-ranging evidence base for semaglutide through real-world evidence studies and additional analysis of the landmark cardiovascular outcomes trial, SELECT, as well as part 1 of the phase 3 ESSENCE trial in metabolic dysfunction-associated steatohepatitis (MASH). Data will also be presented on the wider societal impacts of treating and preventing obesity, alongside analysis of the burden of obesity in adolescents.
'Obesity is one of the greatest healthcare challenges we face globally, impacting the lives of hundreds of millions of people. Without effective interventions, the global burden of obesity and its complications will continue to rise,' said Stephen Gough, senior vice president and head of Chief Medical Office at Novo Nordisk. 'Our broad and robust semaglutide data presented at ECO, including its impact on weight loss in a real-world setting and its early clinical effect on cardiovascular events and death, significantly adds to the growing body of evidence showing the value of semaglutide to individuals, healthcare systems and society.'
'We are dedicated to leading the way in defeating obesity and are pleased to return to ECO to present new, strong semaglutide data,' said Ludovic Helfgott, executive vice president of Product & Portfolio Strategy at Novo Nordisk. 'Our investment into the understanding and treatment of obesity continues to reveal new insights, with semaglutide showing its potential to improve health in obesity, heart disease and liver disease. Our data shows that semaglutide provides early protection against heart disease even before significant weight loss occurs and that for people in treatment, our digital support solutions have the potential to enhance weight loss further.'
Novo Nordisk abstracts to be presented, some of these data for semaglutide are investigational:
Abstract Title
Abstract presentation details
Estimating the effect of overweight and obesity during adolescence on the risk of long-term comorbidities: a population-based retrospective analysis in England between 2008 and 2023
Oral Presentation (AD07.05)
S Senniappan (UK)
12 May, 12:30–12:45 CEST
Estimating the prevalence of overweight and obesity and the incidence of comorbidities in adolescents living with overweight and obesity: a cohort study using routinely collected healthcare data in England between 2008 and 2023
Poster presentation (PO3.038)
12 May, 18:00-19:30 CEST
Association between engagement with the WegovyCare digital self-support app and weight loss in a real-world setting
Oral presentation (AD12.06)
B L Heitmann (Denmark)
13 May, 12:45–13:00 CEST
Early Clinical Benefit of Semaglutide in Adults with Overweight or Obesity and Cardiovascular Disease: A Secondary Analysis of the SELECT Trial
Oral Presentation (AD15.04)
J Plutzky (US)
13 May, 17:15–17:30 CEST
Use and Effectiveness of Once-weekly Semaglutide in US Adults with Overweight or Obesity in Clinical Practice
Poster presentation (PO4.070)
13 May 18:00–19:30 CEST
A personalized treat-to-target approach for obesity management: Integrating changes in adiposity measures with changes in biomarker levels towards reaching low-risk states of incident T2D and ASCVD
Poster presentation (PO4.171)
13 May, 18:00–19:30 CEST
What are the most important research questions within prediabetes? A Priority Setting Partnership in collaboration with patients, healthcare professionals and researchers
Poster presentation (PO4.194)
13 May, 18:00-19:30 CEST
Metrics that matter: identifying endpoints for capturing the broad health impacts of obesity prevention
Poster presentation (PO2.058)
13 May
A novel framework to assess the prevention value of a health intervention
Poster presentation (PO4.143)
13 May
Weight-independent benefits of semaglutide on histology and non-invasive tests in participants with biopsy-defined MASH: Post hoc analysis of the ESSENCE trial part 1
Oral Presentation (Part of accepted scientific symposium: The MASH – Obesity intersection)
P Newsome (UK)
14 May, 09:30–11:00 (presentation time 10:15-10:40) CEST
Predicting weight loss using self-reported, digitally collected, real-world data after initiation of semaglutide treatment
Poster presentation (PO4.095)
Quantifying the Productivity Gains of Semaglutide Treatment in the UK for the Population Eligible for Reimbursement: a Modelling Study Using the Wider Societal Impacts Framework
Poster presentation (PO4.194)
Obesity is a chronic, multi-factorial disease influenced by biological, psychological, and environmental factors that often puts people on the pathway to other serious chronic diseases, including cardiovascular disease (CVD) and metabolic diseases, such as type 2 diabetes, obesity, and MASH.1,2,3 A significant proportion of the cardiovascular risk associated with these diseases is attributable to shared metabolic risk factors.3 CVD accounts for around 70% of deaths in people living with obesity and is the leading cause of death in people with type 2 diabetes, chronic kidney disease and MASH.3, 4, 5, 6
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