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Grass Pollen: A Double Threat to Allergy Patients

Grass Pollen: A Double Threat to Allergy Patients

Medscape2 days ago

Patients with pollen allergy who were exposed to higher concentrations of grass pollen were more likely to have physical symptoms and impairments in day-to-day life.
METHODOLOGY:
Researchers conducted an observational pilot study to assess the association between daily grass pollen concentrations and physical symptoms and daily life impairments experienced by patients with pollen allergy.
The analysis included 53 patients (mean age, 41.8 years; 68% women) with grass pollen-induced allergic rhinitis in Bavaria, Germany, evaluated between May and July 2022.
Researchers collected data for the pollen season 2022 from the Electronic Pollen Information Network of Bavaria. An app-based questionnaire was used to collect patients' data on allergic symptoms and treatment measures.
They used a physical symptoms index to assess patients' daily eye and nose symptoms and a daily overall impairments index to assess impairments in performance, sleep quality, and activities.
TAKEAWAY:
The average grass pollen concentration measured between early May and late July 2022 was 37.1 pollen particles/m 3 .
. A significant association was observed between grass pollen concentration and both the physical symptoms index (regression coefficient [beta], 0.002; P < .001) and impairments in day-to-day life (beta, 0.00064; P < .048).
< .001) and impairments in day-to-day life (beta, 0.00064; < .048). Additionally, pollen levels were significantly associated with performance impairment (beta, 0.0009; P = .027); no significant association was observed with sleep or daily activities.
IN PRACTICE:
'To enhance clinical practice, it is essential to address the gap in adequate medical care for pollen allergy patients and prioritize patient education on recognizing and managing allergic rhinitis,' the authors wrote. 'Advancements in technology-assisted self-monitoring could further empower patients in managing their symptoms and understanding the interplay between environmental triggers and allergic complaints,' they added.
SOURCE:
Jonas Huss, with the Bavarian Health and Food Safety Authority, Munich, Germany, was the corresponding author of the study, which was published online on May 28 in Scientific Reports.
LIMITATIONS:
The study relied on physician-diagnosed allergies and self-reported patient data. Additionally, the absence of individualized air pollution or weather data, a limited sample size, and strict exclusion criteria further limited the generalizability of the findings.
DISCLOSURES:
The study was funded by the Bavarian State Ministry of Health and Care. The authors reported having no conflicts of interest.

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Scientists unveil breakthrough drug that could halt and reverse deadly liver fibrosis
Scientists unveil breakthrough drug that could halt and reverse deadly liver fibrosis

Yahoo

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Scientists unveil breakthrough drug that could halt and reverse deadly liver fibrosis

Liver fibrosis often develops without symptoms and has no approved cure. But researchers at the University of Sunderland have discovered a new enzyme-blocking treatment that could finally help stop or reverse the disease. Dr Maria Teresa Borrello and her team have found that blocking the enzyme HDAC6 with newly developed drugs could reduce liver scarring in people with fibrosis. HDAC6 plays a role in regulating inflammation and cellular stress, and the research suggests it also helps activate hepatic stellate cells, which are responsible for producing collagen, a major driver of scar tissue formation. Dr Borrello, who is a lecturer in Pharmaceutical and Medicinal Chemistry at the University, said her team has developed two new drugs specifically designed to block HDAC6 activity. 'So far, we've seen encouraging laboratory results showing that HDAC6 inhibitors – or blockers – reduce inflammation and cellular stress responses – both of which are key contributors to fibrosis, she said in a release. 'These findings support the idea that HDAC6 is a promising drug target for treating liver fibrosis. We are also starting to understand more about how these compounds work at the molecular level, which is essential for designing better, safer treatments.' The researchers hope their findings will form the basis of new treatments that can significantly improve the lives of people with this condition and potentially other inflammation-related diseases, including skin disorders. 'This research is a step forward in finding a treatment for liver fibrosis. Our HDAC6 inhibitors provide a more targeted approach and by focusing on a key cause of fibrosis, we may be able to stop the disease before it reaches irreversible stages,' Dr Borello said. 'By stopping or reversing the scarring process, we could reduce the need for liver transplants and improve long-term health outcomes.' Researchers believe that targeting the root cause of fibrosis could mark a turning point in the treatment of liver disease. As efforts to tackle chronic conditions evolve, such precision therapies could change how currently untreatable diseases are managed. The UK's leading liver health charity, the British Liver Trust, has welcomed the research findings. "Liver disease often develops without symptoms, and most people only learn they have liver damage when it's too late for effective treatment - usually limited to a liver transplant or lifestyle changes,' Pamela Healy OBE, Chief Executive at the Trust, said. 'While this new research is still in its early stages, it shows promise for developing treatments that could improve, and ultimately save, the lives of thousands affected by liver disease." Liver disease is responsible for approximately four percent of premature deaths globally, with liver fibrosis being one of its most serious and often undetected forms. In the UK alone, an estimated 2 million people are affected. The condition develops when long-term damage to the liver, commonly caused by alcohol use, obesity, or chronic infections, triggers the formation of scar tissue. As the scarring worsens over time, it can lead to life-threatening complications such as liver failure or cancer. Because symptoms often appear only in the advanced stages, many people are unaware they have the disease, and currently, there are no approved treatments to halt or reverse the scarring study has been published in The Febs Journal.

Is Schizophrenia a Personality Disorder?
Is Schizophrenia a Personality Disorder?

Health Line

time5 hours ago

  • Health Line

Is Schizophrenia a Personality Disorder?

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Stigma and fear of judgment may keep you away from peers. Sometimes, the symptoms you're experiencing may contribute to low emotional expression or decreased ability to experience joy through others. Living with schizophrenia can present a number of these challenges, but it doesn't mean you're living with the rigid, long-term patterns of behavior that accompany a personality disorder. Is schizophrenia a personality disorder? Schizophrenia is not a personality disorder. It's a type of psychotic disorder listed in the Diagnostic and Statistical Manual of Mental Disorders, 5 th edition, text revision (DSM-5-TR), under 'schizophrenia spectrum and other psychotic disorders.' Psychotic disorders involve altered perceptions of reality. These experiences make up the symptoms of psychosis, which are key features in all psychotic disorders. Psychotic symptoms include: hallucinations delusions disorganized thinking disorganized motor function negative symptoms What are negative symptoms? 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Personality disorder characteristics tend to be more long-term and constant. They're often noticed in childhood and become enduring, rigid patterns of thought and action throughout life. Is schizophrenia a multiple personality disorder? In 2008, a survey from the National Alliance on Mental Illness (NAMI) found the greatest misconception surrounding schizophrenia was that it involved multiple or 'split' personalities. According to the report, 64% of Americans believe this to be true. Schizophrenia isn't a multiple personality disorder, but symptoms of psychosis can make it seem like someone has morphed into a completely different person. Hallucinations, for example, can mean hearing voices or seeing people who aren't actually there. Talking out loud at a hallucination might make it seem like you're talking with another 'self.' Similarly, delusions can change aspects of your personality. 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You may have an increased chance of developing this condition if you have a family history of schizophrenia. Despite this link and some overlapping symptoms, these conditions aren't the same. Schizotypal personality disorder in the DSM-5-TR is a Cluster A personality disorder that involves overarching eccentric behaviors and beliefs. Like all personality disorders, schizotypal personality disorder features an inner experience different from cultural norms. It emerges in childhood and contributes to challenges in maintaining close interpersonal relationships. The uncommon behaviors and thoughts in schizotypal personality disorder can be similar to hallucinations and delusions in schizophrenia. Delusions are unwavering beliefs in something that can be proven otherwise. When you're experiencing a delusion, no evidence to the contrary will sway your belief, not even seeing, hearing, or participating in undeniable proof. 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Schizotypal personality disorder symptoms According to the DSM-5-TR, symptoms of schizotypal personality disorder can include: a persistent belief that everything happening is directly related to you magical thinking that influences behavior and decisions preoccupation with paranormal phenomena bodily illusions atypical perceptual experiences uncommon, sometimes metaphorical, speech patterns and thinking paranoid ideation suspiciousness atypical emotional responses (or lack thereof) eccentric behavior unkempt appearance persistent social anxiety even in familiar company Living with schizotypal personality disorder may come with transient or passing psychotic episodes. These reality lapses can last minutes to hours and tend to be in response to stress. If they occur, the DSM-5-TR states they rarely meet the criteria for an additional psychotic disorder diagnosis. Treatment options of schizophrenia vs. schizotypal personality disorder Both schizophrenia and schizotypal personality disorder are lifelong conditions that can involve psychotherapy and medications to help lessen their impact. Medications may be used for both disorders. You may be prescribed: antipsychotics antidepressants anxiolytics (anti-anxiety medications) The medications your healthcare team recommends will be based on your symptoms, but antipsychotics are considered a first-line treatment approach when psychosis is present. Psychotherapy can also help you cope with a schizophrenia spectrum condition, though research is limited on how effective it is for schizotypal personality disorder. Common therapies include: cognitive behavioral therapy (CBT) group therapy compliance therapy meta-cognitive training mindfulness therapy narrative therapy Coordinated specialty care (CSC) might also make a difference in your quality of life. CSC involves a multidisciplinary support network to help you adjust to living and working with schizophrenia. Delusions and skewed perceptions, however, can make it difficult to recognize the need for treatment when living with schizophrenia or schizotypal personality disorder.

Sire Search Identifies Top 5 Platforms to Boost Biotech Career Growth
Sire Search Identifies Top 5 Platforms to Boost Biotech Career Growth

Associated Press

time6 hours ago

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Sire Search Identifies Top 5 Platforms to Boost Biotech Career Growth

Hey, biotech folks! Whether you're a lab whiz itching to land your next role in drug discovery or a hiring manager hunting for the perfect candidate to boost your startup, the life sciences world is buzzing with potential. But, real talk—finding the right job or talent in this fast-moving industry can feel like trying to spot a single cell under a microscope. Overwhelming, right? That's were specialized recruitment websites swoop in like career superheroes. I've rounded up the five best platforms to help you navigate the biotech job maze, and guess what? SIRE Searchis leading the charge with its sharp, tailored approach. Let's dive in and see why these sites are your new allies for crushing it in biotech! 1. – Your Career's Guide A recruitment platform that feels like it knows you better than your lab partner. That's SIRE Searchin a nutshell. Based in Haarlem, Netherlands—a charming spot, by the way—SIRE has been shaking up the life sciences scene since 2012. Whether you're into pharmaceuticals, medical devices, or even fast-moving consumer goods (yep, they've got that covered), SIRE's the place to find your next career win. Their reverse recruitment approach is like a secret weapon. Instead of tossing a pile of job listings your way, they do the heavy lifting first. Using data and market insights, their team—packed with recruiters who actually get biotech—handpicks roles that match your skills and goals. One Trustpilot reviewer raved, 'SIRE landed me a job that's spot-on for my expertise. They were quick and genuinely cared!' With a 4-star rating, they're clearly hitting the mark. 2. – The U.S. Biotech Hub Let's zip over to the States for BioSpace, a heavyweight for biotech and pharma jobs. With over 4,000 active listings, this sites like a treasure chest for anyone looking to dive into or climb higher in the U.S. biotech scene. From lab techs to execs, BioSpace has roles for every step of your journey. What's the deal with BioSpace? It's more than a job board—it's a whole community. You can narrow down searches by niche (like gene therapy or clinical trials) or location, so you're not stuck scrolling through irrelevant posts. They also dish out extras like industry updates, career tips, and their 'Best Places to Work' report, which is like a VIP list for biotech companies. The downside? It's mostly U.S.-focused, so it doesn't have SIRE's global reach. But for North American job seekers, BioSpace is a goldmine. 3. – Your Global Career Connector Dreaming of a biotech career that takes you worldwide? Meet Preclinical. With offices in places like the UK, Singapore, and the U.S., this platform hooks up candidates with roles in everything from drug development to regulatory affairs. It's like having a friend who knows the hottest jobs on every continent. Proclinical's strength is precision. Their recruiters dig into what employers need—skills, culture, the whole package—and match that with a huge candidate network. It's like they're playing career matchmaker, and they're good at it. They don't have SIRE's data-driven reverse recruitment trick, but their global scope is a big win for anyone wanting to think beyond borders. Plus, their blog's full of practical tips, like how to tweak your CV or nail an interview, which is super handy. 4. – The Science Lover's Hangout Next up is New Scientist Jobs, the friendly, all-purpose spot for science buffs. It covers a range of fields, but its biotech section is packed with roles in areas like vaccine research or molecular biology. Whether you're in Europe, the U.S., or elsewhere, this platform's global vibe makes it a welcoming place to explore. Why's it worth your time? It's easy to navigate, with filters to zero in on jobs by expertise or location. Their blog's a gem, too, with career advice and industry scoops that keep you in the loop. It's not as biotech-focused as SIRE, so you might need to sift a bit to find the right role. But if you're curious and love poking around, New Scientist Jobs is a solid bet. 5. – The Job-Finding Shortcut Last up is BioPharmGuy, the quirky underdog we're rooting for. Instead of hosting job listings, it points you straight to biotech company career pages, helping you dodge crowded job boards and find hidden opportunities. It's like a map of buried treasure. You can search by region or niche—like cell therapy or diagnostics—which makes it easy to target your sweet spot. The catch? It's more of a DIY experience, so you won't get the hands-on support you'd find with SIRE's recruiters. But for those who enjoy a bit of career sleuthing, BioPharmGuy is a clever tool to stand out. Why SIRE Search Takes the Crown? Let's give a shoutout to SIRE Searchfor stealing the show. Their reverse recruitment strategy is like having a career coach who's always one step ahead. By tapping into data and market trends, they find roles that fit you like a perfectly calibrated pipette. Their recruiters are biotech enthusiasts who speak your language and genuinely care about your next step. SIRE's focus on Europe—where biotech is thriving—gives them the edge, with connections to everyone from tiny startups to massive corporations. One candidate on Trustpilot said, 'SIRE made my job search feel effortless. They found me a role that's exactly where I want to be.' Employers love them, too, thanks to their knack for delivering candidates who nail both the skills and the vibe. Whether you're after a temp role or a corner office, SIRE's your partner in crime. 5 Tips to Nail Your Biotech Job Hunt Ready to hit these websites and land your dream role? Here's how to make it happen: Let's Wrap It Up The biotech world is full of possibilities, and these websites are your key to unlocking them. SIRE Searchleads the pack with its smart, personalized approach and deep love for life sciences. BioSpace, Preclinical, New Scientist Jobs, and BioPharmGuy are also stellar, each bringing their spark to the table. So, spruce up that resume, dive into these platforms, and get ready to make waves in biotech. Your next big opportunity is out there—grab it! Media Contact Company Name: Sire Search Email: Send Email Address:Staten Bolwerk City: 12011 MK Haarlem Country: Netherlands Website: Press Release Distributed by To view the original version on ABNewswire visit: Sire Search Identifies Top 5 Platforms to Boost Biotech Career Growth

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