American climber dies on world's fifth-highest peak in Nepal
KATHMANDU, Nepal — An American mountaineer died on Mount Makalu in eastern Nepal during a climb to raise funds for a children's cancer program, officials said Tuesday, the second death in the Himalayan nation's climbing season that began in March.
The world's fifth-highest mountain, Makalu's peak is 28,000 feet high — almost as tall as Mount Everest, the world's tallest peak at a height of 29,032 feet.
Alexander Pancoe, 39, died Sunday while settling into his sleeping bag at the mountain's second high camp, after returning from an acclimatization trip at the higher camp three, expedition organizer Madison Mountaineering said.
'Alex suddenly became unresponsive,' the company said on its website. 'Despite hours of resuscitation efforts ... they were unable to revive him.'
Nepal's tourism department said it was arranging to bring the body to Kathmandu, the capital.
Pancoe, who survived a brain tumor when younger, had completed the Explorer's Grand Slam — climbing the highest peaks on each of the seven continents and then skiing to both the North and South Poles.
He had been battling chronic myeloid leukemia and was attempting to climb Makalu to raise funds for the pediatric blood cancer program of the Chicago-based Lurie Children's Hospital, said expedition leader Garrett Madison.
He had already raised $1 million to help fund clinical trials and other programs there, Madison added.
In April, a Nepali sherpa died on Mount Annapurna, the world's 10th-highest mountain.
Wedged between India and China, landlocked Nepal is home to eight of the world's 14 highest peaks, including Mount Everest, and its economy is heavily reliant on climbing, trekking and tourism for foreign exchange.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
The Independent
8 hours ago
- The Independent
The surprising health benefits of fecal transplants
Fecal microbiota transplants, used to restore gut health, involve transferring stool from a healthy donor to a recipient. A new University of Chicago study in mice reveals potential long-lasting, unintended health consequences from these transplants due to microorganisms colonizing the entire intestinal tract, creating regional gut mismatches. The study found that transplanted microbes altered intestinal environments, affecting metabolism, behavior, energy balance, and liver function in mice. Researchers advocate for caution and suggest using microorganisms from all regions of the intestine, not just the colon, for transplants. Dr. Eugene Chang, the study's senior author, notes that fecal microbiota transplants can cause changes in host-microbe relationships in different bowel regions that may be difficult to reverse.
The Independent
9 hours ago
- The Independent
‘Poop transplants' have been happening for decades. Now researchers have identified some unintended consequences
Fecal microbiota transplants are common medical procedures dating back decades that can help restore the gut health of people with colon infections - but scientists now warn of newly discovered consequences from the procedure. The 'poop transplant' is the transfer of the stool of a healthy donor to a recipient. The stool contains beneficial bacteria that can improve the patient's gut bacteria, which guards immune health and helps to regulate metabolism. They are approved by the Food and Drug Administration to treat people with common C. diff infections that may cause severe gastrointestinal symptoms and inflammation in hospital patients who have been on antibiotics. Roughly 48,000 procedures are done each year. Now, University of Chicago researchers say a study in mice and experiments with human tissue have revealed some long-lasting and unintended consequences due to transplanting microorganisms from only one section of the digestive tract. 'I think it's a bit of a wakeup call to the field that maybe we shouldn't willy-nilly put large bowel microbes into different parts of the intestine that shouldn't be there,' Dr. Orlando 'Landon' DeLeon, postdoctoral researcher at the university, said in a statement. 'If we're designing good therapeutics, we should be aware of the importance of matching the regional microbiota to their proper environments, so that we provide better overall health benefits.' DeLeon is the lead author of the new research, which was published on Friday in the journal Cell. To reach these conclusions, the authors gave three groups of mice transplants of microorganisms from the middle part of the small intestine that connects to the colon, and a standard fecal transplant from the colon. The test showed that the microorganisms from each transplant were able to colonize the entirety of the intestinal tract in the mice -- not just certain regions. This created what they called regional gut mismatches, lasting for up to three months following a transplant. The microbes also altered their new intestinal environments, 'terraforming' the lining in ways that caused changes in the recipient's metabolism, behavior and energy balance. There were shifts in liver metabolism, including activity in genes associated with immune function. The mice also exhibited different eating behaviors. The gut has several distinct regions with vastly different microbial ecosystems. Imbalances in gut bacteria have been tied to a risk of cancer. 'There are microbes along the entire intestinal tract, and we just study predominately the last third of it (the colon),' DeLeon said. 'So, how can you expect [a transplant], with microbes from a third of the intestinal tract at the end of it, to fix the rest of the intestine?' What this means for human patients may be murky right now, but the authors say more caution is needed with the transplants going forward. They advocate for an approach that would transfer microorganism from all regions of the intestine and not just largely from the colon. In the future, they plan to conduct further study related to how different microbes exert their influence in different parts of the intestine and how the gut regions terraformed by microbiota mismatches can be restored. 'We have absolutely no idea what's in FMT, except that it's a combination of microbes,' Dr. Eugene Chang, the Martin Boyer Professor of Medicine at the university and senior author of the study, said. 'But even a single FMT will cause a change in the host-microbe relationships in these very different regions of the bowel that may be very difficult to reverse.'
Glasgow Times
9 hours ago
- Glasgow Times
D-Day landings boosted by import of ‘wonder drug' to Britain, archives reveal
Production of the antibiotic penicillin had struggled to take hold at a large scale in Britain, despite being discovered in 1928 in London by Sir Alexander Fleming. Attempts to produce substantial quantities of medicine from the bacteria-killing mould had not been achieved by the start of the Second World War. Then prime minister Sir Winston Churchill became increasingly frustrated that Britain had not been able to produce enough penicillin in the preparations for the Normandy landings in 1944. Official papers released by the National Archive – containing handwritten notes by Sir Winston – highlight efforts to boost quantities of the antibiotic, with Britain eventually forced to import it from America. The documents were released ahead of the 81st anniversary of D-Day, the Allied invasion of Normandy on June 6, 1944. Official papers highlight the efforts to boost quantities of penicillin (The National Archives/PA) In one report on February 19, after the issue had been raised in the House of Commons, Sir Winston scrawled in red ink on a Ministry of Supply report noting the Americans were producing greater quantities: 'I am sorry we can't produce more.' On another paper, he complained: 'Your report on penicillin showing that we are only to get about one tenth of the expected output this year, is very disappointing.' Elsewhere in the same file he instructs: 'Let me have proposals for a more abundant supply from Great Britain.' With preparations for D-Day ramped up, efforts to deliver enough American-made penicillin for frontline military personnel soon became a matter of urgency. Decisions needed to be made on the quantities of antibiotic imported, how much to administer to individual patients, and how to get medical staff trained in time. Most British doctors did not know how to issue penicillin – until this point, doctors had nothing available to treat infections like pneumonia and many people died of blood poisoning after minor injuries because no drug existed that could cure them. Royal Navy D-Day veteran John Dennett, 101, at the British Normandy Memorial in Ver-sur-Mer to mark the 81st anniversary of the landings (Gareth Fuller/PA) Early in January 1944, Prof FR Fraser, the Ministry of Health's adviser on the organisation of wartime hospitals, wrote that 50,000-100,000 wounded could be expected from the Second Front. He proposed the Emergency Medical Services might need as many as five billion units of penicillin per month for this. Further documents show discussions on whether the antibiotic should be supplied as calcium or sodium salts, or in tablet form. Ultimately, it was agreed powdered calcium salts would be issued for superficial wounds and sodium salts for use in deep wounds. On May 24 1944, less than a fortnight before D-Day, Prof Fraser reported: 'Sufficient supplies of penicillin are now available for the treatment of battle casualties in EMS hospitals, but not for ordinary civilian patients.' Plans were made for casualties from the frontline in France to be brought back to coastal hospitals in Britain for treatment. A week before D-Day, on May 30 1944, hospitals were instructed to treat battlefield patients en route: 'In an endeavour to prevent the development of gas gangrene and sepsis in wounds the War Office have arranged for the treatment of selected cases by penicillin to be commenced as soon after injury as possible.' Military reenactors watch the sunrise over Gold Beach in Arromanches-les-Bains, Normandy, on the 81st anniversary of the D-Day landings (Gareth Fuller/PA) Injections of penicillin were to be given to them at intervals of not more than five hours and patients would be wearing a yellow label with the letters 'PEN'. The time and size of penicillin doses should be written on it, they were told. Dr Jessamy Carlson, modern records specialist at the National Archives, said: 'File MH 76/184 gives a glimpse into the extraordinary levels of preparation undertaken in advance of the D-Day landings. 'Only six weeks before, penicillin is just reaching our shores in quantities which will allow it to play a major role in improving the outcomes for service personnel wounded in action.' As Allied forces made inroads into Europe, restrictions on the use of penicillin for civilians began to relax, but only in special cases. In July 1944, Ronald Christie, professor of medicine, wrote to Prof Fraser to tell him: 'The War Office approves of American penicillin being used for medical conditions in service patients and for air raid casualties among civilians.' On the home front, demand for the new 'wonder' drug began to increase, according the National Archives. It was decided that penicillin for civilians should only be supplied to larger hospitals where the staff had been properly trained to administer it. Only in 1946 did it become fully available for the general public.
