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HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

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HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

BARCELONA, Spain, June 14, 2025--(BUSINESS WIRE)--Hospital for Special Surgery (HSS) presented a research study at the European Alliance of Associations for Rheumatology (EULAR) Annual Meeting showing that an artificial intelligence (AI)-based model can predict readmissions of pregnant women with lupus by looking at patients' social factors and clinical comorbidities. Systemic lupus erythematosus (SLE), commonly known as lupus, is a chronic autoimmune disease in which the immune system attacks the individual's own healthy tissue, causing pain, inflammation, and eventually damage to various organs. It commonly affects young women, and pregnancy is a particularly vulnerable period for this high-risk population. Although lupus-related medical complications affect pregnancy outcomes, social determinants and economic conditions, known as social determinants of health (SDOH), may also be important in shaping maternal health outcomes. "Pregnant women with lupus have five times higher maternal mortality compared to those without lupus," said Sandhya Shri Kannayiram, MBBS, MD, rheumatology fellow at HSS and principal author of the study. "There is little data on how social factors, including Income, Insurance, housing stability, access to transportation, availability of utilities, and literacy, along with clinical comorbidities, affect pregnancy outcomes in individuals with lupus." To better understand how SDOH impact readmissions for pregnant patients with SLE, the team used ten-year data (from 2011 to 2021) from the National Readmissions Database of the US, encompassing approximately 66,000 hospitalizations in the United States, and counted the number of readmissions within 30 days of discharge during pregnancy and delivery. "We found that approximately 2,500 [pregnant women with lupus] were readmitted to the hospital within 30 days," said Dr. Kannayiram. "We used a supervised 'glass box' machine learning model called the Explainable Boosting Machine (EBM), which helped predict who is likely to return to the hospital within 30 days," said Dr. Kannayiram. She explained that EBM is a form of machine learning with a type of AI that learns from data to make predictions. "It's an AI model that can be trained on the dataset to predict outcomes with transparency and accuracy compared to traditional statistical models," she added. The team specifically examined the major social determinants from the database that may influence readmissions during pregnancy in SLE, including Income and insurance status (public, private, or self-pay). Dr. Kannayiram explained that the results obtained showed patients living in lower-income neighborhoods were nearly twice as likely to be readmitted compared to those from wealthier areas, and those with Medicaid or Medicare insurance were more likely to be readmitted within 30 days. Patients discharged to locations other than home, such as rehabilitation facilities or nursing homes, were also more likely to return. However, they also found unexpected correlations. "We found that the size of hospitals was highly related to readmissions, rather than the location, such as cities or rural areas," said Dr. Kannayiram, with large hospitals being the ones with more readmissions. Additionally, unlike most pregnancy studies, where older mothers are usually at higher risk, this study found that younger women with lupus were more likely to be readmitted. Dr. Kannayiram said that this result may be related to severe lupus in younger individuals since about half of the readmitted patients had Medicare coverage, which may suggest a high prevalence of disability or kidney disease within that younger population. By using the predictive AI model, the team also discovered that income and insurance status were among the top five predictors of 30-day readmission during pregnancy and delivery-related hospitalizations, explained Bella Mehta, MBBS, MS, MD, rheumatologist at HSS and lead author of the study. She noted that these results could inform targeted interventions, such as policy actions to advocate for improved Medicaid and Medicare coverage, as well as post-discharge care coordination. "Integrating SDOH screening into prenatal care for SLE patients, and incorporating a multidisciplinary team of social workers, could reduce preventable readmissions and improve maternal outcomes," added Dr. Mehta. According to Dr. Mehta, in future studies, the team plans to analyze in detail how individual-level social factors, such as housing instability, food insecurity, education, mental health, transportation access, and patient demographics, interact with clinical comorbidities to determine pregnancy outcomes for women with SLE. "This study underscores the vital intersection between clinical care and structural inequality," said Dr. Mehta. "The lupus community and broader maternal health initiatives must not only consider disease management but also address the social factors that influence outcomes." Poster details Title: Predictors of 30-Day Readmissions in Pregnant Patients with Systemic Lupus Erythematosus: The Role of Social Determinants of HealthAuthors: Sandhya Shri Kannayiram, Yiyuan Wu, Lisa Sammaritano, Michael Lockshin, Rich Caruna, D. Ware Branch, Jane E. Salmon, Bella n°: 2325Presentation: June 14th, 2025. 10:00 AM CEST About HSS HSS is the world's leading academic medical center focused on musculoskeletal health. At its core is Hospital for Special Surgery, nationally ranked No. 1 in orthopedics (for the 15th consecutive year), No. 3 in rheumatology by U.S. News & World Report (2024-2025), and the best pediatric orthopedic hospital in NY, NJ and CT by U.S. News & World Report "Best Children's Hospitals" list (2024-2025). In a survey of medical professionals in more than 20 countries by Newsweek, HSS is ranked world #1 in orthopedics for a fifth consecutive year (2025). Founded in 1863, the Hospital has the lowest readmission rates in the nation for orthopedics, and among the lowest infection and complication rates. HSS was the first in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center five consecutive times. An affiliate of Weill Cornell Medical College, HSS has a main campus in New York City and facilities in New Jersey, Connecticut and in the Long Island and Westchester County regions of New York State, as well as in Florida. In addition to patient care, HSS leads the field in research, innovation and education. The HSS Research Institute comprises 20 laboratories and 300 staff members focused on leading the advancement of musculoskeletal health through prevention of degeneration, tissue repair and tissue regeneration. In addition, more than 200 HSS clinical investigators are working to improve patient outcomes through better ways to prevent, diagnose, and treat orthopedic, rheumatic and musculoskeletal diseases. The HSS Innovation Institute works to realize the potential of new drugs, therapeutics and devices. The HSS Education Institute is a trusted leader in advancing musculoskeletal knowledge and research for physicians, nurses, allied health professionals, academic trainees, and consumers in more than 165 countries. The institution is collaborating with medical centers and other organizations to advance the quality and value of musculoskeletal care and to make world-class HSS care more widely accessible nationally and internationally. View source version on Contacts Tracy Hickenbottom/Rachael Rennich212-606-1197mediarelations@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

The Aging Brain: 6 Things You Should Be Doing to Slow Cognitive Decline

CNET

5 hours ago

CNET

The Aging Brain: 6 Things You Should Be Doing to Slow Cognitive Decline

When it comes to healthy aging, we tend to focus a lot on body health by exercising and eating well. One thing you might not be thinking about is brain health. But you should be. Your brain runs the rest of your body, and as we age, it changes, too. Cognition declines over time due to several factors, including age-related structure changes, brain injuries or excess stress hormones. According to the Centers for Disease Control and Prevention, one in nine American adults over 65 report cognitive decline. "The parts of our brain that help with learning information and remembering can become smaller, and the brain can weigh less as we age," said Colleen Marshall, chief clinical officer for Two Chairs. Aging doesn't happen at the same rate for everyone, but we all experience it in one way or another. Focusing on brain fitness now may help you slow the change and ensure your brain stays sharp through the years. How to start nourishing your brain for healthy aging 1) Solve puzzles We'll start with the easiest strategy to integrate into your daily life: puzzles. Solving puzzles can benefit the brain in several ways, from improving memory to boosting problem-solving skills. "They may slow the rate of cognitive decline and how quickly the brain decreases in size as we age," Marshall said. A study published in the journal Neurology reported that playing games like checkers or completing jigsaw puzzles can delay the onset of Alzheimer's by about five years. Different research supports the idea that solving crossword puzzles or journaling can lower the risk of dementia. Experts suggest that puzzles help curb cognitive decline because they expand the brain's cognitive reserve, or the ability to solve and cope with problems. Activities to try include putting together jigsaw puzzles or solving other types of puzzles, such as Sudoku, crosswords, memory games and math problems. 2) Learn a new skill Like stimulating the brain by playing games or solving puzzles, learning a new skill has short-term and long-term advantages. By learning a new skill, you're strategically activating several parts of your brain simultaneously. You're also promoting neuroplasticity by creating new pathways and strengthening those connections as you continue honing the skill. It could be learning a new language, painting or trying out a new sport. Just make sure it's challenging or complex, and continue to practice for the best brain results.3) Prioritize sleep Sleep is one of the most important things you can do for your body. While I'm not saying there's a right or wrong way to sleep, research suggests that how much sleep you get and the quality of your sleep influence your risk for dementia. According to a study published in the Journal of Neuroscience, a single night of sleep deprivation can age your brain. A lot goes on in the brain while we sleep, including clearing out toxins and creating new neural pathways. If you don't get enough sleep, your brain doesn't have time to carry out these functions and cognition suffers. Establishing a bedtime routine can have a big impact on your sleep quality. From reading a book to practicing yoga before bed, integrating relaxation into your night can help boost your sleep. 4) Focus on your nutrition What you eat also will influence the rate of cognitive decline you experience as you age. Studies have found that people who follow the Mediterranean and MIND (Mediterranean Dash Intervention for Neurodegenerative Delay) diets tend to have fewer cognitive impairments and dementias compared to those following other diets. More research is needed to conclude why this is true. However, it might have something to do with the way those diets prioritize foods that protect the brain with anti-inflammatory and antioxidant properties. Read more: Master the Mediterranean Diet With the Help of These Tips and Recipes No matter if you choose to follow a strict diet or just improve your current meal rotation, you'll want to focus on improving your blood sugar and dropping high levels of LDL cholesterol to reduce your risk of dementia. Foods to incorporate into your diet for better brain health: Leafy greens like spinach, kale and lettuce Salmon Dark berries Nuts Greek yogurt Dark chocolate Green tea Vegetables like broccoli and carrots 5) Exercise Studies have found that following an active lifestyle is associated with lower cognitive decline over time. Your heart rate increases when you exercise, which increases blood flow to the brain. This can help spark new development of nerve cells, a process called neurogenesis. Exercise also promotes increased connections between cells, making the brain more adaptive. Generally, any exercise that's good for the body will also help the mind. It doesn't have to be lifting weights; walking, swimming and dancing also achieve the same results. Read more: How Exercise Helps Boost Your Memory-Brain Health as You Age6) Make connections with others Marshall pointed out that prioritizing high-quality relationships with others can benefit the brain. According to a meta-analysis of longitudinal cohort studies, limited or poor relationships were associated with cognitive decline. Prioritizing social contact is an essential part of aging well. Whether spending time with your family or putting yourself out there at your local community center, staying connected is an integral part of aging gracefully. Too long; didn't read? Our brains change as we age; there is no way around it. However, integrating any of these easy habits into your routine can help nourish and safeguard your brain for the future. There are also a few things you should avoid to keep your brain in top shape. Heavy cigarette smoking has been associated with cognitive decline in middle age. Marshall added that heavy drinking, poor diet and unmanaged high blood pressure can also negatively impact the brain as we age. Don't worry; there's still time to turn it around. Even if you smoke now, quitting has the potential to return your risk of cognitive decline to a level that's comparable to those who never smoked.

Yahoo

7 hours ago

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HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

BARCELONA, Spain, June 14, 2025--(BUSINESS WIRE)--Hospital for Special Surgery (HSS) presented a research study at the European Alliance of Associations for Rheumatology (EULAR) Annual Meeting showing that an artificial intelligence (AI)-based model can predict readmissions of pregnant women with lupus by looking at patients' social factors and clinical comorbidities. Systemic lupus erythematosus (SLE), commonly known as lupus, is a chronic autoimmune disease in which the immune system attacks the individual's own healthy tissue, causing pain, inflammation, and eventually damage to various organs. It commonly affects young women, and pregnancy is a particularly vulnerable period for this high-risk population. Although lupus-related medical complications affect pregnancy outcomes, social determinants and economic conditions, known as social determinants of health (SDOH), may also be important in shaping maternal health outcomes. "Pregnant women with lupus have five times higher maternal mortality compared to those without lupus," said Sandhya Shri Kannayiram, MBBS, MD, rheumatology fellow at HSS and principal author of the study. "There is little data on how social factors, including Income, Insurance, housing stability, access to transportation, availability of utilities, and literacy, along with clinical comorbidities, affect pregnancy outcomes in individuals with lupus." To better understand how SDOH impact readmissions for pregnant patients with SLE, the team used ten-year data (from 2011 to 2021) from the National Readmissions Database of the US, encompassing approximately 66,000 hospitalizations in the United States, and counted the number of readmissions within 30 days of discharge during pregnancy and delivery. "We found that approximately 2,500 [pregnant women with lupus] were readmitted to the hospital within 30 days," said Dr. Kannayiram. "We used a supervised 'glass box' machine learning model called the Explainable Boosting Machine (EBM), which helped predict who is likely to return to the hospital within 30 days," said Dr. Kannayiram. She explained that EBM is a form of machine learning with a type of AI that learns from data to make predictions. "It's an AI model that can be trained on the dataset to predict outcomes with transparency and accuracy compared to traditional statistical models," she added. The team specifically examined the major social determinants from the database that may influence readmissions during pregnancy in SLE, including Income and insurance status (public, private, or self-pay). Dr. Kannayiram explained that the results obtained showed patients living in lower-income neighborhoods were nearly twice as likely to be readmitted compared to those from wealthier areas, and those with Medicaid or Medicare insurance were more likely to be readmitted within 30 days. Patients discharged to locations other than home, such as rehabilitation facilities or nursing homes, were also more likely to return. However, they also found unexpected correlations. "We found that the size of hospitals was highly related to readmissions, rather than the location, such as cities or rural areas," said Dr. Kannayiram, with large hospitals being the ones with more readmissions. Additionally, unlike most pregnancy studies, where older mothers are usually at higher risk, this study found that younger women with lupus were more likely to be readmitted. Dr. Kannayiram said that this result may be related to severe lupus in younger individuals since about half of the readmitted patients had Medicare coverage, which may suggest a high prevalence of disability or kidney disease within that younger population. By using the predictive AI model, the team also discovered that income and insurance status were among the top five predictors of 30-day readmission during pregnancy and delivery-related hospitalizations, explained Bella Mehta, MBBS, MS, MD, rheumatologist at HSS and lead author of the study. She noted that these results could inform targeted interventions, such as policy actions to advocate for improved Medicaid and Medicare coverage, as well as post-discharge care coordination. "Integrating SDOH screening into prenatal care for SLE patients, and incorporating a multidisciplinary team of social workers, could reduce preventable readmissions and improve maternal outcomes," added Dr. Mehta. According to Dr. Mehta, in future studies, the team plans to analyze in detail how individual-level social factors, such as housing instability, food insecurity, education, mental health, transportation access, and patient demographics, interact with clinical comorbidities to determine pregnancy outcomes for women with SLE. "This study underscores the vital intersection between clinical care and structural inequality," said Dr. Mehta. "The lupus community and broader maternal health initiatives must not only consider disease management but also address the social factors that influence outcomes." Poster details Title: Predictors of 30-Day Readmissions in Pregnant Patients with Systemic Lupus Erythematosus: The Role of Social Determinants of HealthAuthors: Sandhya Shri Kannayiram, Yiyuan Wu, Lisa Sammaritano, Michael Lockshin, Rich Caruna, D. Ware Branch, Jane E. Salmon, Bella n°: 2325Presentation: June 14th, 2025. 10:00 AM CEST About HSS HSS is the world's leading academic medical center focused on musculoskeletal health. At its core is Hospital for Special Surgery, nationally ranked No. 1 in orthopedics (for the 15th consecutive year), No. 3 in rheumatology by U.S. News & World Report (2024-2025), and the best pediatric orthopedic hospital in NY, NJ and CT by U.S. News & World Report "Best Children's Hospitals" list (2024-2025). In a survey of medical professionals in more than 20 countries by Newsweek, HSS is ranked world #1 in orthopedics for a fifth consecutive year (2025). Founded in 1863, the Hospital has the lowest readmission rates in the nation for orthopedics, and among the lowest infection and complication rates. HSS was the first in New York State to receive Magnet Recognition for Excellence in Nursing Service from the American Nurses Credentialing Center five consecutive times. An affiliate of Weill Cornell Medical College, HSS has a main campus in New York City and facilities in New Jersey, Connecticut and in the Long Island and Westchester County regions of New York State, as well as in Florida. In addition to patient care, HSS leads the field in research, innovation and education. The HSS Research Institute comprises 20 laboratories and 300 staff members focused on leading the advancement of musculoskeletal health through prevention of degeneration, tissue repair and tissue regeneration. In addition, more than 200 HSS clinical investigators are working to improve patient outcomes through better ways to prevent, diagnose, and treat orthopedic, rheumatic and musculoskeletal diseases. The HSS Innovation Institute works to realize the potential of new drugs, therapeutics and devices. The HSS Education Institute is a trusted leader in advancing musculoskeletal knowledge and research for physicians, nurses, allied health professionals, academic trainees, and consumers in more than 165 countries. The institution is collaborating with medical centers and other organizations to advance the quality and value of musculoskeletal care and to make world-class HSS care more widely accessible nationally and internationally. View source version on Contacts Tracy Hickenbottom/Rachael Rennich212-606-1197mediarelations@ Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

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HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

The Aging Brain: 6 Things You Should Be Doing to Slow Cognitive Decline

HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

Cognito Therapeutics to Present New Data on Spectris'™ Impact on Brain Structure in Alzheimer's Disease at AD/PD 2025

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HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

The Aging Brain: 6 Things You Should Be Doing to Slow Cognitive Decline

HSS Study at EULAR 2025 Congress Uses an AI Model to Predict Readmissions of Pregnant Women with Lupus Based on Social Determinants of Health

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