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Do We Actually Need To Wear SPF Every Day? Separating Fact From Fiction

Do We Actually Need To Wear SPF Every Day? Separating Fact From Fiction

Vogue14-05-2025

Charles Rosier and Augustinus Bader, cofounders of the latter's eponymous skincare brand, are telling me over a Zoom call about the brand's latest addition: The Sunscreen. Professor Bader's pale complexion suggests he is a sun avoider, but Rosier, on the other hand, has the kind of sun-kissed visage that denotes frequent winter breaks in the Caribbean, topped up with pit stops to the South of France.
And so, on the eve of launching what Bader calls 'the biggest innovation in the field of sun protection to the market since the existence of SPF,' it seems only fair to ask: how do they personally wear sunscreen? 'I haven't been the biggest user,' admits Rosier, whose favorite holidays in the sun turn out to be Tarifa, the Gulf of Naples, and the Aeolian Islands. 'Let's say, I'm more of an old-school, European-style person who likes to have a little bit of a tan…'
While Rosier's use was haphazard, it turns out fair-skinned Bader was even less of a fan. The noted director of cell techniques and applied stem cell biology at Leipzig University avoided sun cream for decades because of the possibility of exposure to toxic chemicals. Yet they are both wearing it now. 'This is not a [typical] SPF,' explains Bader of the elegant, white bottle with rose-gold trim and the clear label reading 'SPF 50.' Their first foray into sun protection comes after four years of development, hitting the sweet spot of protecting and restoring skin simultaneously. 'It's a shield, plus repair technology,' Bader continues, 'which is a big innovation in the history of SPF. Besides the shield, the repair technology [exists] to focus on inflammation.'
Augustinus Bader isn't alone in its focus. Following six years of research, Sisley has revamped its suncare range with Sunleÿa Anti Aging Facial Sun Care SPF 50+ (it also comes in 30+), designed to help protect elastin and collagen fibers from both UVA and glycation.
Could it be that we're finally learning to live in—and out—of the sun, balancing the joy (and highly essential vitamin D) it gives us with a sensible attitude to protecting our skin from harmful rays? If so, does a 'sensible attitude' mean more sunscreen? Or less? My cynical side can't help but be suspicious of the barrage of emails I receive telling me to wear it every day, even when I live in a country where grey skies are the norm from October through March. Lest we forget, as of 2022, the global sunscreen industry was worth more than $11 billion annually, and is estimated to reach $16 billion by 2029.

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England star Millie Bright pulls out of selection for Women's Euros for health reasons
England star Millie Bright pulls out of selection for Women's Euros for health reasons

Hamilton Spectator

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  • Hamilton Spectator

England star Millie Bright pulls out of selection for Women's Euros for health reasons

England defender Millie Bright withdrew herself from selection for the European Championship on Wednesday because of health reasons. 'Right now I'm not able to give 100% mentally or physically,' Bright wrote in a post on Instagram . The absence of the 31-year-old Bright — a long-time, first-choice center back for her country — is another blow to England coach Sarina Wiegman, who saw experienced goalkeeper Mary Earps announce her retirement from international soccer last week. On Tuesday, another stalwart of the England team — midfielder Fran Kirby — also retired from national team duty. Bright made herself unavailable for the recent England camp featuring games against Portugal and Spain and later said on a podcast: 'Mentally and physically I'm at my limits.' Wiegman said after the 2-1 loss to Spain on Tuesday that she would have a conversation with Bright about her availability for the Euros in Switzerland next month, where England will be defending its title from 2022. The following afternoon, Bright used social media to announce she would not be taking part in the Euros. She described it as 'one of the hardest decisions I've ever had to make' and said it came after 'careful thought and discussions with the team.' 'Football has given me so much, and representing my country has always been my greatest honor,' said Bright, who has made 88 appearances for England and played in the team that won the Euros in 2022 before captaining the side on its run to the World Cup final in 2023. 'My pride and ego tells me to go but I think the team and the fans deserve more.' She said as stepping back from the team 'is the right thing for my health, my future in the game and most importantly the team.' 'It wouldn't be fair,' she said, 'for me to take the place and opportunity away from another player who is ready and able to give everything for the badge and country.' Bright has just helped Chelsea to win the Women's Super League-FA Cup-League Cup treble in the recently completed domestic season. Turbulent week for Wiegman England's squad will be shorn of experience in Switzerland, with confirmation of Bright's absence coming soon after the international retirements of Earps and Kirby – two other members of the Euro 2022-winning team. Earps, a colorful and charismatic presence in the squad, played 53 games for her country but had lost her place in the team to Chelsea's Hannah Hampton. Kirby announced to her England teammates in the locker room after the loss to Spain that she was retiring from internationals. She played 77 games and had been told by Wiegman that she wasn't going to be selected for the Euros. Wiegman will name her final squad for the Euros on Thursday. England's first game of its title defense is against France on July 5. ___ AP soccer:

Are Red Light Masks Worth It?
Are Red Light Masks Worth It?

New York Times

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Are Red Light Masks Worth It?

RORY: It's almost like such a signifier. It's like the prop like if you want to convey something about this person, oh, put a red light mask on her because it means that she's... CAIRA: It's a status symbol. It's like an immediate flag like she got money. RORY: She got money. And she's also- ROSIE: Oh, she's got mask money. CHRISTINE: I'm Christine Cyr Clisset. CAIRA: I'm Caira Blackwell. ROSIE: I'm Rosie Guerin. And you're listening to The Wirecutter Show . CAIRA: This episode is called, Are Red Light Masks Worth It? ROSIE: Hello, my dear pod friends. CHRISTINE: Hello. ROSIE: I wanna talk about this thing I was reminded about this weekend. I was watching that Netflix show, Sirens. It's a new one with Julianne Moore. And she plays this eccentric billionaire. And there's a scene where she is lounging in a very fancy robe and drinking champagne. And she is wearing one of those red light masks. CHRISTINE: Oh yeah. ROSIE: Have you seen these devices? CHRISTINE: Oh yeah, I've seen them everywhere. CHRISTINE: Everywhere. I mean, I have been thinking about buying one for years. ROSIE: I haven't pulled- CAIRA: I've only been seeing them on my timelines for the past like few months. CHRISTINE: Oh you youngins you youngin ROSIE: What I'm hearing is this is not a silly trend that this is a thing that's been in the zeitgeist. This has been around a long time. CHRISTINE: They're supposed to, you know, make you look younger, essentially, like, boost collagen, reduce the look of wrinkles, like... CAIRA: Oh, so it doesn't just make you like an android with red light in your own home? CHRISTINE: Well, there's that too. We just came out with a review of them, which I am so excited about. And I have been waiting, because I've been wanting to get a recommendation. Because I want to have that Android look at home. CAIRA: So I think at the end of this episode, you're going to know which one you're getting. CHRISTINE: Hopefully, yes. Yeah, I think a lot of people who are maybe considering buying one of these, it's not a cheap purchase. There are devices you can get that are like wands that are under $200, which that's still some money. But the actual masks, those are like, 500, some of them can be like 2000. ROSIE: But the question is, okay, you're going to pay $500. Does this thing actually work? CHRISTINE: Well, I think we should find out. I think should get to the bottom of this. ROSIE: We're gonna phone a friend. CAIRA: That's why it's always so cool to work at Wirecutter because we can always phone a friend here So we're gonna talk to Rory Evans today Wirecutter skincare supervising editor who's covered everything from facial cleansers to the best Korean skincare products. CHRISTINE: That's right. So when we're back from the break, we are going to talk with Rory about these LED red light devices. Do they work? Are they worth your money? Will you look 15, 20, 30, 40 years younger if you start using them? ROSIE: Or are you just going to... look like the movie poster for Eyes Wide Shut. CHRISTINE: I mean, for those who don't know that reference,. ROSIE: Who doesn't get that reference?! CAIRA: I had to Google it as you know. ROSIE: Lord in heaven. Alright, we'll be right back. CAIRA: Welcome back. With us now is Rory Evans, who is Wirecutter's Skincare Supervising Editor who's been covering this area for over 20 years. She also previously worked at Allure, Real Simple and Martha Stewart before this. CHRISTINE: Welcome to the show, Rory. RORY: Thanks for having me. CHRISTINE: Today we are going to do a deep dive into LED lights. Some people call these red lights. They're often like these masks or wands that shoot red light at your skin, and I've long wondered whether these things work. So can you explain to us what are these supposed to do? RORY: The light penetrates into different layers of your skin and it boosts the production of collagen and elastin so it's going to make your skin look firmer and it's going to make your wrinkles look less visible. Fine lines are going to look less visible so that is what's happening. ROSIE: So when did this red light therapy for skin come about and what's the backstory? RORY: The backstory is that it was developed by NASA and like any good invention, it was discovered by accident because they were using LEDs, light emitting diodes, to grow plants. And the scientist who was doing the experiment found that lesions on his skin were less pronounced, looked better, so then it made this shift into healing and skin care. CHRISTINE: But they haven't really taken off as a skin care facial treatment until the last decade, right? RORY: Yeah. The treatments are used in dermatologist offices and then there are this home care. And the ones in derm offices are stronger, you use them longer, you might use them for different skin challenges. The derms that I talked to for this guide, almost all of them use them in their offices and have been using them for decades. CHRISTINE: And do they look like vampires like they're so young? RORY: There's one woman who is, she's not like a vampire because, so she looks amazing and I made that point at the end and she was like, "Anything with skin care, it's my genes. It's how much I stayed out of the sun. I knew to stay out of the sun. It's using sunscreen when you're in..." All the things. ROSIE: It's not a secret concoction like the Substance or something. RORY: Yes, exactly. ROSIE: So let's back up for a second because I know nothing about these devices at all. I've seen them, but I want you to hold my hand and walk me through how I would use one if I was gifted one of these. RORY: Okay. ROSIE: Hint, Caira. RORY: Well, it would depend. If you get a wand, you're literally going to move it around your face the way you would, I want to say it's like the way you would shave, just keep moving it around your face. Or using an electric toothbrush, you just wait for the two minute timer, move it to a different quadrant but you would do it for 12 minutes, which is an eternity. CHRISTINE: Yeah, I can barely brush my teeth for two minutes. RORY: Same. Same. It is like the time melts. The clock is waxed, but it takes forever. Or you take a mask and you put it on your face. ROSIE: And you just sit there. RORY: You just sit there. ROSIE: And press a button and then the session just goes? RORY: You press a button and yeah, and it goes and then it turns off in 10 minutes. And Dr. Glynis Ablon, who is one of the doctors that I interviewed for this, she's like, "People think that in order for it to work it has to hurt and this does not hurt at all." Especially with light, with laser, you think there's going to be something that's burning and blasted off your face. It doesn't hurt. CAIRA: It shouldn't hurt, right? RORY: No. Yeah, it shouldn't hurt. And it can feel warm. It shouldn't feel hot. CHRISTINE: Yeah. I've had a professional level one of these used on my face and we wore goggles because the light is so bright. So with these at-home devices, are you supposed to wear goggles? RORY: Yes. And some of the masks have little protective, almost silicone shields around the eyes. A few of them come with the little goggles that you would wear in a tanning coffin. ROSIE: A tanning coffin. CAIRA: I don't like that. CHRISTINE: Vampire, coffins. ROSIE: If they were called tanning coffins when I was in high school, I feel like a lot fewer people would've gone in them. RORY: But still, even I wore those with some masks and I could still just see a wall of red. CAIRA: Oh wow. RORY: So it's intense. CAIRA: But what are you supposed to do when you have these masks on? I've seen some of them literally look like the Phantom of the Opera masks where they have the eye holes so maybe you could watch TV, but it sounds like you're not supposed to keep your eyes open. RORY: People say that. They're like, "I just walk around my house and do my laundry and whatever." That was not my experience. I would recommend, the other thing is it's 10 minutes, just sit down, relax. ROSIE: It's therapeutic. You're supposed to be taking a minute of self-care. RORY: Listen to a podcast. ROSIE: Preferably this one. RORY: Yeah, exactly. I would just recommend not having your eyes open. There were a few, I could very comfortably leave my eyes open, but most of them are really, I don't know, it's intense. It was intense. CAIRA: These sound a little bit too good to be true as most things with skincare that you can do at home. Did a lot of your testers think that these masks work? RORY: That was definitely the case. Our testers were like, I feel better, or I feel like my skin looks less wrinkly, or I feel like my nasolabial folds are less pronounced, or the lines around my mouth, those parentheses that you get around your mouth and crow's feet, they felt like it looked better. Was it the only thing they were doing for their skin at the time? No. That's the challenge of the way we have to test, but they did like it. And the other thing is that I think a lot of people felt like they had nothing to lose and only something to gain. ROSIE: What is a nasolabial fold? RORY: It's the lines between your nose and your lips. CHRISTINE: What separates your cheek area from your lip area? RORY: Small lines. CHRISTINE: Yeah. RORY: Yeah, exactly. CAIRA: How long did you have to use them or did most people on your testing panel have to use them before they saw a difference? RORY: Some people were like for a month and were feeling like it was better. CAIRA: Wow. ROSIE: Every day? Once a week? RORY: As instructed. And I want to say that some of them were like 10 minutes, 5 times a week, every other night, 3 times a week. It really depended on the instructions. ROSIE: So were you taking before and after head shots of everybody testing for efficacy? RORY: No, it was self-reported improvement and enjoyment too. ROSIE: What was the main criteria would you say, in terms of judging? RORY: Did you look less crinkly, wrinkly? Did you look firmer and fresher? And I mean some of it was just user experience too. Some masks had, all the controls were on the masks, so you would be pushing buttons to change modes and change the color of the lights and impossible to tell while it's on, which one you're on. And it's almost like when a door has three locks and you're like, wait, I did that one, that one, and you can't figure out which one you're actually in. Some had wand like remote control wands that were also a little bit tricky. Some were great, some were really uncomfortable to wear. Some were very comfortable to wear. Some were you had to wear eye goggles with it, but wearing the thing with eye goggles and then operating it, was literally groping in the dark if the dark were a wall of the brightest red you've ever seen in your life. CHRISTINE: Why do this to yourself? RORY: It was that too. Just like is this something that I want to use for 10 minutes every night or 5 nights a week or every other night, or however often it's recommended to be used? And the price too. CHRISTINE: LED lights, do they have any negative impacts on your skin? Is there any UV light that's actually penetrating your skin so that it could be damaging in the way that sunlight would be? RORY: No, because UV is at the other end of the spectrum. CHRISTINE: Okay. RORY: So it's ultraviolet and infrared, where in the red, not in the violet end of the spectrum. There are also lots of considerations and contraindications for using it, like lupus. If drugs that cause light sensitivity, if you have light sensitivity and you get migraines, if you have darker skin, it's also, it's one of those things that you want to talk to your dermatologist or your doctor before you try it. And if you try it, spot test it before you go all in on your face because it may cause hyperpigmentation. It may cause a reaction. In some ways it's like any skincare thing. CHRISTINE: So probably a good idea, especially if you have melanated skin, you should be talking to your dermatologist before using one of these devices? RORY: Yeah. Yeah. CHRISTINE: And then if you have something like lupus or you have something where you know you might be impacted by light, you should also be talking to your doctor. RORY: Yeah, I would say talk to your doctor anyhow, just to be on the safe side. I said to my dermatologist, I was like, and she was like, "Oh, I love red light devices." So I was like, okay, that's my go ahead. And she was taking into account my, what's going on with my skin or whatever? So as your dermatologist or doctor would do for you. ROSIE: Are there places you can try these devices out or is it like the bed in a box where you can sleep on it and then- RORY: Well that was one thing that we considered for the guide was that we wanted to make sure that they have solid return policies and good warranties because you try it and you're like, oh, I'm down $350 bucks and this thing doesn't feel good, doesn't fit well. ROSIE: It doesn't work for my skin for whatever reason. RORY: Exactly. So that was a piece of our consideration. ROSIE: So we're talking about devices, these are things that you can line your couch and use at home. What are the considerations and why would someone opt in to a device rather than going for treatment at a dermatologist's office? RORY: Some of it is affordability and some of it I think is also like any piece of skin care is the maintenance in between. So you're going to see a dermatologist for expensive treatment and then you're going to do self-care in between. ROSIE: Did you cap your search in terms of price? RORY: We did. We put a cap on it. We put it at $600 and that was not an easy one to set because it still felt high. None of our picks, I want to say our top pick is just under $400 bucks. ROSIE: They're also, I mean this is speculative, but they're in the zeitgeist more than they've ever been, I think. RORY: Yes. It's almost like such a it's like if you want to convey something about this person, oh, put a red light mask on her because it means that she's... CAIRA: It's a status symbol. It's like an immediate flag like she got money. RORY: She got money. And she's also- ROSIE: Oh, she's got mask money. CHRISTINE: So I have looked at a lot of these. They're all over the place. There's ones on Amazon. Goop has a quite robust page. It's a very, very wide range in prices. Could you just give us what is the cheat sheet of what someone should look for in a red light device? Because I have no idea. Just looking at the prices, it just seems like it's all over the map and I wouldn't really know where to begin. What were you looking for and what's the just simplest list of things to look for? RORY: We were looking for, one, if it was just a straight blue light device, we cut it out of consideration because blue light is used to treat acne. So many of the derms that I talked to were like, there are so many options for treating acne, blue light shouldn't be the only thing. And then we were looking at red light devices that had, bear with me, I'm going to talk about nanometers. I'm going to talk about wavelength. So we looked for ones that had red light in the range of 630 to 650 nanometer for red light. CHRISTINE: And can I just ask, nanometer is a measurement of wavelength, is that what that is? RORY: Yes. CHRISTINE: Okay. RORY: And those numbers, they indicate the color of a light. CAIRA: And that means how deeply they will penetrate the skin? RORY: Yes, exactly. CAIRA: Okay. RORY: And so red light in the 630 to 650 nanometer range, and then the near infrared, that was in the 830 plus range. And then we also looked at irradiance, which is the power over an area, and that's measured in megawatts over square centimeters. It's recommended by the dermatologist that I interviewed … soft masks had at least 30 megawatts over centimeters squared, hard masks had at least 50, and wands were at least 49.5. And also you want to make sure that it's FDA cleared and we made sure that the ones that we have are FDA cleared. CAIRA: But they shouldn't say FDA approved, right? RORY: If it says FDA approved, they're telling tales because the FDA does not approve these devices. They will clear a device, which is to say that the company has done their due diligence and submitted paperwork to say that you cleared a device that's a lot like this and then they get clearance as well. You might not be able to find that information on- CAIRA: The Amazon page. RORY: ... On the Amazon page. You might need to go to the brand page. CAIRA: To the brand page and look it up. ROSIE: So I'm recapping here. The consensus here is that these work. No two people are created equally, so it's hard to say that it will 100% work on you. You got to check with your dermatologist before you jump into this purchase. These aren't cheap. The mask is going to be a more passive experience in terms of sitting back, putting the thing on your face, running a session and repeat. Whereas the wand is going to be a little bit more active, like using an electric toothbrush, you got to run this thing over your face for 12 minutes. That feels like an eternity. RORY: Yes. ROSIE: That's a direct quote from you. And also if you're shopping for these online, you're going to want to look for red light in the 630 to 650 nanometer range and you're going to look for near infrared light in the 800 plus nanometer range. RORY: Yes. CAIRA: Okay. We're going to take a quick break and then when we come back, we're going to get into all the details of the three LED devices that Rory recommends. Be right back. CHRISTINE: Welcome back. Now that we have discussed all of the things that LED lights can do for your skin, Rory, I want to get into the actual picks that you made because you tested a lot of these devices and you recommend three in our guide. You recommend one wand and two masks, right? So can we start out with the wand first? What did you pick and why do you like it? RORY: We chose LightStim for Wrinkles and it costs $200. And at first- ROSIE: It's called LightStim for Wrinkles? RORY: Yeah. That really stopped me. CAIRA: What's it for? It's for wrinkles. CHRISTINE: Surely that marketing group could have come up with a better name. RORY: Well, there are other in the line of LightStim. There are others like LightStim for Acne, LightStim for whatever. We chose LightStim for Wrinkles because it met our criteria for the red light. At first, I will admit, I wasn't underwhelmed, I was like, oh my god, this is it? It seemed dumb simple. You plug it in, you hit a single switch and it turns on and then after three minutes, it shakes a little bit, lets you know to move to a different spot on your face. It was like without bells and whistles and so many of these options have bells and whistles. And then I was like, but wait a minute, where it matters, which is to say the number of LEDs that it has packed on the face of it, is legit. It's 72 LEDs. And that is more than any of the wands that we tested. They were also more densely packed. Those lights were more densely packed than the masks that we tested. CHRISTINE: I think a lot of people, I know when I think of a wand, I think of the Solawave, which is very, very popular and it looks like a little shaver, but this one is actually bigger. ROSIE: It looks like a shower head. RORY: Yes, it does. CHRISTINE: Yeah, yeah, yeah, right. Or a big flashlight or something. So it's got a lot of little LED bulbs in this big round surface. RORY: Yes. And the round surface is maybe a little bit more than two, two and a half inches across and it's got 72 LEDs packed in there. You press it against your face and for a wand it was not as, it didn't require the constant motion. You could just press it against your face, lean against it. I would sometimes do it in meetings because- ROSIE: For research. RORY: ... it's my job. It wasn't as arduous as the Solawave. CAIRA: Why do you guys keep referencing the Solawave? What is that? CHRISTINE: We should explain what the Solawave is. It's not a pick, but I've seen it for years recommended on Instagram and influencers using it on their posts online and stuff. RORY: The Solawave wand is also affordable. It's also one of those things that's always on sale, but we just thought it was too much work. It has 14 LEDs, whereas the LightStim you're looking at it and you're like, I know what I'm getting here. I'm getting a lot of LEDs and the Solawave, it's not as much. It's in the skinnier line. You just have to move it around your face all the time. Whereas I could lean against my LightStim and feeling like I was getting a lot of coverage on my face and being certain of where it was covering on my face. ROSIE: And it's a wand, so you can use it on other parts of your body as well. RORY: And you can use it on your chest. It was enjoyable. It was so straightforward. We liked that. CHRISTINE: So if someone is debating between a mask and a wand, is it just purely like do you prefer to sit with a mask on your face or do you want the ability to use a wand on your face or maybe somewhere else on your body? How do you make that choice? RORY: The wands are more affordable. I always think about, and because I've done this so many times where you buy the thing that feels like the bargain and then you're like only compromise and you hate using it and then you're going to get the real thing anyhow. So it's like if you're going to spend $200 on a wand, just spend $350 on the mask. That's my thinking. ROSIE: Well we spoke about this when you came on talking about facial moisturizers, this idea that the most effective one is the one you're going to actually use. RORY: Yeah. CAIRA: But there is an argument to get a wand if you really think that you want to target other areas that are not your face. RORY: Yes. CAIRA: Because it's very flexible and you can move it around anywhere, whereas most masks are very rigid and you can pretty much only use them on your face, right? RORY: No, because we had flexible masks and rigid masks and then the wands. And the flexible masks you could use elsewhere on your body. CAIRA: Is it as easy as a wand? RORY: Yes. I mean, especially if you're using, if you're doing your upper chest, just lay the thing down on your chest. I have a fresh surgical scar on my arm and I did use, I tested all of these products on my arm with the exception of the rigid masks because they don't fit my elbow. The wands on my elbow were definitely easier to apply, but the mask also was set it and forget it. I would just wrap it and leave it. And I do think that, I can't say which one and I can't say what because it wasn't the only thing I was doing for healing, but my scar is pretty impressively invisible now. ROSIE: That sounds like it's great if you want a device that's easy to use for different parts of your body, you don't mind a little manual labor rolling that thing around. Although you said the head of it is the size of a tennis ball, so that's pretty good coverage. RORY: Yeah, I know. And that's why it felt like you could cover your face. How many tennis balls is my face? ROSIE: Right. I'm constantly asking myself that. RORY: I know. ROSIE: But what if you just want to put something on and zone out for 10 minutes? RORY: We recommended two masks. One is a hard mask and one is a soft mask. And so we recommend the Shark CryoGlow and the Omnilux Men. CAIRA: But why is it called Omnilux for men? What is that? RORY: Oh, I know. The entire time I was working on it, I was thinking about the old Secret ad where it's strong enough for a man, but made for a woman. But it's the other way around. So essentially, it's gray. It's not pink. It literally is gray. It's not pink. CAIRA: For the men. RORY: And it says men on it. It's a little bit crazy. But derms that I talked to mentioned that male skin, men's skin tends to be thicker than women's skin, maybe by like 25%. This mask has a 1072 nanometers That's the wavelength that is going to penetrate a little bit deeper. CAIRA: Okay, so it's just like the strongest option? RORY: Yes. The deepest reaching penetration. CAIRA: Okay. RORY: Exactly. It says it's for men, but we tested another mask that we also really liked. We gave it a worth considering denotation. And that also has 1072. That doesn't mention men anywhere. ROSIE: What's that one called? RORY: That's the CurrentBody. CAIRA: Why would you choose, like I hear one's rigid and one is flexible. It sounds like from everything that we've talked about, what is the case for a rigid mask? But just in general, why would you pick between the two? RORY: Specifically for the CryoGlow, it was so pleasant to use. Literally, everyone who tested it was like, when's my turn with that one again? CAIRA: And this is the rigid mask? RORY: Yeah, yeah, yeah. You know when you try a product and you feel like we all do this at Wirecutter's, like, oh, someone thought this through. Someone thought through. CAIRA: Yeah, good design. RORY: And comfortable, easy to use. It's like they were reading my mail about everything that I didn't like about the other ones and were fixing it before I tried it. CAIRA: Nice. RORY: So I feel like that's the case for the hard mask. CHRISTINE: If somebody was trying to decide, say between one of the soft silicone masks versus the hard masks, is there a decision tree about why you'd want to choose one or the other? RORY: It's a little bit, how are you really going to use it? One of the reasons why we liked the soft masks, a selling point is if you want to lay it on your chest, if you want to hold it sideways and get your neck a little bit and use it as a flexible panel. And the hard mask was, I think it was probably more like if you didn't need that or also if you just wanted to have a very enjoyable, I think in some ways the hard mask, especially our pick, really feels like a self-care moment. CHRISTINE: And it's not that expensive, right? Out of the range, how much does the Cryo Glow cost? RORY: It is $350 bucks. CHRISTINE: Okay. Which is still not nothing. RORY: It's not nothing. CHRISTINE: But when you compare it to a lot of the things you could buy, it's a lot cheaper. So if you're someone listening to this podcast and you're like, I actually think this rigid mask sounds great, but I want to get my neck and my chest. I've seen some of these masks, at least online, I've seen that there are add-ons. You can buy a neck add-on or you can buy it- CAIRA: No, there aren't. CHRISTINE: Yes you can. CAIRA: Oh my God. CHRISTINE: Of course you can. CAIRA: Not mods. CHRISTINE: So do any of these come with add-ons that you could do with your neck? What would you say to someone who is like, I want the most comfortable face mask, but I also want to cover my chest and my neck? RORY: I would say do not get the add-ons. One of the face masks that we tried, Dr. Dennis Gross, they sell like a chest plate. It's so specific and again, you can get the flexible mask and just put it on your chest. CHRISTINE: Just put it on. Okay. So you'd say maybe just get the flexible mask at that point? RORY: Yeah. ROSIE: Okay. Rory, after all this testing, are you going to continue to do this red light therapy at home now that you're done writing the guide? RORY: Yes, and I have definitely... I mean, I keep the LightStim literally at my desk. That is very easy for me to use and it doesn't hurt my eyes. CAIRA: Okay, Rory, so before we wrap, we usually ask our guests one final question, but I'm actually going to flip the script on you today because you've already been here. What is the beauty trend that you hope dies very soon? RORY: I mean, how long do we have? CAIRA: Pick one. RORY: Beef tallow. I would say- CHRISTINE: Are people using beef tallow on their skin? CAIRA: Oh yes, they are. They're claiming that it clears everything. RORY: Yeah, it just seems like, have you been to Target? Have you been to the local drugs or have you been to CVS and there's no option better for your skin than beef tallow? CHRISTINE: Than beef tallow? RORY: Yeah. CHRISTINE: I mean maybe if we're all going back to the land and the apocalypse happens, that's the choice. But yeah, it seems like there are better options. ROSIE: Raise your own cows, make your own beef tallow. All right, Rory, appreciate you. Thanks for coming back on. RORY: Thanks for having me. ROSIE: It's so nice to have Rory on the show. CHRISTINE: So great. ROSIE: She's a delight and such a wealth of knowledge on all things skincare. I'm taking away from this episode, besides sort of some general knowledge about what light therapy is, that there are a variety of types of light therapy. What we're talking about specifically with the wands and the masks, the testers found to be effective is this LED red light therapy, and so I guess what I'm talking away is that the wand is going to be sort of on the lower end of the price range. But it's gonna be a more manual experience where you're really kind of bringing this thing on your face and doing this sort of electric toothbrush type manual labor for what can feel like an eternity, but actually maybe only like 12 minutes. And then the masks are the more kind of sit back, maybe sip, you know, a green juice while you let the light blast over your face and then you'll look 15 again. CAIRA: A sip of green juice with your eyes closed. ROSIE: Right, that is my takeaway. CHRISTINE: I think you need to wear some goggles. I think that you really need to wear some googles. ROSIE: But I'm really intrigued. I mean, I think the takeaway is I'm very intrigued. CHRISTINE: Very intrigued. You both know I was already intrigued, and so now I feel like I've honed in. I want a mask. I want probably the Omnilex Men. I like the idea of having the flexible mask that I can use on different parts of my body, but I will be going to my dermatologist first because I do have some sun damage and I want to make sure that the mask doesn't cause like dark spots to get dark. Or light spots to get lighter. CAIRA: Yeah, I think similarly, I tend, I mean, I have darker skin. I tend to have hyperpigmentation really easily and all that good stuff. Yeah, me too. I just feel like I'm gonna skip this all together and I might just go to my dermatologist when I feel like I need it to get the professional red light therapy treatment. CHRISTINE: And you know, I mean, I think that's like very valid for a lot of people. ROSIE: It makes a lot of sense, and honestly I think maybe the overall takeaway is that whoever is going to pursue purchasing one of these, you probably should get some consult. CHRISTINE: Yeah, from someone you trust, besides us, you know,. CAIRA: We're not your doctor. ROSIE: Besides Dr. Christine and Dr. Caira. Alright well if you want to find out more about wire cutters coverage in general or these red light devices, if you wanna check out any of Rory's reporting, go to our website or you can find a link in the show notes. That's it. On behalf of my dear friends, Caira and Christine, thanks so much for listening. The Wirecutter Show is executive produced by Rosie Guerin and produced by Abigail Keel, engineering support from Maddy Masiello and Nick Pitman. Today's episode was mixed by Catherine Anderson. Original music by Dan Powell, Marion Lozano, Elisheba Ittoop, and Diane Wong. Wirecutter's deputy publisher is Cliff Levy. Ben Frumin is Wirecutter's editor-in-chief. I'm Christine Cyr Clisset. CHRISTINE: I think I want the flexible one. Then my man can use it as well without being embarrassed. ROSIE: My man!

Molecular Health and Axxam enter into a strategic partnership to bolster the discovery of innovative targets in drug development
Molecular Health and Axxam enter into a strategic partnership to bolster the discovery of innovative targets in drug development

Yahoo

time10 hours ago

  • Yahoo

Molecular Health and Axxam enter into a strategic partnership to bolster the discovery of innovative targets in drug development

Pairing data-driven clinical-molecular insights with biological validation to identify relevant drug targets and confirm leads for biopharmaceutical companies MILAN, Italy and HEIDELBERG, Germany, June 04, 2025 (GLOBE NEWSWIRE) -- Axxam S.p.A., a premier provider of integrated early discovery services, and Molecular Health GmbH, a leader in artificial intelligence (AI)-driven development solutions, are announcing a strategic collaboration to accelerate the identification and validation of novel therapeutic targets across a broad range of therapeutic areas. The companies will create unprecedented synergies to deliver precise and clinically driven disease-to-target and target-to-lead solutions to the pharmaceutical and biotech industry, by integrating Molecular Health's digital drug development platform Dataome into DiscoveryMAXX, Axxam's integrated early drug discovery process, combining computational clinical-molecular insight with rigorous biological validation. Dataome curates, integrates and structures molecular, phenotypic and clinical data from public, private and proprietary datasets. Its causal insights support pharmaceutical companies in improving drug development, predicting drug safety, optimizing clinical trials and enabling data-driven investment decisions. As part of Dataome, Molecular Health applies advanced AI to analyze holistic complex datasets, helping their clients to identify novel, high-potential drug targets. These computational predictions can be seamlessly integrated into Axxam's discovery platform, which incorporates decades of expertise in biology, assay development, phenotypic and target-based screening, and compound profiling. Through this partnership, AI-derived targets undergo rigorous experimental validation, using a broad suite of advanced in-vitro technologies – including induced pluripotent stem cell (iPSC)-based models – to ensure biological and disease relevance and translational value. 'Identifying the right target is one of the most critical and challenging steps in drug discovery. At Axxam, we believe that biology-driven validation is key to translating digital assessments and predictions into real-world therapies,' said Ciriaco Maraschiello, CEO of Axxam. 'This strategic partnership between a biology powerhouse like Axxam and a precision medicine-focused AI company like Molecular Health is enabling a new level of accuracy and efficiency in the early drug discovery process, allowing our clients to make more informed decisions, faster, in both preclinical and clinical development.' 'Understanding molecular causalities and variants in phenotypes, diseases and endotypes is essential for pharma and biotech companies to improve efficiency and success rates in drug development', said Friedrich von Bohlen, CEO of Molecular Health. 'The integration of our data/AI-based knowledge, simulations and predictions with Axxam's preclinical biology and chemistry assays and expertise will offer improved and accelerated outcomes in early drug discovery. This will enable our joint clients to gain deeper insights, enhance decision-making, and expand their options for drug discovery and clinical development programs.' By building a bridge between AI-powered clinical-molecular predictions and biological insight, Axxam and Molecular Health are poised to deliver next-generation discovery programs to pharmaceutical innovators worldwide. About Axxam S.p.A. Axxam S.p.A. is a leading provider of integrated discovery services across the life sciences industry. Within the drug discovery disciplines, we support pharma, biotech companies, start-ups, patient foundations as well as academic groups in their journey from hit identification to lead generation, regardless of the therapeutic area and target class. Our services include assay development, high-throughput screening, using either Axxam's high quality compound collections (synthetic and natural) or those provided by clients, hit validation, hit-to-lead and compound management. The same science-driven approach is also applied to identify new bioactive compounds for crop protection, animal health, food, beverage, pet food, cosmetic and perfume industries. For more information, visit About Molecular Health GmbH Molecular Health is a leader in data-driven software technologies for the pharmaceutical and biotechnology industries. For more than a decade, the company has combined human expertise, rigorous data curation, and advanced analytics – including artificial intelligence – to transform the world's biomedical knowledge into actionable insight. The company's Pharma AI solutions power indication and biomarker discovery, target identification and validation, clinical-trial design and simulation, endpoint optimization, and safety prediction. At the core of these capabilities is Dataome, Molecular Health's proprietary technology that integrates and contextualizes biomedical, molecular, phenotypic, and drug data to shed light on the etiology of health and more information, visit Axxam contactsAntonella Solia(Head, Marketing and Lead Generation) Molecular Health GmbH Dr. Marc-Alexander Rauschendorf(Head of Medical Affairs & Marketing) Media RelationsKatja Arnold, Eva Bauer, Laurie Doyle+49-89-210 2280molecularhealth@

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