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Homes for sale in England and Scotland with inside-outside space

Homes for sale in England and Scotland with inside-outside space

Business Mayor02-05-2025

Within the Stockwell triangle, between Little Portugal, Brixton and Clapham North, is a tree-lined street with a two-bedroom ground-floor flat for sale in a converted Victorian terrace property. The owners have extended it with a side and rear return, which houses the open-plan kitchen-dining-living room. This new space has a partly vaulted ceiling and exposed structural steel beams. The sliding doors open back entirely on to the neat six-metre (20ft) garden, which has a patio and fake grass facing a whitewashed brick wall. £775,000. The Modern House, 0203 795 5920
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New method provides key to accessing proteins in ancient human remains
New method provides key to accessing proteins in ancient human remains

Yahoo

time15 hours ago

  • Yahoo

New method provides key to accessing proteins in ancient human remains

A new method developed by researchers at the University of Oxford could provide the key to accessing proteins in ancient human remains. The technique, created by scientists at the Nuffield Department of Medicine, offers a breakthrough in extracting and identifying proteins from preserved soft tissues such as brain, muscle, and skin - sources of biological information that have long remained out of reach. Alexandra Morton-Hayward, a postgraduate researcher who led the study, said: "Until now, studies on ancient proteins have been confined largely to mineralised tissues such as bones and teeth. "But the internal organs - which are a far richer source of biological information - have remained a 'black box' because no established protocol existed for their analysis. Our method changes that." The team tested 10 different extraction techniques on 200-year-old human brain tissue collected from a Victorian workhouse cemetery. Authors of the study (L-R), Dr Sarah Flannery, Alexandra Morton-Hayward, Professor Roman Fischer, and Dr Iolanda Vendrell (Image: Roman Fischer) They found urea, a major component of urine, was able to break down cells and release proteins. The extracted proteins were then separated and identified using liquid chromatography and mass spectrometry. By also using high-field asymmetric waveform ion mobility spectrometry - which separates ions by their movement in an electric field - the researchers increased the number of proteins identified by up to 40 per cent. Ms Morton-Hayward said: "It all comes down to separation: by adding additional steps, you are more likely to confidently identify molecules of interest. "It is a bit like dumping out a bucket of Lego: if you can start to discriminate between pieces by colour, then shape, then size, etc the better chance you have of making something meaningful with it all." Using the full process, the team identified more than 1,200 ancient proteins from just 2.5mg of brain tissue. This is the most diverse set of proteins ever recovered from archaeological material. The researchers believe the method could transform scientists' understanding of health and disease in past populations. Professor Roman Fischer, senior author and researcher at the Centre for Medicines Discovery, said: "By enabling the retrieval of protein biomarkers from ancient soft tissues, this workflow allows us to investigate pathology beyond the skeleton, transforming our ability to understand the health of past populations." Proteins outlast DNA in archaeological remains and reveal more about a person's life and health than genetic material alone. Dr Christiana Scheib, from the University of Cambridge, who was not involved in the study, said: "It is key to first develop the best way to obtain relevant information from these materials, which is what this study does. "This type of fundamental experimental work is crucial for the field to move forward."

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