Latest news with #'sHospital
Time of India
02-06-2025
- Health
- Time of India
Panther captain Aleksander Barkov was awarded the King Clancy and Selke trophies
Aleksander Barkov Florida Panthers captain Aleksander Barkov was recently presented with the prized Selke Trophy and the King Clancy Memorial Trophy. He was announced as a winner and presented with the trophies by the patients from Joe DiMaggio's Children's Hospital. This came to him as a surprise as the children showed up at the Panthers' training facility in Hollywood, Florida. The King Clancy Trophy was awarded to him due to his leadership and contribution to the committee. Patients from DiMaggio's Children's Hospital surprise Aleksander Barkov with the Selke, King Clancy Trophy Aleksander Barkov not only won the King Clancy Trophy for his contribution to society but also the Selke Trophy, an award for being the best defensive forward in the NHL. Commenting on the victory, Barkov shared, "Thank you guys. I know I don't have much time right now to see you guys at the hospital, so we really appreciate you guys coming here. We love giving back to you." When addressing the fact that he won two trophies, he shared that he was "very surprised." He also added, "I was not expecting it at all. When they brought in another trophy, it was pretty overwhelming for me. I am truly honored by that award." While speaking of his association with the hospital, he wrote a special essay on and shared, 'During my first visit, I didn't speak English too well. I saw everything going on -- how incredible the healthcare workers are, and how special the kids are --- but I couldn't really say anything. Now, I've gotten more comfortable with talking. I get to connect with the staff, the kids, and their families. I do what I can to give these kids a reason to smile,' Barkov also added, "For now, if I have an opportunity to do something good, I don't think about it too much. I just do it. But there is one thing I know for sure ... If we win the Cup again, I'm definitely bringing it back to Joe DiMaggio's Children's Hospital." Also Read: Aleksander Barkov's achievement and lifestyle behind NHL success The Joe DiMaggio Children's Hospital treats children with cancer, blood disorders, heart transplants, emergency care and rehabilitation. Florida Panthers captain Barkov has donated $1,600 for every goal and $800 for every assist he has made in the game. Ever since 2019, he has donated over $420,000 to the children's hospital.
Daily Record
23-05-2025
- Entertainment
- Daily Record
Trees set for chop across Stirling route to prepare for Walking of the Marches
An application has been made by council planners to chop back trees to accommodate flags within the parade - which is set for a route through city centre streets. Trees on the route of Stirling's annual traditional Walking of the Marches parade could be cut back to make sure standards literally won't have to be lowered. An application has been lodged by Stirling Council with their own planners seeking permission to chop back 'multiple' trees. The work would involve a proposed crown lift of around between three and five metres of some trees, using a manual pole saw only. The reason given for the work on the route is given as 'to accommodate flags in the parade', which takes place on Saturday May 31. The route of walking of the marches includes: The Rotunda, King's Street; Spittal Street; Bank Street; Baker Street; Friar Street; Barnton Street; Maxwell Place; Viewfield Street; Barnton Street; Maxwell Place; Viewfield Street; Barnton Street; Murray Place; Port Street; Dumbarton Road; Back Walk; Smith Art Gallery; Back Walk; Academy Road; St John Street; Cowane's Hospital. The streets of Stirling are expected to be packed at the end of the month as the city celebrates the tradition of Walking the Marches. This non-political event is free and open to all, celebrating a tradition dating back to the 12th Century which saw Stirling's boundaries inspected and maintained. This year, costumed historical re-enactors from Historia Normannis alongside Caledonia Combat's stuntmen will be helping to bring the period to life. The march will set off from the King Street rotunda at 10.45am and head up to Cowane's hospital. Locals are being asked to expect pipe bands, re-enactors and fun for visitors of all ages as well as crowds along the route and increased visitor numbers. A spokesperson for the organisers said: 'The Walking of the Marches is a tradition that is probably as old as Stirling, dating back to the days before accurate maps when it was necessary to check the burgh boundaries to ensure that no encroachment had taken place. As with other places across Scotland this tradition has developed into an inclusive community celebration of our heritage. 'Where most places ride their Marches, in Stirling we have always walked them; this was done by the Birlawmen, led by the Captain of the Birlawmen. 'Of course, it is no longer necessary to actually check all the boundaries but what we do is a modern interpretation of this tradition. The Birlawmen do check boundary points; the term Birlawman is no longer gender specific but it one of the many traditional terms that are still used and, like their predecessors, the Birlawmen still carry picks and shovels. 'Resplendent in their blue bonnets, the Captain takes reports from the Birlawmen that the Marches have been checked, are intact and have been marked in the traditional manner by the turning of turfs. This report is then conveyed to the Lord Provost, Lord Dean of Guild and Deacon Convenor of the Seven Incorporated Trades who are then invited to accompany the Birlawmen in a colourful celebratory procession through the city to the historic Cowane's Hospital where entertainment is provided.' The Walking of the Marches is a free event and open to all. More information can be found on the Walking the Marches Facebook page, or through Eventbrite.
Yahoo
29-03-2025
- Entertainment
- Yahoo
Audrey's Children: Local Charity Promotes Inspiring Biopic
HENDERSON, Ky. (WEHT) – The Ronald McDonald House Charities of the Ohio Valley invited me to an early screening of the inspiring new biopic Audrey's Children. Screening locally through April 2, Audrey's Children is an inspiring docudrama and biopic that charts the beginning of the Ronald McDonald House and the work of a pediatric oncologist during the late 1960s. Directed by Ami Canaan Mann, Audrey's Children stars Natalie Dormer as Dr. Audrey Evans, the first female Chief of Oncology at the Children's Hospital of Philadelphia. The film begins with Dr. Evans's arrival, and it tells the story of her relationships with her colleagues and young patients. There are three main threads to Audrey's Children. First is her research into pediatric oncology. Dr. Evans catalogs and categorizes pediatric cancer, and the film depicts her work with her colleagues as important and revolutionary in its understanding of how cancer progresses and what new treatments are most effective. Many of the plotlines involve Dr. Evans attempting to get funding and data in her studies. And her treatment of pediatric cancer with multiple forms of chemotherapy both proves successful and runs her afoul with the hospital's administrators. The second plot thread is downplayed and not given as much attention: set in 1969, Dr. Evans contends with sexism and gender discrimination in the workplace. She is often the only woman in rooms of men making life-or-death decisions, and like many women will attest, she has to work twice as hard in order for her ideas to be taken seriously. Finally, Audrey's Children strums some heartbreaking chords in the scenes between Dr. Evans and her patients. Here is where Dormer's performance is particularly strong, as she has great chemistry with the child actors. Dr. Audrey ushers the young patients through scary procedures, and in some of the scenes, when the patients' prognoses seem the most dire, the film is the most affecting and emotional. Unlike many movies seeking to inspire, not all of Audrey's Children's charactershave a happy ending, and the film feels more realistic as a result. As she understands her patients' lives better and interacts with their parents, Dr. Evans comes up with the idea for the Ronald McDonald House, which of course connects to our local charities, as the Ronald McDonald House Charities of the Ohio Valley is mentioned in the film's closing credits. Audrey's Children demonstrates the need for the Ronald McDonald House, as we see families struggling to find housing and transportation while their children fight for their lives. Dormer delivers a moving monologue about the need for comprehensive care for not only the children, but their families as well. Overall, Audrey's Children is a moving and inspiring film about one woman's quest against an impersonal system and the children she saves – physically, medically, emotionally, and spiritually. It plays locally through April 2. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Associated Press
18-03-2025
- Health
- Associated Press
Improving child health: insights from pediatric patient-reported outcome measures
GA, UNITED STATES, March 18, 2025 / / -- Patient-reported outcome measures ( PROMs) are crucial tools for assessing the health and well-being of children, yet their application in pediatrics faces unique challenges due to developmental differences. A recent study provides a comprehensive overview of systematic reviews (SRs) on pediatric PROMs, analyzing 44 SRs published between 2006 and 2022. The study highlights the most recommended PROMs, such as the Pediatric Quality of Life Inventory, and identifies gaps in methodological quality and reporting. This research underscores the need for more diverse and high-quality studies to improve the selection and application of PROMs in pediatric healthcare. Children's health assessments differ significantly from adults due to varying cognitive abilities, language skills, and developmental stages. Patient-reported outcome measures (PROMs), which are self-reported questionnaires, offer valuable insights into a child's health status, but their design and implementation in pediatrics are complex. Challenges include determining the appropriate age for self-reporting and ensuring the reliability of proxy reports from parents or caregivers. Previous studies have shown that children as young as 8 can reliably report their health, but younger children often require proxy reports, which may not accurately reflect their experiences. Based on these challenges, there is a pressing need for more in-depth research to optimize the use of PROMs in pediatric healthcare. A team of researchers from Children's Hospital of Chongqing Medical University and other institutions published a review (DOI: 10.1002/pdi3.77) on June 1, 2024, in Pediatric Discovery, providing an extensive overview of systematic reviews on pediatric PROMs. The study analyzed 44 SRs, identifying 123 recommended PROMs and evaluating their methodological quality. The research highlights the most frequently used PROMs, such as the Pediatric Quality of Life Inventory, and calls for improvements in the reporting of psychometric properties and the development of tailored tools for assessing pediatric PROMs. The study reviewed 44 SRs, encompassing 1,888 studies and 635 different PROMs, with 123 PROMs being recommended. The most frequently recommended PROM was the Pediatric Quality of Life Inventory (PedsQL), followed by the EuroQol five-dimension questionnaire. These PROMs were primarily used to assess quality of life, body functions, and emotional functions. The study found that 36 different conditions were addressed, with mental, behavioral, or neurodevelopmental disorders being the most common. However, the methodological quality of the SRs varied, with only 22.7% scoring high on the AMSTAR tool. Key issues included inconsistent reporting of measurement properties, such as content validity and internal consistency, and a lack of clarity on the appropriate age for self-reporting. The study also highlighted the need for more diverse PROMs to cover a broader range of pediatric conditions and improve the evidence base for their use in clinical practice. Dr. Yaolong Chen, a lead researcher on the study, emphasized, 'The findings highlight the importance of improving the methodological quality of systematic reviews on pediatric PROMs. We need more standardized reporting and tailored tools to ensure that clinicians can select the most appropriate measures for children's health assessments.' The study's findings have significant implications for pediatric healthcare. By identifying gaps in the current use of PROMs, the research paves the way for more targeted and effective health assessments in children. Improved PROMs can enhance communication between healthcare providers, patients, and caregivers, leading to better long-term care management. Future research should focus on developing more diverse PROMs, standardizing reporting methods, and determining the optimal age for self-reporting to ensure reliable and valid health assessments in pediatric populations. This will ultimately contribute to better health outcomes for children and adolescents worldwide. DOI 10.1002/pdi3.77 Original Source URL Lucy Wang BioDesign Research Legal Disclaimer:
Associated Press
18-03-2025
- Health
- Associated Press
New insights into hypospadias: SOX9's role in urethral formation revealed
GA, UNITED STATES, March 18, 2025 / / -- A recent study has uncovered the pivotal role of the transcription factor SOX9 in the development of hypospadias, a common congenital condition that affects male children. The research highlights how SOX9 regulates critical molecular pathways involved in urethral development, including the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition (EMT). The study reveals that reduced SOX9 expression leads to impaired EMT and abnormal Wnt signaling in tissues affected by hypospadias. These findings provide new insights into the condition's molecular underpinnings, potentially paving the way for innovative, targeted therapies. Hypospadias is a widespread congenital disorder, characterized by an abnormal placement of the urethral opening, impacting as many as 3.42% of male children worldwide. Beyond the physical consequences, this condition can lead to psychological and fertility issues. Surgical repair remains the only current treatment, but complications are common, and the genetic and cellular mechanisms involved remain poorly understood. With the prevalence of hypospadias on the rise, coupled with the challenges of surgical treatment, a deeper understanding of its molecular causes is urgently needed. Published (DOI: 10.1002/pdi3.94) on May 14, 2024, in Pediatric Discovery, the study conducted by researchers from the Children's Hospital of Chongqing Medical University delves into the role of SOX9 in the development of hypospadias. The study investigates the expression of SOX9 in foreskin tissues from hypospadias patients, focusing on its influence on the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition (EMT). The research team analyzed foreskin samples from 15 children with hypospadias, comparing them with normal foreskin tissues from children undergoing circumcision. Using molecular techniques such as transcription-polymerase chain reaction (RT-PCR), Western blotting, and immunofluorescence, the researchers found that SOX9 expression was notably downregulated in hypospadias tissues. This downregulation was linked to reduced expression of key components of the Wnt/β-catenin pathway, including Wnt3a, LEF1, and GSK3β. Additionally, mesenchymal markers like Vimentin and α-SMA were also diminished, while epithelial markers such as E-cadherin, Occludin, and ZO-1 were elevated, suggesting a disrupted EMT process. Inhibition of SOX9 in foreskin fibroblasts replicated these effects, further confirming SOX9's crucial role in regulating Wnt/β-catenin signaling and EMT during urethral development. Dr. Xing Liu, the lead researcher, stressed the significance of the findings: 'This is the first study to pinpoint SOX9 as a key player in hypospadias development. By understanding how SOX9 governs Wnt/β-catenin signaling and EMT, we can identify potential new therapeutic strategies to treat this condition.' The implications of these findings extend beyond basic science, with significant potential for clinical application. By elucidating the molecular mechanisms of hypospadias, the study uncovers new therapeutic targets that could lead to non-surgical treatments. Additionally, these insights into the genetic basis of the condition could improve surgical outcomes, offering better predictions and tailored approaches. The research also opens up new possibilities for early diagnosis and intervention, which could help mitigate the psychological and fertility-related challenges faced by affected individuals. DOI 10.1002/pdi3.94 Original Source URL Funding information This work was financed by the National Natural Science Foundation of China (81970571), Natural Science Foundation Project of Science and Technology Commission of Chongqing (2022NSCQ-MSX0328) and Chongqing Medical University Program for Youth Innovation in Future Medicine. Lucy Wang BioDesign Research
