Latest news with #AdamPearson
Yahoo
30-05-2025
- Business
- Yahoo
Astellas Enters Exclusive License Agreement with Evopoint Biosciences for XNW27011, a Novel Clinical-stage Antibody-Drug Conjugate Targeting CLDN18.2
- Agreement grants Astellas exclusive worldwide rights (excluding China's mainland, Hong Kong, Macao and Taiwan region) to develop and commercialize XNW27011 - - XNW27011 has demonstrated encouraging monotherapy efficacy in an ongoing Phase 1/2 study of patients with solid tumors, including gastric cancer, gastroesophageal cancer and pancreatic cancer - - Evopoint to receive a $130 million upfront payment and is eligible to receive up to $70 million near-term payments, and additional milestone payments associated with development, regulatory and commercialization milestones totaling up to $1.34 billion, as well as royalties on net sales of XNW27011, if approved - TOKYO and SUZHOU, China, May 29, 2025 /PRNewswire/ -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Naoki Okamura, "Astellas") and Evopoint Biosciences (Evopoint Biosciences Co., Ltd.) today announced they have entered into an exclusive license agreement for XNW27011, a novel investigational clinical-stage antibody-drug conjugate (ADC) targeting CLDN18.2. The agreement grants Astellas a worldwide (excluding China's mainland, Hong Kong, Macao and Taiwan region) exclusive license to develop and commercialize XNW27011. XNW27011 is currently being evaluated in a Phase 1/2 study in China in patients with CLDN18.2-expressing solid tumors, including gastric cancer, gastroesophageal cancer and pancreatic cancer. It uses a proprietary topoisomerase I inhibitor payload and linker technology, an approach that has demonstrated clinical success in other approved cancer therapies. Astellas has significant expertise in developing therapies that target CLDN18.2, including VYLOYTM, the first CLDN18.2-targeted therapy approved in the world. XNW27011 has the potential to address currently unmet patient need and will expand Astellas' oncology pipeline which currently contains CLDN-targeting therapies utilizing different approaches, as well as ADC's directed to other targets. Under the terms of the agreement, Evopoint will receive a $130 million upfront payment and is eligible to receive up to $70 million near-term payments, and additional milestone payments associated with development, regulatory and commercialization milestones totaling up to $1.34 billion, as well as royalties on net sales of XNW27011, if approved. Adam Pearson, Chief Strategy Officer, Astellas"Astellas is dedicated to advancing innovative therapies for some of the most challenging-to-treat cancers, such as gastric and pancreatic cancer. XNW27011 is a promising new asset that complements Astellas' pipeline and enhances our leading position in precision oncology. We look forward to harnessing our expertise in targeting CLDN18.2 and specialized knowledge in GI cancers to advance XNW27011 and deliver meaningful outcomes to patients." Arthur Qiang, Chairman, Evopoint"XNW27011 is a novel investigational antibody-drug conjugate that has shown great promise in the clinic. Astellas has a proven history of developing and commercializing a strong franchise of innovative cancer therapies. We are pleased to enter into this new license agreement to further our collective goals of bringing new treatment options for patients in need worldwide." About AstellasAstellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at About Evopoint BiosciencesEvopoint Biosciences is an innovative biopharmaceutical company with exceptional capabilities in R&D and commercialization. Since its inception, Evopoint has been committed to improving human health by discovering and developing cutting-edge pharmaceutical solutions that address significant unmet medical needs worldwide. Leveraging diverse discovery platforms in targeted therapy, ADC, and targeted protein degradation (TPD), the company has built a robust pipeline focused on oncology, infectious diseases and metabolic diseases. Learn more at Astellas Cautionary NotesIn this press release, statements made with respect to current plans, estimates, strategies and beliefs and other statements that are not historical facts are forward-looking statements about the future performance of Astellas. These statements are based on management's current assumptions and beliefs in light of the information currently available to it and involve known and unknown risks and uncertainties. A number of factors could cause actual results to differ materially from those discussed in the forward-looking statements. Such factors include, but are not limited to: (i) changes in general economic conditions and in laws and regulations, relating to pharmaceutical markets, (ii) currency exchange rate fluctuations, (iii) delays in new product launches, (iv) the inability of Astellas to market existing and new products effectively, (v) the inability of Astellas to continue to effectively research and develop products accepted by customers in highly competitive markets, and (vi) infringements of Astellas' intellectual property rights by third parties. Information about pharmaceutical products (including products currently in development) which is included in this press release is not intended to constitute an advertisement or medical advice. View original content to download multimedia: SOURCE Astellas Pharma Inc. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Metro
12-05-2025
- General
- Metro
Don't assume life's better for Disabled people just because we're on TV more
'Things are getting better right? I mean for people like you?' 'By people like me,' I reply. 'Do you mean Disabled people?' This is a conversation I feel like I, a physically Disabled woman, am constantly having with my pre-disabled peers. It's almost as though I am asked to reassure them that my life is OK and that they shouldn't feel guilty. I mean it is 2025 after all and 'people like me' are, in many ways, assimilated into mainstream society. Perhaps you've noticed a co-worker has a limb difference, or your favourite television show proudly showcases cast members from the Disability community. Maybe, there are Deaf, Disabled or Neurodivergent classmates at your kid's school. So, things must be better simply because you can see us now more than ever? Yet being more visible after decades of being hidden away by society does not qualify as a better existence or quality of life. I want those people who assume my life is better for being more visible to know that they are seeing the world through an enabled gaze. The truth is that Disabled people face discrimination daily. New research by MoreinCommon has found that 78% of Disabled Britons feel life is harder for Disabled people than non-Disabled people. Over half (51%) think that life in the UK has become harder for us over the past 10 years. I want non-Disabled people to think hard about our struggle, but also to think about us positively. This is why it's so important to celebrate the Disability community in all its multifaceted and vibrant colour, and the Scope Awards aims to do this. The Scope Awards is a celebration of Deaf, Disabled and Neurodivergent people and a way to ultimately amplify our voices. This annual ceremony celebrates those within our society: Disabled people and our allies who place value and pride in our community. And there is a lesson in that for everyone who isn't Disabled. You may know us, but until you listen to us, champion us and give us tangible change and opportunity you are simply objectifying us to feel better about yourself. You shouldn't kid yourself about the reality of discrimination. It takes many forms – like in the workplace, with Disabled people twice as likely to be unemployed. Metro is also the official media partner of 2025 Scope Awards that will take place next month. The ceremony will celebrate the work disabled people and organisations are doing to bring about important change. Hosted by the BAFTA-nominated actor Adam Pearson, unsung heroes, amazing achievements and the incredible accolades of the disabled community are all being honoured at the Kia Oval. There are 38 nominees for the nine Scope Awards: Accessible Product, Celebrity Role Model, Community Group, Inclusive Workplace, Journalist, Marketing Campaign, Media Moment, Purple Pioneer and Social Media Influencer. Life also costs significantly more for us. In fact, the average extra cost of being Disabled is estimated at £1,067 according to Scope. Every single month. And from governments to people in the street, disabled people are constantly vilified. All of my Disabled or Neurodivergent friends have faced online trolling aimed solely at attacking their differences. That crosses over into real life too. Just last week I had an altercation with a taxi driver who attempted to pick me up in a cab without a working ramp. When I told him I'd have to cancel, he became verbally aggressive and screamed: 'It's people like you who are so difficult – if I'd known you used a wheelchair I wouldn't have picked you up.' Ignorance like this still prevails and it is largely because people don't allow us to speak our truths. We still very much live in a world whereby able and enabled privilege prevails and ableism is so ingrained within our culture that most if not all Disabled people, myself included, live a lesser life. For me, the new findings about Disabled people's real-life experiences highlight this. The more visible we are, the more the world has to see the inequalities we face. We aren't hidden away in institutions anymore or kept segregated within our communities. Now, we have a voice and we will scream from the rooftops about ableism. However, people outside the Disabled community often don't like to be told where they are failing, and don't want to hear about our pain. Exposing our truth means others should be called to action, and action costs money and takes time and owning up to past wrongs. This is why I feel as though it's tougher now to be Disabled. We are more malleable when we say nothing. But, here's a reality check: those times are long gone and the Scope awards showcases those within our community who won't be silenced. One in six people are Disabled. Think about this in context to your own family, friends, neighbours and colleagues: we will all have to live and work together to make this world more Disability friendly. And if you struggle to empathise naturally with Disabled people, ask yourself this: Would you want to live in a world that tells you repeatedly that you are lesser than others? More Trending Would you want your own children to miss out on accessing higher education, or accomplishing a milestone like moving into their own home or securing their first job? Would you want to live in fear that your independence is going to be ripped away from you every time a brown envelope lands on your doorstep and you may not be able to feed yourself or leave your home? Because all of this is a reality for Deaf, Disabled and Neurodivergent people like me. View More » My life isn't a tragedy because I was born with a rare condition, but it's tragic that in 2025 we still do not place value on the lives of Disabled people. Do you have a story you'd like to share? Get in touch by emailing Share your views in the comments below. MORE: After 10 years we unmasked our mystery stalker – we couldn't believe who it was MORE: We're living every parent's worst nightmare after bullies left our daughter suicidal MORE: 'When my mum took her own life I discovered her secret battle'
Yahoo
12-03-2025
- Business
- Yahoo
STL offers funds to emergency shelter, outreach and rehousing
ST. LOUIS – The city of St. Louis is accepting a proposal in a bidding process that will allow it to receive funds from the Emergency Solutions Grant (ESG). These funds will be directed for homeless services across the city, beginning July 1, the Office of the Mayor announced today. 'The Emergency Solutions Grant allows the City to fund providers in the community who are doing innovative work to provide shelter, housing, and support to the unhoused,' said Adam Pearson, director of the Department of Human Services. Close Thanks for signing up! Watch for us in your inbox. Subscribe Now Pearson further went on to express gratitude for the U.S. Department of Housing and Urban Development, as well as the Community Development Administration (CDA), for allowing the funds to become available. Multiple component types exist in ESG's funding that are going to the city, which include: Emergency shelter Street outreach Rapid rehousing Homeless prevention Data collection/HMIS Mayor Tishaura Jones also made a statement, expressing thankfulness for the Department of Human Services. Jones said that collaborating with providers for homeless shelters is optimal for helping individuals in the St. Louis area. 'While our city and region move toward a proven housing-first approach, we will continue to use every tool in our toolbox to help unhoused members of our community right now, and I am thankful for everyone who has been and will be involved in that effort,' Jones said. Person struck and killed by Metro train behind Ikea store Unhoused service providers who look to receive ESG funds are asked to submit an application, as well as visit the city's website for more information. Qualifications for applications are determined by their spending, adherence to federal regulations and past performances. The deadline for the application is 4 p.m. on April 2. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Buzz Feed
20-02-2025
- Entertainment
- Buzz Feed
Adam Pearson Has Been The Target Of Disgusting Online Comments, And I Hate That He Even Had To Acknowledge Those Trolls
A Different Man star Adam Pearson fired back at online trolls making insensitive remarks about him. After bumping his head in his bedroom when he was 5, the bump never healed. He was taken to several specialists and was ultimately diagnosed with neurofibromatosis type 1, a rare genetic disorder that causes benign tumors to grow on nerves throughout the body. By the time Adam was 8, the tumors began to increase in size, making his facial deformity more noticeable. During a recent interview with People, the 40-year-old British actor opened up about the bullying he experienced in school, but he refused to feel sorry for himself. 'Anytime The Elephant Man or The Hunchback of Notre Dame was on TV, the next day I'd hear that nickname,' he said. Secondary school was particularly painful: 'I'd take a deep breath before walking through the gates and try to hang on.' 'You can get bogged down in, 'It's not fair. Why is life so cruel?' It doesn't solve anything.' I'll truly never understand the perverse pleasure some people get from being cruel to others. Despite being subjected to such treatment, Adam has continued to thrive on and off-screen. He began his career in TV production for the BBC and Channel 4, and later landed his first feature film alongside Scarlett Johansson in the 2013 movie Under the Skin. Most recently, he starred in the psychological dark comedy A Different Man with Sebastian Stan. The two recently reunited at the 2025 EE BAFTA Awards and while many saw this as the latest celebratory stop for their film, others used it as an opportunity to criticize Adam and his appearance. When the seating chart for the BAFTAs was released, Adam could be seen next to Camila Cabello, both of whom would be presenting awards during the ceremony. Well, an online troll made this disgusting remark about it: "This is genuinely so scary, I would not attend the event if I were Camila." To which Adam responded, "Luckily for everyone you're not Camila and - most importantly - weren't invited. So from me, Adam Pearson, directly to you - take your nonsense opinions elsewhere as I have EXACTLY zero time for your anonymous, ableist nonsense." The original poster has since deleted the tweet, and offered a half-baked apology, while also calling him out for all of the people who came to Adam's defense in their replies. "I made my tweet trying to be funny & it wasn't. I forget that my tweets can actually affect people & even tho you're famous, you still see comments like those. I deeply apologize & have deleted my tweet. I'll take the deserved backlash." "I made an insensitive joke and deleted the tween when it had less than 200 likes," they wrote in a separate post. "I addressed you and apologized. I deleted the tweet before you had even made a post about it. You took that tweet and turned something that was already deleted, into thousands of people harassing me and sending me death threats & news articles made about me." This response came without acknowledging all of the people who piled on their nasty comments about Adam under the original post made about him. Both Adam and the online troll deleted their tweets to each other, but the torment didn't stop there for him. Another online troll shared images of Adam and Warwick Davis. Warwick is widely known for his roles in popular franchises like Harry Potter, Star Wars, and Leprechaun. He was being honored with the BAFTA Fellowship, a lifetime achievement award for his contribution to film and TV. Warick was born with Spondyloepiphyseal Dysplasia Congenita (SEDC), a rare genetic disorder and form of dwarfism that results in short stature and skeletal anomalies that primarily affect the spine and long bones of the arms and legs. Instead of applauding both of their accomplishments, the troll decided to write, "was this an award show or was the circus in town." Are you kidding me? WTF is wrong with people?! Warner Bros. Being the stand-up guy he is, Adam had the best reaction: The original poster has since deleted their tweet after receiving backlash for it. And I couldn't agree more! I'm glad to see him take on these trolls with such vigor, but I'm also extremely frustrated that he had to. Tim P. Whitby / Getty Images
The Independent
17-02-2025
- Entertainment
- The Independent
A Different Man star Adam Pearson's powerful take on imposter syndrome: ‘I don't say disabled any more'
Adam Pearson has had a whirlwind year since starring in A Different Man. The actor, who presented an award at the Bafta film awards in London on Sunday (16 February), reflected on the last year since starring in Aaron Schimberg's dark comedy alongside Sebastian Stan. He told The Independent on the red carpet: "I'm a guy from Croydon, right? But it's, in all sincerity, it's been a year of, like, shaking off the imposter syndrome. "I used to refer to myself as, like, a disabled actor... I don't say disabled anymore. I'm an actor. I'm in this room because I'm the best in the world at what I do."
