Latest news with #Altimmune
Yahoo
21-05-2025
- Business
- Yahoo
Could Altimmune, Inc. (ALT): Analysts See 288% Upside Potential
We recently published an article titled . Altimmune, Inc. (NASDAQ:ALT) was one of the stocks that was covered in that article. Wall Street analysts believe ALT has a 288% upside potential over the next 12 months. A close up of a microscope lens examining a sample of the drug candidate. Altimmune, Inc.(NASDAQ:ALT) is a clinical-stage biopharmaceutical company. It focuses on developing treatments for obesity, metabolic, and liver diseases. ALT's lead product/candidate, pemvidutide, is a GLP-1/glucagon dual receptor agonist, which is currently in clinical development for the treatment of obesity and metabolic associated steatohepatitis (MASH). The mechanism of action for pemvidutide involves the activation of GLP-1 and glucagon receptors, aiming to mimic the effects of diet and exercise on weight loss. This includes suppressing appetite and increasing energy expenditure, while also impacting hepatic fat metabolism, potentially leading to reductions in liver fat and serum lipids. Over 500 subjects have been involved in clinical trials for pemvidutide, showcasing a favorable safety profile and significant clinical benefits. Altimmune is leveraging the differentiated clinical profile of pemvidutide to pursue additional indications, beyond obesity and MASH. In terms of the company's financial performance, Altimmune, Inc.'s (NASDAQ:ALT) first quarterly earnings report for 2025 revealed a modest revenue of $5,000, but still higher than forecasts. Chief Executive Officer, Vipin Garg, spoke during the earnings call on the company's investment in infrastructure to support its key product, pemvidutide. He stated: 'We announced today that we have entered into a credit facility with Hercules Capital for up to $100 million. This is strategically important as we build upon our balance sheet strength and provide flexibility to support our continued development of pemvidutide.' Investors raised concerns about the company's lack of cash holdings which stood at $150 million at the end of the first quarter. However, the $100 million injection mentioned by the CEO offers a ray of hope. Analysts on Wall Street following the stock continue to hold an optimistic opinion about the company's potential. Altimmune, Inc.'s (NASDAQ:ALT) is estimated to have an average twelve-month trading price of $22.38 based on analysts' consensus, an upside of 288.54%. Overall, Altimmune, Inc.'s (NASDAQ:ALT) ranks 10th on our list of 13 Best Multibagger Stocks to Invest in Now. While we acknowledge the potential of ALT to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than ALT and that has 100x upside potential, check out our report about this cheapest AI stock. READ NEXT: 10 Best Low Volatility Stocks to Buy Now and Starter Stock Portfolio: 12 Safe Stocks to Buy Disclosure: None. This article is originally published at Insider Monkey. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
19-05-2025
- Health
- Yahoo
Altimmune Announces Initiation of RECLAIM Phase 2 Trial Evaluating the Efficacy and Safety of Pemvidutide in Alcohol Use Disorder (AUD)
GAITHERSBURG, Md., May 19, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing novel peptide-based therapeutics for liver and cardiometabolic diseases, today announced that it has enrolled the first subject in the RECLAIM Phase 2 trial evaluating the efficacy and safety of pemvidutide in subjects with Alcohol Use Disorder (AUD). Pemvidutide is a novel, investigational GLP-1/glucagon dual receptor agonist under development for the treatment of metabolic dysfunction-associated steatohepatitis (MASH), obesity, AUD and alcohol liver disease (ALD). IMPACT, a Phase 2b trial of pemvidutide in MASH, is expected to read out topline data in the second quarter of 2025, and a Phase 2 trial of pemvidutide in ALD is expected to initiate enrollment in the third quarter of 2025. RECLAIM is a randomized, placebo-controlled trial being conducted at approximately 15 sites in the United States, with Dr. Henry Kranzler, Karl E. Rickels Professor of Psychiatry and Director, Center for Studies of Addiction at the University of Pennsylvania Perelman School of Medicine, serving as the Principal Investigator. The trial is expected to enroll approximately 100 subjects randomized 1:1 to receive either 2.4 mg pemvidutide or placebo weekly for 24 weeks. The primary endpoint of the trial is a change in alcohol consumption, assessed as the change from baseline in the average number of heavy drinking days per week at Week 24, with the key secondary endpoints including the proportion of subjects achieving a 2-level reduction in World Health Organization (WHO) risk drinking level and the absolute change from baseline in average levels of phosphatidylethanol (PEth), a serum biomarker of alcohol intake. An investigational new drug (IND) application for pemvidutide in AUD was filed in December 2024 and was cleared by FDA in January 2025. 'Over 28 million individuals in the U.S. alone have AUD, and the lack of effective treatments has resulted in one of the largest known treatment gaps in this country,' said Dr. Kranzler. 'It has been estimated that less than 10% of patients are currently receiving treatment for AUD and that 2% or less are being treated with any of the 3 medications approved for AUD in the US1. These medications were approved decades ago and have limited beneficial effects and inadequate compliance rates. Thus, there is an urgent need for new therapies for AUD.' 'There are compelling data that GLP-1 agents may reduce the craving for alcohol in addition to reducing food consumption,' said Scott Harris, M.D., Chief Medical Officer of Altimmune. 'In a preclinical hamster model of free-choice alcohol intake, pemvidutide demonstrated a greater than 80% reduction in alcohol preference after the initiation of treatment2. Importantly, AUD is the precursor for alcohol liver disease (ALD), a disease characterized by excess liver fat, liver inflammation and fibrosis with features similar to MASH. In addition, obesity is a major risk factor for MASH, AUD and ALD, and because excess alcohol is a known risk factor for hypertension and dyslipidemia, patients with AUD could benefit further from the metabolic effects of pemvidutide.' About Altimmune Altimmune is a late clinical-stage biopharmaceutical company focused on developing novel peptide-based therapeutics for liver and cardiometabolic diseases. The Company's lead program is pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of MASH, obesity, Alcohol Use Disorder (AUD) and Alcohol Liver Disease (ALD). For more information, please visit Follow @Altimmune, Inc. on LinkedInFollow @AltimmuneInc on X Forward-Looking StatementAny statements made in this press release related to the development or commercialization of product candidates and other business and financial matters, including without limitation, trial results and data, the timing of key milestones for our clinical assets, and the prospects for the utility of, regulatory approval, commercializing or selling any product or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words "may," "could," "should," "anticipate," "believe," "estimate," "expect," "intend," "plan," "predict" and similar expressions and their variants, as they relate to Altimmune, Inc. may identify forward-looking statements. The Company cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward looking statements or historical experience include risks and uncertainties, including risks relating to: delays in regulatory review, manufacturing and supply chain interruptions, access to clinical sites, enrollment, adverse effects on healthcare systems and disruption of the global economy; the reliability of the results of studies relating to human safety and possible adverse effects resulting from the administration of the Company's product candidates; the Company's ability to manufacture clinical trial materials on the timelines anticipated; and the success of future product advancements, including the success of future clinical trials. Further information on the factors and risks that could affect the Company's business, financial conditions and results of operations are contained in the Company's filings with the U.S. Securities and Exchange Commission, including under the heading "Risk Factors" in the Company's most recent annual report on Form 10-K and our other filings with the SEC, which are available at Company Contact:Greg WeaverChief Financial OfficerPhone: 240-654-1450ir@ Investor Contact:Lee RothBurns McClellanPhone: 646-382-3403lroth@ Media Contact:Jake RobisonInizio Evoke, BiotechPhone: 1 SAMHSA 2023 NSDUH Survey 2 Altimmune R&D Day Presentation, slide #47 This press release was published by a CLEAR® Verified individual.
Yahoo
19-05-2025
- Health
- Yahoo
Altimmune Announces Initiation of RECLAIM Phase 2 Trial Evaluating the Efficacy and Safety of Pemvidutide in Alcohol Use Disorder (AUD)
GAITHERSBURG, Md., May 19, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing novel peptide-based therapeutics for liver and cardiometabolic diseases, today announced that it has enrolled the first subject in the RECLAIM Phase 2 trial evaluating the efficacy and safety of pemvidutide in subjects with Alcohol Use Disorder (AUD). Pemvidutide is a novel, investigational GLP-1/glucagon dual receptor agonist under development for the treatment of metabolic dysfunction-associated steatohepatitis (MASH), obesity, AUD and alcohol liver disease (ALD). IMPACT, a Phase 2b trial of pemvidutide in MASH, is expected to read out topline data in the second quarter of 2025, and a Phase 2 trial of pemvidutide in ALD is expected to initiate enrollment in the third quarter of 2025. RECLAIM is a randomized, placebo-controlled trial being conducted at approximately 15 sites in the United States, with Dr. Henry Kranzler, Karl E. Rickels Professor of Psychiatry and Director, Center for Studies of Addiction at the University of Pennsylvania Perelman School of Medicine, serving as the Principal Investigator. The trial is expected to enroll approximately 100 subjects randomized 1:1 to receive either 2.4 mg pemvidutide or placebo weekly for 24 weeks. The primary endpoint of the trial is a change in alcohol consumption, assessed as the change from baseline in the average number of heavy drinking days per week at Week 24, with the key secondary endpoints including the proportion of subjects achieving a 2-level reduction in World Health Organization (WHO) risk drinking level and the absolute change from baseline in average levels of phosphatidylethanol (PEth), a serum biomarker of alcohol intake. An investigational new drug (IND) application for pemvidutide in AUD was filed in December 2024 and was cleared by FDA in January 2025. 'Over 28 million individuals in the U.S. alone have AUD, and the lack of effective treatments has resulted in one of the largest known treatment gaps in this country,' said Dr. Kranzler. 'It has been estimated that less than 10% of patients are currently receiving treatment for AUD and that 2% or less are being treated with any of the 3 medications approved for AUD in the US1. These medications were approved decades ago and have limited beneficial effects and inadequate compliance rates. Thus, there is an urgent need for new therapies for AUD.' 'There are compelling data that GLP-1 agents may reduce the craving for alcohol in addition to reducing food consumption,' said Scott Harris, M.D., Chief Medical Officer of Altimmune. 'In a preclinical hamster model of free-choice alcohol intake, pemvidutide demonstrated a greater than 80% reduction in alcohol preference after the initiation of treatment2. Importantly, AUD is the precursor for alcohol liver disease (ALD), a disease characterized by excess liver fat, liver inflammation and fibrosis with features similar to MASH. In addition, obesity is a major risk factor for MASH, AUD and ALD, and because excess alcohol is a known risk factor for hypertension and dyslipidemia, patients with AUD could benefit further from the metabolic effects of pemvidutide.' About Altimmune Altimmune is a late clinical-stage biopharmaceutical company focused on developing novel peptide-based therapeutics for liver and cardiometabolic diseases. The Company's lead program is pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of MASH, obesity, Alcohol Use Disorder (AUD) and Alcohol Liver Disease (ALD). For more information, please visit Follow @Altimmune, Inc. on LinkedInFollow @AltimmuneInc on X Forward-Looking StatementAny statements made in this press release related to the development or commercialization of product candidates and other business and financial matters, including without limitation, trial results and data, the timing of key milestones for our clinical assets, and the prospects for the utility of, regulatory approval, commercializing or selling any product or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words "may," "could," "should," "anticipate," "believe," "estimate," "expect," "intend," "plan," "predict" and similar expressions and their variants, as they relate to Altimmune, Inc. may identify forward-looking statements. The Company cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward looking statements or historical experience include risks and uncertainties, including risks relating to: delays in regulatory review, manufacturing and supply chain interruptions, access to clinical sites, enrollment, adverse effects on healthcare systems and disruption of the global economy; the reliability of the results of studies relating to human safety and possible adverse effects resulting from the administration of the Company's product candidates; the Company's ability to manufacture clinical trial materials on the timelines anticipated; and the success of future product advancements, including the success of future clinical trials. Further information on the factors and risks that could affect the Company's business, financial conditions and results of operations are contained in the Company's filings with the U.S. Securities and Exchange Commission, including under the heading "Risk Factors" in the Company's most recent annual report on Form 10-K and our other filings with the SEC, which are available at Company Contact:Greg WeaverChief Financial OfficerPhone: 240-654-1450ir@ Investor Contact:Lee RothBurns McClellanPhone: 646-382-3403lroth@ Media Contact:Jake RobisonInizio Evoke, BiotechPhone: 1 SAMHSA 2023 NSDUH Survey 2 Altimmune R&D Day Presentation, slide #47 This press release was published by a CLEAR® Verified in to access your portfolio
Yahoo
14-05-2025
- Business
- Yahoo
Q1 2025 Altimmune Inc Earnings Call
Lee Roth; Investor Relations Adviser; Altimmune Inc Vipin Garg; Chief Executive Officer; Altimmune Inc Scott Harris; Chief Medical Officer; Altimmune Inc Greg Weaver; Chief Financial Officer; Altimmune Inc Yasmeen Rahimi; Analyst; Piper Sandler Liisa Bayko; Analyst; Evercore ISI Roger Song; Analyst; Jefferies Annabel Samimy; Analyst; Stifel Financial Corp Jasmine Fels; Analyst; UBS Securities LLC Mayank Mamtani; Analyst; B. Riley Securities Andy Hsieh; Analyst; William Blair Operator Good day, ladies and gentlemen, and welcome to Altimmune First Quarter 2025 Financial Results Conference Call. After the speakers' presentation, there will be a question-and-answer session. (Operator Instructions) As a reminder, this call is being recorded.I'll now introduce your host for today's conference call, Lee Roth, President of Burns McClellan, Investor Relations Advisors to Altimmune. Lee, you may begin. Lee Roth Thanks Gigi. Good morning everyone. Once again thank you all for joining us for Altimmune's first quarter 2025 financial results and business update conference today's call you will hear from Dr. Vipin Garg, our Chief Executive Officer; Dr. Scott Harris, our Chief Medical Officer; and Greg Weaver, our Chief Financial Officer. Dr. Scot Roberts, our Chief Scientific Officer and Ray Jordt, our Chief Business Officer will join us for the Q&A first quarter 2025 results and corporate update press release was issued earlier this morning and can be found on the Investor Relations section of the Altimmune website. Before we begin, I'd like to remind everyone that remarks made about future expectations, plans and prospects constitute forward-looking statements for purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995. Altimmune cautions that these forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those a full review of the risk factors that could affect the company's future results and operations, we refer you to the company's filings with the Securities and Exchange Commission. I'd also direct you to read the forward-looking statement disclaimer in our press release issued this morning, which is now available on the statements made on this conference call speak only as of today's date, May 13, 2025, and the company does not undertake any obligation to update any of these forward-looking statements to reflect events or circumstances that may occur on or after today. As a reminder, this call is being recorded and will be available for audio replay on the Altimmune that said, it's now my pleasure to turn the call over to Dr. Vipin Garg, President and Chief Executive Officer of Altimmune. Vipin? Vipin Garg Thank you, Lee. Good morning, everyone and thank you for joining us today for our first quarter financial results and corporate you can imagine, we are very excited about the upcoming readout of our IMPACT Phase 2b NASH trial, which we expect to announce this quarter. Based on the class leading liver fat reduction of pemvidutide and the use of biopsy rereads to minimize placebo response, we are confident of achieving the trial's key efficacy and safety objectives. If successful, pemvidutide would become the only incretin to achieve statistical significance on NASH endpoints at only 24 weeks of it will be the first therapy of any kind to combine these effects with clinically meaningful weight loss at this early time point. If approved, we believe that pemvidutide could provide a complete solution for the treatment of announced today that we have entered into a credit facility with Hercules Capital for up to $100 million. This is strategically important as we build upon our balance sheet strength and provide flexibility to support our continued development of will speak further on our financing later on the call. Our recent R&D day event marked an important milestone in pursuing our vision of pemvidutide becoming the treatment of choice in liver and cardiometabolic diseases. We unveiled our plans for Phase 2 trials in alcohol use disorder, or AUD, and alcohol liver disease, or ALD. Both AUD and ALD are areas of significant unmet medical need with limited treatment has the potential to disrupt the treatment paradigm in both these conditions if we are able to demonstrate a reduction in alcohol consumption in combination with an amelioration of fat reduced induced liver inflammation and fibrosis. This profile of clinical benefits was enthusiastically received by various physician groups and patients, which adds to our conviction for developing pemvidutide in these indications. The expansion into these indications demonstrates our commitment to establish pemvidutide as a potential foundational treatment across multiple fibrotic liver diseases and their primary that, I will now turn the call over to Dr. Scott Harris, our Chief Medical Officer, to provide a clinical development update. Scott? Scott Harris Thank you, Vipin. We are approaching an important milestone in our MASH program. The top line data from the IMPACT Phase 2b trial, which are expected in the second quarter. We are pleased to report that the trial enrolled a total of 212 participants with biopsy confirmed F2/F3 MASH, which increased the study power over the original a reminder, the dual primary endpoints are MASH resolution or fibrosis improvement at 24 weeks. We also plan to provide data on key secondary endpoints, including weight loss, non-invasive tests of fibrosis, such as FibroScan and ELF, liver fat reduction, and serum also look forward to reporting an adverse event profile that confirms the safety and tolerability of pemvidutide. As Vipin mentioned, if successful, pemvidutide would become the only incretin to achieve statistical significance on MASH endpoints at only 24 weeks of treatment. Further, it will be the first therapy of any kind to combine these effects with clinically meaningful weight loss at this early time point. While the top line efficacy data readout will be at 24 weeks of treatment, we are continuing to treat patients for a total of 48 weeks. This will allow us to estimate the effect of pemvidutide or MASH biopsy endpoints using non-invasive tests and determine the additional weight loss achieved by these patients at this time are now on the final stages of rereading the biopsies. The baseline patient demographics and characteristics, including age, sex, body weight, BMI, diabetes status, ratio of F2 to F3, liver fat content, non-invasive measures of fibrosis, and liver function are consistent with our expectations and closely approximate other studies in maximize the integrity and robustness of our histology readout, both baseline and end of treatment biopsies for all subjects are being reread in a blinded fashion using independent reads from three pathologists and a modal approach to scoring, similar to recent successful studies in this has shown that re-reading both the baseline and end of treatment biopsies significantly reduces the placebo response rate in MASH trials and implementing this procedure will add to the likelihood of trial the most compelling reason we are confident heading into the IMPACT readout is that our Phase 1b MASLD study demonstrated a dose dependent liver fat reduction of up to 76.4%, which is greater than that associated with other successful trials and is class leading for MASH that liver fat reduction has been shown to be the principal driver of MASH resolution and fibrosis improvement in MASH clinical trials. Given our confidence in the upcoming data, we are preparing for the initiation of a Phase 3 trial in NASH and intend to hold the end of Phase 2 meeting with the FDA in the fourth quarter of this year for this indication. This timeline would allow us to initiate a registrational program in early now to two additional indications that we unveiled at our March R&D day event, Alcohol Use Disorder, or AUD, and Alcohol Liver Disease, or ALD, we are progressing towards Phase 2 trial initiations in these indications in Q2 and Q3, respectively. The Phase 2 trial in AUD will evaluate pemvidutide versus placebo in approximately one hundred patients over a 24-week in the pemvidutide arm will receive the 2.4 milligram dose titrated over eight weeks to maximize tolerability in this patient population. The primary efficacy endpoint is the patient reported change in heavy drinking days with the timeline follow back method as established by FDA guidance, with key secondary endpoints of changes in alcohol consumption by PEF and weight to our AUD trial, the Phase 2 ALD trial will evaluate pemvidutide versus placebo in approximately 100 patients, but over a 48-week treatment period. We will employ a 2.4 milligram dose of pemvidutide with the same dose titration method as in AUD. The key endpoint, change in liver stiffness measurement by FibroScan, will be assessed at 24 week and 48 weeks, along with key secondary endpoints of change in alcohol consumption and weight AUD and ALD are large patient populations with treatment options that either have proven ineffective in clinical practice in the case of AUD or don't exist in the case of ALD. Our market research suggests the drug with the target profile of pemvidutide, one that reduces alcohol consumption, liver inflammation, and body weight would be well received by patients and obesity is recognized to be a key risk factor for poor outcomes in both AUD and ALD, and not unexpectedly patients with these conditions have a high incidence of metabolic abnormalities, including hypertension and hyperlipidemia. If these efficacy trials are successful in AUD and ALD, we believe that pemvidutide has the potential to redefine the approach to the treatment of these serious and ALD are the two most frequent conditions leading to liver transplantation in the United States. So the long term potential benefits of pemvidutide, if positive, are significant. We are excited to initiate the trials and look forward to sharing our progress along the that, I'll now turn it over to Greg Weaver, our Chief Financial Officer, to review our financial results for the first quarter. Greg? Greg Weaver Thank you, Scott, and good morning, everyone. Let me begin with adding some color around our cash position, our recent use of the ATM and today's announcement of the credit facility with Hercules Capital. I am quite happy with the progress we have made over the recent months in building the cash runway required to support the pemvidutide clinical development program in MASH, ALD, and AUD. I am confident that the cash position we construct will support the needs of the pemvidutide program over about the ATM facility. This is one of several financing tools available to us. We have raised $35 million net off the facility in the first quarter of 2025, an additional $16 million since April $100 million credit facility announced this morning is another important piece of the financing strategy and Hercules is a high quality partner. The facility provides tranche funding that is optional, flexible and significantly extends our cash runway. There's a $15 million funding at closing up front and an additional $25 million available in 2025 subject to milestones that align with our business plans. The remaining $60 million on the facility is available beginning in 2026 and subject to milestones and of the facility include interest only for 24 months, which can be extended up to 42 months. The duration of the facility is 48 months. Terms are at market rates and no warrants are included in the facility. We view Hercules as a long-term partner with the ability to grow alongside us as we continue to advance to briefly comment on the Q1 financial results, we ended the first quarter of 2025 with $150 million in cash, cash equivalents and short-term investments as compared to $132 million at year-end 2024. The increase in our cash balance is related to equity sales off the ATM facility totaling the $35 million during the first quarter.R&D expenses were $15.8 million for the three months ended March 31, 2025 compared to $21.5 million same period of 2024. R&D expenses in the first quarter included $9.2 million of direct costs related to the development of pemvidutide specifically to upfront CRO costs for the IMPACT trial.G&A expenses were $6 million for the quarter ended March 31, 2025 compared to $5.3 million in the same period of 2024. The increase was primarily related to a $500,000 increase in and other labor related loss for the first quarter of 2025 was $19.6 million, $0.26 a share compared to a net loss of $24.4 million or $0.34 a share for the first quarter of the prior year that, I'll now turn the call back to Vipin for closing remarks. Vipin? Vipin Garg Thank you, Greg. We are entering a truly exciting time for Altimmune with the upcoming MASH data and the initiation of our AUD and ALD phase 2 trials. We expect 2025 to be a transformative year for the company. This concludes our formal remarks, and we would now like to open the line to take questions. Operator? Operator (Operator Instructions) Our first question comes from the line of Yasmeen Rahimi from Piper Sandler. Yasmeen Rahimi Good morning team. Thank you so much for all the great updates and very much looking forward to the IMPACT study reading out here in 2Q. Two first one is Scott, you mentioned that you guys are analyzing the baseline biopsies again. Have you had a chance to maybe provide some commentary around what the distribution F2 and F3 are and sort of how representative this Phase 2b population baseline characteristics are versus maybe some of the other Phase 2b successful Phase 2bs that we have seen? That's question two is directed to Vipin. I think speaking with investors we always find that they are excited about pemvidutide but may need help to think about post impact. What is the ideal population within MASH obese that would be ideal for pemvee? If you could provide color there that would be really then the third one is obviously upon positive data from the IMPACT study you do have the opportunity to think about partnering this asset if you could provide also Vipin and team some commentary around how you're thinking about partnership opportunities. So appreciate if you could tackle these three part questions and I'll jump back in the queue. Vipin Garg Absolutely. Thanks for your questions. Yes Scott, you want to take the first question? Scott Harris Yes, well, yes, we're in the absolute final stages of rereading the biopsies and what we're going to present are the demographics of that final qualifying population. So based on that we can't give you precise numbers. We would say in confidence. If you look at the other studies in terms of the age of the patients, the average proportion of women, the F2, F3 distribution, the distribution of diabetics, the fibrous skin scores, the Elf, the liver fat at baseline, the ALT levels, if you look at what we're seeing in the population that will be evaluated as that data comes to us, it looks very, very similar to other studies. So I think that investors can look at this and say that this will be very meaningful in terms of its comparability to other studies. Vipin Garg In terms of your question about the patient population? Yes. What we are doing is we're really leveraging the unique features of pemvidutide, which really combines, which combines direct effect in the liver with weight loss. So really the way we look at MASH is, it's MASH with obesity. As you know, 80% of the patients, 80% to 90% of patients with the MASH have obesity. So we're treating both the root cause of MASH, which is obesity, as well as the serious condition that results from obesity, which is liver by combining these two effects, we're really bringing these two features to the table and really we believe that's added value proposition for MASH and even the other indication that we are pursuing. So everything we are doing has a common element here where we are looking at obesity as this important secondary endpoint. So we think that really gives us an advantage in terms of identify the patient population that would be most benefited from regards to your second question, as far as partnering is concerned, as we have stated, our goal is to move forward into phase 3 development of pemvidutide as quickly as possible. We are putting all of the pieces in place to make that happen. Along the way we are open to discussions and if a compelling partnership comes together, we'll certainly look at it. But that's not going to be the gating factor in terms of our ability to move forward with Phase 3 in MASH as well as in AUD and ALD. Yasmeen Rahimi Thank you so much. Operator Thank you. One moment for our next question. Our next question comes from the line of Liisa Bayko from Evercore. Liisa Bayko Hi there. Thanks for taking the questions and congratulations on the progress. Can you talk a little bit about, what you're seeing in the study in terms of discontinuations, how you're handling the discontinuations in terms of the data, and how should we think about any loss from the re-reads and things like that? Curious. Thanks. Scott Harris Yes. Liisa, let me answer that question. I can't give you absolute numbers and study discontinuations, but what I can say is looking across the trial, the discontinuations that we're seeing and also those due to adverse events, we're very, very happy with the data that we're seeing so far. The trial has been going very well, especially with regards to discontinuations. Obviously we'll have that data at the time of the readout. The discontinuations are handled in different ways in you know, some compounds have looked at completer analyses, others have done what's called the full intention to treat, where all discontinuations are treating as non-responders. And then there's the midway, which is an imputation method which has been used in other trials as well. Our goal is to have all that information available at the time of the readout. I can't give you finite information on the rereads at this point, but it's what we're seeing is in line with what we had projected for patients who qualify. Liisa Bayko Okay, great. And then just one more question. I've been getting some questions on the importance of weight loss in this study because it really is obviously a MASH first study and weight loss is sort of secondary. So I guess how do you see the importance and how do we think about benchmarking weight loss in this study? I know you said to expect something like semaglutide, but what does that actually really mean? And I know this study will have a combination of patients with MASH diabetics. They won't be encouraged necessarily on lifestyle and other factors. So taking that all together, how should we think about how much weight loss to expect in a study like this? Thank you. Scott Harris Yes, great question, Liisa. Weight loss is extremely important. If you look at the patient population up through F3, they ate predominantly of the comorbidities of obesity and the cardiovascular risk. And if you don't achieve meaningful weight loss in the treatment of mashed patients, you're really [pitching holing] the product into a late F3, F4 type population to treat fibrosis. And the goal is to be holistic and treat all the patients from the least severe to the most severe and we think we have that in our Vipin mentioned before in his comments, and I repeated that, first of all, we'll be the only incretin reading out of 24 weeks. And that will differentiate us from the other compound because speed is effectiveness and when you're treating people with F3, they may not have a lot of time before they get into F4 once again into F3 they start progressing very quickly, as little as two years. You really wonder if you want to have a slow acting drug, one that works indirectly by weight loss as being your factor. You need to have direct action within the liver and our ability to read out at 24 weeks is really going to differentiate us from the incretins because we'll have both the weight loss and the direct acting effects, and compared to the other compounds reading out at 24 weeks, particularly the FGF 21s will have meaningful weight we will be a complete solution for MASH. We think that with successful readout both in the MASH endpoints in the weight loss, we will be highly differentiated not only against the incretins, but all compounds. Now, regarding your question about the weight loss that we expect, as you know, in the semaglutide trial they had a weight loss of about 10% at 72 weeks. That has to be scaled back to what you would expect at 24 weeks, going one third of the amount of our position is that any clinically significant, clinically meaningful weight loss that we see will be highly differentiating, but I think that we can roughly project that it would be very similar to semaglutide. As you mentioned, lifestyle interventions like diet and exercise are not used in MASH trials. That compares against weight loss trials where it is, so you tend to have lower placebo response rates. So all in all, I think that comparing this to the semaglutide trial at 24 weeks, something that's meaningful and clinically significant, will be very similar to semaglutide in its weight loss, but then clearly differentiate from the FGF21s by providing significant weight loss, which these compounds don't one other point is, as I mentioned in my comments, although we are reading out now this quarter at 24 weeks, we are also reading out by the end of the year at 48 weeks so that we will have a lot of information. Another catalyst in the second half of the year, we are going to have 48-week weight loss. We are also going to have non-invasive testing that will allow us to predict what the biopsy results would have been at week 48 had we done a biopsy at that you know from other studies, the biopsy response grows with time. So anything we see at 24 weeks will be magnified and even greater in the 48-week readout. Liisa Bayko Very helpful, thank you. And then just final question from me. As you think about phase 3 and I know you'll be pending, all this data meeting with FDA towards the end of the year is taking the higher dose into phase 3 consideration. And also I know you're really focused on kind of like how rapid the response is and how are you thinking about a potentially earlier six month endpoint? Thank you. Scott Harris Well, those are great questions, Lisa. So we're strongly considering taking the 2.4 milligram dose into Phase 3. And it's not because we expect better MASH effects, it's that we expect to get better weight loss, reminding you that the 1.8 milligram dose that we have in this trial is not the optimal dose for achieving weight loss. Pertinent to your prior question, that has to be understood in looking at the data that we will get higher weight loss if we employ the 2.4 milligram dose in Phase 3 as we regarding the more rapid response, the FDA and their guidance does not provide a time course for these trials. One possibility here, as you mentioned, would be to do readouts at not only the end of a year, 48 weeks or 52 weeks, but also at six months. That's something we're strongly considering for two reasons. The first is that it would then also make put a stake in the ground for earlier, more rapid mash effects. But second, it would also allow us to read out the trial results six months earlier. So both of those elements, adding the 2.4 milligram dose and doing an earlier readout are something that's strongly being considered. We are writing that program as we speak. We are well ahead of our timeline for having an end of Phase 2 meeting with the FDA in the fourth quarter, and these are things that we will discuss with them and I think they'll be very open to that discussion. Liisa Bayko Thank you so much for answering all my questions. Operator Thank you. One moment for our next question. Our next question comes from the line of Roger Song from Jefferies. Roger Song Excellent. Thanks, team, for the update. And then taking our question, I have a couple questions related to the IMPACTS study as well. The first one is understanding the trial is well overpowered for both endpoints, but just curious how you think about which endpoints are a bit harder to hit based on all the historical data. And then that's number two is your recent ESO data regarding this MASH resolution index, the translation to the MASH biopsy. So how you think about that index will correlate with the fibrosis improvement as well. Thank you. Scott Harris Yes, Roger. Well, as you mentioned, the trial is extremely well powered and by enrolling additional patients, we've even added to the likelihood of trial success. Historically, the fibrosis improvement endpoint has been harder to hit than the MASH resolution endpoint. I think that's a well established our trial, we have dual endpoints, which mean that we can hit either MASH resolution or fibrosis improvement to be successful. But that being the case, we believe that we'll be successful in hitting both endpoints based on all the factors that were mentioned. In terms of what was presented at EASL that was a new index developed by Rohit Loomba at UCSD, who also developed the concept of a 30% decrease. Liver fat content was also associated with, with MASH resolution, and he's continued to evolve this to getting an index that's even more sensitive and specific than that. And this mash resolution index combines liver fat reduction, the change in ALT level and baseline AST level, and it has an area under the curve in an ROC analysis approaching 0.9, which is very, very predictive with high sensitivity and on that index, applying it to our original data, in the 1.8 milligram dose group, our highest dose group, over 90% of patients will be hitting MASH resolution. That's extremely important. What it comes down to, Roger, is basically this liver fat reduction continues to be the greatest driver of MASH resolution of fibrosis improvement, shown consistently in all trials and pretty much accepted by experts as being the primary driving force for hitting MASH resolution and also fibrosis improvement. And we also have the highest liver fat content, the highest liver fat content reduction of any compound that's right now in active development for based on all those factors, the power of the study, the readouts that we keep having by applying indices like the MASH Resolution Index or liver fat reduction, what we know about the science, we are very, very confident about the trial's success. I would also add to that, as I did before in my comments, that controlling the placebo response is key to obtaining statistical significance. And the best way to do that is to use a method of taking all the biopsies at the end of the trial, scrambling them so the pathologist is blind as to when the biopsy actually was done and then rereading them on a blinded know that biopsy results are upgraded in severity early in the trial and downgraded later in the trial for a variety of reasons. It's been shown consistently based on that a placebo patient who biologically has no change will have a response simply based on the sequence of the biopsy reads. So scrambling all the biopsies so the pathologist is unaware of the timing and sequence has been shown in clinical trials to reduce the placebo response rate. So we think that three important factors. First, are magnitude of liver fat reduction, second, the sample size that we're using going into the readout, and third, the rereading of the biopsies all move us towards trial success. Roger Song Excellent. Thank you. Thank you, Scott. Operator Thank you. One moment for our next question. Our next question comes from the line of Annabel Samimy from Stifel. Annabel Samimy Hi, thanks for taking my questions. I just want to follow on. The comments about the Phase 3 program. We all know that one of the issues that plagues mass development is the long development pathway. So if you're successful here in achieving the fibrosis response in six months and realize that you're going to design the phase 3 program with a 6-month do you see any avenue to tighten the development timelines or will FDA be still sticking with its typical years long pathway? And how do you see this evolving over time, especially as we see additional movement on these biomarkers at the recent conferences? Do you see greater acceptance from the FDA from that? And I guess I have to ask a follow up question to that. Just generally speaking, how have your interactions with FDA changed with all the movement there? Anything to the positive or negative that you are seeing? Thanks. Scott Harris Hey, thanks Annabel. Let me handle those questions. We believe we have the opportunity here to shorten that development path. For one, we could have a readout at six months. We may combine that, by the way, with having two readouts, one at six months and one at 12 months, in different patient populations so that patients only have to go through two biopsies, one at baseline and one at either six months or a separate group cohort in 12 we have not made final decisions about that. I think Liisa in her prior comments was absolutely correct. There's an opportunity that has to be looked at, but again, we have to look at it with the FDA. So we can't make any firm announcements about that, only the fact that we're looking at that. We are very encouraged by the enrollment rate that we had in the IMPACT trial. We have been told it's the fastest enrolling trial today date. It shows that patients like the drug and that investigators enjoyed putting their patients in the trial. And one of the big motivating factors was the fact that people could lose weight, but they also liked the tolerability of the drug. We think that will play out in the final results of the trial, the tolerability and adverse we think that combining a faster enrollment ramp, we could also accelerate the timeline. You are absolutely correct that there's a great deal of interest in biomarkers. I think that there's greater and greater acceptance over the course of time. It has to meet the FDA's legal standards. Ultimately FDA is a body governed by laws and regulations in terms of what they consider to be proof. There's every evidence that they want to move away from the biopsy endpoints, but whether they've met that standard is yet to be seen. We think that going into our program that we are probably going to need biopsy endpoints for efficacy. But those noninvasive tests are very important because holistically, showing the entire response, both the biopsy response and the non-invasive test is shown to be going back to our IMPACT program, as you are aware, we have a biopsy readout at 24 weeks. We don't have it at week 48 weeks. We didn't want to subject the patients to another biopsy. We didn't think that they would accept that going into a trial. But nonetheless, in getting to your point here, we have the biomarkers both at week 24 and week 48. We could use that to model the response. We saw that in the recent data with Resmitteram where they were able to give a forecast of their response in cirrhotics with their FibroScan results in their open label study at one and two years. We believe that using that biomarker data for four weeks creates a very important catalyst for us also at the end of the your last question about FDA interactions, we haven't noticed any difference. We are not aware that there's been any meaningful changes in any of the FDA divisions with which we interact with MASH, that would be liver and nutrition. We've not seen any changes. We've not had any formal interactions with the agency since our last meeting with them but we will be meeting with them in the fourth quarter of this year and we don't anticipate there will be any difference from our interactions with in the past. Vipin Garg Hey Annabel. I just wanted to add one more point to the trial size and the efficiency of trial. One thing to keep in mind that we have a very large safety database on pemvidutide, unlike other MASH programs because of our database in obesity, as well as a very successful end of Phase 2 meeting we've already had with the FDA from a safety perspective, safety and tolerability perspective. So that should give us additional reason in terms of designing the trial for Phase 3 for MASH where we might be able to get more efficiency. In other words, we may not need as many patients exposed to drug because we already have a very sizable safety database. Annabel Samimy Fantastic. Thank you. Operator Thank you. One moment for our next question. Our next question comes from the line of Eliana Merle from UBS. Jasmine Fels Hey this is Jasmine on for Eliana. Thanks so much for taking our question. So when you meet with the FDA for your end of Phase 2 after IMPACT, do you expect to discuss MASH F4 Cirrhosis with them at that time? And just what can you say about your latest plans and timelines there?And then second question. Can you just confirm for us your cash running Runway at the Hercules facility? And are there any specifics that you can share on what that Runway includes? Thanks. Vipin Garg Scott, do you want to take the first question? Scott Harris Yes, Jasmine, I'll take the first question, then I'll hand it over to Greg for the second. So we are extremely interested in F4. We believe that we will be successful in F4. If you look at the populations of F4 that have enrolled in trials to date, it's been an early F4. Patients who are considered child A child by the child's puturcot classification. These are people who have good liver synthetic function, so haven't developed the complications of cirrhosis and they also have high liver consequently, although they are technically F4, they're, they're behaving like they're F3. And we think we're going to be extremely successful in F3. And I think that forecast we're going to be extremely successful in F4. So yes, we have drawn out an F4 trial. Now, we can't give you details on that until we get confirmation with the agency, but to your question, we intend to discuss F4 with the FDA. I would imagine that we would have a fibrosis improvement improvement trial that we would use for accelerated approval in F4 as well as follow these people to outcome to full approval. So you're absolutely right. We're very interested. This is going to be a big part of our meeting and I think we are going to have a high probability of success in F4.I want to also remind everyone that our drug has both metabolic and direct effects on MASH. Right. So back to my original point and Liisa's point about the importance of weight loss. We will clearly be able to treat the metabolic abnormalities of F0, F1, F2 and even F3. But we have the direct effects that are going to be potent for F3 and F4. So unlike some other drugs that might be restricted to certain points in MASH development, say the FGF21s to F3, F4, the other incretins, F0, F1 and F2, we have the opportunity to treat all of MASH. In other words, we can be a complete solution for the disease, both F0. Well, from F0 to F4. Greg. Greg Weaver Thanks, Scott. And Jasmine, Good question. Let me add a little color around our Hercules facility that we announced this morning. And the effect on the Runway? Positive effect on our Runway. The facility is broken into four tranches. The first will be funded this week. Upon closing, we disclosed that as $15 million. The second tranche available later this year and then the balance across 2026. I'll break down the Runway answer in two on today's cash position gives us Runway in Q3 of 2026. And if you layer on top the optional draws, if we were to draw all of them, it could extend the Runway for as much as another year. Now that's more details to be disclosed in the 10-Q to file later today. Jasmine Fels Okay, Super helpful. Thanks so much. Operator Thank you. One moment for our next question. Our next question comes from the line of Mayank Mamtani from B Riley. Mayank Mamtani Good morning, team. Thanks for taking your questions and congrats on the recent progress. Scott, I don't know if I heard from you. Could you comment on the range of placebo responses you are expecting on fibrosis and MASH resolution endpoints? As you mentioned, we've seen a relatively broad range in prior trials and if you're able to comment at all, sorry to push you here on the female to male ratio and what baseline weight is relative to your prior Phase 1b MASLD study, if you could maybe comment on that and then I have a follow up. Scott Harris Mayank. I'm sorry, I didn't hear the second part of the question. I heard the first part about the range of placebo response. Could you repeat the second and then I'll... Mayank Mamtani Yes. Sorry, yes. The female to male ratio and then the baseline weight relative to your priority Phase 1b MASLD study. So both baseline demographics questions. Scott Harris Yes, the first question is the range of placebo response has been wide in these trials. In the semaglutide Phase 2 trial it was 32%. And we've seen other readouts in 20%. We've even seen readouts in single digits. We think that the unifying factor here is how you handle the placebo response and in the trials that have re-read their biopsies by scrambling them, we're seeing placebo responses for fibrosis improvement between about 7% and 13%. So we can't be absolute about what our placebo response is. We think that our trial is very well powered because we have a better treatment effect and a larger sample size than those trials that read out successfully. But we would hope that we would drive down the placebo response to those the baseline characteristics as I mentioned before, we are in the final stages of rereading the biopsies so the exact numbers are not available to us. But we think we're very close and rather than getting into numbers that we're just going to have to reannounce, which could be confusing to people, we think it's better to say that the range of females to males, things like the baseline weight, will be very similar not only to other trials in the space if you line them up and we've done that, but also as what our targets I think you're going to be very happy when you see that. But until we have the final numbers, we're a little reluctant to put them out there because it could create confusion. Mayank Mamtani Understood, thank you. And with secondary endpoints you may include as part of your top line release next month and obviously want to understand which NIT should be focused on at this 24 week time point versus maybe the 48 week because the 48 week could be important as you also think about powering the long term outcomes trial as part of your end of Phase 2 FDA discussion. So if you could maybe segment that, that would be helpful. Scott Harris Right, I want to first start by saying that we don't believe that we need the 48-week data to meet with the FDA, their sponsors that met with 24-week data. It will be helpful in the discussions, and we can certainly add it in. But you're correct, those non-invasive tests are going to be extremely helpful for us to predict and model the changes in the liver biopsy results that would have occurred had we done the biopsy at week the primary. Endpoints that we'll read out will be mashed resolution of fibrosis improvement by the FDA guideline definitions. The key secondary endpoints will be things such as weight loss, liver fat reduction, changes and non-invasive tests such as fiber scan, and EF will also have liver fat reduction by MRI, PDFF. And we'll have adverse events, discontinuations and study demographics. I believe that would be a comprehensive view of what we'll have and probably what we'll also have at week 48 as well. Mayank Mamtani Understood. And lastly, could you touch on the impact you believe based on pemvi's mechanism would be on bone and muscle health and or muscle health. Thanks for taking a question. Scott Harris Well, bone health is extremely important. You are seeing accelerated bone loss with other compounds. There was a recent readout at ASLD and was also published of a 5% bone mineral density loss versus placebo in cirrhotic patients. You have to also recognize that in a cirrhotic population placebos are losing bone density and it could be as much as 5% over the trial duration of 96 weeks based on what we know from other adding in the natural 5% with the 5% that you lose with FGF21s, that's significant, that's 10% and that has to be looked at very carefully. That's not something that we're seeing with pemvedutide. We're not seeing it with the FGF20 with the GLP1s. As you are aware, lean mass preservation is extremely important in this population. We know that in the semaglutide data where in two trials they lost approximately 40% of their body weight as lean mass. They had a four to seven fold higher rate of pelvic and hip fractures and this was seen as susceptible populations. That's the key that you see it in the elderly and you see it in postmenopausal women, which is not an insignificant number or proportion of the patients that are being treated with these consequently these are extremely important features of drugs as you're saying here. Mayank, it's important not just to look at the MASH effects in the weight loss, but holistically at the whole patient. And we believe the fact that we have class leading effects in lean mass preservation, we lose only 21.9% of our body weight loss as lean mass over 48 weeks. Glucagon appears to preserve muscle and lean mass and that's going to be extremely important in all populations that are obese and overweight. Not just an obesity population but a MASH population with obesity as well. Mayank Mamtani Thank you. Look forward to the data update. Operator Thank you. One moment for our next question. Our next question comes from the line of Jon Woolaben from Citizens. Hi, this is Kathryn on for Jon. I have kind of a quick question about the speed that you expect liver fat as well as histologic change with the GLP glucagon agonist? Whether you expect any differentiation from some of the others that we've seen, I guess mainly cervidutide. Is there any reason to believe that pemvidutide should be faster? And also in terms of biomarkers, are there any that you expect to change from the 24-week readout to the 48-week readout in particular or is it more of you're expecting to see sustained improvements both at the later time point. Thank you. Scott Harris Yes, great question, Kathryn. So speed is important. Speed first of all implies efficacy. The faster you work, the more efficacious you are, and speed is important. F3 patients, comparison to cirrhosis and complications within two years. We know that from the data. And the change in liver fat content predicts the histological change at 24-weeks. So, speed of liver fat content reduction, speed of histologic changes. Now the 76.4% is at 24 weeks. We also have very similar effects at 12 weeks. That data has been published in J Hepatology and in fact, in our own internal data, we're even seeing these effects as early as six weeks. So we believe that we not only have the most potent drug, but also the fastest acting regarding cervedutide, that molecule has a ratio of GLP-1 to glucagon of 8:1. We are 1:1. We have a much greater amount of glucagon in our molecule. And it's the glucagon that's driving the change in liver fat reduction. That's what it is. So we believe that what we're seeing at 24 weeks would not be achievable by a compound with lower glucagon believe that it's contributing some to cervidutide, but if you look at their liver fat reduction, it's lower. It's in the range of 58% to 62%. So we believe that we have a molecule, more glucagon, more liver fat reduction, faster liver fat reduction, faster histological change, and that we are an agent that can read out at 24 weeks. In contrast to cervidutide, we don't think that they could do it. So we believe that we'll be differentiated against all of the prior incretins that have read out not only through tirzepatide and semaglutide, but also cerberdutide as regarding your second question, we believe the biomarker response will grow between 24 week and 48 weeks. There's been a lot of talk in this conference call regarding nits and the fact they're becoming more and more reliable and predictive of what's going on. We saw a lot of attention being placed on the change in the FibroScan data and the cirrhotic cohorts and the Resmiteron biomarkers are getting there. They are there, in fact. And we think that what we see at 24 weeks and we'll report out on that will grow over 48 weeks. We think they will be all of them. They all move in tandem. ELF and FibroScan are felt to be at this point the best non-invasive tests. And in fact, there's even talk now of combining the two for prognosis, a combined score of ELF and think we're going to have meaningful results in both and we think those results at 24 weeks will be even better at 48 weeks and will be an indicator of how we would have done at 48 weeks with a biopsy at that time point. And that will be in the fourth quarter of this year. Thank you so much. Operator Thank you. One moment for our next question. Our next question comes from the line of Andy Hsieh from William Blair. Andy Hsieh Great. Thanks for taking our question. Just one quick one for us. We are just wondering about the overlap between clinical sites that you use for obesity and MASH compared to potential sites for AUD and ALD that you look to activate in the coming quarters. Thank you. Scott Harris Hi Andy. Thanks for the question. There is some overlap. I don't have the data in front of me right now. I can't give you percentages. But the underlying unifying feature of all these patients is obesity and many sites specialize in this area as well as they would. Obesity and liver disease are MASH. So there's obviously going to be some overlap. But offhand I don't have those numbers in front of me right So the sites that we picked for AUD and ALD will also have some overlap with the MASH and obesity populations as well. But again, I don't have that number in front of me to provide for you on this call. Operator Thank you. At this time, I would now like to turn the conference back over to Vipin Garg for closing remarks. Vipin Garg Thank you everybody for joining our call today. As always, we appreciate your continued support and look forward to keeping you updated in the months ahead. Have a wonderful rest of your day. Operator This concludes today's conference call. Thank you for participating. You may now disconnect. Sign in to access your portfolio
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01-05-2025
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Will Pfizer Acquire Altimmune or Viking Therapeutics After Its Obesity Pill Setback?
Altimmune and Viking Therapeutics have promising obesity drugs and could be great acquisition targets for Pfizer. Pfizer should be able to easily fund an acquisition of either small drugmaker. However, Pfizer could hold off on the acquisitions front to see how its obesity drug PF-07976016 fares in clinical testing. The market for obesity drugs presents one of the most lucrative targets for biopharmaceutical companies. Eli Lilly and Novo Nordisk are already raking in billions of dollars in sales with their weight-loss drugs. Other drugmakers are eyeing the market as well. Pfizer (NYSE: PFE) is certainly in that group. However, the company finds itself at a distinct disadvantage after it recently threw in the towel on experimental obesity pill danuglipron because of safety concerns. Could Pfizer solve the issue by acquiring an up-and-coming biotech with a promising obesity drug in clinical development? Where to invest $1,000 right now? Our analyst team just revealed what they believe are the 10 best stocks to buy right now. Continue » The good news for Pfizer is that it shouldn't have any problems finding an acquisition candidate if it chooses to go that route. I can think of two great targets off the top of my head. Let's start with Altimmune (NASDAQ: ALT). The company has what it calls "a pipeline in a product" with experimental GLP-1/glucagon dual receptor agonist pemvidutide. Altimmune met with the U.S. Food and Drug Administration in November 2024 at the end of successful phase 2 testing of the drug in treating obesity. It expects to report results from a phase 2 study of pemvidutide in liver disorder metabolic-associated steatohepatitis (MASH) in the second quarter of 2025. Altimmune also plans to advance the drug into phase 2 studies later this year as a potential treatment of alcohol use disorder and alcohol-associated liver disease. Viking Therapeutics (NASDAQ: VKTX) stands out as another potential acquisition target for Pfizer. The company expects to begin phase 3 testing of a subcutaneous version of GLP-1/GIP receptor dual agonist VK2735 in treating obesity this year. It's conducting a phase 2 study of an oral formulation of the drug, with results anticipated in the second half of 2025. Like Altimmune, Viking has a promising pipeline candidate targeting MASH, which is also known as nonalcoholic steatohepatitis. The company reported positive phase 2 results for its MASH drug, VK2809, last year. In addition, Viking is developing VK0214 as a potential treatment for the rare genetic disorder X-linked adrenoleukodystrophy (X-ALD). Pfizer's cash, cash equivalents, and short-term investments totaled nearly $20.5 billion at the end of 2024. The big pharmaceutical company raked in revenue of $63.6 billion last year with a profit of over $8 billion. The main negative for the company is its huge debt load of around $64 billion. Still, Pfizer appears to be in a good financial position to move forward with a bolt-on acquisition. I think buying either Altimmune or Viking would be a relatively painless deal for Pfizer. Altimmune's market cap is currently below $400 million. Even if we assumed a hefty premium to close a takeover of the company, Pfizer should be able to fund the transaction without taking on additional debt. Acquiring Viking wouldn't be quite as cheap, with its market cap of almost $3 billion. However, Pfizer should be able to finance a buyout of Viking with its cash stockpile without breaking a sweat if it wanted to make a deal. But will Pfizer choose to acquire either Altimmune or Viking? I'm not sure. Although danuglipron is no longer a contender, Pfizer still has another experimental oral obesity drug in phase 2 testing -- PF-07976016. I wouldn't be surprised if Pfizer waited to get a better feel for how PF-07976016 fares in clinical development before making a decision on potentially pursuing an acquisition. However, the company probably can't wait too long. Other big drugmakers seeking to enter the obesity market could have their sights set on Altimmune and Viking, too. Before you buy stock in Pfizer, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Pfizer wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $598,818!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $666,416!* Now, it's worth noting Stock Advisor's total average return is 872% — a market-crushing outperformance compared to 160% for the S&P 500. Don't miss out on the latest top 10 list, available when you join . See the 10 stocks » *Stock Advisor returns as of April 28, 2025 Keith Speights has positions in Pfizer. The Motley Fool has positions in and recommends Pfizer. The Motley Fool recommends Novo Nordisk and Viking Therapeutics. The Motley Fool has a disclosure policy. Will Pfizer Acquire Altimmune or Viking Therapeutics After Its Obesity Pill Setback? was originally published by The Motley Fool
