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Associated Press
07-05-2025
- Business
- Associated Press
Alterity Therapeutics Announces Multiple Oral and Poster Presentations to be Featured at the International MSA Congress
MELBOURNE, Australia and SAN FRANCISCO, May 07, 2025 (GLOBE NEWSWIRE) -- Alterity Therapeutics (ASX: ATH, NASDAQ: ATHE) ('Alterity' or 'the Company'), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative diseases, today announced that multiple oral and poster presentations related to Alterity's clinical programs in Multiple System Atrophy (MSA) will be featured at the 2025 International MSA Congress taking place May 9 - 11, 2025 in Boston, MA, USA. The Congress is presented by Mission MSA, a non-profit organization dedicated to improving the quality of life and building hope for people affected by MSA through support services, educational resources, research funding, and community engagement. David Stamler, M.D., Chief Executive Officer of Alterity, commented, 'We are excited to play a prominent role at the MSA Congress which brings together a noteworthy group of physicians and scientists as well as patients and care partners, all of whom are focused on advancing MSA research and care. Mission MSA is one of the primary patient education and advocacy organizations for the disease in the U.S., and we are also proud to support the event as a sponsor. We look forward to presenting our double-blind Phase 2 data for ATH434 as well as our bioMUSE natural history study with our colleagues at Vanderbilt University Medical Center. Our clinical advancements in MSA continue to generate significant interest throughout the community, bolstered by the recent Fast Track Designation for ATH434 that was granted by the US FDA.' Type: Oral Presentation Session: Opening Plenary: Toward Disease Modifying Therapies of MSA Title: ATH434 Slowed Disease Progression in a Phase 2 Study in Multiple System Atrophy Presenter: David Stamler, M.D., Chief Executive Officer of Alterity Date/Time: Friday, May 9, 2025 at 9:10 AM EDT (USA) Type: Oral Presentation Session: Biomarkers in MSA: Imaging Title: MSA Atrophy Index (MSAai): A Quantitative Imaging Marker for Diagnosis and Monitoring of Multiple System Atrophy Presenter: Amy Brown, M.D., M.S., Assistant Professor, Movement Disorders Division, Department of Neurology, Vanderbilt University Medical Center Date/Time: Saturday, May 10, 2025 at 2:55 PM EDT Type: Poster Session Title: ATH434 Slowed Disease Progression in a Phase 2 Study in Multiple System Atrophy Presenter: David Stamler, M.D., Chief Executive Officer of Alterity Date/Time: Saturday, May 10, 2025 at 12:00 PM EDT Poster: #85 Type: Poster Session Title: Cutaneous Phosphorylated Alpha-Synuclein Deposition Informs Autonomic Function in Individuals with Early-Stage Multiple System Atrophy Presenter: Leah Mann, PhD, Postdoctoral Research Fellow, Vanderbilt University Medical Center Date/Time: Saturday, May 10, 2025 at 12:00 PM EDT Poster: #86 About ATH434 Alterity's lead candidate, ATH434, is an oral agent designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. ATH434 has been shown preclinically to reduce α-synuclein pathology and preserve neuronal function by restoring normal iron balance in the brain in preclinical models. As an iron chaperone, it has excellent potential to treat Parkinson's disease as well as various Parkinsonian disorders such as Multiple System Atrophy (MSA). Phase 1 studies have demonstrated the agent is well tolerated and achieved brain levels comparable to efficacious levels in animal models of MSA. Positive results from the randomized, double-blind, placebo-controlled Phase 2 clinical trial in patients with MSA demonstrated robust clinical efficacy, target engagement on key biomarkers, and a favorable safety profile. A second Phase 2 open-label biomarker trial in patients with more advanced MSA is ongoing. ATH434 has been granted Fast Track Designation by the U.S. FDA, and Orphan Drug Designation by the U.S. FDA and the European Commission for the treatment of MSA. About ATH434-201 Phase 2 Clinical Trial The ATH434-201 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled investigation of 12 months treatment with ATH434 in patients with MSA. The study evaluated the efficacy, safety and pharmacokinetics of ATH434 as well as the effect of ATH434 on neuroimaging and protein biomarkers. Wearable sensors were employed to evaluate motor activities outside of the clinic. The study enrolled 77 adults who were randomly assigned to receive ATH434 50 mg or 75 mg twice daily or matching placebo. The data showed that, compared to placebo, ATH434 produced clinically and statistically significant improvement on the modified Unified Multiple System Atrophy Rating Scale (UMSARS) Part I, a functional rating scale that assesses disability on activities of daily living affected in MSA. Additional efficacy assessments demonstrated improvement consistent with the positive UMSARS Part I findings including trends in improved motor performance on the Parkinson's Plus rating scale, the Clinical Global Impression of Severity Scale, and the Orthostatic Hypotension Symptom Assessment (a patient reported outcome). Wearable sensor data indicated that ATH434 also led to increased activity in an outpatient setting. Biomarkers were used to evaluate potential drug effect and target engagement relative to placebo. Both dose levels stabilized or reduced iron accumulation in MSA affected brain regions with trends in preservation of brain volume. ATH434 was well tolerated with similar adverse event rates compared to placebo and no serious adverse events attributed to ATH434. Additional information on the Phase 2 trial can be found by Identifier: NCT05109091 . About bioMUSE Biomarkers of progression in Multiple System Atrophy (bioMUSE) is a natural history study that aims to track the progression of individuals with MSA, a Parkinsonian disorder without approved therapy. The study is being conducted in collaboration with Vanderbilt University Medical Center in the U.S. under the direction of Daniel Claassen, M.D., M.S., Professor of Neurology and Principal Investigator. Natural history studies are important for characterizing disease progression in selected patient populations. The study has provided rich data for optimizing the design of Alterity's randomized ATH434-201 Phase 2 clinical trial and enrolled approximately 20 individuals with clinically probable or clinically established MSA. BioMUSE continues to provide vital information on early stage MSA patients, informs the selection of biomarkers suitable to evaluate target engagement and preliminary efficacy, and delivers clinical data to characterize disease progression in a patient population that mirrors those currently enrolling in the Phase 2 clinical trial. About Multiple System Atrophy Multiple System Atrophy (MSA) is a rare, neurodegenerative disease characterized by failure of the autonomic nervous system and impaired movement. The symptoms reflect the progressive loss of function and death of different types of nerve cells in the brain and spinal cord. It is a rapidly progressive disease and causes profound disability. MSA is a Parkinsonian disorder characterized by a variable combination of slowed movement and/or rigidity, autonomic instability that affects involuntary functions such as blood pressure maintenance and bladder control, and impaired balance and/or coordination that predisposes to falls. A pathological hallmark of MSA is the accumulation of the protein α-synuclein within glia, the support cells of the central nervous system, and neuron loss in multiple brain regions. MSA affects at least 15,000 individuals in the U.S., and while some of the symptoms of MSA can be treated with medications, currently there are no drugs that are able to slow disease progression and there is no cure.1 1 Multiple System Atrophy | National Institute of Neurological Disorders and Stroke ( About Alterity Therapeutics Limited Alterity Therapeutics is a clinical stage biotechnology company dedicated to creating an alternate future for people living with neurodegenerative diseases. The Company is initially focused on developing disease modifying therapies in Parkinson's disease and related disorders. Alterity recently reported positive data for its lead asset, ATH434, in a Phase 2 clinical trial in participants with Multiple System Atrophy (MSA), a rare and rapidly progressive Parkinsonian disorder. ATH434 is also being evaluated in a Phase 2 clinical trial in advanced MSA. In addition, Alterity has a broad drug discovery platform generating patentable chemical compounds to treat the underlying pathology of neurological diseases. The Company is based in Melbourne, Australia, and San Francisco, California, USA. For further information please visit the Company's website at . Authorisation & Additional information This announcement was authorized by David Stamler, CEO of Alterity Therapeutics Limited. Investor and Media Contacts: Australia Millie Macdonald Head of Investor Relations and Business Development [email protected] +61 468 304 742 Ana Luiza Harrop [email protected] +61 452 510 255 U.S. Remy Bernarda [email protected] +1 (415) 203-6386 Forward Looking Statements This press release contains 'forward-looking statements' within the meaning of section 27A of the Securities Act of 1933 and section 21E of the Securities Exchange Act of 1934. The Company has tried to identify such forward-looking statements by use of such words as 'expects,' 'intends,' 'hopes,' 'anticipates,' 'believes,' 'could,' 'may,' 'evidences' and 'estimates,' and other similar expressions, but these words are not the exclusive means of identifying such statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements are described in the sections titled 'Risk Factors' in the Company's filings with the SEC, including its most recent Annual Report on Form 20-F as well as reports on Form 6-K, including, but not limited to the following: statements relating to the Company's drug development program, including, but not limited to the initiation, progress and outcomes of clinical trials of the Company's drug development program, including, but not limited to, ATH434, and any other statements that are not historical facts. Such statements involve risks and uncertainties, including, but not limited to, those risks and uncertainties relating to the difficulties or delays in financing, development, testing, regulatory approval, production and marketing of the Company's drug components, including, but not limited to, ATH434, the ability of the Company to procure additional future sources of financing, unexpected adverse side effects or inadequate therapeutic efficacy of the Company's drug compounds, including, but not limited to, ATH434, that could slow or prevent products coming to market, the uncertainty of obtaining patent protection for the Company's intellectual property or trade secrets, the uncertainty of successfully enforcing the Company's patent rights and the uncertainty of the Company freedom to operate. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.
Buzz Feed
30-01-2025
- Health
- Buzz Feed
Worried About Catching A Cold? There's 1 Product You'll Want To Have On Hand
We hope you love our recommendations! Some may have been sent as samples, but all were independently selected by our editors. Just FYI, BuzzFeed and its publishing partners may collect a share of sales and/or other compensation from the links on this page. Protect your nose, protect your health. With cold and flu season officially here, you're likely extra cautious about washing your hands and sneezing into your elbow. And while those are both great measures, experts say you also want to think about your nose. Specifically, what's going into it. 'The nasal apparatus is designed to be the first step in fighting off infection and filtering out irritants in the environment,' Dr. Amy Brown, board-certified pulmonologist and assistant professor of pediatrics at New York Medical College School of Medicine, previously told us. 'The nose has its own internal humidification system that allows it to adapt to changes in the external environment easily,' In the winter, when the air is extra cold and dry, your nose goes into humidifying overdrive, weakening its ability to filter. Per Dr. Brown, when your nasal filtration lags, your immune defense lowers, potentially letting viruses into your body. Further, when your nose is all dry, it jeopardizes the mucus layer in your nose, which protects and blocks viruses and bacteria. Cold weather is a large culprit for a dry nose, Dr. Brown says your nose passage can also dry out from things like smoking, air pollutants, allergies and even nose picking. 'If there are excessive amounts of irritants or infectious particles in the environment, the nose has to work harder on filtration and then also may not keep up with promoting ideal humidification, which then leads to dryness,' she previously said. Brown says for short-term help with a dry nose, you can visit a steam room, stay hydrated, limit scented items and try saline-based nasal sprays. Yet, if you're looking for big help, you may want to grab a humidifier for your home. 'Ensuring appropriate ideal humidity in your indoor dwelling space is really the key for ongoing, long-term relief,' Brown said. 1. Pure Enrichment MistAire 0.4-gallon tabletop humidifier Lowe's Made for spaces up to 250 square feet, this tabletop humidifier is great for bedrooms or offices. With an auto shut-off feature, the 1.7-liter tank can run up to 25 hours between fills. It's a straightforward machine with two-speed settings and a mist nozzle that gives 360-degree coverage of your space. Promising review: "I've got to say, this humidifier has been a game-changer for me. It's like a breath of fresh air, literally. My allergies have been way more manageable since I started using it, and I'm sleeping like a baby again. Especially I'm from Denver which is a Mile High city, has less oxygen and almost no humidity in the air, it is very difficult for people as they suffer with nose bleeds and constant irritation. This humidifier outright removed this issue. Plus, my dry skin feels so much better. And I've noticed my plants are thriving too, which is a nice bonus. Definitely worth the investment." — Bharath Get it from Lowe's for $39.99. 2. Lacidoll 5.3-gallon large room humidifier Amazon Offering cool and warm mist, this large-format humidifier holds a whopping 5.3 gallons of water, working to up to 3,000 square feet with either cool or warm mist. Choose how humid you want your space for up to 12 hours, with a variety of levels and mist modes. An essential oil diffuser makes this machine a little more fun, letting you fill your space with spa-like aromas. It's a top-filling design, so you don't have to worry about leaks or pulling out a water box to refill and the brand offers a one-year warranty and 24-hour tech support. Promising review:"I recently purchased this great humidifier, and I couldn't be happier with my decision! This product has truly transformed my indoor air quality. The setup was incredibly easy, and I appreciated the sleek design that fits perfectly in any room. One of the standout features is its adjustable humidity settings, which allow me to customize the humidity level according to my preference. The whisper-quiet operation is a huge plus, making it ideal for use during the night without disturbing my sleep. Not to mention, the tank capacity is impressive, providing hours of continuous mist without frequent refills. I've noticed a significant improvement in overall comfort since I started using it. If you're considering getting a humidifier, I highly recommend this humidifier. It delivers excellent performance and has quickly become an essential part of my home. Truly a five-star product!!!" — WaltM 3. Dreo smart bedroom humidifier Amazon Clocking in at just under $50, this Dreo smart humidifier gives you plenty of bells and whistles at the best price. It's a smart humidifier that you can control and adjust via the app on your phone or with voice control with Alexa or Google Assistant. The 4-liter tank can run up to 32 hours with a night-light feature to boot. Promising review:"I have this in multiple rooms and love them! They are reasonable priced and have lasted me years!! Super quite. Easy to maintain and clean. The perfect amount of mist and I love how I can control everything with my phone! With a wood burner in the house, these are a must! Super quiet as well!" — erika Get it from Amazon for $48.44+ (available in five colors). 4. Levoit 4.5 liter warm and cool humidifier Amazon Known for its home appliances, Levoit makes quality air purifiers, fans and of course, humidifiers. This superstar option has nearly every feature you could want from smart control via the Levoit app, from essential oil diffusing to warm and cool mist options. The handy top-fill design lets you easily fill the 4.5-liter tank and use the auto mode to set your space to your preferred humidity level automatically. Promising review: "This humidifier works quietly and efficiently. It features an auto mode that stops operation once the set humidity level is reached. You can also choose warm mist if desired. By installing the app, you can access more detailed settings, and the app installation process is quick and straightforward. Cleaning is also convenient. Overall, I highly recommend it. It definitely deserves a high rating." — Angela 5. Frida Baby 3-in-1 cool mist humidifier with diffuser and color changing nightlight Amazon A humidifier, diffuser and night-light make this baby-friendly device a great addition to any nursery or kid's room. The single knob is easy to control, with a half-gallon tank that can run up to 24 hours covering up to 320 square feet. The color-changing night-light brings a soothing energy to a space and the auto-stop feature gives you extra peace of mind. Promising review:"I love this in my nursery. It has been super helpful when my baby is congested. You can control the steam. There is a night-light on it that you can use or not. You can adjust the direction you would like that steam to go. The humidifier is super quiet along with easy to clean." — Abigail Vandeventer 6. Levoit 3 liter humidifier with oil diffuser Amazon Another Levoit option, reviewers praise this model for being a simple, straightforward humidifier that's easy to use, easy to sleep with, and super quiet. The 3-liter tank works for 25 hours, covering up to 290 square feet. Add a drop of your favorite essential to the bottom for a peaceful aroma. Promising review: "This humidifier is fantastic. It has a knob to control the amount of humidity it releases. It is very easy to put together and use. With a wider opening cleaning it is a breeze." — Lis Get it from Amazon for $43.99 (available in two colors). 7. Afloia 2-in-1 air purifier and humidifier Amazon Looking to consolidate home appliances? This option from Afloia gives you an air purifier with a detachable humidifier. The air purifier has three stages of filtration that clean air up to five times an hour in rooms up to 438 square feet, while the humidifier holds a half-gallon of water and can work continuously with the purifier for 12 hours. Promising review:"I love this Afloia HEPA Air Purifier with Humidifier! Our house is super dry because of winter and having the heat on all the time! Was looking at getting a purifier and humidifier and found this during my search and it's amazing. Super quiet and we have it in our living room and already notice a huge difference with the air quality." — Misha Stange 8. Amazon At first glance, this option may look more like a storage container or ottoman than a humidifier. Yet, from the brand Carepod, this TikTok-loved cube-shaped humidifier offers cool and warm mist with a 4.2-liter tank. Easily break it down into three parts (that are all easy to clean), with an automatic shut-off when the water is low. Promising review:"This humidifier is the best! Firstly, it is easy to clean with only three parts to wash, making maintenance a breeze. Additionally, it is dishwasher safe for added convenience. Secondly, the warm mist it emits is incredibly beneficial during the winter nights, unlike most other humidifiers that tend to circulate cool air, leading to increased heating costs. Lastly, its sleek design makes it a stylish addition to any room in your house, instantly enhancing the decor while serving its purpose effectively." — Gaheon Kim 9. CVS Holding 33 ounces, this portable humidifier is smaller than a Stanley 40-ounce cup and can run up to four hours between fills. It has an easy timer setting with an automatic shut-off with four mist settings. Great for traveling, small spaces or folks that need a lightweight, easy-to-move option. Promising review:"Bought this for my mother in law to have in her assisted living apt. It's just the right size, and easy for her to handle and refill." — Doretta Get it from CVS for $29.99. A bedside option from a smaller brand 10. Canopy bedside humidifier 2.0 Created to inhibit mold with parts that can go in the dishwasher, this option from Canopy sells itself. The 2.5-liter tank can run up to 36 hours and is suited for rooms up to 500 square feet. It has a special filtration system to deter mold buildup, a warm reading light, a white noise machine and an aroma diffuser all in one. The perfect bedsi de companion, this baby will earn its spot on your nightstand. Find it in a bunch of cute colors, too. Promising review:"We are so happy with this! We live in VT and rely on wood stove heat all winter. Using other brand machines we are refilling every 6-8 hours of use. This one, on highest level, lasts at least 12-15 hours. We love that it doesn't spew a thick cloud and still is noticeably different in our living and dining room, both. Worth the money for that, the easy to clean tank (why is that not the standard ?!?) and the time it lasts on." — kassandra S. 11. Amazon While proper humidity is the goal, Brown says you want to be sure not to overdo it, as over-humidifying a space can actually make it harder to breathe and can encourage mold to grow. Per the EPA, you want the humidity level in your home to be ideally around 30-50%. How the heck can you tell if you've achieved that? A hygrometer is basically a thermometer for humility and tells you the percentage. This highly-rated option also gives you the temperature of your home, allowing you to really be in tune with what's happening. While some of the fancier models on our list have humidity sensors built-in, this is a great add-on if you're buying a budget model with fewer features, and you can use it in your home year-round.
