Latest news with #Angelini
Yahoo
14-05-2025
- Business
- Yahoo
Angelini Ventures Invests into $39 Million Series A Extension Round for Therini Bio, a Clinical Stage Company Developing Fibrin-targeting Immunotherapies for Neurodegenerative Diseases
Angelini Ventures joins top-tier investor syndicate Investment will fund Phase 1b studies evaluating Therini Bio's lead candidate, THN391, for the treatment of Alzheimer's Disease (AD) and Diabetic Macular Edema (DME), as well as support development of a fibrin/VEGF bispecific Investment demonstrates Angelini's continued strategic focus in neurodegenerative disease Rome, Italy, 14 May 2025 – Angelini Ventures, the corporate venture firm of Angelini Industries focused on investing in companies developing innovative solutions in BioTech and Digital Health, today announces its participation in a $39 million extension of the Series A financing round for Therini Bio, a US-based clinical-stage biotech company developing fibrin-targeting immunotherapies for neurodegenerative diseases driven by vascular dysfunction. Angelini Ventures joins a syndicate of top-tier international healthcare investors in Therini Bio, including new investor Apollo Health Ventures and existing investors SV Health Investors' Biotech Fund and the Dementia Discovery Fund, Dolby Family Ventures, Eli Lilly and Company, Foundation for a Better World, MRL Ventures Fund and Sanofi Ventures. This latest close brings the total raised by Therini Bio, in its Series A round – first announced in April 2023 – to $75 million. This investment builds on Angelini Ventures' expertise in neurodegeneration, following its recent investments in Neumirna Therapeutics and Arclight Therapeutics. The funds raised by Therini Bio through its extended Series A financing will enable the company to advance Phase 1b studies evaluating its lead candidate, THN391, a potential first-in-class monoclonal antibody designed to selectively block fibrin-mediated neuroinflammation, for the treatment of Alzheimer's Disease (AD) and Diabetic Macular Edema (DME), as well as support development of a fibrin/VEGF bispecific. Thomas Thestrup, Ph.D., Senior Principal at Angelini Ventures and deal lead, said 'We are proud to support Therini Bio's mission to address the underlying vascular and inflammatory drivers of neurodegenerative disease through a truly novel approach. As an active investor in companies developing next-generation treatments for neurodegenerative and other CNS disorders, we are excited about Therini Bio's first-in-class selective antibody therapy targeting fibrin-mediated inflammation, offering a groundbreaking path to transform the treatment of diseases such as Alzheimer's and Diabetic Macular Edema.' Fabrizio Calisti, M.D., Medical Director at Angelini Ventures, will join Therini Bio's Board of Directors as a Board Observer. Tara Nickerson, Ph.D., Chief Executive Officer of Therini Bio, said 'We are deeply grateful to partner with such a distinguished investor group, both new and old. Their support enables us to significantly advance our shared vision of delivering patients a rational, innovative approach to potentially treat their debilitating conditions, including AD and DME. We look forward to advancing the Phase 1b trials to demonstrate the benefit of this novel mechanism in patients.' Notes to EditorsAbout Angelini Ventures Angelini Ventures, the venture capital arm of Angelini Industries, is a Series A and Series B investment firm focused on accelerating disruptive innovations and trends in BioTech and Digital Health. Angelini Ventures will invest €300 million across a global portfolio in Europe and North America, drawing on a global team, strategic advisors and partners to help entrepreneurs scale their businesses into transformative category-leading companies. To date, Angelini Ventures has invested around €100 million into 18 companies covering a range of therapeutic areas and modalities. Angelini Ventures' BioTech portfolio includes Nuevocor, Neumirna, Cour Pharmaceuticals, Nouscom, Pretzel Therapeutics and Freya Biosciences. The Company's Digital Health portfolio includes Vantis Health, Avation, Cadence Neuroscience, Nobi, Noctrix and Serenis. About Angelini Industries Angelini Industries is a multinational industrial group founded in Ancona in 1919 by Francesco Angelini. Today, Angelini Industries represents a solid and diversified industrial reality that employs approximately 5,800 employees and operates in 21 countries around the world with revenues of over two billion euros, generated in the health, industrial technology and consumer goods sectors. A targeted investment strategy for growth, constant commitment to research and development, deep knowledge of markets and business sectors, make Angelini Industries one of the Italian companies of excellence in the sectors in which it About Therini Bio Therini Bio is a clinical-stage biotech company developing immunotherapies for neuroinflammation in diseases driven by vascular dysfunction. Therini is developing a pipeline of potential first-in-class therapies selectively targeting toxic fibrin accumulation for diseases, including Alzheimer's disease and Diabetic Macular Edema, where destructive neuroinflammation plays a central role in the disease process. Therini Bio's top-tier syndicate of life sciences investors includes the Alzheimer's Drug Discovery Foundation, Angelini Ventures, Apollo Health Ventures, SV Health Investors' Biotech Fund and Dementia Discovery Fund, Dolby Family Ventures, Dreavent Biotech Investments, Eli Lilly and Company, Foundation for a Better World, MRL Ventures Fund, the therapeutics-focused corporate venture fund of Merck & Co., Inc., and Sanofi Ventures. For more information, visit ContactsAngelini VenturesMartina Palmese, Communications Media contacts for Italy - SEC Newgate ItaliaDaniele Pinosa, Tel. +39 3357233872Fausta Tagliarini; Tel. +39 3476474513Daniele Murgia; Tel. +39 3384330031 Media contacts outside Italy - MEDiSTRAVA Sylvie Berrebi, Sandi Greenwood, Mark Swallowangeliniventures@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
BBC News
12-04-2025
- Health
- BBC News
Award for heart surgeon who created sewing machine-inspired device
A surgeon who was inspired by his aunt's sewing machine to invent a pioneering heart surgery device has been given an Gianni Angelini, a surgeon at the Bristol Royal Infirmary, was one of many surgeons faced with the problem of being unable to stitch a moving heart during coronary artery while visiting his family in Italy in the 1990s, he watched his aunt use a sewing machine to stitch a pair of his trousers - and was inspired to create a stabilising surgical has now been honoured with a Lifetime Achievement Award from the International Society for Coronary Artery Surgery for his work on The Angelini articulated stabiliser. "I was visiting the family," said Prof Angelini. "I'd just bought a pair of trousers which needed to be shortened."My aunty, a seamstress, was doing the job. And suddenly, I saw the foot of the sewing machine which was pressing against the trousers."And I realised then, I needed something like that."Prof Angelini and his team at the Bristol Heart Institute then pioneered a new technique to perform coronary artery bypass surgery on a beating heart using his enables operations to take place without having to slow the patient's heart down, which improves how the heart is protected and increases the chances of survival for this, a bypass machine had to be used to pump blood around the patient so the heart could remain still and be operated on – a procedure which can come with complications. Prof Angelini designed the stabiliser device and devoted two years of his career to its development. The device was made of stainless steel and cost about £800, but it could be reused hundreds of disposable stabilisers are more commercially available, prototypes like Prof Angelini's stabiliser have paved the way for modern-day inventions. He said: "When I started my training in the early 1980s, the mortality for coronary artery bypass surgery was around 15% to 20%; now it is down to 1% to 2%."In 2024, Prof Angelini was named as one of the Seven Wise Cardiac Surgeons of the Golden Age of the 1990s, a reference to the Ancient Greek tradition of naming the seven wisest men. Prof Angelini said he was honoured alongside some of his heroes at the Old Greek Parliament."It was very exciting, because the other six people were what I'd describe as my heroes," he said."I was really the baby of the bunch because these guys were the generation before mine."I felt pleased with this as a recognition from my peers and to be in the presence of such distinguished surgeons."
Reuters
01-04-2025
- Business
- Reuters
Angelini Pharma still keen on deals after failed Recordati bid
MILAN, April 1 (Reuters) - Italian drugmaker Angelini Pharma is keen on M&A, even after its offer to buy bigger rival Recordati ( opens new tab fell through despite having the support of potential financial partners, its Chief Executive Sergio Marullo di Condojanni said on Tuesday Media speculation over Recordati's future rose in the second half of last year, after majority shareholder CVC Capital Partners ( opens new tab hired investment banks JP Morgan and Goldman Sachs to explore options for the drugmaker. Keep up with the latest medical breakthroughs and healthcare trends with the Reuters Health Rounds newsletter. Sign up here. Some reports named Angelini Pharma as a potential buyer of CVC's 51.8% stake in Recordati, but the private equity firm in January said had not had talks with Angelini's managers or shareholders and did not foresee any. "It would have been a very big operation for us, as Recordati has a market cap of over 10 billion euros ($10.78 billion). There was a lot of interest from financial partners with whom we could have bought a controlling stake," Marullo di Condojanni said on the sidelines of conference in Milan. From Angelini's point of view, the offer was "very convincing," he said. "Perhaps we could have let it go earlier but we were very persistent," he added. Marullo di Condojanni said his group was still interested in M&A deals in Italy, where he said small, profitable players had no incentive to grow, meaning there was a lack of companies of sufficient scale to invest in innovation. ($1 = 0.9273 euros)
Yahoo
24-03-2025
- General
- Yahoo
She's been named CT's ‘Outstanding Young Farmer.' She hopes to inspire more women to choose agriculture
Allyson Angelini grew up in Ledyard and has run Full Heart Farm in her hometown since 2012. Recently, the 37-year-old received statewide recognition when she was named Connecticut's 2025 Outstanding Young Farmer during Ag Day at the State Capitol. 'I'm most excited about this award mostly because I hope it encourages other first-generation, young farmers out there. It shows that there is a path toward making a living in Connecticut on a small-scale farm,' Angelini said. Angelini said the most meaningful part of receiving the award came after the ceremony. 'A very young farmer came up and introduced herself and shyly said, 'So, you, like, did it?'' Angelini said. 'I was able to just stand there and honestly answer, 'Yes.' So even if I am not feeling particularly outstanding, I think it's pretty great for young female farmers to see that it's 100% possible to start their own farm.' Angelini said she is proud of the 'girl power' aspect of winning the award. 'Women in agriculture play a crucial role and whenever there is a woman recognized in agriculture, I will always do a happy dance,' she said. According to the 2022 Census of Agriculture from the U.S. Department of Agriculture's National Agricultural Statistics Service, 32% of the state farms were new and beginning farms, which means they have had less than 10 years of production history, and 41% of those are led by women producers. Angelini was nominated for the award by Amanda Fargo-Johnson, the Connecticut Resource Conservation & Development's agricultural programs director. 'This is a great honor that the CT Department of Agriculture awards each year in partnership with the Connecticut Agricultural Information Council as a way to highlight the importance of young people entering the agriculture industry in the state,' Fargo-Johnson said. 'This award is a testament to the long days of work and planning it takes to operate a farm full time in a state where its expensive to access land and compete in the market with high labor and energy costs. Allyson being recognized will bring awareness to the importance small scale farms have in the state as well as the ability for young and female farmers to know it can be achieved.' Fargo-Johnson believes that Angelini is a strong candidate for the national award. The 10 finalists will be selected in early September and will be honored at the Outstanding Farmers of American Convention next February. 'What makes Allyson such a great example is that even though she's been farming for 14 years she started on her own at the very young age of 24 years old. She's a great role model to girls looking to pursue a career in agriculture,' Fargo-Johnson said. Angelini is a Ledyard High School graduate. She attended University of Massachusetts Amherst to study journalism with the hopes of being layout editor for a food magazine. She said she soon discovered her true passion turned to small-scale farming. She switched her major to sustainable agriculture and, as a junior, studied abroad in Tuscany, Italy working on a 1,500-acre organic farm. 'That was the first time I lived and worked on a farm, and I loved it,' Angelini said. Angelini interned and worked at several farms in her early 20s. She worked at dairy farms, Christmas tree farms, berry farms and others. At 23 years old, she applied for the USDA's Beginning Farmer and Rancher Development Program in order to qualify for a grant to buy farmland. Just 10 months later, Angelini was able to work on her own farm. 'It was a tiny piece of land and wasn't really a farm. It wasn't in good condition. But I closed on the property when I was 24 and single,' Angelini said. 'I worked 20 hours a day fixing up the house and clearing the land.' Now, Angelini is married and has four children with her husband, Keith: Henry 11, Cora 9, Sadie 7 and Lila 3. She said Full Heart Farm, located on 193 Iron St. in Ledyard, is a family-first farm. 'That means the kids always come first,' Angelini said. 'People who work for me, their families come first. Setting boundaries with the farm were important. It will suck every bit of energy out of you. We are happy with our work, and we produce so many beautiful things.' The property is 6¼ acres and the family grows on less than two acres. They have no full-time employees but have a rotation of four to six part-time workers. Full Heart Farm produces 300 different varieties of vegetables and cut flowers. 'Most people know if they are looking for something unusual to come here. We grow a lot of carrots of many different colors,' Angelini said. 'We've been selling more carrots to schools in an effort to improve access to healthy food at lunch. We also grow 40 different types of tomatoes and 16 different types of radicchios.' Among the most popular flowers are ranunculus and peonies as well as 3,000 dahlia plants in rainbow varieties. The farm primarily sells its product through a farm-share program but will open in the spring for Mother's Day and Easter flower sales. 'We are bracing ourselves for whatever climate-related weather challenges we will have this year,' Angelini said. 'It's difficult to predict and unrelenting. Small farms have been struggling with the loss of federal funding from so many directions this winter. In some ways we haven't stabilized our markets since the pandemic. Things feel erratic like they did in 2021. It's strange to feel you are outstanding but it's hard to feel outstanding when you are struggling in so many things.' She said it's been harder to plan for the weather as the years have gone by. 'We used to have a plan and for the most part everything went according to plan, and it was relatively easy to predict,' Angelini said. 'Then we experience extended dry periods followed by flooding. It makes it difficult to manage a farm. …Just Sunday night we had three and a half inches of rain. It's a month's worth of rain in one fell swoop. The ground is still frozen and there's nowhere for the water to go. 'For someone who loves statistics and planning, you can make a great decision, but nature always reminds us to stay humble,' she added. In addition to farming, Angelini does outreach with schools, libraries and colleges and had taught with the Cornell Small Farms Program for over a decade. 'My daily work is growing food, but my big-picture work is educating people about small-scale farming and honoring agriculture and why it's so important,' Angelini said.
